Disposable biological reaction membrane

Abstract

The utility model discloses a disposable biological reaction membrane, which relates to the technical field of biological reaction membranes and comprises a membrane body with six layers. The thickness of the substrate is 100 [mu] m; wherein the top layer is a contact layer; the contact layer is made of ultra-low density polyethylene; the bottom of the contact layer and the waterproof layer are integrally arranged through the second nylon layer. The side, away from the second nylon layer, of the waterproof layer and the blocking layer are integrally arranged. One side far away from the waterproof layer is integrated with the bottom layer through a first nylon layer; by controlling the thickness of the membrane body, extractable substances and immersions in the membrane body are effectively reduced when organisms react, so that the stability of the organisms when the organisms react on the reaction membrane is effectively ensured, and external substances entering a biological reaction system are effectively avoided through the barrier layer and the waterproof layer.

Description

TECHNICAL FIELD

[0001] The utility model relates to biological reaction membrane technical field, specifically one -time biological reaction is used membrane. BACKGROUND

[0002] The one-time biological reaction membrane is a kind of disposable consumables used in biological reaction process;The reaction membrane has good biocompatibility, does not interfere with the biological reaction in the process, high permeability, can effectively realize the nutrition position required by biological reaction to pass smoothly, ensure the smooth progress of reaction, one-time use, effectively avoid cross contamination, effectively guarantee the safety and reliability of biological reaction;Effectively guarantee the accuracy of experimental data;

[0003] Now the traditional reaction membrane has higher requirement to the use scene of reaction membrane when using, so that the reaction membrane is influenced by external environment, and biological reaction cannot proceed smoothly, which can interfere with biological reaction, and cannot effectively guarantee the structure of biological reaction.

[0004] Through the retrieval, Chinese patent publication No.CN202322554780.1 discloses a high-barrier multilayer composite film for disposable bioreactor;Including heat-seal friction-resistant layer, polarity group separation layer and internal culture solution contact layer arranged from top to bottom, the heat-seal friction-resistant layer and the polarity group separation layer are connected with upper support layer, the upper support layer is integrally bonded with the heat-seal friction-resistant layer and the polarity group separation layer by a compatible agent, the polarity group separation layer and the internal culture solution contact layer are connected with lower support layer, the lower support layer is integrally bonded with the polarity group separation layer by a compatible agent, the multilayer composite film is prepared by continuous eleven-layer co-extrusion casting method;

[0005] The reaction membrane in the above patent has more layers, which can affect the transparency of the reaction membrane when using, and the more layers, the more extractables and immersives in each layer of material, which can affect the reaction of reactants. UTILITY MODEL CONTENT

[0006] The utility model aims at providing a kind of one-time biological reaction membrane, in the structure, the thickness of membrane body is 100 μm, effectively guaranteeing transparency, avoiding the situation that biological reaction leaks by barrier layer and waterproof layer, effectively strengthening the friction resistance and fatigue resistance of bottom layer and contact layer by two nylon layers, effectively guaranteeing the support of biological reaction, the thickness of membrane body is strictly controlled each time, effectively reduce the number of extractables and immersives, avoid the interference of biological reaction, to solve the problems of the above background technique.

[0007] To achieve the above object, the utility model provides the following technical scheme:

[0008] A disposable biological reaction membrane, comprising a membrane body, the membrane body has six layers, the thickness is 100um, wherein the top is a contact layer, the contact layer is made of ultralow density polyethylene, the bottom of the contact layer is integrally arranged with a waterproof layer through a second nylon layer, the waterproof layer is integrally arranged with a barrier layer on the side away from the second nylon layer, and the side away from the waterproof layer is integrally arranged with a bottom layer through a first nylon layer.

[0009] As a further technical scheme of the utility model, the contact layer is made of ultralow density polyethylene, and the thickness is 20um; the contact layer is integrally arranged with the second nylon layer, effectively enhancing the friction resistance and biocompatibility of the contact layer.

[0010] As a further technical scheme of the utility model, the barrier layer is made of ethylene-vinyl alcohol copolymer, and the thickness is 15um; the barrier layer effectively enhances the gas barrier function, prevents unwanted substances from entering the reaction system, and avoids affecting the quality of biological reaction.

[0011] As a further technical scheme of the utility model, the waterproof layer is made of polyethylene material, and the thickness is 15um; effectively avoiding the leakage of nutrient solution, oxygen or metabolic products during the reaction of the organism; ensuring the stability of the biological reaction.

[0012] As a further technical scheme of the utility model, the sum of the thicknesses of the first nylon layer and the second nylon layer is 20um; enhancing the bending resistance and puncture resistance of the membrane body.

[0013] As a further technical scheme of the utility model, the bottom layer is made of linear low density polyethylene, and the thickness is 30um; the bottom layer is the thickest, effectively ensuring the friction resistance of the bottom layer during use, and avoiding damage to the bottom layer during use.

[0014] Compared with the prior art, the utility model has the beneficial effects that:

[0015] 1. The utility model effectively reduces the extractables and immersives in the membrane body during the reaction of the organism, thereby effectively ensuring the stability of the reaction of the organism on the reaction membrane, and effectively avoiding external substances from entering the biological reaction system through the barrier layer and the waterproof layer. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 It is the three-dimensional structure schematic diagram of the utility model.

[0017] Figure 2This utility model Figure 1 A breakdown diagram.

[0018] Figure 3 This utility model Figure 3 A schematic diagram of the bottom structure.

[0019] In the diagram: 1-bottom layer, 2-first nylon layer, 3-barrier layer, 4-waterproof layer, 5-second nylon layer, 6-contact layer. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] Please see Figures 1-3 In this embodiment of the present invention, a disposable bioreactor membrane is provided, comprising a membrane body having six layers with a thickness of 100 μm; the top layer is a contact layer 6 made of ultra-low density polyethylene; the bottom of the contact layer 6 is integrally formed with a waterproof layer 4 via a second nylon layer 5; the side of the waterproof layer 4 away from the second nylon layer 5 is integrally formed with a barrier layer 3; the side of the waterproof layer 4 away from the waterproof layer 4 is integrally formed with a bottom layer 1 via a first nylon layer 2.

[0022] The contact layer 6 is made of ultra-low density polyethylene with a thickness of 20 μm;

[0023] The barrier layer 3 is made of ethylene-vinyl alcohol copolymer and has a thickness of 15 μm;

[0024] By adopting the above technical solution and controlling the thickness of the membrane body, the amount of extractable and infiltrated substances inside the membrane body is effectively reduced during biological reaction, thereby effectively ensuring the stability of biological reaction on the reaction membrane. The barrier layer and waterproof layer effectively prevent external substances from entering the biological reaction system.

[0025] In this embodiment, the waterproof layer 4 is made of polyethylene material and has a thickness of 15μm;

[0026] The sum of the thicknesses of the first nylon layer 2 and the second nylon layer 5 is 20 μm;

[0027] The bottom layer 1 is made of linear low-density polyethylene with a thickness of 30 μm;

[0028] By adopting the above technical solution, the reaction membrane can be effectively guaranteed to have good abrasion resistance during use. By controlling the thickness of each layer, the transparency during biological reactions can be effectively guaranteed, making it easy to observe.

[0029] The working principle of this invention is as follows: by controlling the thickness of the membrane body, the amount of extractable and infiltrated substances inside the membrane body is reduced during biological reaction, thereby effectively ensuring the stability of biological reaction on the membrane. The barrier layer and waterproof layer effectively prevent external substances from entering the biological reaction system.

[0030] This effectively ensures that the reaction membrane has good abrasion resistance during use, and by controlling the thickness of each layer, it effectively ensures transparency during biological reactions, making it easy to observe.

[0031] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0032] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A disposable bioreactor membrane, characterized in that: The membrane body has six layers with a thickness of 100 μm. The top layer is a contact layer (6) made of ultra-low density polyethylene. The bottom of the contact layer (6) is integrally formed with the waterproof layer (4) through a second nylon layer (5). The side of the waterproof layer (4) away from the second nylon layer (5) is integrally formed with the barrier layer (3). The side away from the waterproof layer (4) is integrally formed with the bottom layer (1) through a first nylon layer (2).

2. The disposable bioreactor membrane according to claim 1, characterized in that: The contact layer (6) is made of ultra-low density polyethylene with a thickness of 20 μm.

3. The disposable bioreactor membrane according to claim 1, characterized in that: The barrier layer (3) is made of ethylene-vinyl alcohol copolymer and has a thickness of 15 μm.

4. The disposable bioreactor membrane according to claim 1, characterized in that: The waterproof layer (4) is made of polyethylene material and has a thickness of 15 μm.

5. The disposable bioreactor membrane according to claim 1, characterized in that: The sum of the thicknesses of the first nylon layer (2) and the second nylon layer (5) is 20 μm.

6. The disposable bioreactor membrane according to claim 1, characterized in that: The bottom layer (1) is made of linear low-density polyethylene with a thickness of 30 μm.

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