Injection preparation device
By designing a series αβ valve and stirring mechanism, combined with nitrogen filling and weighing device monitoring, the problem of uneven mixing of the injection was solved, achieving uniform mixing of the injection and stability of its efficacy.
Patent Information
- Application Number
- CN202520355251.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-03
- Publication Date
- 2026-02-06
- Estimated Expiration
- 2035-03-03
AI Technical Summary
In existing technologies, it is difficult to guarantee the uniformity of injections, especially when the ratio of active pharmaceutical ingredients is uneven, which affects the efficacy of the drug.
The first αβ valve in series controls the amount of material input to the mixing tank from the two batching tanks, and the stirring mechanism and nitrogen aeration system ensure that the material is fully mixed in an oxygen-free environment. The material quality is monitored by a weighing device, and the mixing uniformity is improved by using multiple rotating shafts and a dispersing disc.
This process ensures uniform mixing of the injection, guarantees the accuracy of the active pharmaceutical ingredient ratio and the stability of the efficacy, and improves the overall quality of the injection.
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Figure CN223874845U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to chemical preparation field, especially injectant preparation device. BACKGROUND
[0002] The injectant generally includes main medicine, solvent and additional agent component, the solvent can be good at dissolving medicine component, the osmotic pressure regulator can also provide energy for human body except for the effect of maintaining human body cell osmotic pressure. Such as the application number for CN201510757194.4 invention patent discloses a preparation method, the preparation method needs fixed proportion main medicine and solvent to prepare injectant, how to ensure that main medicine proportion is the key point and key. SUMMARY
[0003] The utility model discloses at least one of the technical problems in the prior art. To this end, the utility model provides an injectant preparation device, which can improve the uniformity of the injectant.
[0004] The injectant preparation device according to the first aspect of the utility model, comprising:
[0005] The ingredient tank is provided with two, and the upper end of the ingredient tank is provided with an ingredient feeding pipe, and the lower end is provided with an ingredient discharging pipe;
[0006] The liquid preparation tank is internally provided with a stirring mechanism, and the top of the liquid preparation tank is provided with an auxiliary material feeding pipe and a mixing feeding pipe; the bottom of the liquid preparation tank is provided with a mixing discharging pipe;
[0007] The mixing tank is provided with two first feeding ports and one discharging port, wherein the two first feeding ports are connected with the two ingredient discharging pipes respectively, and the discharging port is connected with the mixing feeding pipe;
[0008] The ingredient discharging pipe is provided with a first alpha beta valve, and the two first alpha beta valves are connected in series to synchronize the on-off of the two first alpha beta valves.
[0009] The injectant preparation device according to the utility model has the following beneficial effects: the series-connected first alpha beta valves can control the material quantity of the two ingredient tanks input into the mixing tank, ensure that different substances in the two ingredient tanks can be mixed in equal proportions, and improve the uniformity of the injectant.
[0010] According to some embodiments of the utility model, the mixing tank is internally provided with a first weighing device, and the first weighing device is electrically connected with the two first alpha beta valves to control the on-off of the two first alpha beta valves.
[0011] According to some embodiments of the present application, the mixing tank is provided with a second feeding port, and the bottom of the liquid preparation tank is provided with an auxiliary material discharging pipe.
[0012] According to some embodiments of the present application, the ingredient feeding pipe is provided with a second alpha-beta valve, and the ingredient tank is internally provided with a second weighing device, and the second weighing device is electrically connected with the second alpha-beta valve to control the on-off of the second alpha-beta valve.
[0013] According to some embodiments of the present application, the mixing feeding pipe is provided with a third alpha-beta valve.
[0014] According to some embodiments of the present application, further comprising a nitrogen tank, wherein,
[0015] The top sidewall of the ingredient tank is provided with a first exhaust pipe, and the bottom sidewall of the ingredient tank is provided with a first air inlet;
[0016] The top sidewall of the liquid preparation tank is provided with a second exhaust pipe, and the bottom sidewall of the ingredient tank is provided with a second air inlet;
[0017] The top sidewall of the mixing tank is provided with a third exhaust pipe, and the bottom sidewall of the mixing tank is provided with a third air inlet;
[0018] The nitrogen tank is provided with a gas supply port, a first nitrogen pipe is connected between the gas supply port and the first air inlet, and the first nitrogen pipe is provided with a first one-way valve; a second nitrogen pipe is connected between the gas supply port and the second air inlet, and the second nitrogen pipe is provided with a second one-way valve; and a third nitrogen pipe is connected between the gas supply port and the third air inlet, and the third nitrogen pipe is provided with a third one-way valve.
[0019] According to some embodiments of the present application, the sidewall of the liquid preparation tank is provided with a constant volume pipe, the constant volume pipe is connected with a low-oxygen water tank, and the constant volume pipe is provided with a fourth alpha-beta valve.
[0020] According to some embodiments of the present application, the stirring mechanism comprises:
[0021] A first rotating shaft is rotatably inserted into the middle part of the liquid preparation tank, and the first rotating shaft is connected with a first driving motor;
[0022] A first stirring paddle is fixedly connected to the end of the first rotating shaft extending into the inside of the liquid preparation tank, and the first stirring paddle is in an anchor shape.
[0023] A second stirring paddle is fixedly connected to the shaft body of the first rotating shaft, and the second stirring paddle extends outward and downward from the shaft body of the first rotating shaft.
[0024] According to some embodiments of the utility model, still include a plurality of second rotation axis, the second rotation axis rotatablely install in the liquid preparation tank, a plurality of the second rotation axis around the first rotation axis ring around setting, the axle body of second rotation axis is fixedly connected with a plurality of dispersion disc, second rotation axis is connected with second drive motor.
[0025] According to some embodiments of the utility model, the edge of dispersion disc is provided with a plurality of arc convex.
[0026] The additional aspects and advantages of the utility model will be partly given in the following description, some will become obvious from the following description, or be understood by the practice of the utility model. BRIEF DESCRIPTION OF DRAWINGS
[0027] The utility model will be further explained in combination with the drawings and examples, wherein:
[0028] Figure 1 It is the schematic diagram of injection preparation device of the utility model embodiment;
[0029] Figure 2 It is the schematic diagram of stirring mechanism of injection preparation device of the utility model embodiment;
[0030] Figure 3 It is the schematic diagram of second stirring paddle of injection preparation device of the utility model embodiment;
[0031] Figure 4 It is the schematic diagram of dispersion disc of injection preparation device of the utility model embodiment.
[0032] 100, ingredient tank;110, ingredient feed pipe;111, second αβ valve;120, ingredient discharge pipe;121, first αβ valve;130, first exhaust pipe;140, first air inlet;150, second weigher;
[0033] 200, liquid preparation tank;210, auxiliary material feed pipe;220, mixing material feed pipe;221, third αβ valve;230, mixing material discharge pipe;240, auxiliary material discharge pipe;260, second exhaust pipe;270, second air inlet;280, constant volume pipe;281, fourth αβ valve;
[0034] 300, mixing tank;310, first feed port;320, discharge port;330, first weigher;340, second feed port;350, third exhaust pipe;360, third air inlet;
[0035] 400, stirring mechanism; 410, first rotating shaft; 411, first driving motor; 420, first stirring paddle; 430, second stirring paddle; 440, second rotating shaft; 441, dispersion disc; 4411, protrusion; 442, second driving motor;
[0036] 500, nitrogen tank; 510, gas supply port; 511, first nitrogen pipe; 5111, first one-way valve; 512, second nitrogen pipe; 5121, second one-way valve; 513, third nitrogen pipe; 5131, third one-way valve; DETAILED DESCRIPTION
[0037] The embodiments of the present application are described in detail below, and examples of the embodiments are shown in the drawings, wherein the same or similar notations represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary, and are only used to explain the present application, and cannot be understood as a limitation of the present application.
[0038] In the description of the present application, it is understood that, if the orientation description, such as up, down, front, back, left, right and the like, is described, the orientation or positional relationship shown in the drawings is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present application.
[0039] In the description of the present application, the meaning of several is one or more, the meaning of multiple is more than two, greater than, less than, more than and the like are not included in the number, above, below, within and the like are included in the number. If it is described as first, second, it is only used for the purpose of distinguishing technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features or the sequence of indicated technical features.
[0040] In the description of the present application, unless otherwise explicitly limited, the words such as setting, installing, connecting and the like should be broadly understood, and the skilled in the art can reasonably determine the specific meaning of the above words in the present application according to the specific content of the technical scheme.
[0041] Reference Figure 1The utility model discloses an injection preparation device, including batching tank 100, liquid preparation tank 200 and mixing tank 300, batching tank 100 is provided with two, and batching tank 100 upper end is provided with batching feed pipe 110, and lower end is provided with batching discharge pipe 120, liquid preparation tank 200 is built in stirring mechanism 400, and the top of liquid preparation tank 200 is provided with auxiliary material feed pipe 210 and mixing feed pipe 220, and the bottom of liquid preparation tank 200 is provided with mixing discharge pipe 230, mixing tank 300 is provided with two first feed port 310 and a discharge port 320, wherein two feed ports are connected with two batching discharge pipes 120 respectively, and the discharge port 320 is connected with mixing feed pipe 220, wherein, batching discharge pipe 120 is provided with first alpha beta valve 121, and two first alpha beta valves 121 are connected in series to make two first alpha beta valves 121 synchronous on-off.
[0042] In actual use, batching tank 100 inputs main material A and main material B into mixing tank 300 at constant ratio, and then inputs into liquid preparation tank 200, wherein, auxiliary material is pre-injected into liquid preparation tank 200, and is stirred and mixed by stirring mechanism 400, after uniform mixing, mixes with main material (A+B) injected by mixing tank 300, and is stirred uniformly by stirring mechanism 400, and finally, the first alpha beta valve 121 connected in series can control the material quantity of two batching tanks 100 input into mixing tank 300, to ensure that different substances in two batching tanks 100 can be mixed at equal ratio, and the uniformity of injection is improved.
[0043] Wherein, main material A is high-activity material, main material B is hydroxypropyl-beta-cyclodextrin, and auxiliary material is the mixture of sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, disodium edetate and the like.
[0044] Specifically, the first weighing apparatus 330 is built in mixing tank 300, and the first weighing apparatus 330 is electrically connected with the two first alpha beta valves 121 to control the on-off of the two first alpha beta valves 121. The first weighing apparatus 330 timely monitors the mass of main material (A+B) in mixing tank 300, and when the mass reaches the preset value of the system, the first weighing apparatus 330 synchronously controls the on-off of the two first alpha beta valves 121, to ensure that the mass of main material of injection prepared at a time is constant.
[0045] In some embodiments, the mixing tank 300 is provided with a second feed port 340, the bottom of the liquid preparation tank 200 is provided with an auxiliary material discharge pipe 240, and the second feed port 340 is connected with the auxiliary material discharge pipe 240. Before injecting main material A and main material B into the mixing tank 300, the auxiliary material is input through the auxiliary material discharge pipe 240 of the liquid preparation tank 200 to flush the mixing tank 300, and the internal space of the mixing tank 300 is soaked with the auxiliary material before mixing with the main material, which can improve the mixing degree of the injection.
[0046] Preferably, the ingredient feeding pipe 110 is provided with a second αβ valve 111, and the ingredient tank 100 is provided with a second weighing device 150, and the second weighing device 150 and the second αβ valve 111 are electrically connected to control the on-off of the second αβ valve 111. Referring to the above embodiment, the specific mass of the main material A or the main material B entering the ingredient tank 100 is controlled through timely monitoring of the second weighing device 150.
[0047] Further, the mixing feeding pipe 220 is provided with a third αβ valve 221 for controlling the mixing feeding pipe 220, and it is necessary to mention that the first αβ valve 121, the second αβ valve 111 and the third αβ valve 221 can all ensure the sealing effect in the transmission process.
[0048] In some specific embodiments, the injection preparation device further comprises a nitrogen tank 500, wherein,
[0049] The top side wall of the ingredient tank 100 is provided with a first exhaust pipe 130, and the bottom side wall of the ingredient tank 100 is provided with a first air inlet 140;
[0050] The top side wall of the ingredient tank 100 is provided with a first exhaust pipe 130, and the bottom side wall of the ingredient tank 100 is provided with a first air inlet 140;
[0051] The top side wall of the ingredient tank 100 is provided with a first exhaust pipe 130, and the bottom side wall of the ingredient tank 100 is provided with a first air inlet 140;
[0052] The nitrogen tank 500 is provided with a gas supply port 510, the gas supply port 510 and the first air inlet 140 are connected by a first nitrogen pipe 511, and the first nitrogen pipe 511 is provided with a first one-way valve 5111; the gas supply port 510 and the second air inlet 270 are connected by a second nitrogen pipe 512, and the second nitrogen pipe 512 is provided with a second one-way valve 5121; the gas supply port 510 and the third air inlet 360 are connected by a third nitrogen pipe 513, and the third nitrogen pipe 513 is provided with a third one-way valve 5131.
[0053] The ingredient tank 100, the ingredient tank 200 and the mixing tank 300 can be filled with nitrogen through the nitrogen pipe, so that the main material and the auxiliary material can be fully stirred and mixed in an oxygen-free space.
[0054] In some embodiments, the side wall of the ingredient tank 200 is provided with a constant volume pipe 280, the constant volume pipe 280 is connected with a low-oxygen water tank, and the constant volume pipe 280 is provided with a fourth αβ valve 281. The substances are filled in the whole to complete the processing of the whole injection under the premise that the total mass of the main material and the auxiliary material is guaranteed.
[0055] It is necessary to mention that, referring to the above embodiment, Figure 2, the stirring mechanism 400 comprises the liquid preparation tank 200, a first rotating shaft 410, a first stirring paddle 420 and a second stirring paddle 430; the first rotating shaft 410 is rotatably inserted into the middle part of the liquid preparation tank 200, and the first rotating shaft 410 is connected with a first driving motor 411; the first stirring paddle 420 is fixedly connected to the end of the end part of the first rotating shaft 410 extending into the inside of the liquid preparation tank 200, and the first stirring paddle 420 is in an anchor shape; Figure 2 , the first stirring paddle 420 is in an anchor shape; Figure 2 and Figure 3 the second stirring paddle 430 is fixedly connected to the shaft body of the first rotating shaft 410, and the second stirring paddle 430 extends outward and downward from the shaft body of the first rotating shaft 410.
[0056] In actual use, the liquid preparation tank 200 is used for carrying, the rotating shaft rotates under the driving of the first driving motor 411, and drives the first stirring paddle 420 and the second stirring paddle 430 fixed on the rotating shaft to rotate. In the process of rotation, the first stirring paddle 420 in an anchor shape drives the material in the inside of the liquid preparation tank 200 to have a spiral upward movement trend, and the second stirring paddle 430 drives the material in the inside of the liquid preparation tank 200 to have a spiral downward movement trend. Through the two opposite rotation trends of the material in the inside of the liquid preparation tank 200, the upward turbulent flow caused by the first stirring paddle 420 collides and mixes with the downward turbulent flow caused by the second stirring paddle 430, increases the collision and combination opportunities of the main material and the auxiliary material, and thus the materials in the two turbulent flows are more uniformly mixed together.
[0057] It is to be noted that Figure 2 the stirring mechanism 400 further comprises a plurality of second rotating shafts 440, the second rotating shafts 440 are rotatably inserted into the liquid preparation tank 200, the plurality of second rotating shafts 440 are arranged around the first rotating shaft 410, a plurality of dispersion discs 441 are fixedly connected to the shaft body of each second rotating shaft 440, and each second rotating shaft 440 is connected with a second driving motor 442. In the mixing process, the regular turbulent flow formed by the first stirring paddle 420 and the second stirring paddle 430 promotes the mutual collision and mixing of the main material and the auxiliary material, and relatively, the dispersion discs 441 fixed to the second rotating shafts 440 can scatter the main material and the auxiliary material in the turbulent flow in different directions, so that the main material and the auxiliary material irregularly shoot to different areas of the liquid preparation tank 200, and thus the whole material is further more uniformly mixed. In order to ensure that the main material and the auxiliary material in the turbulent flow are scattered to different areas of the liquid preparation tank 200, further, the rotating speed of the second driving motor 442 is greater than the rotating speed of the first driving motor 411.
[0058] In order to further make the material more uniformly mixed, it is to be noted that Figure 4The edge of the dispersion disc 441 is provided with a plurality of arc-shaped protrusions 4411, which can impact and disperse the liquid at high speed, so as to achieve the state of rapid mixing, dispersion and refinement, and improve the uniformity of mixing.
[0059] The above has made detailed description on the embodiments of the utility model in combination with the drawings, but the utility model is not limited to the above-mentioned embodiments, and various changes can be made within the knowledge range possessed by the ordinary skilled in the art without departing from the purpose of the utility model.
Claims
1. A device for preparing an injection, characterized in that it comprises: The utility model relates to a kind of automatic mixing system of liquid medicine, including: Ingredient tank (100) is provided with two, the upper end of the ingredient tank (100) is provided with ingredient feed pipe (110), and the lower end is provided with ingredient discharge pipe (120); Liquid preparation tank (200) is built-in with stirring mechanism (400), the top of the liquid preparation tank (200) is provided with auxiliary material feed pipe (210) and mixing feed pipe (220), and the bottom of the liquid preparation tank (200) is provided with mixing discharge pipe (230); Mixing tank (300) is provided with two first feed ports (310) and one discharge port (320), wherein two the first feed ports (310) are connected with two the ingredient discharge pipe (120) respectively, and the discharge port (320) is connected with the mixing feed pipe (220); Wherein, the ingredient discharge pipe (120) is provided with first alpha beta valve (121), and two the first alpha beta valve (121) are connected in series, to make two the first alpha beta valve (121) synchronous on-off.
2. The injection preparation device according to claim 1, characterized in that The mixing tank (300) is built-in with first weigher (330), and the first weigher (330) is electrically connected with two the first alpha beta valve (121), to control two the first alpha beta valve (121) on-off.
3. The injection preparation device according to claim 1, characterized in that The mixing tank (300) is provided with second feed port (340), the bottom of the liquid preparation tank (200) is provided with auxiliary material discharge pipe (240), and the second feed port (340) is connected with the auxiliary material discharge pipe (240).
4. The injection preparation device of claim 1, wherein, The ingredient feed pipe (110) is provided with second alpha beta valve (111), and the ingredient tank (100) is built-in with second weigher (150), and the second weigher (150) is electrically connected with the second alpha beta valve (111), to control the second alpha beta valve (111) on-off.
5. The injection preparation device of claim 1, wherein, The mixing feed pipe (220) is provided with third alpha beta valve (221).
6. The injection preparation device of claim 1, wherein, Also include nitrogen tank (500), wherein, The top side wall of the ingredient tank (100) is provided with first exhaust pipe (130), and the bottom side wall of the ingredient tank (100) is provided with first air inlet (140); The top side wall of the liquid preparation tank (200) is provided with second exhaust pipe (260), and the bottom side wall of the ingredient tank (100) is provided with second air inlet (270); The top side wall of the mixing tank (300) is provided with third exhaust pipe (350), and the bottom side wall of the mixing tank (300) is provided with third air inlet (360); The nitrogen tank (500) is provided with gas supply port (510), and the gas supply port (510) is connected with the first air inlet (140) between first nitrogen tube (511), and the first nitrogen tube (511) is provided with first check valve (5111);The gas supply port (510) and the second air inlet (270) are connected with second nitrogen tube (512), and the second nitrogen tube (512) is provided with second check valve (5121);The gas supply port (510) and the third air inlet (360) are connected with third nitrogen tube (513), and the third nitrogen tube (513) is provided with third check valve (5131).
7. The injection preparation device of claim 1, wherein, The side wall of the liquid preparation tank (200) is provided with a constant volume pipe (280), a low-oxygen water tank is connected to the constant volume pipe (280), and the constant volume pipe (280) is provided with a fourth alpha beta valve (281).
8. The injection preparation device of claim 1, wherein, The stirring mechanism (400) comprises: A first rotating shaft (410) is rotatably inserted into the middle part of the liquid preparation tank (200), and the first rotating shaft (410) is connected with a first driving motor (411); A first stirring paddle (420) is fixedly connected to the end of the end of the first rotating shaft (410) extending into the inside of the liquid preparation tank (200), and the first stirring paddle (420) is in an anchor shape; A second stirring paddle (430) is fixedly connected to the shaft body of the first rotating shaft (410), and the second stirring paddle (430) extends outward and downward from the shaft body of the first rotating shaft (410).
9. The injection preparation device according to claim 8, characterized in that A plurality of second rotating shafts (440) are rotatably inserted into the liquid preparation tank (200), and the plurality of second rotating shafts (440) are arranged around the first rotating shaft (410), the shaft body of the second rotating shaft (440) is fixedly connected with a plurality of dispersion discs (441), and the second rotating shaft (440) is connected with a second driving motor (442).
10. The injection preparation device according to claim 9, characterized in that The edge of the dispersion disc (441) is provided with a plurality of arc-shaped protrusions (4411).
Citation Information
Patent Citations
Injection solvent and preparation method and application thereof
CN105267143A