Purification column equipment for positron radiopharmaceutical purification

Abstract

The utility model discloses purification column equipment for positron radiopharmaceutical purification, which belongs to the technical field of pharmaceutical purification, and adopts the technical scheme that the purification column equipment comprises a column tube body, the bottom of the column tube body is fixedly connected with a supporting mechanism, and the surface of the supporting mechanism is connected with a splitting mechanism in a sliding manner; the top of the column pipe body is movably connected with a pipe cover, the top of the pipe cover is fixedly connected with a filling pipe, the bottom of the column pipe body is fixedly connected with a liquid outlet pipe, and a supporting mechanism limiting ring is fixedly connected to the bottom of the inner side of the column pipe body and provides a basic supporting point for the whole supporting structure. A limiting rod penetrates through a limiting block, is fixed at the top of a limiting ring and is matched with a sieve plate and a connecting hole in the limiting block, so that precise guidance is provided for sliding of the sieve plate, the sieve plate can only move in the direction of the limiting rod, and the separation efficiency is improved. The operation accuracy of the splitting mechanism is ensured, and the splitting mechanism is provided with three sieve plates.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of medicine purification technology, especially a kind of purification column equipment for positron radioactive medicine purification. BACKGROUND

[0002] A kind of purification column equipment for positron radioactive medicine purification is a columnar device integrated with multiple adsorption materials, mainly used to remove impurities in the crude product of positron radioactive medicine, adjust solution pH value, and finally obtain the radioactive medicine meeting the requirements of clinical injection.

[0003] For the above problems, the existing patent provides a solution, but the existing integrated purification column simplifies the steps, but the filler layer cannot be flexibly adjusted in sequence or proportion after being fixed, which makes it difficult to adapt to different drug characteristics, thereby reducing the purification efficiency and application range.

[0004] Therefore, a kind of purification column equipment for positron radioactive medicine purification is proposed. UTILITY MODEL CONTENT

[0005] The utility model aims to provide a kind of purification column equipment for positron radioactive medicine purification, which can solve the problem that the existing integrated purification column of existing drug purification simplifies the steps, but the filler layer cannot be flexibly adjusted in sequence or proportion after being fixed, which makes it difficult to adapt to different drug characteristics, thereby reducing the purification efficiency and application range.

[0006] To achieve the above object, the utility model provides the following technical scheme: a kind of purification column equipment for positron radioactive medicine purification, including column pipe body, the bottom of column pipe body is fixedly connected with support mechanism, the surface of support mechanism is slidably connected with split mechanism, the top of column pipe body is movably connected with pipe cover, the top of pipe cover is fixedly connected with filling pipe, the bottom of column pipe body is fixedly connected with liquid outlet pipe;

[0007] The split mechanism includes three sieve plates, adsorption grooves, a plurality of limiting blocks, connecting holes and adsorption magnets, the sieve plates are slidably connected to the surface of the support mechanism, the adsorption grooves are opened at the top of the sieve plates, the limiting blocks are fixedly connected to the inner side of the adsorption grooves and the top of the support mechanism, the connecting holes are respectively opened in the inner side of the sieve plates and the inner side of the limiting blocks, the connecting holes are used in cooperation with the support mechanism, and the adsorption magnets are fixedly connected to the bottom of the sieve plates.

[0008] Preferably, the support mechanism includes a limiting ring, a sterile filter membrane and a limiting rod, and the limiting ring is fixedly connected to the bottom of the inner side of the column pipe body.

[0009] Preferably, the sterile filter membrane is fixedly connected to the inner side of the limiting ring, and the limiting block is fixedly connected to the top of the limiting ring.

[0010] Preferably, the limiting rod is fixedly connected at the top of the limiting ring, the connecting hole is slidably connected on the surface of the limiting rod, and the adsorption surface at the bottom of the adsorption magnet is magnetically connected with the top of the limiting ring.

[0011] Preferably, the top of the filling pipe is rotatably connected with a twist cap, and the surface of the twist cap is engraved with anti-skid lines.

[0012] Preferably, the top of the three sieve plates is respectively placed with ion exchange resin, octadecylsilane bonded silica gel and aluminum oxide particles.

[0013] Preferably, the inner side of the adsorption groove is engraved with anti-skid lines, and the inner side of the adsorption groove is coated with anticorrosive paint.

[0014] Preferably, the bottom of the liquid outlet pipe is fixedly connected with a flow regulating valve, and the surface of the flow regulating valve is coated with anticorrosive paint.

[0015] Compared with the prior art, the application has the beneficial effects that:

[0016] 1. The limiting ring of the supporting mechanism is fixedly connected at the bottom of the inner side of the column pipe body, thereby providing a basic support point for the entire supporting structure, ensuring that the split mechanism, the column pipe body and the internal components remain stable during the purification process, preventing shaking and displacement, the limiting rod penetrates through the limiting block and is fixed at the top of the limiting ring, cooperates with the connecting holes on the sieve plate and the limiting block, provides precise guidance for the sliding of the sieve plate, and ensures the accuracy of the operation of the split mechanism.

[0017] 2. The split mechanism is provided with three sieve plates, and the sieve plates can slide on the surface of the supporting mechanism, cooperates with the connecting holes and the supporting mechanism, can flexibly change the position of the sieve plate according to the characteristics of different positron emitting radiopharmaceuticals, and then adjust the order and proportion of the adsorption materials such as ion exchange resin, octadecylsilane bonded silica gel and aluminum oxide particles placed on the sieve plate, thereby significantly improving the adaptability of the purification column to different drugs, and improving the purification efficiency and effect. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a whole structure diagram of the purification column device for positron emitting radiopharmaceutical purification.

[0019] Figure 2 It is an exploded schematic view of the column pipe body, the supporting mechanism and the split mechanism.

[0020] Figure 3 It is a whole structure diagram of the split mechanism.

[0021] Figure 4 It is a whole structure diagram of the supporting mechanism.

[0022] Figure 5 It is the structure schematic view of the adsorption groove of the utility model.

[0023] In the figure, 1, column pipe body;2, support mechanism;21, limit ring;22, sterile filter membrane;23, limit rod;3, split mechanism;31, sieve plate;32, adsorption groove;33, limit block;34, connecting hole;35, adsorption magnet;4, pipe cover;5, filling pipe;6, liquid outlet pipe;7, twist cover;8, ion exchange resin;9, octadecylsilane bonded silica gel;10, aluminium oxide particle;11, flow regulating valve. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative work belong to the protection scope of the utility model.

[0025] Please refer to Figures 1-5 The utility model provides technical scheme:

[0026] A kind of purification column equipment for positron radioactive medicine purification, including column pipe body 1, the bottom of column pipe body 1 is fixedly connected with support mechanism 2, the surface of support mechanism 2 is slidably connected with split mechanism 3, the top of column pipe body 1 is movably connected with pipe cover 4, the top of pipe cover 4 is fixedly connected with filling pipe 5, the bottom of column pipe body 1 is fixedly connected with liquid outlet pipe 6;

[0027] Split mechanism 3 includes three sieve plates 31, adsorption groove 32, several limit blocks 33, connecting holes 34 and adsorption magnets 35, sieve plate 31 is slidably connected on the surface of support mechanism 2, adsorption groove 32 is opened in the top of sieve plate 31, limit block 33 is fixedly connected at the inner side of adsorption groove 32 and the top of support mechanism 2 respectively, connecting hole 34 is opened at the inner side of sieve plate 31 and the inner side of limit block 33 respectively, connecting hole 34 is used in conjunction with support mechanism 2, and adsorption magnet 35 is fixedly connected at the bottom of sieve plate 31.

[0028] In the embodiment, the support mechanism 2, the splitting mechanism 3 and the drug solution are accommodated by being arranged to provide necessary space for the drug purification process, the tube cover 4 can effectively close the opening at the top of the column tube body 1 during the drug purification process, prevent external impurities from entering the column tube body 1, avoid pollution to the drug solution, ensure the purity of the purification process, the filling pipe 5 provides a convenient channel for adding the drug solution to be purified into the column tube body 1, facilitates the injection operation of the drug solution by the operator, improves the work efficiency, the liquid outlet pipe 6 is used for discharging the purified drug solution, ensures that the purified drug can smoothly flow out of the equipment for subsequent processing and use, the screen plate 31 can slide on the surface of the limiting rod 23, by adjusting the position of the screen plate 31, the order and proportion of different adsorption materials can be flexibly changed to adapt to the purification needs of different positron emitting radiopharmaceuticals, improve the purification efficiency and quality, the adsorption groove 32 can connect the screen plate 31 and the screen plate 31 through the adsorption magnet 35, the limiting block 33 can limit the adsorption magnet 35, at the same time, cooperates with the limiting rod 23 and the connecting hole 34 to ensure the stability and accuracy of the sliding of the screen plate 31, the connecting hole 34 is slidably connected with the limiting rod 23, provides a track for the movement of the screen plate 31, enables the screen plate 31 to smoothly slide along the limiting rod 23, realizes the flexible adjustment function of the splitting mechanism 3, the adsorption magnet 35 can magnetically connect the same screen plate 31, and can magnetically connect with the limiting ring 21, increases the stability of the connection between the screen plate 31 and the support mechanism 2.

[0029] Specifically, as shown in Figure 4 The support mechanism 2 includes a limiting ring 21, a sterile filter membrane 22 and a limiting rod 23, and the limiting ring 21 is fixedly connected to the bottom of the inner side of the column tube body 1.

[0030] Specifically, as shown in Figure 4 The sterile filter membrane 22 is fixedly connected to the inner side of the limiting ring 21, and the limiting block 33 is fixedly connected to the top of the limiting ring 21.

[0031] Specifically, as shown in Figure 4 The limiting rod 23 penetrates through the limiting block 33 and is fixedly connected to the top of the limiting ring 21, the connecting hole 34 is slidably connected to the surface of the limiting rod 23, and the adsorption surface at the bottom of the adsorption magnet 35 is magnetically connected to the top of the limiting ring 21.

[0032] In the embodiment, the limiting ring 21 is arranged to provide a stable support base for the whole support structure, ensuring the stable installation of the sterile filter membrane 22, the limiting rod 23 and the disassembly mechanism 3, and ensuring the stability of the whole structure of the equipment. The sterile filter membrane 22 can effectively filter the drug solution flowing through it, remove impurity particles, microorganisms and the like, and ensure the sterility and purity of the purified drug, meeting the clinical use standard. The limiting rod 23 cooperates with the connecting hole 34 to provide guidance for the sliding of the sieve plate 31, ensuring that the sieve plate 31 can accurately move when adjusting the position, and at the same time enhancing the stability of the whole support structure, making the connection of the disassembly mechanism 3 and the support mechanism 2 more firm.

[0033] Specifically, as shown in Figure 2 , the top of the filling pipe 5 is rotatably connected with a twist cap 7, and the surface of the twist cap 7 is engraved with anti-skid lines.

[0034] Specifically, as shown in Figure 3 , Figure 5 , the top of each of the three sieve plates 31 is placed with ion exchange resin 8, octadecylsilane bonded silica gel 9 and aluminum oxide particles 10.

[0035] In the embodiment, the twist cap 7 is arranged, which can be easily opened and closed by rotating the twist cap 7. The anti-skid lines are arranged to increase the friction between the hand and the twist cap 7. The ion exchange resin 8, octadecylsilane bonded silica gel 9 and aluminum oxide particles 10 are arranged. The ion exchange resin 8 can undergo ion exchange reaction with ionic impurities in the drug solution, effectively removing the charged impurities in the solution, adjusting the ion composition and pH of the drug solution. The octadecylsilane bonded silica gel 9 has hydrophobicity and can interact with drug molecules and impurity molecules through hydrophobic interaction to adsorb and separate organic impurities in the drug solution. For some less polar impurities, the octadecylsilane bonded silica gel 9 can achieve good separation and purification effect, further improving the purity of the drug. The aluminum oxide particles 10 have adsorption capacity for certain specific impurities in the drug solution, such as some metal ions and polar molecules. They can remove impurities according to the characteristics of the drug, and also have a certain decolorizing effect, improving the appearance and quality of the drug solution. The combination of these three kinds of adsorbents can comprehensively remove various impurities in the positron emitting radiopharmaceuticals, significantly improve the purification effect, and meet the purification needs of different drugs.

[0036] Specifically, as shown in Figure 5 , the inner side of the adsorption groove 32 is engraved with anti-skid lines, and the inner side of the adsorption groove 32 is coated with anti-corrosion paint.

[0037] Specifically, as shown in Figure 2 , the bottom of the liquid outlet pipe 6 is fixedly connected with a flow regulating valve 11, and the surface of the flow regulating valve 11 is coated with anti-corrosion paint.

[0038] In the embodiment: by setting the anti-skid lines, the stability of the magnetic adsorption between the adsorption groove 32 and the adsorption magnet 35 is increased, by setting the anti-corrosion paint, the service life of the adsorption groove 32 can be prolonged, the structural integrity of the sieve plate 31 is ensured, the equipment maintenance cost is reduced, by setting the flow regulating valve 11, the operator can flexibly adjust the flow regulating valve 11 according to the actual purification demand and experimental conditions, accurately control the outflow speed of the purified drug solution, by setting the anti-corrosion paint, the flow regulating valve 11 can resist the corrosion of the drug solution.

[0039] Working principle: first, before the purification of the positron emitting radiopharmaceutical, the user adjusts the combination mode of the adsorption material according to the characteristics of the to-be-purified drug by operating the split mechanism 3, overcomes the magnetic attraction force between the adsorption magnet 35 and the limiting ring 21, slides the sieve plate 31 along the limiting rod 23, changes the position of the sieve plate 31 by cooperating the connecting hole 34 with the limiting rod 23, and then adjusts the order and proportion of the ion exchange resin 8, the octadecylsilane bonded silica gel 9 and the aluminum oxide particles 10 placed on the sieve plate 31, then, after adjusting the adsorption material, the user rotates the twist cap 7 at the top of the filling pipe 5, opens the filling pipe 5, and pours the to-be-purified drug solution into the column body 1 through the filling pipe 5, the drug solution flows downward under the action of gravity, first, the drug solution flows through the sieve plate 31 placed with different adsorption materials in turn, the ion exchange resin 8 will react with the ion impurities in the drug solution to remove the charged impurities and adjust the ion composition and pH of the solution, the octadecylsilane bonded silica gel 9 can adsorb and separate organic impurities by hydrophobic interaction with drug molecules and impurity molecules, especially for impurities with smaller polarity, the aluminum oxide particles 10 can adsorb specific impurities in the drug solution, such as metal ions and polar molecules, and also can decolorize to improve the appearance and quality of the drug solution, then, the drug solution passes through the sterile filter membrane 22, which can filter out impurity particles and microorganisms in the solution to ensure the sterility of the drug, at this time, the purified drug solution is discharged through the outlet pipe 6, the user can operate the flow regulating valve 11 at the bottom of the outlet pipe 6 according to the actual demand to control the outflow speed of the drug solution, finally, after the purification work is completed, if the adsorption material needs to be replaced or the equipment needs to be maintained, the sieve plate 31 can be taken out by sliding along the limiting rod 23 again for subsequent processing.

[0040] The above is only a preferred embodiment of the present application, and is not intended to limit the present application, any modification, equivalent replacement and improvement made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A purification column device for positron radiopharmaceutical purification comprising a column tube body (1), characterized in that: The bottom of the column tube body (1) is fixedly connected with a supporting mechanism (2), the surface of the supporting mechanism (2) is slidably connected with a disassembly mechanism (3), the top of the column tube body (1) is movably connected with a pipe cover (4), the top of the pipe cover (4) is fixedly connected with a filling pipe (5), and the bottom of the column tube body (1) is fixedly connected with a liquid outlet pipe (6). The disassembly mechanism (3) comprises three sieve plates (31), an adsorption groove (32), a plurality of limiting blocks (33), connecting holes (34) and adsorption magnets (35), the sieve plate (31) is slidably connected to the surface of the supporting mechanism (2), the adsorption groove (32) is arranged at the top of the sieve plate (31), the limiting blocks (33) are fixedly connected to the inner side of the adsorption groove (32) and the top of the supporting mechanism (2) respectively, the connecting holes (34) are arranged on the inner side of the sieve plate (31) and the inner side of the limiting block (33) respectively, the connecting holes (34) are used in cooperation with the supporting mechanism (2), and the adsorption magnets (35) are fixedly connected to the bottom of the sieve plate (31).

2. A purification column apparatus for positron emitting radiopharmaceutical purification according to claim 1, characterized in that: The supporting mechanism (2) comprises a limiting ring (21), a sterile filter membrane (22) and a limiting rod (23), and the limiting ring (21) is fixedly connected to the bottom of the inner side of the column tube body (1).

3. A purification column apparatus for positron emitting radiopharmaceutical purification according to claim 2, characterized in that: The sterile filter membrane (22) is fixedly connected to the inner side of the limiting ring (21), and the limiting block (33) is fixedly connected to the top of the limiting ring (21).

4. A purification column apparatus for positron emitting radiopharmaceutical purification according to claim 2, characterized in that: The limiting rod (23) penetrates through the limiting block (33) and is fixedly connected to the top of the limiting ring (21), the connecting hole (34) is slidably connected to the surface of the limiting rod (23), and the adsorption surface of the bottom of the adsorption magnet (35) is magnetically connected to the top of the limiting ring (21).

5. A purification column apparatus for positron emitting radiopharmaceutical purification according to claim 1, characterized in that: The top of the filling pipe (5) is rotatably connected with a twist cap (7), and the surface of the twist cap (7) is provided with anti-skid lines.

6. A purification column apparatus for positron emitting radiopharmaceutical purification according to claim 1, characterized in that: Ion exchange resin (8), octadecylsilane bonded silica (9) and aluminum oxide particles (10) are respectively arranged on the top of the three sieve plates (31).

7. A purification column apparatus for positron emitting radiopharmaceutical purification according to claim 1, characterized in that: Anti-skid lines are arranged on the inner side of the adsorption groove (32), and the inner side of the adsorption groove (32) is coated with anticorrosive paint.

8. A purification column apparatus for positron emitting radiopharmaceutical purification according to claim 1, characterized in that: The bottom of the liquid outlet pipe (6) is fixedly connected with a flow regulating valve (11), and the surface of the flow regulating valve (11) is coated with anticorrosive paint.

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