Device for continuous flow production of PEG (polyethylene glycol) derivative modified superparamagnetic ferrite nanoparticles

Abstract

The utility model relates to the technical field of production of nano composite materials, in particular to a device for producing PEG (Polyethylene Glycol) derivative modified superparamagnetic ferrite nano particles in a continuous flow manner. Comprising a PEG derivative ligand liquid storage tank, a superparamagnetic ferrite nanoparticle liquid storage tank, a washing liquid storage tank, a pH adjusting liquid storage tank, a metering pump, a static mixer, a tubular reactor, a constant temperature box, a centrifugal machine, a flow valve and a control module and is connected with a mixing part, a reaction part, a washing part and a centrifugal separation part through pipelines. And continuous flowing and automatic production of the materials are realized under the control of the control module.

Description

Technical Field

[0001] This invention relates to the field of nanocomposite material production technology, specifically to an apparatus for continuous flow production of PEG derivative-modified superparamagnetic ferrite nanoparticles. Background Technology

[0002] Ligand exchange is an important method for surface functionalization of nanomaterials. Through precise surface chemical regulation, ligand exchange endows nanoparticles with multifunctional properties. Modifying and replacing the crude phase nanoparticles with PEG derivatives can improve their dispersibility, and introducing functional groups can achieve PEG modification. It is particularly suitable for the hydrophilic modification of hydrophobic superparamagnetic ferrite nanoparticles. When using ligand exchange to produce PEG derivative-modified superparamagnetic ferrite nanoparticles, accurate control of ligand concentration and molar ratio, reaction temperature and time, and selection of a suitable solvent system are crucial. Otherwise, the PEG derivative-modified superparamagnetic ferrite nanoparticles produced by ligand exchange will exhibit poor colloidal stability, easily leading to particle aggregation, and a decrease in coating thickness and saturation magnetization.

[0003] Existing batch production methods using ligand exchange yield low outputs, insufficient for large-scale production. Acids can promote the concentration of PEG derivatives in the reaction system for modifying superparamagnetic ferrite nanoparticles, increase the amount of PEG derivatives on the surface of the nanoparticles, and reduce the amount of organic solvents used. Traditional batch-based large-scale production is time-consuming, requires more manpower, and involves numerous steps that are difficult to dynamically control in real time, often resulting in substandard final products. To achieve scale-up production and maintain pH stability in the reaction system, a flow synthesis approach combined with automated equipment is used to replace manual operations. This enables continuous flow production of raw material mixing, reaction, washing, and centrifugation, further improving the yield and quality rate of PEG derivative-modified superparamagnetic ferrite nanoparticles. Utility Model Content

[0004] The apparatus for continuous flow production of PEG derivative-modified superparamagnetic ferrite nanoparticles described in this invention connects mixing, reaction, washing, and centrifugal separation components via pipelines, and achieves continuous material flow and automated production under the control of a control module.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a continuous flow apparatus for producing PEG derivative-modified superparamagnetic ferrite nanoparticles, comprising: a PEG derivative ligand storage tank, a superparamagnetic ferrite nanoparticle storage tank, a washing liquid storage tank, a pH adjustment liquid storage tank, a metering pump, a static mixer, a tubular reactor, a constant temperature chamber, a centrifuge, a flow valve, and a control module. The PEG derivative ligand storage tank and the superparamagnetic ferrite nanoparticle storage tank are respectively connected to the static mixer via a metering pump circuit. The static mixer is connected to the tubular reactor via a flow valve circuit. The pH adjustment liquid storage tank is connected to the tubular reactor via a metering pump circuit. The tubular reactor is connected to the centrifuge via a flow valve circuit. The tubular reactor is located within the constant temperature chamber. The metering pump and the flow valve are electrically connected to the control module.

[0006] Preferably, the PEG derivative ligand storage tank and the superparamagnetic ferrite nanoparticle storage tank are further equipped with a level gauge and a stirring device, which are electrically connected to the control module.

[0007] Preferably, the PEG derivative ligand storage tank, the superparamagnetic ferrite nanoparticle storage tank, and the detergent storage tank are made of tetrafluoroethylene, stainless steel, or glass.

[0008] Preferably, the pH adjusting solution storage tank is made of acid and alkali resistant material.

[0009] Preferably, the metering pump is a ceramic metering pump, a PVDF metering pump, or a Hastelloy metering pump.

[0010] Preferably, the metering pump is a precision peristaltic pump.

[0011] Preferably, the static mixer is a transparent static mixer resistant to organic materials.

[0012] Preferably, the constant temperature chamber is one of a water bath constant temperature chamber, an oil bath constant temperature chamber, or a blower constant temperature chamber.

[0013] Preferably, the flow valve is a stainless steel flow valve, a polytetrafluoroethylene flow valve, or a glass rotor flow valve.

[0014] Preferably, the centrifuge is a tubular centrifuge.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0016] 1. It can accurately control the ligand concentration and molar ratio, as well as the reaction temperature and time, thereby improving the colloidal stability of PEG derivative-modified superparamagnetic ferrite nanoparticles, inhibiting particle aggregation, and mitigating the decrease in coating thickness and saturation magnetization.

[0017] 2. To meet the needs of expanded production, automated equipment is used to replace manual operations, enabling continuous flow production of raw material mixing, reaction, washing, and centrifugal separation.

[0018] 3. This equipment can effectively control the pH value of the reaction system, increase the number of PEG derivatives modified on the surface of superparamagnetic ferrite nanoparticles, and reduce the amount of organic solvent used. Attached Figure Description

[0019] Figure 1 This is a structural schematic diagram of an embodiment of the present utility model.

[0020] In the diagram: 1. PEG derivative ligand storage tank, 2. Superparamagnetic ferrite nanoparticle storage tank, 3. Washing solution storage tank, 4. pH adjustment solution storage tank, 5. Metering pump, 6. Static mixer, 7. Tubular reactor, 8. Incubator, 9. Centrifuge, 10. Flow valve, 11. Control module. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] Example

[0023] As attached Figure 1 The apparatus shown is for continuous flow production of PEG derivative-modified superparamagnetic ferrite nanoparticles, comprising: a PEG derivative ligand storage tank 1, a superparamagnetic ferrite nanoparticle storage tank 2, a washing solution storage tank 3, a pH adjustment solution storage tank 4, a metering pump 5, a static mixer 6, a tubular reactor 7, a constant temperature chamber 8, a centrifuge 9, a flow valve 10, and a control module 11. The PEG derivative ligand storage tank 1 and the superparamagnetic ferrite nanoparticle storage tank 2 are respectively connected to the static mixer 6 via the metering pump 5. The static mixer 6 is connected to the tubular reactor 7 via the flow valve 11. The pH adjustment solution storage tank 4 is connected to the tubular reactor 7 via the metering pump. The tubular reactor 7 is connected to the centrifuge 9 via the metering pump. The washing solution storage tank 3 is connected to the centrifuge 9 via the flow valve. The tubular reactor 7 is located inside the constant temperature chamber 8. The metering pump 5 and the flow valve 10 are electrically connected to the control module 11.

[0024] This embodiment is the most basic implementation. After power is switched on, the control module 11 operates the electronically controlled metering pump 5. The PEG derivative ligand solution in the PEG derivative ligand storage tank 1 and the superparamagnetic ferrite nanoparticles in the superparamagnetic ferrite nanoparticle storage tank 2 enter the static mixer 6 through the metering pump 5, respectively. Subsequently, the control module 11 controls the thermostat 8 to operate until the preset temperature is reached, and then controls the electronically controlled flow valve 10 to operate. The reaction liquid in the static mixer 6 enters the tubular reactor 7 through the flow valve 10. Simultaneously, the control module 11 controls the metering pump to operate, injecting the pH adjusting solution from the pH adjusting solution storage tank 4 into the tubular reactor 7 through the metering pump. Then, the control module 11 controls the flow valve connected to the washing liquid storage tank 3 to operate, allowing the washing liquid to enter the centrifuge 9. The reaction liquid in the tubular reactor 7 also simultaneously enters the centrifuge 9. The control module 11 controls the centrifuge 9 to operate, obtaining PEG derivative-modified superparamagnetic ferrite nanoparticles and waste liquid.

[0025] The above embodiments are provided merely for the purpose of describing the present invention and are not intended to limit the scope of the present invention. All equivalent substitutions and modifications made without departing from the spirit and principles of the present invention should be covered within the scope of the present invention.

Claims

1. An apparatus for continuous flow production of PEG derivative modified superparamagnetic ferrite nanoparticles, comprising: The PEG derivative ligand storage tank, the superparamagnetic ferrite nano-particle storage tank, the washing liquid storage tank, the pH adjusting liquid storage tank, the metering pump, the static mixer, the tubular reactor, the thermostat, the centrifuge, the flow valve, and the control module are characterized in that the PEG derivative ligand storage tank and the superparamagnetic ferrite nano-particle storage tank are respectively connected to the static mixer through a metering pump liquid path, the static mixer is connected to the tubular reactor through a flow valve liquid path, the pH adjusting liquid storage tank is connected to the tubular reactor through a metering pump liquid path, the tubular reactor is connected to the centrifuge, the washing liquid storage tank is connected to the centrifuge through a flow valve liquid path, the tubular reactor is in the thermostat, and the metering pump and the flow valve are electrically connected to the control module.

2. The apparatus for continuous flow production of PEG derivative modified superparamagnetic ferrite nanoparticles according to claim 1, characterized in that, The PEG derivative ligand storage tank and the superparamagnetic ferrite nano-particle storage tank are further provided with a liquid level meter and a stirring device, and the liquid level meter and the stirring device are electrically connected to the control module.

3. The apparatus for continuous flow production of PEG derivative modified superparamagnetic ferrite nanoparticles according to claim 1, characterized in that, The PEG derivative ligand storage tank, the superparamagnetic ferrite nano-particle storage tank, and the washing liquid storage tank are one of tetrafluoroethylene, stainless steel, or glass.

4. The apparatus for continuous flow production of PEG derivative modified superparamagnetic ferrite nanoparticles according to claim 1, characterized in that, The pH adjusting liquid storage tank is an acid and alkali corrosion resistant material storage tank.

5. The apparatus for continuous flow production of PEG derivative modified superparamagnetic ferrite nanoparticles according to claim 1, wherein, The metering pump is a ceramic metering pump, a PVDF metering pump, or a hastelloy metering pump.

6. The apparatus for continuous flow production of PEG derivative modified superparamagnetic ferrite nanoparticles according to claim 1, wherein, The metering pump is a precision peristaltic pump.

7. The apparatus for continuous flow production of PEG derivative modified superparamagnetic ferrite nanoparticles according to claim 1, wherein, The static mixer is a transparent organic material resistant static mixer.

8. The apparatus for continuous flow production of PEG derivative modified superparamagnetic ferrite nanoparticles according to claim 1, wherein, The thermostat is one of a water bath thermostat, an oil bath thermostat, or an air blast thermostat.

9. The apparatus for continuous flow production of PEG derivative modified superparamagnetic ferrite nanoparticles according to claim 1, wherein, The flow valve is a stainless steel flow valve, a polytetrafluoroethylene flow valve, or a glass rotor flow valve.

10. The apparatus for continuous flow production of PEG derivative modified superparamagnetic ferrite nanoparticles according to claim 1, characterized in that, The centrifuge is a tubular centrifuge.

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