Granular medicine granulator for biopharmacy

Abstract

The utility model discloses a biopharmacy granular medicine granulator, including bottom plate, bottom plate top is equipped with support plate, machine body, granulation plate, feed box, feed chute, crushing subassembly, feeding subassembly, mounting rack, granulation subassembly, bottom plate one side is equipped with screening subassembly, sieve plate, aggregate drawer, blanking chute. According to the granular medicine granulator for biological pharmacy, the screening assembly, the screen plate, the feeding assembly, the granulation assembly and the smashing assembly are arranged, medicine powder can be evenly smashed and granulated, medicine particles are screened after granulation, the screening speed is high, the screening efficiency is high, labor is effectively reduced, and the quality of the medicine particles is improved.

Description

Technical Field

[0001] This utility model relates to the field of granulation production technology for granulated drugs, specifically to a granulation machine for biopharmaceuticals. Background Technology

[0002] Biopharmaceuticals have become an indispensable part of people's lives. In biopharmaceutical manufacturing, it is necessary to process raw materials into granules. Therefore, in the process of drug production, the raw materials of the drug need to be mixed and then extruded to make the drug into granules.

[0003] A biopharmaceutical granulator, disclosed in CN 208405376 U, includes a base plate. Support frames are connected to the upper surface of the base plate via support ears on both sides. A support plate is located at the lower center of the support frames, dividing the two sides of the support frames into material-holding grooves. A third electric telescopic rod drives the upper end of a second pressure column to insert into a through-hole in the support plate. Then, a first electric telescopic rod drives the first pressure column downwards, thereby pressing the drug powder inside the through-hole of the support plate into granules, making production more convenient and faster. A linear motor drives a scraper to move left and right, scraping the raw material in the material-holding grooves into the through-hole of the support plate, further facilitating production. This biopharmaceutical granulator has a simple structure and is easy to operate, saving significant manpower and greatly increasing the speed of drug production, making granulation more convenient.

[0004] However, the aforementioned device still has the following problems in use. Although it can granulate drug powder into granules, it lacks a sieving function and cannot quickly separate the granulated drug granules from the drug powder or small, non-granulated particles. A significant amount of manpower and resources are still required for sieving after drug granulation, and manual sieving is slow, resulting in both wasted manpower and low efficiency. Therefore, we propose a new granulation machine for biopharmaceuticals. Utility Model Content

[0005] The main objective of this invention is to provide a granulation machine for biopharmaceuticals, which can effectively solve the problems in the background art.

[0006] To achieve the above objectives, the technical solution adopted by this utility model is as follows: a granulation machine for biopharmaceutical granules, comprising a base plate, a support plate symmetrically fixedly connected to the top of the base plate, an organism fixedly connected to the top of the support plate, a granulation plate fixedly connected to one end of the organism, a feed box fixedly connected to the upper part of the other end of the organism, the feed box communicating with the inner cavity of the organism, a feed trough fixedly connected to the top of the feed box, a crushing component provided in the inner cavity of the feed box, a feeding component provided in the inner cavity of the organism, a mounting frame fixedly connected to one side of the granulation plate, a granulation component mounted on the mounting frame, a screening component fixedly connected to one side of the base plate, and the upper part of the side walls of the screening component... The system includes a sieve plate and a screening assembly comprising a screening frame, inclined troughs, spring dampers, a motor, and a cam. The screening frame is fixedly connected to one side of a base plate. Inclined troughs, penetrating at both ends, are symmetrically opened on both sides of the screening frame. The two sides of the sieve plate are slidably connected to the inner cavity of the inclined troughs. Several spring dampers are uniformly fixedly connected to the inner cavity of one inclined trough, with the other end of each spring damper fixedly connected to the side wall of the sieve plate. An installation groove is opened at the bottom of another inclined trough. The motor is fixedly connected to the inner cavity of the installation groove. The cam is fixedly connected to the output end of the motor and is positioned within the inner cavity of the inclined trough. A material collection drawer is slidably inserted into the side wall of the screening frame, and a material discharge trough is fixedly connected to one side of the screening frame.

[0007] As a further description of the above technical solution, a groove is opened on one side of the sieve plate, and the side wall of the cam fits into the groove.

[0008] As a further description of the above technical solution, the two ends of the inclined chute are set at different heights, and the material discharge chute is set on one side of the lowest point of the inclined chute, and the bottom of the screen plate abuts against the material discharge chute.

[0009] As a further description of the above technical solution, the granulation assembly includes a third motor and a rotating blade. The third motor is fixedly connected to the side wall of the mounting frame, and the output end of the third motor is fixedly connected to the rotating blade through the mounting frame. The rotating blade is rotatably connected to one side of the granulation plate.

[0010] As a further description of the above technical solution, the feeding assembly includes a second motor and a feeding screw. The second motor is fixedly connected to one side of the machine body, and the output end of the second motor is fixedly connected to the feeding screw through the side wall of the machine body. The feeding screw is rotatably connected to the side wall of the inner cavity of the machine body.

[0011] As a further description of the above technical solution, the crushing assembly includes a motor, crushing rollers, a drive gear, and a driven gear. The two crushing rollers are rotatably connected to the inner wall of the feed box, and the crushing blades of the two crushing rollers are interlocked. The drive gear and the driven gear are rotatably connected to the side wall of the feed box and are meshed together. The motor is fixedly connected to the other side wall of the feed box. The output end of the motor passes through the side wall of the feed box and is fixedly connected to one crushing roller. The other end of this crushing roller is fixedly connected to the drive gear, and the driven gear is fixedly connected to one end of the other crushing roller.

[0012] Compared with the prior art, the present invention has the following beneficial effects:

[0013] 1. By setting up screening components, sieve plates, feeding troughs, and collection drawers, after the medicine powder is made into granules by the granulation component, it falls onto the sieve plate. The motor is started, driving the cam to rotate. Since the cam is an ellipse with one end larger than the other, and the side wall of the groove is in contact with the side wall of the cam, under the elastic force of the spring damper, as the cam rotates, the two side walls of the sieve plate can swing left and right in the inclined groove cavity. This can screen and separate the granules falling onto the sieve plate, so that the formed medicine granules fall into the feeding trough, while the medicine powder or small, unformed granules fall into the collection drawer. The screening speed is fast, the screening efficiency is high, and the waste of manpower is effectively reduced.

[0014] 2. By setting up a feeding assembly, granulation plate, and granulation unit, the powdered medicine, after being pulverized by the crushing assembly, enters the inner cavity of the machine. At this time, motor two is started, driving the feeding screw to rotate, pushing the powder to the granulation plate, where it is extruded through the granulation holes. Simultaneously, motor three is started, driving the rotating blades to rotate. The rotating blades cut the powder, and the multiple cutters of the rotating blades quickly granulate the powder extruded from the granulation holes, achieving high efficiency in granulation. The granulated medicine then falls onto a sieve plate for further sieving.

[0015] 3. By setting up a feeding trough and crushing components, when granulation of granulated drugs is required, the drug powder is first put into the feeding box through the feeding trough. At the same time, motor one is started. Motor one drives one crushing roller to rotate. This crushing roller drives the drive gear to rotate, which in turn drives the driven gear to rotate, thereby driving the other crushing roller to rotate. At this time, the two crushing rollers rotate towards each other, and the crushing blades on the two crushing rollers interlock with each other, which can crush the large particles in the drug powder fed from the feeding trough. The crushing effect is good, crushing the drug powder into particles of uniform size, preventing large particles of drug powder from being unable to pass through the granulation holes of the granulation plate, thus preventing blockage of the granulation plate and waste of drug powder. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of a granulator for biopharmaceutical drugs proposed in this utility model;

[0017] Figure 2 This is a schematic diagram of the internal structure of a granulator for biopharmaceutical drugs proposed in this utility model;

[0018] Figure 3 This is an exploded view of the screening component of a granulator for biopharmaceutical drugs proposed in this utility model.

[0019] Figure 4 This is a schematic diagram of the pulverizing component structure of a granulator for biopharmaceutical granulation proposed in this utility model.

[0020] In the diagram: 1. Base plate; 2. Support plate; 3. Machine body; 4. Feed box; 5. Feed chute; 6. Crushing assembly; 7. Feeding assembly; 8. Granulating plate; 9. Granulating assembly; 10. Screening assembly; 11. Screen plate; 12. Mounting frame; 13. Discharge chute; 14. Collection drawer; 15. Groove; 6.1 Motor 1; 6.2 Crushing roller; 6.3 Drive gear; 6.4 Driven gear; 7.1 Motor 2; 7.2 Feeding screw; 9.1 Motor 3; 9.2 Rotating blade; 10.1 Screening frame; 10.2 Inclined chute; 10.3 Spring damper; 10.4 Motor 4; 10.5 Cam. Detailed Implementation

[0021] To make the technical means, creative features, and objectives of this utility model easier to understand, the following describes this utility model in conjunction with specific embodiments.

[0022] In the description of this utility model, it should be noted that the terms "upper," "lower," "inner," "outer," "front end," "rear end," "both ends," "one end," and "the other end," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. In addition, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0023] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," "connected," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0024] Please see Figure 1-4 This utility model provides a technical solution: a granulator for biopharmaceutical granulation, comprising a base plate 1, a support plate 2 symmetrically fixedly connected to the top of the base plate 1, an organism 3 fixedly connected to the top of the support plate 2, a granulation plate 8 fixedly connected to one end of the organism 3, and a feed box 4 fixedly connected to the upper part of the other end of the organism 3, the feed box 4 communicating with the inner cavity of the organism 3, a feed trough 5 fixedly connected to the top of the feed box 4, a crushing component 6 provided in the inner cavity of the feed box 4, a feeding component 7 provided in the inner cavity of the organism 3, a mounting frame 12 fixedly connected to one side of the granulation plate 8, a granulation component 9 provided on the mounting frame 12, a screening component 10 fixedly connected to one side of the base plate 1, a sieve plate 11 provided on the upper part of both side walls of the screening component 10, a plurality of screening holes evenly opened on the sieve plate 11, the screening component 10 including a screening frame 10.1, an inclined trough 10.2, a spring damper 10.3, a motor 10.4, and a cam 10.5, the screening frame 10.1 being fixedly connected to... On one side of the base plate 1, the two side walls of the screening frame 10.1 are symmetrically provided with inclined grooves 10.2 that pass through both ends. The two sides of the screen plate 11 are slidably connected to the inner cavity of the inclined groove 10.2. Several spring dampers 10.3 are uniformly fixedly connected to the inner cavity of one inclined groove 10.2. The other end of the spring damper 10.3 is fixedly connected to the side wall of the screen plate 11. The bottom of the other inclined groove 10.2 is provided with an installation groove. The motor 10.4 is fixedly connected to the inner cavity of the installation groove. The cam 10.5 is fixedly connected to the output end of the motor 10.4 and is set in the inner cavity of the inclined groove 10.2. The cam 10.5 is set as an ellipse with one end larger than the other. The side wall of the screening frame 10.1 is slidably inserted with a collection drawer 14, which is convenient to be pulled out for cleaning and recycling after the collection drawer 14 is full of medicine powder. The side of the screening frame 10.1 is fixedly connected with a discharge trough 13. After the granulated and screened medicine particles fall into the discharge trough 13, they can be processed for the next step.

[0025] Specifically, such as Figure 1As shown, the granulation assembly 9 includes a motor 9.1 and a rotating blade 9.2. The motor 9.1 is fixedly connected to the side wall of the mounting frame 12, and the output end of the motor 9.1 passes through the mounting frame 12 and is fixedly connected to the rotating blade 9.2. The rotating blade 9.2 is rotatably connected to one side of the granulation plate 8 via a bearing. Simultaneously, as the drug powder is extruded from the granulation holes of the granulation plate 8, the motor 9.1 is started, driving the rotating blade 9.2 to rotate. The rotating blade 9.2 then cuts the drug powder. The multiple cutters of the rotating blade 9.2 rapidly granulate the drug powder extruded from the granulation holes of the granulation plate 8, achieving high granulation efficiency. The granulated drug powder then falls onto the sieve plate 11 for sieving.

[0026] Specifically, such as Figure 2 As shown, the feeding assembly 7 includes a second motor 7.1 and a feeding screw 7.2. The second motor 7.1 is fixedly connected to one side of the machine body 3, and the output end of the second motor 7.1 passes through the side wall of the machine body 3 and is fixedly connected to the feeding screw 7.2. The feeding screw 7.2 is rotatably connected to the inner wall of the machine body 3 via a bearing. The powdered medicine after being crushed by the crushing assembly 6 enters the inner cavity of the machine body 3. At this time, the second motor 7.1 is started, driving the feeding screw 7.2 to rotate, pushing the powder to the granulation plate 8, and causing the powder to be squeezed out from the granulation holes of the granulation plate 8. Then the granulation assembly 9 can be turned on to start the granulation work.

[0027] Specifically, such as Figure 3 As shown, a groove 15 is opened on one side of the sieve plate 11, and the side wall of the cam 10.5 fits into the groove 15. The two ends of the inclined chute 10.2 are set at different heights, and the discharge chute 13 is set on one side of the lowest point of the inclined chute 10.2. The bottom of the sieve plate 11 abuts against the discharge chute 13, so that the sieved granular medicine can fall from the sieve plate 11 into the discharge chute 13. After the medicine powder is granulated into granules by the granulation component 9, it falls onto the sieve plate 11. The motor 10.4 is started, driving the cam 10.5 to rotate. Since the cam 10.5 is an ellipse with one end larger than the other, and the side wall of the groove 15 is in contact with the side wall of the cam 10.5, under the elastic force of the spring damper 10.3, as the cam 10.5 rotates, the two side walls of the sieve plate 11 can swing left and right in the inner cavity of the inclined groove 10.2. This allows the granules falling onto the sieve plate 11 to be screened and separated, so that the formed medicine granules fall into the feeding trough 13, while the medicine powder or small, unformed granules fall into the collection drawer 14. The screening speed is fast, the screening efficiency is high, and the waste of manpower is effectively reduced.

[0028] Specifically, such as Figure 2 , Figure 4As shown, the crushing assembly 6 includes a motor 6.1, crushing rollers 6.2, a driving gear 6.3, and a driven gear 6.4. Two crushing rollers 6.2 are rotatably connected to the inner wall of the feed box 4, and the crushing blades of the two crushing rollers 6.2 are interlocked. The driving gear 6.3 and the driven gear 6.4 are rotatably connected to the side wall of the feed box 4 and are meshed together. The motor 6.1 is fixedly connected to the other side wall of the feed box 4. The output end of the motor 6.1 passes through the side wall of the feed box 4 and is fixedly connected to one crushing roller 6.2. The other end of this crushing roller 6.2 is fixedly connected to the driving gear 6.3. The driven gear 6.4 is fixedly connected to one end of the other crushing roller 6.2 through a connecting rod. When granulation of granulated drugs is required, the drug powder is first placed into the feed box 4 through the feed trough 5. At the same time, the motor 6.1 is started. The motor 6.1 drives one crushing roller 6.2 to rotate. This crushing roller 6.2 drives the drive gear 6.3 to rotate, which in turn drives the driven gear 6.4 to rotate, thereby driving the other crushing roller 6.2 to rotate. At this time, the two crushing rollers 6.2 rotate towards each other, and the crushing blades on the two crushing rollers 6.2 interlock with each other, which can crush the large particles in the drug powder fed from the feed trough 5. The crushing effect is good, crushing the drug powder into particles of uniform size, preventing large particles of drug powder from being unable to pass through the granulation holes of the granulation plate 8, thus preventing blockage of the granulation plate 8 and waste of drug powder.

[0029] It should be noted that this utility model is a granulator for biopharmaceutical granulation. When granulation is required, the drug powder is first placed into the feed box 4 through the feed trough 5. At the same time, the motor 6.1 is started. The motor 6.1 drives one crushing roller 6.2 to rotate. This crushing roller 6.2 drives the drive gear 6.3 to rotate, which in turn drives the driven gear 6.4 to rotate, thereby driving the other crushing roller 6.2 to rotate. At this time, the two crushing rollers 6.2 rotate towards each other, and the crushing blades on the two crushing rollers 6.2 interlock, which can crush the large particles in the drug powder fed from the feed trough 5. The crushing effect is good, crushing the drug powder into particles of uniform size, preventing large particles of drug powder from being unable to pass through the granulation holes of the granulation plate 8, thus preventing blockage of the granulation plate 8 and waste of drug powder.

[0030] The pulverized medicine powder, after being crushed by the pulverizing component 6, enters the inner cavity of the machine body 3. At this time, motor 2 7.1 is started, driving the feeding screw 7.2 to rotate, pushing the medicine powder to the granulation plate 8, and causing the medicine powder to be extruded from the granulation holes of the granulation plate 8. Simultaneously, motor 3 9.1 is started, driving the rotating blade 9.2 to rotate. The rotating blade 9.2 can cut the medicine powder. The multiple cutters of the rotating blade 9.2 quickly granulate the medicine powder extruded from the granulation holes of the granulation plate 8, achieving a high granulation efficiency for the granulated medicine. The granulated medicine then falls onto the sieve plate 11 for sieving.

[0031] After the medicine powder is granulated into granules by the granulation component 9, it falls onto the sieve plate 11. The motor 10.4 is started, driving the cam 10.5 to rotate. Since the cam 10.5 is an ellipse with one end larger than the other, and the side wall of the groove 15 is in contact with the side wall of the cam 10.5, under the elastic force of the spring damper 10.3, as the cam 10.5 rotates, the two side walls of the sieve plate 11 can swing left and right in the inner cavity of the inclined groove 10.2. This allows the granules falling onto the sieve plate 11 to be screened and separated, so that the formed medicine granules fall into the feeding trough 13, while the medicine powder or small, unformed granules fall into the collection drawer 14. The screening speed is fast, the screening efficiency is high, and the waste of manpower is effectively reduced.

[0032] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A granulator for biopharmaceutical applications, comprising a base plate (1), characterized in that, The bottom plate (1) is symmetrically fixedly connected to the top of the support plate (2), and the support plate (2) is fixedly connected to the top of the body (3). One end of the body (3) is fixedly connected to the granulation plate (8), and the other end of the body (3) is fixedly connected to the upper part of the feed box (4), which is in communication with the inner cavity of the body (3). The top of the feed box (4) is fixedly connected to the feed trough (5), and the inner cavity of the feed box (4) is provided with a crushing component (6). The body (3) has a feeding assembly (7) in its inner cavity. A mounting frame (12) is fixedly connected to one side of the granulation plate (8). A granulation assembly (9) is provided on the mounting frame (12). A screening assembly (10) is fixedly connected to one side of the bottom plate (1). Screening plates (11) are provided on the upper part of the two side walls of the screening assembly (10). The screening assembly (10) includes a screening frame (10.1), an inclined chute (10.2), a spring damper (10.3), and a motor (10). 4) Cam (10.5), the screening frame (10.1) is fixedly connected to one side of the base plate (1), the screening frame (10.1) has symmetrical inclined grooves (10.2) with both ends through it on both sides, the screen plate (11) is slidably connected to the inner cavity of the inclined groove (10.2) on both sides, and a number of spring dampers (10.3) are evenly fixedly connected to the inner cavity of one of the inclined grooves (10.2), the other end of the spring damper (10.3) is connected to the side wall of the screen plate (11). The other inclined groove (10.2) is fixedly connected to the bottom of the inclined groove (10.2), and the motor (10.4) is fixedly connected to the inner cavity of the mounting groove. The cam (10.5) is fixedly connected to the output end of the motor (10.4) and the cam (10.5) is set in the inner cavity of the inclined groove (10.2). The screening rack (10.1) is slidably inserted with a material collection drawer (14) on its side wall, and a material discharge chute (13) is fixedly connected to one side of the screening rack (10.1).

2. The granulator for biopharmaceutical granulation according to claim 1, characterized in that, The sieve plate (11) has a groove (15) on one side, and the side wall of the cam (10.5) fits into the groove (15).

3. A granulator for biopharmaceutical applications according to claim 2, characterized in that, The inclined chute (10.2) is set at one high and one low at both ends, and the material discharge chute (13) is set on one side of the lowest point of the inclined chute (10.2), and the bottom of the screen plate (11) abuts against the material discharge chute (13).

4. The granulator for biopharmaceutical drugs according to claim 1, characterized in that, The granulation assembly (9) includes a motor (9.1) and a rotating blade (9.2). The motor (9.1) is fixedly connected to the side wall of the mounting frame (12). The output end of the motor (9.1) passes through the mounting frame (12) and is fixedly connected to the rotating blade (9.2). The rotating blade (9.2) is rotatably connected to one side of the granulation plate (8).

5. A granulator for biopharmaceutical granulation according to claim 1, characterized in that, The feeding assembly (7) includes a second motor (7.1) and a feeding screw (7.2). The second motor (7.1) is fixedly connected to one side of the machine body (3). The output end of the second motor (7.1) passes through the side wall of the machine body (3) and is fixedly connected to the feeding screw (7.2). The feeding screw (7.2) is rotatably connected to the inner wall of the machine body (3).

6. A granulator for biopharmaceutical granulation according to claim 1, characterized in that, The crushing assembly (6) includes a motor (6.1), a crushing roller (6.2), a drive gear (6.3), and a driven gear (6.4). The two crushing rollers (6.2) are rotatably connected to the inner wall of the feed box (4), and the crushing blades of the two crushing rollers (6.2) are interlocked. The drive gear (6.3) and the driven gear (6.4) are rotatably connected to the side wall of the feed box (4), and the drive gear (6.3) and the driven gear (6.4) are meshed together. The motor (6.1) is fixedly connected to the other side wall of the feed box (4). The output end of the motor (6.1) passes through the side wall of the feed box (4) and is fixedly connected to one crushing roller (6.2). The other end of this crushing roller (6.2) is fixedly connected to the drive gear (6.3), and the driven gear (6.4) is fixedly connected to one end of the other crushing roller (6.2).

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