Temperature control device of biological living specimen transfer box

Abstract

The utility model relates to the technical field of biological specimen preservation, in particular to a temperature control device of a biological living specimen transfer box, which is provided with an outer box body for placing the biological living specimen transfer box. An active temperature control unit and an emergency temperature control unit are arranged in an inner cavity of the outer box body, passive temperature control units used for sealing are arranged on the outer surface and the joint face of the outer box body, and a waterproof touch screen, an audible and visual alarm and an emergency knob used for manually switching a standby mode during power failure are further arranged on the front face of the outer box body. The temperature control precision of the biological living specimen transfer box can be improved; energy consumption is reduced, and the service life of the transfer box is prolonged; self-adaptive temperature adjustment is achieved, and different environment temperature changes are adapted; preparing an emergency temperature control device to deal with emergencies; and the requirement that a constant temperature environment needs to be kept in the transferring process of the biological living specimens is met.

Description

Technical Field

[0001] This utility model relates to the field of medical equipment technology, and in particular to a temperature control device for a biological live specimen transfer box. Background Technology

[0002] The cold chain logistics industry primarily serves the food and pharmaceutical sectors, and is a vital industry related to national livelihoods. With globalization and the expansion of the food supply chain, cold chain logistics has become even more crucial. The pharmaceutical and medical industries are key areas for cold chain logistics, as biopharmaceuticals, vaccines, and blood products require storage and transportation at low temperatures, thus necessitating a large amount of cold chain equipment and facilities.

[0003] Currently, live biological specimens require a constant temperature environment during transfer to ensure their viability. Existing transfer boxes typically use simple ice packs or dry ice for cooling, which has three drawbacks: 1) Insufficient temperature control precision, making it difficult to meet the preservation requirements of biological specimens; 2) High energy consumption, making it difficult to maintain a stable temperature during long-term transfer; 3) Lack of adaptive adjustment function, failing to automatically adjust according to changes in ambient temperature. Therefore, there is an urgent need for a temperature control device for live biological specimen transfer boxes. Utility Model Content

[0004] This utility model discloses a temperature control device for a biological live specimen transfer box, which aims to solve the technical problems existing in the prior art.

[0005] The present invention adopts the following technical solution:

[0006] A temperature control device for a biological live specimen transfer box includes an outer casing and an active temperature control unit, an emergency temperature control unit, a passive temperature control unit installed in the inner chamber of the outer casing for sealing, and a waterproof touch screen for real-time display of temperature measurement information; wherein...

[0007] The active temperature control unit includes a circuit board and a semiconductor module for bidirectional temperature control connected to the circuit board, multiple temperature sensors evenly distributed in the inner chamber for real-time temperature measurement, and a PID controller for regulating the semiconductor module.

[0008] The emergency temperature control unit includes a PCM phase change material plate embedded in the inner wall of the outer casing to provide latent heat when the temperature changes, and a spare ice box slot into which ice can be inserted.

[0009] The passive temperature control unit includes a vacuum insulation plate attached to the outer wall of the box, an aerogel filling layer for gaps, a magnetic lock for connecting the top cover and the box, and a sealing ring located around the magnetic lock for sealing.

[0010] In some embodiments, the outer casing includes a casing body and a casing top cover connected by the magnetic lock. The casing top cover is equipped with an opening handle. The outer surface of the casing body is equipped with the vacuum insulation plate. The right side wall of the casing body is provided with an external interface. The bottom of the casing body is provided with a charging port for the power module and wheels for easy movement.

[0011] In some embodiments, the front of the outer casing is also provided with a waterproof touch screen, an audible and visual alarm, and an emergency knob for manually switching to a standby mode in case of power failure. The waterproof touch screen and the audible and visual alarm are both connected to the circuit board. The waterproof touch screen is also provided with touch screen buttons for setting temperature control data. A protective cover is also installed above the emergency knob to prevent accidental touch.

[0012] In some embodiments, the circuit board includes a temperature acquisition module connected to a temperature sensor via wires, a storage module for data storage, a PLC control module for continuously detecting the temperature of the inner chamber based on the temperature data acquired by the temperature sensor and controlling the data storage, a battery module for powering the device, and a microcontroller for controlling the temperature sensor to measure temperature and connected to the controller. It also includes a wireless communication module for transmitting information between the microcontroller and the controller.

[0013] In some embodiments, at least two equally spaced, horizontally arranged magnetic locks are provided on each plane connecting the box body and the box cover, such that when the box cover is placed on the upper end of the box body, all the magnetic locks are simultaneously attracted and locked. A double-layer silicone sealing ring is attached to the periphery of the magnetic locks, so that the inner cavity of the outer box is in a sealed state.

[0014] In some embodiments, the external interface is connected to the liquid nitrogen tank via a pipeline. Beneficial effects

[0015] This utility model discloses a temperature control device for a biological live specimen transfer box. Compared with the prior art, this utility model has the following advantages:

[0016] A temperature control device for a biological specimen transfer box includes an outer casing for housing the transfer box. The outer casing contains an active temperature control unit and an emergency temperature control unit within its internal chamber. Passive temperature control units for sealing are located on the outer surface and joint surfaces of the outer casing. The front of the outer casing also features a waterproof touchscreen, an audible and visual alarm, and an emergency knob for manually switching to a standby mode in case of power failure. This three-stage temperature control architecture improves the temperature control accuracy of the biological specimen transfer box; reduces energy consumption and extends the box's lifespan; enables adaptive temperature adjustment to adapt to different environmental temperature changes; provides an emergency temperature control device to handle unforeseen circumstances; and meets the requirement of maintaining a constant temperature environment for biological specimens during transfer. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below, constituting a part of this utility model. The illustrative embodiments of this utility model and their descriptions explain this utility model and do not constitute an improper limitation of this utility model; in the drawings:

[0018] Figure 1 This is a schematic diagram of the technical solution of the temperature control device for the biological live specimen transfer box disclosed in this utility model embodiment;

[0019] Figure 2 for Figure 1 External view;

[0020] Figure 3 for Figure 2 View from direction B;

[0021] Figure 4 for Figure 1 AA section view;

[0022] Figure 5 This is a block diagram of the circuit board.

[0023] In the picture:

[0024] 1. Outer casing; 11. Casing body; 12. Casing top cover; 13. Opening handle; 14. External interface; 15. Charging port; 16. Inner chamber; 17. Wheels; 2. Active temperature control unit; 21. Semiconductor module; 22. Temperature sensor; 23. Circuit board; 231. PID controller; 232. Temperature acquisition module; 233. Microcontroller; 234. Wireless communication module; 235. Storage module; 236. Positioning module; 237. Power module; 237. Controller; 24. Wire; 25. Passive temperature control unit; 31. Vacuum insulation plate; 32. Aerogel filling layer; 33. Double-layer silicone sealing ring; 34. Magnetic lock; 4. Emergency temperature control unit; 41. PCM phase change material plate; 42. Spare ice box slot; 5. Emergency knob; 6. Protective cover; 7. Liquid nitrogen tank; 8. Waterproof touch screen; 9. Audible and visual alarm. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of this utility model clearer, the technical solutions of this utility model will be clearly and completely described below in conjunction with specific embodiments and corresponding drawings. In the description of this utility model, it should be noted that the term "comprising" mentioned in the specification and claims is an open-ended term and should therefore be interpreted as "including but not limited to".

[0026] In the description of this utility model, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0027] Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments; based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0028] like Figures 1-5 As shown, the technical solution disclosed in this utility model is as follows:

[0029] A temperature control device for a biological live specimen transfer box includes an outer casing 1, an active temperature control unit 2, an emergency temperature control unit 4, a passive temperature control unit 3 for sealing on the outer surface and joint surfaces of the outer casing 1, and a waterproof touch screen 8 for real-time display of temperature measurement information, all installed in an inner chamber 16 of the outer casing 1.

[0030] The active temperature control unit 2 includes a circuit board 23 and a semiconductor module 21 connected to the circuit board 23 for bidirectional temperature control, multiple temperature sensors 22 evenly distributed in the inner chamber 16 for real-time temperature measurement, and a PID controller 231 for regulating the semiconductor module 21.

[0031] The emergency temperature control unit 4 includes a PCM phase change material plate 41 embedded in the inner wall of the outer casing 1 to provide latent heat when the temperature changes, and a spare ice box slot 42 into which ice can be inserted.

[0032] The passive temperature control unit 3 includes a vacuum insulation plate 31 that is attached to the outer wall of the box, an aerogel filling layer 32 for gaps, a magnetic lock 34 for connecting the box body 11 and the box cover 12, and a double-layer silicone sealing ring 33 located around the magnetic lock 34 for sealing.

[0033] like Figures 1-5 As shown, the preferred embodiment of this utility model is as follows:

[0034] A temperature control device for a biological live specimen transfer box includes an outer casing 1 and an active temperature control unit 2, an emergency temperature control unit 4, and a passive temperature control unit 3 installed on the outer surface and joint surfaces of the outer casing 1 for sealing.

[0035] The outer casing 1 includes a casing body 11 and a casing top cover 12 connected by the magnetic lock 34, forming an inner cavity 16. The top of the casing top cover 12 is equipped with an opening handle 13. The outer surface of the casing body 11 is equipped with a vacuum heat insulation plate 31. The right side wall of the casing body 11 is provided with an external interface 14, which can be connected to the liquid nitrogen tank 7 through a pipeline. The bottom of the casing body 11 is provided with a charging port 15, and the bottom of the casing body 11 is also equipped with wheels 17 to facilitate the movement of the casing. In this embodiment, Type-CPD fast charging is selected.

[0036] The front of the outer casing 1 is also equipped with a waterproof touch screen 8, an audible and visual alarm 9, and an emergency knob 5 for manually switching the power mode in case of power failure. The waterproof touch screen 8, the audible and visual alarm 9, and the emergency knob 5 are all connected to the circuit board 23 via wires 25. The waterproof touch screen 8 is also equipped with touch screen buttons for setting temperature control data. The emergency knob 5 is also equipped with a protective cover 6 to prevent accidental touch.

[0037] The waterproof touchscreen 8 is preset to a one-click start mode. The waterproof touchscreen 8 can also be wirelessly connected to an external controller 24, which can be a tablet computer or a mobile phone.

[0038] The audible and visual alarm 9 emits an audible and visual alarm when the temperature exceeds the limit, the power is interrupted, or there is severe vibration. The microcontroller 233 of the circuit board 23 sends specific information to a tablet computer or mobile phone.

[0039] The active temperature control unit 2 includes a circuit board 23 and a semiconductor module 21 for bidirectional temperature control connected to the circuit board 23 via wires 25, and multiple temperature sensors 22 evenly distributed in the inner chamber 16 for real-time temperature measurement.

[0040] The circuit board 23 includes a PID controller 231 for regulating the semiconductor module 21, a temperature acquisition module 232 connected to the temperature sensor 22 via wires 25, a storage module 235 for data storage, a microcontroller 233, a wireless communication module 234, a positioning module 236 for recording data related to the transportation path and ambient temperature, and a power supply module 237 for power supply. The microcontroller 233 controls the PID controller 231 to regulate the semiconductor module 21 based on the temperature data collected by the temperature sensor 22 and connects to an external controller 23 via the wireless communication module 234, i.e., to a tablet computer or mobile phone. The power supply module 237 includes a rechargeable battery and a backup power supply. The rechargeable battery is matched with the charging port 15. In this embodiment, a removable lithium battery with a capacity of 24V / 10Ah and a battery life of 12 hours is selected. The backup power supply is a supercapacitor, which is also connected to the audible and visual alarm 9. When the rechargeable battery is inconvenient to charge and has insufficient power, the emergency knob 5 can be manually turned to use the backup power supply. When the backup power supply is insufficient, the audible and visual alarm 9 will sound.

[0041] The emergency knob 5 is also equipped with a protective cover 6 to prevent accidental contact.

[0042] The PID controller 341 adjusts the temperature of the semiconductor module 21 in real time. In this embodiment, the semiconductor module 21 uses a thermoelectric cooler (TEC), which can perform bidirectional temperature control for both cooling and heating. The response speed is <30 seconds, which is fast. The PID controller 341 uses a PID algorithm to dynamically adjust parameters according to the ambient temperature, reducing overshoot fluctuations and ensuring that the internal temperature meets the temperature field requirements of the chamber. At the same time, the power of the thermoelectric cooler (TEC) can be selected according to the chamber volume. For example, a 10L volume requires ≥60W of cooling power to achieve an accuracy of ±0.3℃.

[0043] The temperature control sensors 22 are evenly distributed in the inner chamber 16 of the housing, with no fewer than 4 sensors. In this embodiment, 6 temperature control sensors 22 are set. The temperature control sensors 22 are selected as high-precision PT1000 platinum resistance thermometers with an accuracy of ±0.1℃ to avoid local temperature differences and accurately measure the temperature.

[0044] The emergency temperature control unit 4 includes a PCM phase change material plate 41 embedded in the inner wall of the outer casing 1 to provide latent heat when the temperature changes, and a spare ice box slot 42 into which ice can be inserted. In this embodiment, the PCM phase change material plate 41 is paraffin-based PCM with an energy storage density ≥200kJ / kg. It can maintain the temperature for 4-8 hours after power failure and is connected to the circuit board 23. The spare ice box slot 42 can be used to insert dry ice or ice packs during ultra-low temperature transportation.

[0045] When the temperature fluctuation inside the chamber exceeds the limit (±2℃), the system will automatically switch to the backup paraffin-based PCM or activate the backup cooling chip.

[0046] When the top cover 12 of the chamber is opened abnormally, the thermoelectric cooler (TEC) is triggered to cool down the sample quickly, thus protecting the sample, and the audible and visual alarm 9 is also triggered.

[0047] The passive temperature control unit 3 includes a vacuum insulation plate 31 that is attached to the outer wall of the box, an aerogel filling layer 32 for gaps, a magnetic lock 34 for connecting the box body 11 and the box cover 12, and a double-layer silicone sealing ring 33 located around the magnetic lock 34 for sealing.

[0048] The vacuum insulation board 31 selected in this embodiment has a thermal conductivity of ≤0.004 W / (m·K) and a thickness of 10-20mm, and is used on the outer wall of the box body 11.

[0049] The aerogel filling layer 32 is used in areas prone to heat leakage, such as door gaps and seams.

[0050] At least two equally spaced, horizontally arranged magnetic latches 34 are provided on each plane connecting the main body 11 and the upper cover 12. The upper end of each magnetic latch 34 is connected to the lower edge of the upper cover 12, so that when the upper cover 12 is placed on the upper part of the main body 11, all the magnetic latches 34 are simultaneously attracted to the magnetic sheet (not shown in the figure) provided on the main body 11 and locked. The double-layer silicone sealing ring 33 is attached to the outer joint of the magnetic latches 34 to play a sealing role, so that the inner cavity 16 of the outer box 1 is sealed. The heat leakage rate is ≤5 W / ㎡·h under a temperature difference of 25℃.

[0051] The commonly used temperature modes and scene adaptations are as follows:

[0052] Constant temperature mode: such as 4℃, -20℃, 37℃, for cell culture, tissue samples, and live animals, can use a semiconductor cooling chip (TEC) main controller and PCM phase change material plate for auxiliary temperature control;

[0053] Gradient mode: such as -20℃→4℃, used for staged thawing / warming (such as embryo transportation), and segmented PID controller control according to user preset program;

[0054] Ultra-low temperature mode: such as -80℃, used for transporting virus samples and special biological materials, using an external liquid nitrogen tank interface.

[0055] The embodiments of the present invention have been described above with reference to the accompanying drawings. However, the present invention is not limited to the specific embodiments described above. The specific embodiments described above are merely illustrative and not restrictive. Those skilled in the art can make many other forms under the guidance of the present invention without departing from the spirit and scope of the claims, and all of these forms are within the protection scope of the present invention.

Claims

1. A temperature control device for a biological live specimen transfer box, characterized in that: It includes an outer casing and an active temperature control unit, an emergency temperature control unit, a passive temperature control unit installed on the outer surface and joint surfaces of the outer casing for sealing, and a waterproof touch screen for real-time display of temperature measurement information, all installed within the inner cavity of the outer casing; wherein, The active temperature control unit includes a circuit board and a semiconductor module for bidirectional temperature control connected to the circuit board, multiple temperature sensors evenly distributed in the inner chamber for real-time temperature measurement, and a PID controller for regulating the semiconductor module. The emergency temperature control unit includes a PCM phase change material plate embedded in the inner wall of the outer casing to provide latent heat when the temperature changes, and a spare ice box slot into which ice can be inserted. The passive temperature control unit includes a vacuum insulation plate attached to the outer wall of the box, an aerogel filling layer for gaps, a magnetic lock for connecting the top cover and the box, and a sealing ring located around the magnetic lock for sealing.

2. The temperature control device for the biological live specimen transfer box according to claim 1, characterized in that: The outer casing includes a casing body and a casing top cover connected by the magnetic lock. The casing top cover is equipped with an opening handle. The outer surface of the casing body is covered with the vacuum insulation plate. The right side wall of the casing body is provided with an external interface. The bottom of the casing body is provided with a power module charging port and wheels for easy movement.

3. The temperature control device for the biological live specimen transfer box according to claim 2, characterized in that: The front of the outer casing is also equipped with a waterproof touch screen, an audible and visual alarm, and an emergency knob for manually switching to standby mode in case of power failure. The waterproof touch screen and the audible and visual alarm are both connected to the circuit board. The waterproof touch screen is also equipped with touch screen buttons for setting temperature control data. The emergency knob is also equipped with a protective cover to prevent accidental touch.

4. The temperature control device for the biological live specimen transfer box according to claim 3, characterized in that: The circuit board includes a temperature acquisition module connected to a temperature sensor via wires, a storage module for data storage, a PLC control module for constantly detecting the temperature of the inner chamber based on the temperature data acquired by the temperature sensor and controlling the data storage, a battery module for powering the device, and a microcontroller for controlling the temperature sensor to measure temperature and connected to the controller. It also includes a wireless communication module for transmitting information between the microcontroller and the controller.

5. The temperature control device for the biological live specimen transfer box according to claim 2, characterized in that: At least two magnetic locks are provided on each plane connecting the box body and the box cover, arranged horizontally at equal intervals, so that when the box cover is placed on the top of the box body, all the magnetic locks are simultaneously attracted and locked. A double-layer silicone sealing ring is attached to the periphery of the magnetic locks, so that the inner cavity of the outer box is in a sealed state.

6. The temperature control device for the biological live specimen transfer box according to claim 2, characterized in that: The external interface is connected to the liquid nitrogen tank via a pipeline.

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