Vacuum rectification equipment for biopharmacy

Abstract

The utility model discloses vacuum rectification equipment for biopharmacy, which relates to the technical field of biopharmacy equipment and comprises a vacuum rectification mechanism, and the vacuum rectification mechanism comprises a rectification tower, a controller, an air inlet pipe, a feed pipe, a vacuum pump and a discharge pipe. The gas-liquid contact area can be greatly increased, the tower plate is of a corrugated structure, vent holes are formed in wave crests and wave troughs, when liquid flows through the tower plate, a thick liquid film can be formed on the corrugated surface, gas penetrates through the liquid film through the vent holes, the gas-liquid contact time is prolonged, the gas-liquid contact strength is improved, gas-liquid contact is more sufficient, and the gas-liquid separation efficiency is improved. Steam makes full contact with liquid flowing from top to bottom on the surface of the filler for mass transfer and heat transfer, light components and heavy components are separated, meanwhile, the multiple turbulent flow blades enable gas and liquid to generate turbulent flow, the contact effect is further enhanced, the device can enable more gas and liquid molecules to participate in the mass transfer process, and the separation efficiency is effectively improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to biological pharmacy equipment technical field especially relates to a biological pharmacy is with vacuum rectification equipment. BACKGROUND

[0002] Biological pharmacy refers to the research results such as microbiology, biology, medicine, biochemistry, from organism, biological tissue, cell, organ, body fluid etc., comprehensive utilization microbiology, chemistry, biochemistry, biotechnology, pharmacy etc. The principle and method of science manufacturing a kind of product for preventing, treating and diagnosing, in biological pharmacy process, vacuum rectification is an important separation and purification technology, usually separates high-purity target product from biological fermentation broth or other biological pharmacy raw materials through vacuum rectification equipment.

[0003] As Chinese patent CN214551330U discloses a kind of biological pharmacy is with vacuum rectification equipment, including support table, the middle part of support table is fixedly installed with rectification tank, the upper part of rectification tank is connected with sealing upper cover, rectification tank, the upper surface of support table and located the right side of rectification tank is fixedly installed with support, the upper end of support is fixedly installed with cold water pipe, cooling pipe is fixedly sleeved in the inside of cold water pipe, the inner surface of cold water pipe and the outer surface of cooling pipe are all set with wave pattern.

[0004] The internal structure design of traditional vacuum rectification equipment rectification tower is not reasonable enough, gas-liquid contact area and contact time are limited, so that gas-liquid two phases cannot be fully mixed and contacted, many gas-liquid molecules cannot realize effective mass transfer process, so that light and heavy components cannot be fully separated, affect product purity, to solve the above problems, a kind of biological pharmacy is with vacuum rectification equipment. Utility model content

[0005] The utility model aims at solving the problems in prior art and proposes a kind of biological pharmacy is with vacuum rectification equipment.

[0006] In order to achieve the above object, the utility model discloses the following technical scheme: A kind of vacuum rectification equipment for biopharmaceutical, including vacuum rectification mechanism, the vacuum rectification mechanism includes rectifying column, controller, air inlet pipe, feed pipe, vacuum pump and discharge pipe, the outer side of one end of the discharge pipe is fixedly connected with cooling assembly, the top wall of the rectifying column is fixedly connected with fixed plate, and the both sides of the fixed plate are uniformly fixedly connected with multiple spoiler blades, the top end inner wall of the rectifying column is fixedly installed with annular distribution pipe, and the outer edge annular array of the distribution pipe is fixedly connected with multiple spray heads, one end of the feed pipe is fixedly communicated with the outside of distribution pipe, the inside of the rectifying column is fixedly connected with rectification component, the rectification component includes multiple alternately arranged packing plate and tray, the outside of the packing plate is provided with multiple mesh, the tray adopts corrugated structure, and the wave crest and wave trough of the tray are penetrated and provided with air hole.

[0007] Preferably, the top of the rectifying column is fixedly connected with vacuum pipe, and one end of the top of the rectifying column is fixedly communicated with one end of the discharge pipe.

[0008] Preferably, one end of the vacuum pipe is fixedly connected with the top of the vacuum pump, and the bottom end of the vacuum pump is fixedly installed with the outside of the rectifying column.

[0009] Preferably, one end of the outside of the rectifying column is fixedly connected with temperature sensor, and the other end of the outside of the rectifying column is fixedly connected with vacuum sensor.

[0010] Preferably, the front side of the rectifying column is fixedly installed with the both ends of the controller, and the bottom of the rectifying column is fixedly installed with support frame.

[0011] Preferably, the temperature sensor and vacuum sensor are signal connected with the controller.

[0012] Compared with the prior art, the utility model has the advantages and positive effects that:

[0013] 1、In the utility model, by setting rectification component, rectification component includes multiple alternately arranged packing plate and tray, packing plate adopts three-dimensional porous wire mesh material, can greatly increase gas-liquid contact area, tray adopts corrugated structure, wave crest and wave trough are provided with air hole, when liquid flows through tray, will form thicker liquid film on corrugated surface, gas passes through air hole and penetrates liquid film, increases the time and intensity of gas-liquid contact, makes gas-liquid contact more fully, vapor and from top to bottom flowing liquid are fully contacted on packing surface and carry out mass transfer and heat transfer, and light and heavy components are separated, and multiple spoiler blades make gas-liquid turbulent flow, further strengthen contact effect, the device can let more gas-liquid molecules participate in mass transfer process, effectively improve separation efficiency.

[0014] 2、The device can greatly increase the gas-liquid contact area through the rectification assembly, and the turbulent flow effect generated by the plurality of turbulence vanes significantly prolongs the contact time of the gas-liquid in the tower, so that the components with similar boiling points can more fully exchange heat and mass, realize more accurate separation, and improve product purity. BRIEF DESCRIPTION OF DRAWINGS

[0015] Figure 1 A perspective view of a biological pharmaceutical vacuum rectification equipment is provided for the utility model;

[0016] Figure 2 A rear side structure schematic view of a biological pharmaceutical vacuum rectification equipment is provided for the utility model;

[0017] Figure 3 A front view of a biological pharmaceutical vacuum rectification equipment is provided for the utility model;

[0018] Figure 4 A biological pharmaceutical vacuum rectification equipment is provided for the utility model; Figure 3 A detail enlarged view of A in the utility model.

[0019] Legend: 1, vacuum rectification mechanism; 2, rectification assembly; 11, support frame; 12, rectification tower; 13, controller; 14, air inlet pipe; 15, temperature sensor; 16, vacuum sensor; 17, feed pipe; 18, distribution pipe; 19, vacuum pipe; 110, discharge pipe; 111, cooling assembly; 112, vacuum pump; 113, fixed plate; 114, turbulence vane; 115, spray head; 21, filler plate; 22, tray; 23, mesh; 24, air hole. DETAILED DESCRIPTION

[0020] In order to more clearly understand the above-mentioned purposes, features and advantages of the utility model, the utility model will be further described below in combination with the drawings and examples. It should be noted that the embodiments of the present application and the features in the examples can be combined with each other without conflict.

[0021] In the following description, many specific details are set forth in order to provide a thorough understanding of the utility model, however, the utility model can also be implemented in other ways different from the description herein, therefore, the utility model is not limited to the specific embodiments disclosed in the following disclosure.

[0022] Example one: as Figure 1 - Figure 4The utility model provides a kind of vacuum rectification equipment for biopharmaceuticals, including vacuum rectification mechanism 1, vacuum rectification mechanism 1 includes rectifying column 12, controller 13, air inlet pipe 14, feed pipe 17, vacuum pump 112 and discharge pipe 110, one end outside of discharge pipe 110 is fixedly connected with cooling assembly 111, the top wall of rectifying column 12 is fixedly connected with fixed plate 113, and multiple turbulence vanes 114 are uniformly fixedly connected in the both sides symmetry of fixed plate 113, one end of feed pipe 17 is fixedly communicated with the outside of distribution pipe 18, rectifying column 12 is fixedly connected with rectification assembly 2 in its inside, rectification assembly 2 includes multiple alternately arranged packing plate 21 and tray 22, multiple mesh 23 are arranged on the outside of packing plate 21, tray 22 adopts corrugated structure, and air hole 24 is penetrated and arranged at the wave crest and wave trough of tray 22.

[0023] The specific settings and effects of the present embodiment are as follows: steam enters the packing plate 21 and tray 22 of the rectification assembly 2 during flow. The packing plate 21 is made of three-dimensional porous wire mesh material, which can greatly increase the gas-liquid contact area. The tray 22 adopts a corrugated structure, and the wave crest and wave trough are provided with air holes 24. When the liquid flows through the tray 22, a relatively thick liquid film is formed on the corrugated surface. The gas passes through the liquid film through the air holes 24, increasing the gas-liquid contact time and intensity, making the gas-liquid contact more sufficient. The steam and the liquid flowing from top to bottom fully contact on the packing surface for mass transfer and heat transfer, and the light and heavy components are separated. At the same time, the multiple turbulence vanes 114 make the gas-liquid produce turbulent flow, further strengthening the contact effect. The device can make more gas-liquid molecules participate in the mass transfer process, effectively improve the separation efficiency, reduce the number of repeated rectification operations, reduce the production cost, and improve the quality and purity of the biopharmaceutical product.

[0024] Embodiment two: as Figure 1 - Figure 3 As shown, the inner wall of the top end of the rectifying column 12 is fixedly installed with an annular distribution pipe 18, and the outer edge of the distribution pipe 18 is fixedly connected with multiple spray heads 115 in an annular array. The top of the rectifying column 12 is fixedly connected with a vacuum pipe 19, and one end of the top of the rectifying column 12 is fixedly communicated with one end of the discharge pipe 110. One end of the vacuum pipe 19 is fixedly connected with the top of the vacuum pump 112. The bottom end of the vacuum pump 112 is fixedly installed with the outside of the rectifying column 12. One end of the outside of the rectifying column 12 is fixedly connected with a temperature sensor 15, and the other end of the outside of the rectifying column 12 is fixedly connected with a vacuum sensor 16. The front side of the rectifying column 12 is fixedly installed with both ends of the controller 13, and the bottom of the rectifying column 12 is fixedly installed with a support frame 11. The temperature sensor 15 and the vacuum sensor 16 are signal connected with the controller 13.

[0025] The effect achieved by the whole embodiment is that the biological pharmaceutical raw materials are continuously conveyed into the feeding pipe 17 and finally into the distribution pipe 18, which is provided with multiple spray heads 115 towards the tower, the spray heads 115 uniformly disperse the raw materials into fine droplets and spray them into the rectifying tower 12 at different angles, so that the droplets rapidly contact with the rising gas.

[0026] The method of using and working principle of the device are as follows: the rectifying tower 12 is vertically installed on a stable base, the equipment is comprehensively checked to ensure that each component is firmly installed and has no leakage, professional instruments are used to calibrate the temperature sensor 15 and the vacuum sensor 16 to ensure the accuracy of the measurement data, the biological pharmaceutical raw materials are continuously conveyed into the feeding pipe 17 and finally into the distribution pipe 18, which is provided with multiple spray heads 115 towards the tower, the spray heads 115 uniformly disperse the raw materials into fine droplets and spray them into the rectifying tower 12 at different angles, so that the droplets rapidly contact with the rising gas; at the same time, the heating device is started while conveying the biological pharmaceutical raw materials, the tower body temperature is accurately adjusted by the controller 13 according to the component characteristics and process requirements of the biological pharmaceutical, and the vacuum pump 112 is started, the vacuum degree in the tower is adjusted to a suitable range by the vacuum pump 112 and the vacuum pipe 19, the steam is conveyed into the tower through the air inlet pipe 14 and flows upward, the steam enters the packing plate 21 and the tower plate 22 of the rectifying assembly 2 during the flow process; the packing plate 21 is made of three-dimensional porous wire mesh material and is subjected to hydrophilic treatment on the surface, has a very high specific surface area, and can greatly increase the gas-liquid contact area, in addition, the tower plate 22 has a corrugated structure, air holes 24 are arranged at the wave crests and troughs, when the liquid flows through the tower plate 22, a relatively thick liquid film is formed on the corrugated surface, the gas passes through the liquid film through the air holes 24, which increases the time and intensity of gas-liquid contact, so that the gas-liquid contact is more sufficient, the steam fully contacts with the liquid flowing downward on the packing surface to perform mass and heat transfer, the light and heavy components are separated, and the multiple turbulence vanes 114 make the gas and liquid produce turbulent flow, which further strengthens the contact effect, the device can make more gas-liquid molecules participate in the mass transfer process, effectively improve the separation efficiency, reduce the number of repeated rectification operations, reduce the production cost, improve the quality and purity of the biological pharmaceutical product, and enhance the market competitiveness of the product, the tower top steam enters the discharge pipe 110 and is condensed into liquid under the cooling effect of the circulating cooling water of the cooling assembly 111, and the high-purity biological pharmaceutical product is collected;

[0027] At the same time, the device can greatly increase the gas-liquid contact area through the rectifying assembly 2, and the turbulent flow effect generated by the multiple turbulence vanes 114 significantly prolongs the contact time of the gas and liquid in the tower, so that the components with similar boiling points can more fully exchange heat and mass to achieve more accurate separation and improve the product purity.

[0028] The above merely describes preferred embodiments of the present application, and is not intended to limit the present application in other forms, and any skilled person in the art can modify or change the above disclosed technical content to equivalent embodiments applied to other fields with equivalent changes, but any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present application without departing from the technical scheme of the present application still falls within the protection scope of the present application.

Claims

1. A vacuum rectification device for biopharmaceuticals, comprising a vacuum rectification mechanism (1), wherein the vacuum rectification mechanism (1) comprises a rectification tower (12), a controller (13), an air inlet pipe (14), a feed pipe (17), a vacuum pump (112) and a discharge pipe (110), one end of the discharge pipe (110) is fixedly connected with a cooling assembly (111) outside, characterized in that: The top wall of the rectifying tower (12) is fixedly connected with a fixed plate (113), a plurality of spoiler blades (114) are fixedly and uniformly connected on the two sides of the fixed plate (113) in a symmetrical manner, an annular distribution pipe (18) is fixedly installed on the inner wall of the top end of the rectifying tower (12), a plurality of spray heads (115) are fixedly and annularly arranged on the outer edge of the distribution pipe (18), one end of the feed pipe (17) is fixedly communicated with the outer side of the distribution pipe (18), a rectifying assembly (2) is fixedly connected inside the rectifying tower (12), the rectifying assembly (2) comprises a plurality of alternately arranged filler plates (21) and trays (22), a plurality of mesh holes (23) are arranged on the outer side of the filler plate (21), the tray (22) adopts a corrugated structure, and a ventilation hole (24) is formed through the wave crest and wave trough of the tray (22). ​ 2. The biopharmaceutical vacuum rectification apparatus according to claim 1, characterized by: The top of the rectifying tower (12) is fixedly connected with a vacuum pipe (19), and one end of the top of the rectifying tower (12) is fixedly communicated with one end of a discharge pipe (110).

3. The biopharmaceutical vacuum rectification apparatus according to claim 2, characterized by: One end of the vacuum pipe (19) is fixedly connected with the top of a vacuum pump (112), and the bottom end of the vacuum pump (112) is fixedly installed on the outer side of the rectifying tower (12).

4. The biopharmaceutical vacuum rectification apparatus according to claim 3, characterized by: One end of the outer side of the rectifying tower (12) is fixedly connected with a temperature sensor (15), and the other end of the outer side of the rectifying tower (12) is fixedly connected with a vacuum sensor (16).

5. The biopharmaceutical vacuum rectification apparatus according to claim 1, wherein: The front side of the rectifying tower (12) is fixedly installed with the two ends of a controller (13), and the bottom of the rectifying tower (12) is fixedly installed with a support frame (11).

6. The biopharmaceutical vacuum rectification apparatus according to claim 4, wherein: The temperature sensor (15) and the vacuum sensor (16) are signal connected with the controller (13).

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