Modular low-pressure ursodesoxycholic acid separation assembly

Abstract

The utility model relates to the technical field of chemical separation, and discloses a modularized low-pressure ursodesoxycholic acid separation assembly which comprises a material disc, a partition plate is fixedly connected to the inner wall of the material disc, a connecting disc is rotatably connected to the lower surface of the material disc, and a stirring cabin is fixedly connected to the lower surface of the connecting disc. A second discharging pipe is fixedly connected to the interior of the stirring bin, a first valve is rotationally connected to one side of the outer wall of the second discharging pipe, a filtering bin is fixedly connected to the outer wall of the second discharging pipe, and a filtering assembly is arranged on one side of the inner wall of the filtering bin and comprises a sliding rail. According to the utility model, the effect of enabling materials to enter the filtering cabin is achieved by opening the valve I, the effect of carrying out multi-stage filtering on the materials is achieved by installing the coarse filtering net and the fine filtering net in the filtering cabin, and the effect of effectively improving the purity and the quality of products is achieved by carrying out finer and more thorough separation on the materials.

Description

Technical Field

[0001] This utility model relates to the field of chemical separation technology, and in particular to a modular low-pressure ursodeoxycholic acid separation component. Background Technology

[0002] Ursodeoxycholic acid (UDCA) is an important pharmaceutical ingredient, and its separation and purification process is crucial. With the pharmaceutical industry's increasing demands for drug quality and production efficiency, the development of a highly efficient, stable, and easy-to-operate / maintain modular low-pressure UDCA separation unit has become an urgent need for industry development. This separation unit must not only be able to accurately extract high-purity UDCA from complex mixtures, but also adapt to the needs of production at different scales, reducing production costs while ensuring product quality.

[0003] Currently, traditional separation equipment for ursodeoxycholic acid (UDCA) separation processes often employs relatively simple structures. For example, some equipment uses only a single filtration device or simple sedimentation for separation. In filtration, ordinary fixed filter screens are commonly used, relying on gravity or simple pressure differences to force the material through the screen and achieve solid-liquid separation. Sedimentation utilizes the density differences of the components in the material, allowing heavier impurities to settle under static conditions, thus achieving preliminary separation. In the mixing stage, a single agitator blade is often used, driven by a motor to rotate and mix the material.

[0004] However, these traditional separation technologies have shortcomings. One prominent problem is the low material separation efficiency, making it difficult to achieve fine and thorough separation of ursodeoxycholic acid. The use of simple filtration and sedimentation methods fails to effectively remove minute impurities and colloidal substances from the material, resulting in the final product's purity and quality failing to meet high standards. For example, when using ordinary fixed filters, some small-particle impurities can easily pass through the filter and mix into the ursodeoxycholic acid product, affecting its pharmaceutical efficacy and safety. This not only limits the product's application in the high-end pharmaceutical market but also increases the cost of subsequent purification and refining, reduces production efficiency, and fails to meet the growing market demand. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides a modular low-pressure ursodeoxycholic acid separation component, which aims to improve the problem of low material separation efficiency and difficulty in fine and thorough separation of ursodeoxycholic acid in existing separation components.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a modular low-pressure ursodeoxycholic acid separation component, comprising a material tray, a partition fixedly connected to the inner wall of the material tray, a connecting plate rotatably connected to the lower surface of the material tray, a stirring chamber fixedly connected to the lower surface of the connecting plate, a discharge pipe II fixedly connected inside the stirring chamber, a valve I rotatably connected to one side of the outer wall of the discharge pipe II, a filter chamber fixedly connected to the outer wall of the discharge pipe II, and a filter assembly provided on one side of the inner wall of the filter chamber;

[0007] The filter assembly includes a slide rail, one side of the outer wall of the slide rail is fixedly connected to one side of the inner wall of the filter chamber, a coarse filter screen is slidably connected to the inner wall of the slide rail, a sealing strip is fixedly connected to one side of the outer wall of the coarse filter screen, a fine filter screen is slidably connected to the inner wall of the filter chamber, a discharge pipe is fixedly connected to the outer wall of the filter chamber, and a valve is rotatably connected to the outer wall of the discharge pipe.

[0008] Furthermore, a motor is fixedly connected to the upper surface of the connecting plate, a rotating shaft is fixedly connected to the output end of the motor, a connecting plate is fixedly connected to the outer wall of the rotating shaft, a second stirring blade is fixedly connected to the lower surface of the connecting plate, and a first stirring blade is fixedly connected to the lower surface of the rotating shaft.

[0009] Furthermore, a jacket is fixedly connected to the outer wall of the connecting plate, and an electric heating coil is fixedly connected inside the jacket.

[0010] Furthermore, a guide plate is fixedly connected to the inner wall of the mixing chamber, and the guide plate is used to change the flow direction and path of the material.

[0011] Furthermore, a support column is fixedly connected to the outer wall of the jacket, and the support column serves to support the components on it.

[0012] Furthermore, the outer wall of the fine filter screen is slidably connected to the inner wall of the slide rail, and the slide rail serves to limit the movement of the fine filter screen.

[0013] Furthermore, the inner wall of the jacket is fixedly connected to the outer wall of the mixing chamber, and the mixing chamber serves to provide a reaction site for the materials inside.

[0014] Furthermore, a sealing strip is fixedly connected to one side of the outer wall of the fine filter screen, and the sealing strip serves to seal the filter chamber.

[0015] This utility model has the following beneficial effects:

[0016] 1. In this utility model, by opening valve one, the material is allowed to enter the filter chamber. At this time, by installing coarse and fine filter screens in the filter chamber, the material is filtered in multiple stages. This results in a finer and more thorough separation of the material, effectively improving the purity and quality of the product. Furthermore, by using a slide rail in the filter chamber and installing the filter element on the slide rail, the filter element can be easily replaced by simply pulling it out, thus ensuring the stability of the separation effect.

[0017] 2. In this utility model, by installing stirring blade one and stirring blade two, the stirring area is made wider, and the material flow between adjacent blades complements each other. At this time, by installing baffles on the inner wall of the stirring chamber, the flow direction and path of the material are changed. At this time, the material forms a more uniform flow under the action of stirring blade one and stirring blade two, making the reaction process more stable and predictable, thereby improving the controllability and reliability of the entire separation process. Attached Figure Description

[0018] Figure 1 This is a three-dimensional structural diagram of a modular low-pressure ursodeoxycholic acid separation component proposed in this utility model.

[0019] Figure 2 This is a schematic diagram of the jacket structure of a modular low-pressure ursodeoxycholic acid separation component proposed in this utility model.

[0020] Figure 3 This is a schematic diagram of the stirring chamber structure of a modular low-pressure ursodeoxycholic acid separation component proposed in this utility model.

[0021] Figure 4 This is a schematic diagram of the filter chamber structure of a modular low-pressure ursodeoxycholic acid separation component proposed in this utility model.

[0022] Legend:

[0023] 1. Material tray; 2. Baffle plate; 3. Motor; 4. Jacket; 5. Heating coil; 6. Filter chamber; 7. Discharge pipe one; 8. Mixing chamber; 9. Connecting plate; 10. Rotating shaft; 11. Mixing blade one; 12. Connecting plate; 13. Mixing blade two; 14. Guide plate; 15. Discharge pipe two; 16. Valve one; 17. Slide rail; 18. Coarse filter screen; 19. Fine filter screen; 20. Sealing strip; 21. Valve two; 22. Support column. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Reference Figure 1 , Figure 2 and Figure 4 This utility model provides an embodiment of a modular low-pressure ursodeoxycholic acid separation component, comprising a material tray 1 for holding raw materials, a partition 2 fixedly connected to the inner wall of the material tray 1 for separation, a connecting plate 9 rotatably connected to the lower surface of the material tray 1, and a stirring chamber 8 fixedly connected to the lower surface of the connecting plate 9 for providing a reaction site, a discharge pipe 15 fixedly connected inside the stirring chamber 8, a valve 16 rotatably connected to one side of the outer wall of the discharge pipe 15, a filter chamber 6 fixedly connected to the outer wall of the discharge pipe 15 for filtering the reactants, a filter assembly provided on one side of the inner wall of the filter chamber 6, the filter assembly including a slide rail 17, a coarse filter screen 18 slidably connected to the inner wall of the slide rail 17, and a sealing strip 20 fixedly connected to one side of the outer wall of the coarse filter screen 18 for sealing, the inner wall of the filter chamber 6... A fine filter screen 19 and a coarse filter screen 18 are slidably connected to filter the reactants. A discharge pipe 7 is fixedly connected to the outer wall of the filter chamber 6. A valve 21 is rotatably connected to the outer wall of the discharge pipe 7. A jacket 4 is fixedly connected to the outer wall of the connecting plate 9. An electric heating coil 5 is fixedly connected inside the jacket 4 to provide heat. A guide plate 14 is fixedly connected to the inner wall of the stirring chamber 8 to change the flow direction and path of the material. A support column 22 is fixedly connected to the outer wall of the jacket 4 to support the components above it. The outer wall of the fine filter screen 19 is slidably connected to the inner wall of the slide rail 17 to limit the movement of the fine filter screen 19. The inner wall of the jacket 4 is fixedly connected to the outer wall of the stirring chamber 8, which provides a reaction site for the materials inside. A sealing strip 20 is fixedly connected to one side of the outer wall of the fine filter screen 19 to seal the filter chamber 6.

[0026] Specifically, multiple baffles 2 are firmly fixed to the inner wall of the material tray 1. The baffles 2 can effectively separate different types of materials or different batches of raw materials to be processed, avoiding mutual interference and ensuring that the materials can enter the mixing chamber 8 in a predetermined order and proportion during subsequent operations, thereby improving the accuracy and stability of the entire separation process. The lower surface of the material tray 1 is connected to the connecting tray 9 through a precise rotating connection structure. The connecting tray 9 not only acts as a bridge connecting the material tray 1 and the mixing chamber 8, but also supports other important components. The mixing chamber 8 is firmly fixed to the lower surface of the connecting tray 9. The mixing chamber 8 is the core reaction area of ​​the entire separation assembly. The discharge pipe 2 15 is fixedly connected inside the mixing chamber 8. The discharge pipe 2 15 is like the material discharge pipe of the mixing chamber 8. The material output channel, after the material in the mixing chamber 8 has completed sufficient mixing and chemical reaction, will be transported to the subsequent filtration stage through the discharge pipe 2 15. A valve 1 16 is rotatably connected to one side of the outer wall of the discharge pipe 2 15. Valve 1 16 acts as a precise flow control switch, allowing operators to flexibly control the discharge speed and flow rate according to actual production needs and process requirements, ensuring that the material enters the filtration chamber 6 smoothly and orderly. A guide plate 14 is fixedly connected to the inner wall of the mixing chamber 8. The guide plate 14 has an ingenious design; it cleverly changes the flow direction and path of the material. When the mixing device in the mixing chamber 8 is working, the material begins to flow under the action of the mixing force, and the guide plate 14 guides this flowing material, making the material flow smoothly and orderly. A complex and ordered flow field is formed, which greatly improves the mixing effect of materials, allowing them to fully contact each other, thereby accelerating the chemical reaction and improving the separation efficiency of ursodeoxycholic acid. The outer wall of the connecting plate 9 is tightly fixed to the jacket 4, and the jacket 4 is fixedly connected to the heating coil 5. The jacket 4 and the heating coil 5 together constitute a highly efficient temperature control system. In the separation process of ursodeoxycholic acid, temperature has a crucial impact on the reaction rate and effect. The heating coil 5 can heat according to the preset temperature value. The heat is evenly transferred to the stirring chamber 8 through the jacket 4, so that the materials in the stirring chamber 8 are always in the most suitable reaction temperature environment, whether it is necessary to raise the temperature to accelerate the reaction or maintain a constant temperature to ensure the stability of the reaction. This temperature control system plays a crucial role, effectively improving the selectivity and conversion rate of the reaction. A support column 22 is fixedly connected to the outer wall of the jacket 4. This support column 22 acts as a solid pillar for the entire separation assembly, steadily supporting the various components and ensuring the stability of the entire device during operation. It can withstand the weight of components such as the stirring chamber 8, connecting plate 9, and material plate 1, while also reducing the impact of external vibrations or other factors on the operation of the device, ensuring the relative stability of the various components. This provides a reliable foundation for the smooth processing and efficient separation of materials. The outer wall of the discharge pipe 15 is fixedly connected to the filter chamber 6, which is a key component for filtering impurities from the stirred material. A filter assembly is installed on one side of the inner wall of the filter chamber 6.The filter assembly mainly consists of a slide rail 17, a coarse filter screen 18, and a fine filter screen 19. One side of the outer wall of the slide rail 17 is firmly fixed to one side of the inner wall of the filter chamber 6. It acts as the movement track for the coarse and fine filter screens 18 and 19. The slide rail 17 not only precisely limits the movement of the coarse and fine filter screens 18 and 19, ensuring they remain in the correct position during filtration, but also facilitates the installation, disassembly, and replacement of the filter screens by operators. When the filter screens need cleaning or are damaged due to long-term use, operators can easily remove them along the slide rail 17 for maintenance, greatly improving the ease of equipment maintenance. A sealing strip 20 is fixedly connected to one side of the outer wall of the coarse filter screen 18. The coarse filter screen 18 is mainly used to intercept larger particulate impurities in the material, such as unreacted solid particles and impurity clumps. It can initially filter out most visible impurities, reducing the filtration burden on the subsequent fine filter screen 19 and improving the efficiency of the entire filtration system. The sealing strip 20 plays a crucial sealing role, tightly fitting against the inner wall of the filter chamber 6 to prevent... To prevent material leakage from the gap between the coarse filter screen 18 and the filter chamber 6 during the filtration process, ensuring that only material filtered by the coarse filter screen 18 can enter the subsequent fine filter screen 19 filtration stage, the outer wall of the fine filter screen 19 is slidably connected to the inner wall of the slide rail 17. The fine filter screen 19 has a higher filtration precision and is mainly used to filter out tiny particulate impurities and colloidal substances in the material, further improving the purity of the ursodeoxycholic acid solution. Similarly, a sealing strip 20 is also fixedly connected to one side of the outer wall of the fine filter screen 19. The design of the double sealing strip 20 further enhances the filtration chamber. The airtight seal of filter chamber 6 ensures the integrity and efficiency of the filtration process. A discharge pipe 7 is fixedly connected to the outer wall of filter chamber 6, serving as the output channel for the filtered material. A valve 21 is rotatably connected to the outer wall of discharge pipe 7, controlling the discharge of the filtered material. Operators can flexibly open or close valve 21 and adjust the discharge speed according to the needs of subsequent processes, ensuring that the filtered material smoothly enters the next processing stage, achieving continuous and automated ursodeoxycholic acid separation.

[0027] Reference Figure 1 and Figure 3 A motor 3 is fixedly connected to the upper surface of the connecting plate 9. The motor 3 is used to provide power. A rotating shaft 10 is fixedly connected to the output end of the motor 3. The rotating shaft 10 plays the role of transmitting power. A connecting plate 12 is fixedly connected to the outer wall of the rotating shaft 10. A stirring blade 2 13 is fixedly connected to the lower surface of the connecting plate 12. A stirring blade 11 is fixedly connected to the lower surface of the rotating shaft 10. The stirring blade 2 13 and the stirring blade 11 are used to make the raw materials more fully mixed.

[0028] Specifically, the motor 3 is securely fixed to the upper surface of the connecting plate 9. As the power source of the entire mixing system, the importance of the motor 3 is self-evident. After being powered on, the motor 3 can output stable and strong power, providing the necessary kinetic energy for the operation of subsequent components. The output end of the motor 3 is precisely fixed to the rotating shaft 10. The rotating shaft 10 acts as an energy transmission link between the motor 3 and the mixing components. The rotational power generated by the motor 3 is efficiently and stably transmitted to each mixing component through the rotating shaft 10, ensuring the continuity and stability of the entire mixing process. Simultaneously, the rotating shaft 10, by its own... The rigid structure ensures good stability during high-speed rotation, preventing shaking or deformation from affecting the mixing effect. A connecting plate 12 is firmly fixed to the outer wall of the rotating shaft 10. The connecting plate 12 plays a crucial role in connecting and supporting the second mixing blade 13. It transmits the rotational motion of the rotating shaft 10 to the second mixing blade 13, allowing the second mixing blade 13 to move in a circular motion along with the rotating shaft 10. Furthermore, the design of the connecting plate 12 allows for reasonable adjustment of the installation position and angle of the second mixing blade 13 according to actual mixing needs, achieving more comprehensive and effective mixing of materials. The lower surface of the connecting plate 12 is tightly... A second stirring blade 13 is tightly fixedly connected to the mixing chamber 8. The second stirring blade 13 plays a crucial role in the entire mixing process. When the rotating shaft 10 drives the connecting plate 12 to rotate, the second stirring blade 13 rotates at high speed. The shape and structural design of the second stirring blade 13 generate a strong stirring force on the material during rotation, causing the material to produce complex flow patterns within the mixing chamber 8, including axial and radial flow. This complex flow promotes thorough mixing between materials, allowing the crude ursodeoxycholic acid to fully contact with various purification reagents and solvents, accelerating the chemical reaction and improving reaction efficiency. The rotating shaft 10 is shown in the table below. The surface is also firmly fixedly connected to the stirring blade 11. The stirring blade 11 and the stirring blade 2 13 work together to complete the stirring task. The stirring blade 11 is located at the bottom of the stirring chamber 8. During rotation, it can effectively stir and turn the material near the bottom, preventing the material from accumulating or settling at the bottom. The shape and size design of the stirring blade 11 fully considers the characteristics and flow requirements of the material at the bottom. It can generate strong shear force to break up any material clumps that may form at the bottom, so that the material can be more evenly distributed and mixed in the entire stirring chamber 8, further improving the separation effect of ursodeoxycholic acid.

[0029] Working Principle: In processing ursodeoxycholic acid (UDCA), the UDCA-containing material is placed in a material tray 1. The baffle 2 installed inside the material tray 1 provides initial separation. Rotating the material tray 1 aligns its internal through-holes with those in the connecting tray 9, allowing the material to sequentially enter the mixing chamber 8 through the through-holes in the connecting tray 9. Once the reactants enter the mixing chamber 8, the motor 3 is activated, providing power to rotate the rotating shaft 10. The rotating shaft 10 then rotates the connecting plate 12 on the outer wall and the two stirring blades 11 and 13 on its lower surface, thus mixing the material in the mixing chamber 8. This ensures sufficient contact between the materials, allowing for appropriate chemical or physical mixing processes, promoting the separation of UDCA. Simultaneously, the guide plate 14 fixedly installed on the inner wall of the mixing chamber 8 alters the flow direction and path of the material, resulting in a more... The complex flow field further enhances the mixing effect. After mixing, by opening valve 16 on one side of the outer wall of discharge pipe 15, the material in mixing chamber 8 enters filter chamber 6 through discharge pipe 15. The material first undergoes preliminary filtration through coarse filter screen 18 to intercept larger particles. After preliminary filtration, the material enters fine filter screen 19 for multiple filtrations, resulting in finer and more thorough separation, effectively improving the purity and quality of the product. Sealing strips 20 are installed on the outer walls of both coarse and fine filter screens 18 and 19 to seal the filter chamber 6. A slide rail 17 is installed inside the filter chamber 6, with the inner wall of the slide rail 17 slidably connecting the coarse and fine filter screens 18 and 19. When replacing the filter element, the operator only needs to pull the filter element out of the slide rail 17 to replace it, thereby improving the efficiency of material filtration and separation.

[0030] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A modular separation assembly for low pressure ursodeoxycholic acid, comprising a material tray (1), characterized in that: The inner wall of the material disc (1) is fixedly connected with a partition (2), the lower surface of the material disc (1) is rotatably connected with a connecting disc (9), the lower surface of the connecting disc (9) is fixedly connected with a stirring cabin (8), the inside of the stirring cabin (8) is fixedly connected with a discharge pipe two (15), one side of the outer wall of the discharge pipe two (15) is rotatably connected with a valve one (16), the outer wall of the discharge pipe two (15) is fixedly connected with a filter cabin (6), one side of the inner wall of the filter cabin (6) is provided with a filter assembly; The filter assembly comprises a sliding rail (17), one side of the outer wall of the sliding rail (17) is fixedly connected to one side of the inner wall of the filter cabin (6), the inner wall of the sliding rail (17) is slidably connected with a coarse filter screen (18), one side of the outer wall of the coarse filter screen (18) is fixedly connected with a sealing strip (20), the inner wall of the filter cabin (6) is slidably connected with a fine filter screen (19), the outer wall of the filter cabin (6) is fixedly connected with a discharge pipe one (7), and the outer wall of the discharge pipe one (7) is rotatably connected with a valve two (21).

2. A modular low pressure ursodeoxycholic acid separation assembly according to claim 1, characterized in that: The upper surface of the connecting disc (9) is fixedly connected with a motor (3), the output end of the motor (3) is fixedly connected with a rotating shaft (10), the outer wall of the rotating shaft (10) is fixedly connected with a connecting plate (12), the lower surface of the connecting plate (12) is fixedly connected with a stirring blade two (13), and the lower surface of the rotating shaft (10) is fixedly connected with a stirring blade one (11).

3. The modular low pressure ursodeoxycholic acid separation assembly of claim 1, wherein: The outer wall of the connecting disc (9) is fixedly connected with a jacket (4), and the inside of the jacket (4) is fixedly connected with an electric heating ring (5).

4. The modular low pressure ursodeoxycholic acid separation assembly of claim 2, wherein: The inner wall of the stirring cabin (8) is fixedly connected with a guide plate (14), and the guide plate (14) is used for changing the flow direction and path of the material.

5. The modular low pressure ursodeoxycholic acid separation assembly of claim 3, wherein: The outer wall of the jacket (4) is fixedly connected with a supporting column (22), and the supporting column (22) supports the components above.

6. The modular low pressure ursodeoxycholic acid separation assembly of claim 1, wherein: The outer wall of the fine filter screen (19) is slidably connected to the inner wall of the sliding rail (17), and the sliding rail (17) limits the movement of the fine filter screen (19).

7. The modular low pressure ursodeoxycholic acid separation assembly of claim 5, wherein: The inner wall of the jacket (4) is fixedly connected to the outer wall of the stirring cabin (8), and the stirring cabin (8) provides a reaction site for the material inside.

8. The modular low pressure ursodeoxycholic acid separation assembly of claim 1, wherein: One side of the outer wall of the fine filter screen (19) is fixedly connected with a sealing strip (20), and the sealing strip (20) seals the filter cabin (6).

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