Antibody concentration device

Abstract

The utility model provides an antibody concentration device, which relates to the technical field of antibody concentration and comprises a main board, a dialysis device is mounted at the top end of the main board, a concentration device main body is mounted on one side of the dialysis device, and a PEG (polyethylene glycol) recovery device is mounted on one side of the concentration device main body. Two connecting pipes are arranged among the dialysis device, the concentration device main body and the PEG recovery device, the dialysis device, the concentration device main body and the PEG recovery device are communicated through the connecting pipes, and mounting plates are arranged on the two sides of the bottom end of the main plate. During installation, the bidirectional screw can be driven to rotate through operation of the motor, so that the two moving blocks move in opposite directions under limiting of the limiting columns, the multiple sets of connecting blocks are driven to move in opposite directions, and at the moment, the device can conduct clamping installation according to actual installation requirements; and traditional bolt installation can still be carried out through the installation plate and the installation holes, and the practicability is higher.

Description

Technical Field

[0001] This utility model relates to the field of antibody concentration technology, and in particular to an antibody concentration device. Background Technology

[0002] In the fields of biotechnology and medical research, the preparation and application of antibodies are extremely widespread. Antibodies play a crucial role in disease diagnosis, immunotherapy, and basic biological research. During antibody production, whether using hybridoma technology to prepare monoclonal antibodies or employing genetic engineering techniques to produce recombinant antibodies, the initial antibody solution often has a low concentration.

[0003] Currently, one type of antibody concentration device has poor sealing of the pipelines when connecting various components, which easily leads to leakage and reduces its practicality. In addition, the existing antibody concentration device can only be installed and disassembled by multiple bolts, and cannot be changed to a simpler installation and disassembly method according to actual needs, which has great limitations and poor practicality. Utility Model Content

[0004] The purpose of this utility model is to solve the problems of poor sealing of pipes when connecting various components in the existing technology, which easily leads to leakage, poor practicality, and the fact that the whole can only be installed and disassembled by multiple bolts, which cannot be changed to a simpler installation and disassembly method according to actual needs, thus having great limitations. Therefore, an antibody concentration device is proposed.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: an antibody concentration device, comprising a main board, a dialysis device mounted on the top of the main board, a concentration device body mounted on one side of the dialysis device, and a PEG recovery device mounted on one side of the concentration device body. Two connecting pipes are provided between the dialysis device, the concentration device body, and the PEG recovery device, and the dialysis device, the concentration device body, and the PEG recovery device are connected through the connecting pipes. Mounting plates are provided on both sides of the bottom of the main board. The main board contains a driving structure for driving the two mounting plates to move in opposite directions. Multiple mounting holes are provided in the mounting plates.

[0006] Preferably, the drive structure includes a motor located at one end of the motherboard. The output end of the motor passes through one side of the motherboard and is fixed with a bidirectional screw. Both ends of the outer wall of the bidirectional screw are threaded with movable blocks. The ends of the two movable blocks away from the bidirectional screw are slidably connected to a limit post. The bottom ends of the two movable blocks are fixed with multiple connecting blocks. The bottom ends of the connecting blocks pass through the bottom end of the motherboard and are respectively fixed to their corresponding mounting plates.

[0007] Preferably, a sealing sleeve is fixed to the outer wall of one of the opposite ends of the two connecting pipes, and a rubber sealing plate is fixed to the end of one of the sealing sleeves facing the other sealing sleeve. A sealing groove matching the rubber sealing plate is opened at one end of the sealing sleeve.

[0008] Preferably, a flange is fixed to the outer wall of each of the two sealing sleeves, and the two flanges are fixed together by a second bolt.

[0009] Preferably, the end of the bidirectional screw away from the motor is rotatably connected to the main board, both ends of the limiting post are fixed to the main board, the bottom end of the main board is provided with a moving groove that matches the connecting block, a bracket is fixed on the outer wall of the main board, and the motor is installed on the end of the bracket facing the main board.

[0010] Preferably, the bottom of the dialysis device, the concentration device body, and the PEG recovery device are all fixed with a fixing plate, and the fixing plate is fixed to the main board by a first bolt.

[0011] Compared with the prior art, the advantages and positive effects of this utility model are as follows:

[0012] In this invention, during installation, the motor drives the bidirectional screw to rotate, causing two moving blocks to move towards each other under the limit of the limiting post, thereby driving multiple sets of connecting blocks to move towards each other. At this time, this device can perform clamping installation according to actual installation requirements. When there is no clamping point at the installation position, traditional bolt installation can still be performed through the mounting plate and mounting holes, making it more practical. In addition, through the setting of the sealing sleeve, when two connecting pipes are connected, the rubber sealing plate at one end of one sealing sleeve will be inserted into the sealing groove inside the other sealing sleeve. Through the elastic stretching of the rubber sealing plate, the sealing groove will be completely filled, achieving the effect of sealing the gap between the two connecting pipes. Finally, the installation is completed by flange and second bolt. Attached Figure Description

[0013] Figure 1 A perspective view of an antibody concentration device is provided for this utility model;

[0014] Figure 2 A bottom-view perspective view of an antibody concentration device is provided for this utility model;

[0015] Figure 3 This invention provides a schematic diagram of the external structure of the connecting tube of an antibody concentration device;

[0016] Figure 4 This invention provides a schematic diagram of the driving structure of an antibody concentration device.

[0017] Legend: 1. Main board; 2. Fixing plate; 3. First bolt; 5. Connecting pipe; 6. Sealing sleeve; 7. Rubber sealing plate; 8. Sealing groove; 9. Flange; 10. Second bolt; 11. Mounting plate; 12. Mounting hole; 13. Drive structure; 1301. Motor; 1302. Bidirectional screw; 1303. Moving block; 1304. Limiting post; 1305. Connecting block; 14. Moving groove; 15. Support; 16. Dialysis device; 17. Concentration device body; 18. PEG recovery device. Detailed Implementation

[0018] To better understand the above-mentioned objectives, features, and advantages of this utility model, the present utility model will be further described below with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.

[0019] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the present invention is not limited to the specific embodiments disclosed in the following specification.

[0020] Example 1, such as Figure 1-4 As shown, this utility model provides an antibody concentration device, including a main board 1. A dialysis device 16 is installed at the top of the main board 1. A concentration device body 17 is installed on one side of the dialysis device 16. A PEG recovery device 18 is installed on one side of the concentration device body 17. Two connecting pipes 5 are provided between the dialysis device 16, the concentration device body 17 and the PEG recovery device 18. The dialysis device 16, the concentration device body 17 and the PEG recovery device 18 are connected through the connecting pipes 5. Mounting plates 11 are provided on both sides of the bottom end of the main board 1. The main board 1 is provided with a driving structure 13 for driving the two mounting plates 11 to move in opposite directions. Multiple mounting holes 12 are opened in the mounting plates 11.

[0021] The overall effect of Embodiment 1 is that, through the arrangement of the dialysis device 16, the concentration device body 17, and the PEG recovery device 18, the antibody passes through the dialysis device 16, the concentration device body 17, and the PEG recovery device 18 from left to right, achieving a concentration effect. The connecting pipe 5 is used to connect the dialysis device 16, the concentration device body 17, and the PEG recovery device 18. The drive structure 13 can drive the two mounting plates 11 to move in opposite directions. When the main board 1 is installed, if there is a clamping point at the installation position, the main board 1 can be clamped and installed by the opposite movement of the two mounting plates 11. When there is no clamping point, the main board 1 can still be installed by traditional bolts through the mounting plates 11 and the mounting holes 12, making it more practical.

[0022] Example 2, as Figure 1-4 As shown, the drive structure 13 includes a motor 1301 located at one end of the main board 1. The output end of the motor 1301 passes through one side of the main board 1 and is fixed with a bidirectional screw 1302. Both ends of the outer wall of the bidirectional screw 1302 are threadedly connected to moving blocks 1303. The ends of the two moving blocks 1303 away from the bidirectional screw 1302 are slidably connected to a limit post 1304. The bottom ends of the two moving blocks 1303 are fixed with multiple connecting blocks 1305. The bottom ends of the connecting blocks 1305 pass through the bottom end of the main board 1 and are respectively fixed to their corresponding mounting plates 11. The outer walls of the opposite ends of the two connecting pipes 5 are fixed with sealing sleeves 6. A rubber sealing plate is fixed to the end of one sealing sleeve 6 facing the other sealing sleeve 6. 7. One end of the sealing sleeve 6 is provided with a sealing groove 8 that matches the rubber sealing plate 7. Flanges 9 are fixed on the outer walls of both sealing sleeves 6. The two flanges 9 are fixed together by the second bolt 10. The end of the bidirectional screw 1302 away from the motor 1301 is rotatably connected to the main board 1. Both ends of the limiting post 1304 are fixed to the main board 1. The bottom end of the main board 1 is provided with a moving groove 14 that matches the connecting block 1305. A bracket 15 is fixed on the outer wall of the main board 1. The motor 1301 is installed on the end of the bracket 15 facing the main board 1. The bottom ends of the dialysis device 16, the concentration device body 17 and the PEG recovery device 18 are all fixed with fixing plates 2. The fixing plates 2 are fixed to the main board 1 by the first bolt 3.

[0023] The overall effect of Embodiment 2 is that, during installation, the operation of the motor 1301 drives the bidirectional screw 1302 to rotate, causing the two moving blocks 1303 to move towards each other under the limitation of the limiting post 1304, thereby driving multiple sets of connecting blocks 1305 to move towards each other. At this time, the device can be clamped and installed according to the actual installation requirements. When there is no clamping point at the installation position, traditional bolt installation can still be performed through the mounting plate 11 and mounting hole 12, which is more practical. In addition, through the setting of the sealing sleeve 6, when the two connecting pipes 5 are connected, the rubber sealing plate 7 at one end of one sealing sleeve 6 will be inserted into the sealing groove 8 in the other sealing sleeve 6. Through the elastic stretching of the rubber sealing plate 7, the sealing groove 8 will be completely filled, achieving the effect of sealing the gap between the two connecting pipes 5. Finally, the installation is carried out through the flange 9 and the second bolt 10. Through the setting of the fixing plate 2 and the first bolt 3, the dialysis device 16, the concentration device body 17 and the PEG recovery device 18 can also be installed and disassembled separately, which is convenient for maintenance and replacement.

[0024] Working principle: When in use, the antibody passes through the dialysis unit 16, the concentration unit 17, and the PEG recovery unit 18 sequentially from left to right, achieving concentration. The connecting pipe 5 connects the dialysis unit 16, the concentration unit 17, and the PEG recovery unit 18. During installation, the motor 1301 drives the bidirectional screw 1302, causing two moving blocks 1303 to move towards each other under the constraint of the limiting post 1304, thereby driving multiple sets of connecting blocks 1305 to move towards each other. When the device is in motion, it can be clamped and installed according to the actual installation requirements. When there is no clamping point at the installation position, it can still be installed with traditional bolts through the mounting plate 11 and mounting hole 12, which is more practical. In addition, through the setting of the sealing sleeve 6, when the two connecting pipes 5 are connected, the rubber sealing plate 7 at one end of one sealing sleeve 6 will be inserted into the sealing groove 8 in the other sealing sleeve 6. Through the elastic stretching of the rubber sealing plate 7, it will completely fill the sealing groove 8, achieving the effect of sealing the gap between the two connecting pipes 5. Finally, it is installed through the flange 9 and the second bolt 10.

[0025] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present utility model without departing from the technical solution of the present utility model shall still fall within the protection scope of the technical solution of the present utility model.

Claims

1. An antibody concentration device comprising a main plate (1), characterized in that: The top end of the main plate (1) is provided with a dialysis device (16), one side of the dialysis device (16) is provided with a concentration device body (17), one side of the concentration device body (17) is provided with a PEG recovery device (18), two connecting pipes (5) are arranged between the dialysis device (16), the concentration device body (17) and the PEG recovery device (18), the dialysis device (16), the concentration device body (17) and the PEG recovery device (18) are communicated through the connecting pipes (5), and the bottom end of the main plate (1) is provided with mounting plates (11) on both sides.

2. An antibody concentration device according to claim 1, wherein: The driving structure (13) comprises a motor (1301) arranged at one end of the main plate (1), the output end of the motor (1301) penetrates one side of the main plate (1) and is fixedly connected with a bidirectional screw rod (1302), the outer walls of both ends of the bidirectional screw rod (1302) are threadedly connected with moving blocks (1303), the ends of the moving blocks (1303) away from the bidirectional screw rod (1302) are jointly and slidably connected with a limiting column (1304), the bottoms of the moving blocks (1303) are fixedly connected with a plurality of connecting blocks (1305), and the bottoms of the connecting blocks (1305) penetrate the bottom end of the main plate (1) and are fixedly connected with the corresponding mounting plates (11).

3. The antibody concentration device of claim 1, wherein: The outer walls of the opposite ends of the two connecting pipes (5) are fixedly connected with sealing sleeves (6), one end of one of the sealing sleeves (6) is fixedly connected with a rubber sealing plate (7) facing the other sealing sleeve (6), and one end of the sealing sleeve (6) is provided with a sealing groove (8) matched with the rubber sealing plate (7).

4. An antibody concentration device according to claim 3, wherein: The outer walls of the two sealing sleeves (6) are fixedly connected with flanges (9), and the two flanges (9) are fixedly connected through the second bolts (10).

5. An antibody concentration device according to claim 2, wherein: The end of the bidirectional screw rod (1302) away from the motor (1301) is rotatably connected with the main plate (1), the two ends of the limiting column (1304) are fixedly connected with the main plate (1), the bottom end of the main plate (1) is provided with a moving groove (14) matched with the connecting block (1305), the outer wall of the main plate (1) is fixedly connected with a support (15), and the motor (1301) is arranged at one end of the support (15) facing the main plate (1).

6. The antibody concentration device of claim 1, wherein: The bottoms of the dialysis device (16), the concentration device body (17) and the PEG recovery device (18) are fixedly connected with fixing plates (2), and the fixing plates (2) are fixedly connected with the main plate (1) through the first bolts (3).

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