Adjustable small and medium-sized chromatographic column quick-mounting structure

Abstract

The utility model provides an adjustable small and medium-sized chromatographic column quick-mounting structure which comprises an upper cover movably mounted on the outer side wall of a column barrel of a chromatographic column, a flange plate is detachably mounted at the bottom of the upper cover; a closed space is formed between the flange and the upper cover, and a column bottom flange is arranged in the closed space; a threaded hole is formed in the flange plate, and the interior of the threaded hole is in threaded connection with a locking bolt capable of enabling the column bottom flange to abut against the bottom of the column barrel. According to the utility model, the clamping groove and the column clamp are used for limiting and fixing, and the flange plate is in threaded connection with the upper cover, so that the installation process is greatly simplified; therefore, the number of the screws is reduced, the installation difficulty is reduced, and the installation precision and stability are improved. By optimizing the design and installation mode of the sealing ring and the screwing and pressing effect of the locking bolt, the tighter sealing effect is achieved; therefore, liquid leakage is effectively prevented, and the separation efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography preparation equipment technology, and in particular to an adjustable small and medium-sized quick-assembly structure for chromatography columns. Background Technology

[0002] Liquid chromatography (LC), as an important separation and analysis technique, is widely used in chemistry, biology, medicine, and other fields. Its core lies in using a pump to generate pressure to accelerate the mobile phase through a pre-packed chromatographic column, achieving efficient separation of components in a mixture. In preparative LC, this technique is further applied to extract and purify target compounds from complex mixtures. Preparative LC equipment typically consists of components such as a pump, injector, column, detector, and fraction collector, capable of handling large volumes of samples and performing separation at high flow rates, thereby achieving efficient extraction and purification of target compounds. However, with the continuous development of LC technology, the requirements for preparative equipment are becoming increasingly stringent. Traditional preparative equipment has revealed some technical problems in its design and use, such as complex installation, poor sealing performance, and easy damage to components. These problems seriously affect the stability and separation efficiency of the equipment.

[0003] From the perspective of existing technology, in some traditional liquid chromatography preparation equipment, the bottom of the column barrel is generally connected and fixed by a large number of screws through a double flange structure, which makes the installation process cumbersome and time-consuming. This not only increases the difficulty of operation, but may also lead to a decline in equipment performance due to improper installation. Utility Model Content

[0004] To address the problems of traditional preparation equipment in terms of installation, sealing performance, component durability, and maintenance costs, this utility model provides an adjustable small-to-medium-sized chromatography column quick-assembly structure.

[0005] The adjustable small-to-medium-sized chromatography column quick-assembly structure provided by this utility model adopts the following technical solution:

[0006] An adjustable small-to-medium-sized chromatography column quick-assembly structure includes an upper cover movably installed on the outer wall of the column barrel of the chromatography column; a flange is detachably installed at the bottom of the upper cover; the flange forms a sealed space between the upper cover and the column bottom flange is provided in the sealed space; the flange has a threaded hole inside, and a locking bolt that can press the column bottom flange against the bottom of the column barrel is threaded inside the threaded hole.

[0007] Furthermore, the inner wall of the top cover and the outer wall of the column barrel are both provided with slots; a column clip is provided inside the slot; there are two column clips, which are used to limit and fix the top cover and the column barrel.

[0008] Furthermore, the outer side wall of the flange is provided with external threads, and the inner side wall of the upper cover is provided with internal threads, and the flange and the upper cover are connected by threads.

[0009] Furthermore, a sealing ring is snapped onto the side wall of the column base flange near the column barrel; the sealing ring is made of rubber.

[0010] Furthermore, when the flange is threaded to the top cover and the flange abuts against the inner wall of the top cover, the sealing ring on the outer wall of the column base flange just contacts the bottom opening of the column barrel.

[0011] Furthermore, when the locking screw is threaded to the flange and the locking screw abuts against the outer wall of the column base flange, the locking screw can be further tightened to compress the sealing ring.

[0012] In summary, the beneficial effects of this utility model are as follows:

[0013] This invention simplifies the installation process by using slots and pin clips for positioning and fixing, as well as a threaded connection between the flange and the top cover. This not only reduces the number of screws and lowers the installation difficulty, but also improves the installation accuracy and stability. Furthermore, by optimizing the design and installation method of the sealing ring, and the tightening action of the locking bolts, a tighter sealing effect is achieved. This effectively prevents liquid leakage and improves separation efficiency. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0015] Figure 2 This is a schematic diagram of the overall internal structure of this utility model;

[0016] Figure 3 This utility model Figure 2 An enlarged schematic diagram of part A in the middle;

[0017] Figure 4 This is a schematic diagram of the installation of the column base flange of this utility model.

[0018] As shown in the figure: 1-Column barrel, 2-Top cover, 21-Column clip, 3-Flange, 31-Column bottom flange, 32-Sealing ring, 33-Filter layer, 4-Locking screw. Detailed Implementation

[0019] The following is in conjunction with the appendix Figure 1-4 The present invention will be further described in detail below:

[0020] This utility model discloses an adjustable, small-to-medium-sized chromatography column quick-assembly structure, such as... Figure 1 , 3As shown in Figure 4, the system includes an upper cover 2 movably mounted on the outer wall of the column barrel 1 of the chromatography column; a flange 3 detachably mounted on the bottom of the upper cover 2; the flange 3 forms a sealed space between the upper cover 2 and the column barrel 1, and a column bottom flange 31 is disposed within this sealed space; a threaded hole is provided inside the flange 3, and a locking screw 4 is threaded inside the threaded hole to press the column bottom flange 31 against the bottom of the column barrel 1; in this embodiment, during installation, the upper cover 2 is first installed on the outer wall of the column barrel 1, and then the flange 3 is installed at the bottom of the upper cover 2; the column bottom flange 31 is pre-placed into the sealed space formed by the upper cover 2 and the flange 3; finally, by installing and rotating the locking screw 4, it is gradually pushed into the threaded hole of the flange 3 until the column bottom flange 31 is tightly pressed against the bottom of the column barrel 1; in this embodiment, the column bottom flange 31 and the column barrel 1 can be tightly connected by rotating the locking screw 4, without the need for a large number of screws, thereby saving installation time and reducing installation difficulty;

[0021] A filter layer 33 is provided on the surface of the column base flange;

[0022] like Figure 3 , 4 As shown, both the inner wall of the top cover 2 and the outer wall of the column barrel 1 are provided with slots; column clips 21 are provided inside the slots; there are two column clips 21, which are used to limit and fix the top cover 2 and the column barrel 1; in this embodiment, during the installation process, when the top cover 2 and the column barrel 1 are aligned, the column clips 21 are pushed into or locked into the slots of both; since there are two column clips 21, they can provide stable limiting effects on both sides of the top cover 2 and the column barrel 1, respectively, preventing the top cover 2 from moving or rotating in the vertical direction; this limiting and fixing method improves the connection stability between the top cover 2 and the column barrel 1, making the entire chromatography column structure more robust and reliable;

[0023] like Figure 3 , 4As shown, the outer wall of flange 3 has external threads, and the inner wall of top cover 2 has internal threads. Flange 3 and top cover 2 are connected by threads. A sealing ring 32 is snapped onto the side wall of column base flange 31 near column barrel 1. The sealing ring 32 is made of rubber. When flange 3 is threaded to top cover 2 and flange 3 abuts against the inner wall of top cover 2, the sealing ring 32 on the outer wall of column base flange 31 is in contact with the bottom opening of column barrel 1. When locking screw 4 is threaded to flange 3 and locking screw 4 abuts against the outer wall of column base flange 31, locking screw 4... The sealing ring 32 can be further tightened by screwing. In this embodiment, the upper cover 2 and the column barrel 1 are initially aligned and placed, and then the two are fixed in the slot by the column clip 21. Next, the external thread of the flange 3 is aligned with the internal thread of the upper cover 2 and rotated to connect until it is tight. Then, by rotating the locking screw 4, it is gradually inserted into the threaded hole of the flange 3 until the column bottom flange 31 is tightly pressed against the bottom of the column barrel 1. At the same time, the sealing ring 32 is deformed due to the pressure, filling the tiny gaps and achieving a tight seal, thus completing the installation of the entire chromatography column.

[0024] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. The various components mentioned in this utility model are common technologies in the existing field. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A quick-assembly structure for adjustable small-to-medium-sized chromatography columns, characterized in that, Including, activity installs the upper cover (2) of the outer side wall of the column barrel (1) of chromatography column;The bottom of the upper cover (2) is detachably installed with flange plate (3);The flange plate (3) forms a closed space between the upper cover (2), and the column bottom flange (31) is arranged in the closed space;The inside of the flange plate (3) is provided with a threaded hole, and the threaded hole is internally threaded with a locking screw (4) that can abut the column bottom flange (31) against the bottom of the column barrel (1).

2. The quick-mount structure of a small and medium-sized chromatographic column with adjustable according to claim 1, characterized in that The inner side wall of the upper cover (2) and the outer side wall of the column barrel (1) are provided with clamping grooves;The inside of the clamping groove is provided with a column clamp (21);The number of the column clamp (21) is two, which is used for limiting and fixing between the upper cover (2) and the column barrel (1).

3. The quick-mount structure of a small and medium-sized chromatographic column with adjustable according to claim 1, characterized in that The outer side wall of the flange plate (3) is provided with external threads, and the inner side wall of the upper cover (2) is provided with internal threads, and the flange plate (3) and the upper cover (2) are connected by threads.

4. The quick-mount structure of a small and medium-sized chromatographic column according to claim 3, characterized in that The column bottom flange (31) is provided with a sealing ring (32) on the side wall close to the column barrel (1);The sealing ring (32) is made of rubber.

5. The quick-mount structure of a small and medium-sized chromatographic column with an adjustable size according to claim 4, characterized in that When the flange plate (3) and the upper cover (2) are connected by threads to the inner side wall of the upper cover (2) of the flange plate (3), the sealing ring (32) of the outer side wall of the column bottom flange (31) is just in contact with the bottom opening of the column barrel (1).

6. The quick-mount structure of a small and medium-sized chromatographic column with an adjustable size according to claim 5, characterized in that When the locking screw (4) and the flange plate (3) are connected by threads to the outer side wall of the column bottom flange (31) of the locking screw (4), the locking screw (4) can further screw the sealing ring (32) tightly.

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