Multi-parameter electrochemical test paper containing coding electrode
By setting breakpoints on coded electrodes in electrochemical test strips, the target analyte and calibration parameters are automatically identified, solving the problems of batch-to-batch differences and manual mode switching, thus improving measurement accuracy and user experience.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-06
- Publication Date
- 2026-03-13
AI Technical Summary
Existing electrochemical test strips suffer from significant batch-to-batch variations due to differences in manufacturing processes and raw materials. This necessitates frequent calibration and manual switching of detection modes, impacting measurement accuracy and user experience.
The multi-parameter electrochemical test strip with coded electrodes automatically identifies the target analyte and calibration parameters by setting breakpoints on the electrode layer to form different conductive combinations, thus avoiding the need for users to manually insert code cards.
It enables test strips to automatically identify the type of target substance and calibration parameters, improving measurement accuracy and user experience, and reducing user operation steps, especially reducing the risk of misoperation for elderly users.
Smart Images
Figure CN223992853U_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of biosensing technology, and specifically relates to a multi-parameter electrochemical test paper containing coded electrodes. Background Technology
[0002] Blood glucose test strips based on electrochemical reaction principles are widely used in POCT (Point of Care Testing) diagnostics, characterized by short detection time, speed, and small blood volume input. These products utilize screen printing technology to print a biosensor onto a PET (Polyethylene Terephthalate) substrate, and then apply enzyme solution to the substrate for rapid detection of the target analyte.
[0003] However, these test strip biosensors are affected by manufacturing processes, batch-to-batch variations in raw materials, and the production environment, resulting in batch-to-batch variations in the final product. Therefore, each batch of electrochemical sensors requires calibration with matching electrochemical parameters before use. In actual use, users need to repeatedly insert the code card for calibration before testing. From a user experience perspective, the different electrochemical parameters from multiple batches can easily lead to user confusion, affecting the accuracy of measurement results. Furthermore, when using the testing device to detect different types of targets, such as blood glucose, blood ketones, and uric acid, users need to manually switch the corresponding detection mode. On the one hand, manually switching modes is cumbersome; on the other hand, users, especially elderly users, sometimes overlook mode switching, leading to incorrect test results. Utility Model Content
[0004] In view of this, the purpose of this utility model is to provide a simple and highly operable multi-parameter electrochemical test strip containing coded electrodes, which can help users automatically identify the type of target analyte detected by the test strip, while eliminating the need for frequent replacement of the code card for parameter calibration, thus greatly improving the user experience.
[0005] To achieve the above objectives, the present invention adopts the following technical solution:
[0006] This invention provides a multi-parameter electrochemical test strip containing a coded electrode, comprising, from bottom to top, a substrate, an electrode layer, an insulating layer, a reagent layer, and a detection injection channel. The electrode layer includes a detection electrode and a coded electrode. The detection electrode includes a working electrode and a counter electrode. The coded electrode includes a first coded electrode unit and a second coded electrode unit.
[0007] The first encoding electrode unit includes at least four first electrode blocks and at least three first connecting lines for electrically connecting the first electrode blocks. Breakpoints are selectively set on the first connecting lines, and the first electrode blocks form different conductive combinations by switching the first connecting lines on and off, thereby providing first encoding information for a variety of calibration parameters.
[0008] The second encoding electrode unit is disposed at the pin of the working electrode and / or the counter electrode. At each pin, it includes at least two second electrode blocks and at least one second connecting line for electrically connecting the second electrode blocks. Breakpoints are selectively set on the second connecting line, and second encoding information for multiple target detection categories is formed by switching the second connecting line on and off.
[0009] Preferably, the number of the first electrode blocks is M×N, where M×N is an integer from 4 to 10 and M is an integer greater than or equal to 2, and they are arranged in a matrix structure of M rows and N columns; the first connecting line includes a first coded connecting line, a second coded connecting line and a third coded connecting line;
[0010] Among them, the first electrode blocks located in the same column are connected one-to-one by the first coding connection line, and the first electrode blocks located in the first row extend upwards by a second coding connection line, and the third coding connection line connects each second coding connection line in sequence.
[0011] By selectively setting breakpoints at different locations on the first connecting line, various forms of conductive combinations of the first electrode block can be obtained.
[0012] Preferably, the second encoding electrode unit has two second electrode blocks at the pins of both the working electrode and the counter electrode.
[0013] Preferably, the first encoding electrode unit is nested in the blank area inside the detection electrode.
[0014] Preferably, the first electrode block and the second electrode block are one or a combination of carbon electrodes, silver electrodes, and gold electrodes.
[0015] Preferably, the first electrode block and the second electrode block are shaped as one or a combination of rectangles, circles, and rhombuses.
[0016] Preferably, the first connecting line and the second connecting line are silver wires and / or carbon wires.
[0017] Preferably, the first and second coding connection lines are silver wires, and the third coding connection line is a carbon wire. Based on the resistance difference between the silver wire and the carbon wire, the first coding information of various calibration parameters is provided in a way that combines on / off and impedance.
[0018] Preferably, the detection electrode and the encoding electrode are located on the same side of the substrate and are on the same horizontal plane.
[0019] The beneficial effects of this utility model are:
[0020] (1) The multi-parameter electrochemical test strip with coded electrodes provided by this utility model allows the detection device to automatically identify the target substance type of the test strip during testing, eliminating the need for the user to manually switch detection modes. Simultaneously, the detection device can automatically identify the coded information of the test strip's calibration parameters, eliminating the need for the user to repeatedly insert the code card for parameter calibration. This avoids inaccurate test results caused by users, especially middle-aged and elderly users, using incorrect detection modes or inserting the wrong code card, thus improving the user experience.
[0021] (2) The number of electrode blocks of the coding electrode in the test paper of this utility model can be flexibly adjusted according to the amount of coding parameter information. It can not only encode different electrochemical parameters by connecting the wires, but also encode by combining the connection and impedance through the different resistance values of the connecting wires, thus enriching the coding information without changing the structure of the test paper. Attached Figure Description
[0022] Figure 1 This is a schematic diagram of the structure of a multi-parameter electrochemical test paper including a coded electrode according to an embodiment of the present invention;
[0023] Figure 2 This is a schematic diagram of the structure of the detection electrode and the encoding electrode according to an embodiment of the present invention;
[0024] Figure 3 This is a schematic diagram of the detection electrode and encoding electrode according to another embodiment of the present invention;
[0025] Figure 4 This is a schematic diagram of the detection electrode and encoding electrode according to another embodiment of the present invention.
[0026] In the diagram: 01, substrate; 02, working electrode; 03, encoding electrode; 04, counter electrode; 05, insulating layer; 06, enzyme layer; 07, siphon channel; 08, logo membrane strip; 09, breakpoint; 10, first encoding electrode unit; 101, first electrode block; 1011, first electrode block one; 1012, first electrode block two; 1013, first electrode block three; 1014, first electrode block four; 1015, first electrode block five; 1016, first electrode block six; 102, first connecting line; 1021, first encoding connecting line; 1022, second encoding connecting line; 1023, third encoding connecting line; 20, second encoding electrode unit; 201, second electrode block; 2011, second electrode block one; 2012, second electrode block two; 2013, second electrode block three; 2014, second electrode block four; 202, second connecting line. Detailed Implementation
[0027] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present utility model and are not intended to limit the present utility model.
[0028] In the description of this utility model, it should be understood that the terms "upper," "lower," "front," "rear," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.
[0029] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation", "connection" and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, an integral connection, or a detachable connection; they can refer to the internal connection of two components; they can refer to a direct connection or an indirect connection through an intermediate medium. For those skilled in the art, the specific meaning of the above terms in this utility model can be understood according to the specific circumstances.
[0030] Example 1
[0031] Figure 1This is a schematic diagram of the structure of a multi-parameter electrochemical test strip including a coded electrode according to an embodiment of the present invention. As shown in the figure, it includes, from bottom to top, a substrate 01, an electrode layer, an insulating layer 05, a reagent layer, and a detection injection channel. Specifically, in conjunction with... Figure 2 and Figure 4 An electrode layer is printed on the same side of the substrate 01, including a detection electrode and an encoding electrode 03 on the same horizontal plane. The detection electrode includes a working electrode 02 and a counter electrode 04, and the encoding electrode 03 includes a first encoding electrode unit 10 and a second encoding electrode unit 20. An insulating layer 05 is disposed on the electrode layer, and a reagent layer, in this embodiment, is an enzyme layer 06, disposed on the insulating layer 05. The enzyme layer 06 contains enzymes for catalyzing specific chemical reactions and converting the biochemical reactions into detectable electrical signals, thereby enabling the detection of specific target substances, such as blood glucose, blood ketones, and uric acid. A siphon channel 07 is covered on the enzyme layer 06 as a sample introduction channel. Under the siphon effect, the liquid sample can be automatically guided to the detection area without external force. Finally, in order to display the brand or logo of the electrochemical test strip and facilitate users to identify the source and type of the test strip, a logo film strip 08 is also covered.
[0032] Furthermore, such as Figures 2-4 As shown, the first encoding electrode unit 10 includes at least four first electrode blocks 101 and at least three first connecting lines 102 electrically connecting the first electrode blocks 101. Breakpoints 09 are selectively set on the first connecting lines 102. By switching the first connecting lines 102 on and off, different conductive combinations are formed on the first electrode blocks 101, thereby providing multiple electrochemical parameters and forming first encoding information for multiple calibration parameters. The second encoding electrode unit 20 is disposed at the pins of the working electrode 02 and the counter electrode 04. At each pin, it includes at least two second electrode blocks 201 and at least one second connecting line 202 electrically connecting the second electrode blocks 201. Breakpoints 09 are set on the second connecting lines 202. By switching the second connecting lines 202 on and off, second encoding information for the detection of different target substances, such as blood glucose, blood ketones, uric acid, etc., is formed for use in electrochemical test strips to identify different target substances.
[0033] Furthermore, the first encoding electrode unit 10 is nested within the blank area inside the detection electrode. The number of first electrode blocks 101 is M×N, where M×N is preferably an integer from 4 to 10, and M is an integer greater than or equal to 2. This is because if the number of first electrode blocks 101 is too small, it cannot generate enough first encoding information; if the number of first electrode blocks 101 is too large, there will not be enough space on the substrate 01. Further, the first electrode blocks 101 are arranged in a matrix layout structure of M rows and N columns. More preferably, M is an integer from 2 to 3, and N is an integer from 2 to 5, because too many rows may exceed the detection area of the detection device. Meanwhile, the first connecting line 102 further includes a first encoding connecting line 1021, a second encoding connecting line 1022, and a third encoding connecting line 1023. In this design, the first electrode blocks 101 located in the same column are connected one-to-one by first coded connection lines 1021. Each first electrode block 101 in the first row extends upwards by a second coded connection line 1022, and a third coded connection line 1023 connects each second coded connection line 1022 sequentially. Breakpoints 09 are selectively set at different positions on the first connection lines 102. By controlling the continuity of the first connection lines 102, various conductive combinations of the first electrode blocks 101 are obtained, thereby enabling the electrochemical test paper to generate multiple first coded information for calibration parameters.
[0034] It should be noted that, in this embodiment, the first electrode block 101 and the second electrode block 201 are both preferably one or a combination of carbon electrodes, silver electrodes, and gold electrodes, and their shapes include, but are not limited to, one or a combination of rectangles, circles, and rhombuses. The first connecting line 102 and the second connecting line 202 are both preferably one or a combination of silver wires and carbon wires.
[0035] Furthermore, the principle behind the electrochemical test strip structure's ability to generate multiple coded information is as follows: Contacts corresponding to the first electrode blocks 101 and second electrode blocks 201 of the coded electrode 03 are provided at corresponding positions on the detection device. When the electrochemical test strip is inserted into the detection device, each contact connects to the first electrode block 101 and the second electrode block 201 respectively, forming an electrical circuit. Due to the breakpoint 09, each second electrode block 201 has different conductive connection combinations. By determining whether there is a conductive connection between adjacent second electrode blocks 201, the detection device can identify the conductive combination between each second electrode block 201, thereby determining the target substance detected by the electrochemical test strip. Following the same principle, by determining the conductive connection combinations between each first electrode block 101, the detection device can further determine the first coded information of the test strip's calibration parameters, and then call the matching calibration parameters for calibration, ensuring the accuracy of subsequent detection results.
[0036] Example 2
[0037] like Figure 2 As shown, the multi-parameter electrochemical test paper with coded electrodes in this embodiment has a first coded electrode unit 10 containing six first electrode blocks 101, namely first electrode block one 1011, first electrode block two 1012, first electrode block three 1013, first electrode block four 1014, first electrode block five 1015 and first electrode block six 1016, arranged in a matrix structure of 2 rows and 3 columns, wherein first electrode block one 1011, first electrode block two 1012 and first electrode block three 1013 are located in the upper row, and first electrode block four 1014, first electrode block five 1015 and first electrode block six 1016 are located in the lower row. The first electrode block 1011 is electrically connected to the first electrode block 4 1014, the first electrode block 2 1012 is connected to the first electrode block 5 1015, and the first electrode block 3 1013 is connected to the first electrode block 6 1016 via first coding connection lines 1021. Each of the first electrode blocks 1011, 2 1012, and 3 1013 extends upwards via a second coding connection line 1022. A third coding connection line 1023 connects the three second coding connection lines 1022 sequentially. Breakpoints 09 are set at different positions on the first coding connection lines 1021, 2 1022, and 3 1023. By switching the first connection lines 102 open and closed, the six first electrode blocks 101 can form different conductive combinations, thereby generating first coding information for various calibration parameters. In this embodiment, six breakpoints 09 can be set. Excluding cases where all first connection lines 102 are cut off and cannot be recognized, the total number of first coding information that can be formed is:
[0038] Furthermore, in this embodiment, the second encoding electrode unit 20 is provided with two second electrode blocks 201 at the pins of the working electrode 02 and the counter electrode, specifically second electrode block one 2011, second electrode block two 2012, second electrode block three 2013, and second electrode block four 2014. Second electrode block one 2011 and second electrode block two 2012, and second electrode block three 2013 and second electrode block four 2014 are electrically connected via second connecting lines 202. By setting a breakpoint 09 on the second connecting line 202, the second electrode blocks 201 can form different conductive combinations for electrochemical test strips that identify and detect different target substances. For example, the second electrode block 1 2011 and the second electrode block 2012, and the second electrode block 3 2013 and the second electrode block 4 2014 are all connected to form the recognition sites for the blood glucose test strip. Conversely, the second electrode block 1 2011 is disconnected from the second electrode block 2012, and the second electrode block 3 2013 is connected to the second electrode block 4 2014 to form the recognition sites for the uric acid test strip. Similarly, the second electrode block 1 2011 is connected to the second electrode block 2012, and the second electrode block 3 2013 is disconnected from the second electrode block 4 2014 to form the recognition sites for the blood ketone test strip. This allows for the automatic identification of the target analyte type detected by the electrochemical test strip during the testing process.
[0039] Example 3
[0040] like Figure 4 As shown, the multi-parameter electrochemical test paper with coded electrodes in this embodiment has four first electrode blocks 101 in its first coded electrode unit 10: first electrode block one 1011, first electrode block two 1012, first electrode block four 1014, and first electrode block five 1015, arranged in a 2-row, 2-column layout. First electrode blocks one 1011 and first electrode block two 1012 are located in the upper row, while first electrode blocks four 1014 and first electrode block five 1015 are located in the lower row. First electrode blocks one 1011 and first electrode block four 1014, and first electrode blocks two 1012 and first electrode block five 1015 are electrically connected via first coded connecting lines 1021. First electrode blocks one 1011 and first electrode block two 1012 each extend upwards with a second coded connecting line 1022, and a third coded connecting line 1023 connects the two second coded connecting lines 1022. Breakpoints 09 are set at different positions on the first connecting line 102. By switching the first connecting line 102 on and off, the four first electrode blocks 101 can form different conductive combinations, thereby forming the first coded information of various calibration parameters.
[0041] Specifically, in this embodiment, the number of breakpoints 09 that can be set is 3. After deducting the cases where all first connection lines 102 are cut and cannot be identified, the total number of first encoded information that can be formed is: The specific configurations are as follows: Code 1 is when all four first electrode blocks (1011, 1012, 1014, and 1015) are connected together; Code 2 is when all four first electrode blocks (1011, 1012, and 1015) are connected together; Code 3 is when all four first electrode blocks (1011 and 1014) are connected together, and Code 4 is when all four first electrode blocks (1012 and 1015) are connected together; Code 5 is when all four first electrode blocks (1012 and 1015) are connected together; Code 6 is when all four first electrode blocks (1011 and 1012) are connected together; and Code 7 is when all four first electrode blocks (1011 and 1012) are connected together. The arrangement of the second encoding electrode unit 20 is the same as in Embodiment 2, and will not be repeated here.
[0042] It should be understood that when the number of first electrode blocks 101 in the first coding electrode unit 10 is further increased, such as to 8 or 10, the amount of first coding information that can be formed will further increase. No schematic diagram is provided here for further explanation. When the number of first electrode blocks 101 is 8 and arranged in 2 rows and 4 columns, the number of breakpoints 09 that can be set is 9. Excluding cases where all first connection lines 102 are cut and cannot be recognized, the total number of first coding information formed is: There are 10 first electrode blocks 101 arranged in 2 rows and 5 columns. The number of breakpoints 09 that can be set is 12. Excluding cases where all first connecting lines 102 are cut and cannot be identified, the total number of first encoded information that can be formed is:
[0043] Considering the actual width of the electrochemical test paper, the number of first electrode blocks 101 is 8 or 10, which will be less in actual use, but it is still within the protection scope of this utility model.
[0044] It should be noted that, in addition to using on / off switching for the identification of the first encoded information, this embodiment of the invention can also utilize a combination of on / off switching and impedance for identification. For example... Figure 3 As shown, the third coding connection line 1023 is set as a carbon wire, and the remaining coding connection lines are set as silver wires. Based on the resistance difference between carbon wires and silver wires, while keeping the connection and identification methods at other positions unchanged, the first coding information can also be identified by measuring the impedance between the first electrode block 1011 and the first electrode block 2 1012, the first electrode block 2 1012 and the first electrode block 3 1013, and the first electrode block 1011 and the first electrode block 3 1013 through the detection device.
Claims
1. A multi-parameter electrochemical test paper comprising a code electrode, sequentially comprising from bottom to top a substrate (01), an electrode layer, an insulation layer (05), a reagent layer and a detection sample inlet channel, the electrode layer comprising a detection electrode and a code electrode (03), the detection electrode comprising a working electrode (02) and a counter electrode (04), characterized in that, The coding electrode (03) comprises a first coding electrode unit (10) and a second coding electrode unit (20), wherein, The first coding electrode unit (10) comprises at least four first electrode blocks (101) and at least three first connecting lines (102) for electrically connecting the first electrode blocks (101), and a breakpoint (09) is selectively arranged on the first connecting line (102), and the first electrode blocks (101) form different conductive combinations by the on-off of the first connecting line (102), thereby providing first coding information of multiple calibration parameters; The second coding electrode unit (20) is arranged at the pins of the working electrode (02) and / or the counter electrode (04), and comprises at least two second electrode blocks (201) and at least one second connecting line (202) for electrically connecting the second electrode blocks (201) at each pin, and a breakpoint (09) is selectively arranged on the second connecting line (202), and second coding information of multiple target detection categories is formed by the on-off of the second connecting line (202).
2. The multi-parameter electrochemical test strip comprising an encoded electrode of claim 1, wherein, The number of the first electrode blocks (101) is M×N, M×N is an integer of 4-10, M is an integer greater than or equal to 2, and the first electrode blocks (101) are arranged in a matrix structure of M rows and N columns; the first connecting line (102) comprises a first coding connecting line (1021), a second coding connecting line (1022) and a third coding connecting line (1023); Wherein, the first electrode blocks (101) in the same column are connected one by one through the first coding connecting line (1021), the first electrode blocks (101) in the first row extend upward to form a second coding connecting line (1022) respectively, and the third coding connecting line (1023) connects the second coding connecting lines (1022) in turn. The breakpoint (09) is selectively arranged at different positions of the first connecting line (102), thereby obtaining multiple forms of conductive combinations of the first electrode blocks (101).
3. The multi-parameter electrochemical test paper comprising an encoded electrode according to claim 2, wherein, The number of the second electrode blocks (201) arranged at the pins of the working electrode (02) and the counter electrode (04) in the second coding electrode unit (20) is 2.
4. The multi-parameter electrochemical test strip comprising an encoded electrode according to any one of claims 1-3, wherein, The first coding electrode unit (10) is arranged in a blank area inside the detection electrode.
5. The multi-parameter electrochemical test strip comprising an encoded electrode according to any one of claims 1-3, wherein, The first electrode blocks (101) and the second electrode blocks (201) are one or a combination of multiple of carbon electrode, silver electrode and gold electrode.
6. The multi-parameter electrochemical test paper comprising an encoded electrode according to claim 5, wherein, The shapes of the first electrode blocks (101) and the second electrode blocks (201) are one or a combination of multiple of rectangle, circle and diamond.
7. The multi-parameter electrochemical test strip containing an encoded electrode according to claim 2 or 3, wherein, The first connecting line (102) and the second connecting line (202) are silver wire and / or carbon wire.
8. The multi-parameter electrochemical test paper comprising an encoded electrode according to claim 7, wherein, The first coding connecting line (1021) and the second coding connecting line (1022) are arranged as silver wire, and the third coding connecting line (1023) is arranged as carbon wire, and based on the resistance difference between silver wire and carbon wire, the first coding information of multiple calibration parameters is provided in a combination of on-off and impedance.
9. The multi-parameter electrochemical test strip comprising an encoded electrode according to any one of claims 1-3, wherein, The detection electrode and the coding electrode (03) are located on the same side of the substrate (01) and in the same horizontal plane.