Serum separation device for batch extraction

Abstract

The utility model relates to the technical field of serum separation, in particular to a batch extraction serum separation device which comprises a reciprocating type shaking table body, a supporting plate is installed on one side wall of the reciprocating type shaking table body, and two clamping mechanisms are symmetrically installed on the two sides of the top end of the supporting plate. The support plate is mounted on one side wall of the reciprocating type shaking table body, and the two clamping mechanisms composed of the sliding grooves, the two-way lead screws, the clamping blocks and the motors are symmetrically mounted on the two side walls of the support plate; an extraction mechanism consisting of an electromagnetic valve, an air extraction main pipe, a negative pressure pump, an air extraction branch pipe, a storage bottle and a telescopic suction pipe is mounted between the top end of the supporting plate and the clamping mechanism, so that the serum separation device can be used for simultaneously and respectively extracting separated serum in four animal blood samples when being used; according to the device, the complicated operation of manual repeated extraction is omitted, the labor intensity of workers is reduced, the extraction efficiency of separated serum in animal blood samples is effectively improved, and efficient preparation of serum products is facilitated.

Description

Technical Field

[0001] This application relates to the field of serum separation technology, and in particular to a serum separation device for batch extraction. Background Technology

[0002] Serum products are a class of biological products extracted and processed from human or animal serum. Serum is the liquid portion of blood, rich in antibodies, proteins, hormones, enzymes, and other components. Serum products are widely used in the medical field, particularly in immunotherapy, vaccine production, and disease detection. In large-scale production, serum products are primarily obtained by separating serum from the blood of farmed animals.

[0003] Currently, when separating serum from extracted animal blood samples, the main method is to place the storage bottle containing the animal blood sample on a reciprocating shaker. The continuous shaking of the reciprocating shaker ensures that the animal blood sample comes into full contact with the corresponding separation reagent. After shaking, the serum is then extracted step by step using a syringe.

[0004] While existing serum separation devices can separate serum from animal blood samples and extract the separated serum through repeated manual aspiration, this manual aspiration operation not only involves high labor intensity but also results in low collection efficiency of the separated serum from animal blood samples, which is not conducive to the efficient preparation of serum products. Summary of the Invention

[0005] To address the shortcomings of existing technologies, the purpose of this application is to provide a serum separation device for batch extraction that is labor-intensive and has high separation efficiency.

[0006] The above-mentioned objective of this application is achieved through the following technical solution:

[0007] A batch serum extraction separation device includes a reciprocating shaker body. A support plate is installed on one side wall of the reciprocating shaker body. Two clamping mechanisms are symmetrically installed on both sides of the top of the support plate. Each clamping mechanism includes a sliding groove, a bidirectional lead screw, clamping blocks, and a motor. The sliding groove is formed on the side of the top of the support plate. The bidirectional lead screw is installed in the sliding groove and has two sections with opposite threads. Two clamping blocks are installed at each section of the bidirectional lead screw with opposite threads. The motor is installed on one side wall of the support plate, directly opposite the bidirectional lead screw. At the end; a suction mechanism is installed between the top support of the support plate and the two corresponding clamping blocks. The suction mechanism includes a solenoid valve, a main suction pipe, a negative pressure pump, a suction branch pipe, a storage bottle, and a telescopic suction tube. The main suction pipe is installed in the middle of the top of the support plate. The suction branch pipes are symmetrically installed on both sides of the main suction pipe. The solenoid valve is installed on the suction branch pipe. The storage bottle is installed between the two symmetrical clamping blocks on the clamping mechanism. The telescopic suction tube is installed in the middle of the bottom of the storage bottle. The negative pressure pump is installed on the top of the support plate on one side of the main suction pipe.

[0008] Optionally, a placement seat is also installed at the top of the reciprocating shaker body, and a limit component is installed on the placement seat.

[0009] Optionally, the limiting assembly includes a sponge sleeve, a clamping rod, a sliding rod, and a limiting bolt. There are two sliding rods, which are symmetrically installed on both sides of the upper end of the placement seat. The clamping rod is slidably installed between the two sliding rods. The limiting bolt is installed at both ends of the clamping rod, and the sponge sleeve is installed in the middle of the outer wall of the clamping rod.

[0010] Optionally, the sponge sleeve is bonded to the clamp rod, and there are two sets of clamp rods, with two in each set.

[0011] Optionally, a support pad is also installed at each of the four corners of the bottom of the reciprocating shaker body, and the support pad is screwed into the reciprocating shaker body.

[0012] Optionally, the bidirectional lead screw passes through the clamping block and is threadedly connected to the clamping block, and the clamping block is slidably engaged with the slide groove.

[0013] Optionally, the clamping surface of the clamping block has an arc-shaped structure, the bidirectional lead screw is rotatably engaged with the slide groove, and the motor is connected to the bidirectional lead screw coupling.

[0014] Optionally, the negative pressure pump is connected to the main suction pipe via a pipeline, and the suction branch pipe is welded to the main suction pipe.

[0015] Optionally, the storage bottle is made of transparent material, the suction tube is inserted into the storage bottle, and both the storage bottle and the telescopic straw are made of disposable material.

[0016] In summary, this application includes at least one of the following beneficial technical effects:

[0017] This invention features a support plate installed on one side wall of a reciprocating shaker body, and two clamping mechanisms symmetrically installed on the two side walls of the support plate, each consisting of a sliding groove, a bidirectional lead screw, a clamping block, and a motor. An extraction mechanism, consisting of a solenoid valve, a main suction pipe, a negative pressure pump, a suction branch pipe, a storage bottle, and a telescopic suction tube, is installed between the top of the support plate and the clamping mechanisms. This allows the serum separation device to simultaneously extract serum from four animal blood samples, eliminating the tedious manual extraction process, reducing labor intensity, and effectively improving the extraction efficiency of serum from animal blood samples, facilitating the efficient preparation of serum products. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure provided in the embodiments of this application;

[0019] Figure 2 This is a schematic diagram of the support plate and clamping mechanism provided in the embodiments of this application;

[0020] Figure 3 This is a schematic diagram of the structure of the clamping block provided in an embodiment of this application;

[0021] Figure 4 This is provided by the embodiments of this application. Figure 2 Enlarged view of point A in the middle.

[0022] Explanation of reference numerals in the attached drawings: 1. Extraction mechanism; 11. Solenoid valve; 12. Main extraction pipe; 13. Negative pressure pump; 14. Extraction branch pipe; 15. Storage bottle; 16. Telescopic suction tube; 2. Support plate; 3. Placement seat; 4. Support pad; 5. Reciprocating shaker body; 6. Limiting component; 61. Sponge sleeve; 62. Clamping rod; 63. Slide rod; 64. Limiting bolt; 7. Clamping mechanism; 71. Slide groove; 72. Two-way lead screw; 73. Clamping block; 74. Motor. Detailed Implementation

[0023] The present application will be further described in detail below with reference to the accompanying drawings.

[0024] To better understand the technical solutions presented in the embodiments of this application, the working principle of serum separation and aspiration from animal blood samples will be introduced first.

[0025] Currently, the main method for separating serum from animal blood samples is to place the storage bottle containing the animal blood sample on a reciprocating shaker. The continuous shaking of the reciprocating shaker ensures that the animal blood sample comes into full contact with the corresponding separation reagent. After shaking, the serum is then extracted step by step using a syringe.

[0026] Please see Figures 1-4 This application discloses a batch serum extraction separation device, including a reciprocating shaker body 5. A support plate 2 is installed on one side wall of the reciprocating shaker body 5. Two clamping mechanisms 7 are symmetrically installed on both sides of the top of the support plate 2. The clamping mechanism 7 includes a slide groove 71, a bidirectional lead screw 72, clamping blocks 73, and a motor 74. The slide groove 71 is formed on the side of the top of the support plate 2. The bidirectional lead screw 72 is installed in the slide groove 71. The bidirectional lead screw 72 has two sections with opposite threads. Two clamping blocks 73 are installed at each section of the bidirectional lead screw 72 with opposite threads. The motor 74 is installed on one side wall of the support plate 2, directly opposite to the bidirectional lead screw 72. At the end of the lead screw 72, a suction mechanism 1 is installed between the top support of the support plate 2 and the two corresponding clamping blocks 73. The suction mechanism 1 includes a solenoid valve 11, a main suction pipe 12, a negative pressure pump 13, a suction branch pipe 14, a storage bottle 15, and a telescopic suction tube 16. The main suction pipe 12 is installed at the middle of the top of the support plate 2, and the suction branch pipes 14 are symmetrically installed on both sides of the main suction pipe 12. The solenoid valve 11 is installed on the suction branch pipe 14. The storage bottle 15 is installed between the two symmetrical clamping blocks 73 on the clamping mechanism 7. The telescopic suction tube 16 is installed at the middle of the bottom of the storage bottle 15. The negative pressure pump 13 is installed at the top of the support plate 2 on one side of the main suction pipe 12.

[0027] Specifically, when extracting serum separated from an animal blood sample, the storage bottle 15 is first placed between two clamping blocks 73 in the clamping mechanism 7. Then, under the action of the motor 74, the bidirectional lead screw 72 is rotated so that the clamping blocks 73 on both sides of the storage bottle 15 move closer to each other under the action of threaded transmission during the rotation of the bidirectional lead screw 72, thereby achieving clamping and limiting of the storage bottle 15. Then, the telescopic pipette 16 is simply inserted into the serum separated from the animal blood sample, and under the action of the negative pressure pump 13, the main suction pipe 12, and the suction branch pipe 14, a negative pressure is formed inside the storage bottle 15, so that the serum separated from the animal blood sample can be conveniently extracted under the negative pressure suction.

[0028] Please see Figure 1 The top of the reciprocating rocker body 5 is also equipped with a placement seat 3, and a limit component 6 is installed on the placement seat 3.

[0029] In one implementation, the placement seat 3 is connected to the shaking component built into the reciprocating shaker body 5 to ensure convenient shaking of the animal blood sample when shaking and separating it. The limiting component 6 is mainly used to clamp and limit the reagent bottle containing the animal blood sample.

[0030] Please see Figure 1 The limiting component 6 includes a sponge sleeve 61, a clamping rod 62, a sliding rod 63, and a limiting bolt 64. There are two sliding rods 63, which are symmetrically installed on both sides of the upper end of the placement seat 3. The clamping rod 62 is slidably installed between the two sliding rods 63. The limiting bolt 64 is installed at both ends of the clamping rod 62, and the sponge sleeve 61 is installed in the middle of the outer wall of the clamping rod 62.

[0031] As one implementation method, when limiting the reagent bottle containing animal blood samples, the corresponding reagent bottle is first placed between each set of clamping rods 62, and directly below the storage bottle 15 corresponding to the reagent bottle position. Then, the two clamping rods 62 are brought into contact with the sides of the reagent bottle, and the limiting bolts 64 are tightened so that the reagent bottle is reliably clamped and fixed under the action of the clamping rods 62, thereby preventing the reagent bottle from sliding and falling when the serum in the animal blood sample is shaken and separated.

[0032] Please see Figure 1 The sponge sleeve 61 is bonded to the clamp rod 62. There are two sets of clamp rods 62, with two rods in each set.

[0033] As one implementation, the sponge sleeve 61 provides a larger contact area between the clamping rod 62 and the reagent bottle containing animal blood when it is clamped and limited, ensuring stable clamping of the reagent bottle.

[0034] Please see Figure 1 A support pad 4 is installed at each of the four corners of the bottom of the reciprocating rocker body 5, and the support pad 4 is screwed into the reciprocating rocker body 5.

[0035] As one implementation method, the support 4 can ensure the stable placement of the reciprocating rocker body 5 and prevent the reciprocating rocker body 5 from tilting.

[0036] Please see Figure 1 The bidirectional lead screw 72 passes through the clamping block 73 and is threadedly connected to the clamping block 73. The clamping block 73 is slidably engaged with the slide groove 71.

[0037] In one implementation, after the bidirectional lead screw 72 rotates, the clamping block 73 will move conveniently along the slide groove 71 under the action of the threaded transmission, so as to clamp and limit the storage bottle 15 under the action of the clamping block 73.

[0038] Please see Figures 1-4 The clamping surface of the clamping block 73 has an arc-shaped structure, the bidirectional lead screw 72 is rotatably engaged with the slide groove 71, and the motor 74 is connected to the bidirectional lead screw 72 by a coupling.

[0039] As one implementation method, making the clamping surface of the clamping block 73 arc-shaped can ensure that the clamping block 73 and the reagent bottle have sufficient clamping area. The rotational installation method makes the rotation of the bidirectional lead screw 72 driven by the motor 74 more convenient.

[0040] Please see Figure 1 The negative pressure pump 13 is connected to the main exhaust pipe 12 through a pipe, and the exhaust branch pipe 14 is welded to the main exhaust pipe 12.

[0041] In one implementation, the negative pressure pump 13 mainly extracts gas from the storage bottle 15 through the main extraction pipe 12 and the branch extraction pipe 14, so that the storage bottle 15 is in a negative pressure state.

[0042] Please see Figure 1 The storage bottle 15 is made of transparent material, and the suction tube 14 is inserted into the storage bottle 15. Both the storage bottle 15 and the telescopic straw 16 are made of disposable material.

[0043] As one implementation method, the disposable storage bottle 15 and the telescopic straw 16 can avoid cross-infection during serum separation from animal blood samples.

[0044] The specific working principle is as follows: When separating serum from animal blood samples, the reagent bottle containing the animal blood sample is first placed between two adjacent clamps 62, with the reagent bottle directly below the corresponding storage bottle 15. Then, the position of the reagent bottle is limited by the clamps 62 and the limiting bolts 64. Next, the reciprocating shaker body 5 is started to shake the placement seat 3. After shaking for a period of time, the serum in the animal blood sample in the reagent bottle can be easily separated. After the serum is separated from the animal blood sample, the telescopic pipette 16 is inserted into the corresponding storage bottle. The serum in the reagent bottle is then extracted by creating a negative pressure inside the storage bottle 15 under the action of the negative pressure pump 13, the main suction pipe 12, and the suction branch pipe 14. The serum separated from the animal blood sample can then be easily extracted under the negative pressure suction. This separation and extraction method not only allows for the simultaneous extraction of serum from four animal blood samples, eliminating the tedious manual extraction process and reducing labor intensity, but also effectively improves the extraction efficiency of serum separated from animal blood samples, facilitating the efficient preparation of serum products.

[0045] The embodiments described in this specific implementation are preferred embodiments of this application and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A bulk withdrawal serum separation device, characterized by: The reciprocating shaker body (5) is provided with a support plate (2) on one side wall, two clamping mechanisms (7) are symmetrically arranged at the top of the support plate (2), the clamping mechanism (7) comprises a sliding groove (71), a bidirectional screw rod (72), a clamping block (73) and a motor (74), the sliding groove (71) is formed on the side of the top of the support plate (2), the bidirectional screw rod (72) is arranged in the sliding groove (71), the bidirectional screw rod (72) is provided with two thread sections with opposite rotation directions, two clamping blocks (73) are arranged on each thread section with opposite rotation directions of the bidirectional screw rod (72), and the motor (74) is arranged on one side wall of the support plate (2) and faces the end of the bidirectional screw rod (72); an extraction mechanism (1) is arranged between the top of the support plate (2) and the corresponding two clamping blocks (73), the extraction mechanism (1) comprises an electromagnetic valve (11), an air extraction main pipe (12), a negative pressure pump (13), an air extraction branch pipe (14), a storage bottle (15) and a telescopic suction pipe (16), the air extraction main pipe (12) is arranged at the middle of the top of the support plate (2), the air extraction branch pipe (14) is symmetrically arranged at the two sides of the air extraction main pipe (12), the electromagnetic valve (11) is arranged on the air extraction branch pipe (14), the storage bottle (15) is arranged between the two clamping blocks (73) symmetrically arranged on the clamping mechanism (7), the telescopic suction pipe (16) is arranged at the middle of the bottom of the storage bottle (15), and the negative pressure pump (13) is arranged at the top of the support plate (2) and located at one side of the air extraction main pipe (12).

2. A bulk withdrawal serum separation device according to claim 1, wherein: The reciprocating shaker body (5) is provided with a support plate (2) on one side wall, two clamping mechanisms (7) are symmetrically arranged at the top of the support plate (2), the clamping mechanism (7) comprises a sliding groove (71), a bidirectional screw rod (72), a clamping block (73) and a motor (74), the sliding groove (71) is formed on the side of the top of the support plate (2), the bidirectional screw rod (72) is arranged in the sliding groove (71), the bidirectional screw rod (72) is provided with two thread sections with opposite rotation directions, two clamping blocks (73) are arranged on each thread section with opposite rotation directions of the bidirectional screw rod (72), and the motor (74) is arranged on one side wall of the support plate (2) and faces the end of the bidirectional screw rod (72); an extraction mechanism (1) is arranged between the top of the support plate (2) and the corresponding two clamping blocks (73), the extraction mechanism (1) comprises an electromagnetic valve (11), an air extraction main pipe (12), a negative pressure pump (13), an air extraction branch pipe (14), a storage bottle (15) and a telescopic suction pipe (16), the air extraction main pipe (12) is arranged at the middle of the top of the support plate (2), the air extraction branch pipe (14) is symmetrically arranged at the two sides of the air extraction main pipe (12), the electromagnetic valve (11) is arranged on the air extraction branch pipe (14), the storage bottle (15) is arranged between the two clamping blocks (73) symmetrically arranged on the clamping mechanism (7), the telescopic suction pipe (16) is arranged at the middle of the bottom of the storage bottle (15), and the negative pressure pump (13) is arranged at the top of the support plate (2) and located at one side of the air extraction main pipe (12).

3. A bulk withdrawal serum separation device according to claim 2, wherein: The reciprocating shaker body (5) is provided with a support plate (2) on one side wall, two clamping mechanisms (7) are symmetrically arranged at the top of the support plate (2), the clamping mechanism (7) comprises a sliding groove (71), a bidirectional screw rod (72), a clamping block (73) and a motor (74), the sliding groove (71) is formed on the side of the top of the support plate (2), the bidirectional screw rod (72) is arranged in the sliding groove (71), the bidirectional screw rod (72) is provided with two thread sections with opposite rotation directions, two clamping blocks (73) are arranged on each thread section with opposite rotation directions of the bidirectional screw rod (72), and the motor (74) is arranged on one side wall of the support plate (2) and faces the end of the bidirectional screw rod (72); an extraction mechanism (1) is arranged between the top of the support plate (2) and the corresponding two clamping blocks (73), the extraction mechanism (1) comprises an electromagnetic valve (11), an air extraction main pipe (12), a negative pressure pump (13), an air extraction branch pipe (14), a storage bottle (15) and a telescopic suction pipe (16), the air extraction main pipe (12) is arranged at the middle of the top of the support plate (2), the air extraction branch pipe (14) is symmetrically arranged at the two sides of the air extraction main pipe (12), the electromagnetic valve (11) is arranged on the air extraction branch pipe (14), the storage bottle (15) is arranged between the two clamping blocks (73) symmetrically arranged on the clamping mechanism (7), the telescopic suction pipe (16) is arranged at the middle of the bottom of the storage bottle (15), and the negative pressure pump (13) is arranged at the top of the support plate (2) and located at one side of the air extraction main pipe (12).

4. A bulk withdrawal serum separation device according to claim 3, wherein: ​ 5. A bulk withdrawal serum separation device as defined in claim 1, wherein: ​ 6. A bulk withdrawal serum separation device as defined in claim 1, wherein: ​ 7. A bulk withdrawal serum separation device as defined in claim 1, wherein: ​ 8. A bulk withdrawal serum separation device according to claim 7, wherein: The negative pressure pump (13) is connected with the air extraction main pipe (12) through a pipeline, and the air extraction branch pipe (14) is welded with the air extraction main pipe (12).

9. A bulk withdrawal serum separation device according to claim 7, wherein: The storage bottle (15) is made of transparent material, the air extraction branch pipe (14) is inserted with the storage bottle (15), and the storage bottle (15) and the telescopic straw (16) are made of disposable material.

Images