Experimental device for rat smoke exposure
By using a sealing mechanism consisting of an acrylic plate and guide rails in the rat smoke exposure experimental device, the problems of poor sealing and limited space were solved, the stability of smoke concentration and the reliability of experimental data were improved, and the complexity and cost of the device were reduced.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-28
- Publication Date
- 2026-03-24
AI Technical Summary
Existing rat smoke exposure experimental devices suffer from problems such as poor sealing, unstable smoke concentration, cramped space, and stress response caused by animal overcrowding, which affect the reproducibility of experiments and the authenticity of data.
The system employs a fixing assembly consisting of four sets of side rods, two sets of top rods, and two sets of fixing rods, combined with a sealing mechanism made of acrylic plates and guide rails, to provide a stable smoke environment and reduce animal crowding and fecal contamination through positioning, collection, and storage mechanisms.
This approach achieves stability in smoke concentration and improves rat comfort, enhancing the reliability and accessibility of experimental data while reducing device cost and installation complexity.
Smart Images
Figure CN224022567U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to rat experiment device technical field, concretely relates to an experiment device for rat smoke exposure. BACKGROUND
[0002] Rat smoke exposure experiment is an important means for studying respiratory diseases and air pollution toxicological mechanism, and the traditional experiment device adopts a closed metal cabin body or glass box structure, which has the following defects: the metal cabin body needs to maintain smoke concentration uniformity through a complex pipeline system (such as a multi-point air inlet valve and a vortex mixer), but the pipeline dead angle is easy to cause local concentration deviation (more than ± 15%), and the equipment cost is high (more than 100,000 yuan per set), which is difficult for small and medium-sized laboratories to bear.
[0003] In the implementation of the present application, it is found that the existing glass box has the following problems: although the transparency is high, the sealing performance is poor (depending on the compression of silica gel strips, the air leakage rate is more than 5% per hour), it is difficult to maintain a stable smoke exposure environment for a long time (such as PM2.5 concentration fluctuation is more than 20%), which affects the repeatability of the experiment, in addition, the internal space of the traditional device is cramped (single box contains less than 3 rats), and the stress reaction caused by animal crowding will cause the serum cortisol level to rise by 30%-50%, which interferes with the authenticity of key data such as inflammatory factors.
[0004] Therefore, an experiment device for rat smoke exposure is provided. CONTENT OF THE UTILITY MODEL
[0005] The utility model aims at: in order to solve the problem that the existing glass box has high transparency, but poor sealing performance (depending on the compression of silica gel strips, the air leakage rate is more than 5% per hour), it is difficult to maintain a stable smoke exposure environment for a long time (such as PM2.5 concentration fluctuation is more than 20%), which affects the repeatability of the experiment, in addition, the internal space of the traditional device is cramped (single box contains less than 3 rats), and the stress reaction caused by animal crowding will cause the serum cortisol level to rise by 30%-50%, which interferes with the authenticity of key data such as inflammatory factors, the utility model provides an experiment device for rat smoke exposure.
[0006] The utility model adopts the following technical scheme in order to realize the above-mentioned purpose:
[0007] An experimental device for rat smoke exposure, comprising a fixing assembly, the fixing assembly comprises four groups of side rods, two groups of top rods and two groups of fixing rods, the two groups of top rods and the two groups of fixing rods are installed between the four groups of side rods, a sealing mechanism for sealing a rat experimental space is installed at the outer end of the fixing assembly, a collecting mechanism for collecting rat feces is installed at the inner wall bottom of the sealing mechanism, a limiting mechanism for limiting the moving position of a rat cage is installed in the collecting mechanism, a storage mechanism for storing the rat cage is installed in the fixing assembly, a positioning mechanism for positioning the rat cage at the upper end position of the collecting mechanism is installed between the four groups of side rods.
[0008] Further, the sealing mechanism comprises two groups of guide rails and two groups of first acrylic plates, the two groups of first acrylic plates are respectively bonded between the two groups of top rods and the two groups of fixing rods, the outer ends of the four groups of side rods are bonded with four groups of second acrylic plates, the two groups of guide rails are respectively installed in the interiors of the front side one group of top rods and the front side one group of fixing rods, and the back surface of the front side one group of second acrylic plates is installed on the front surface of the two groups of guide rails.
[0009] Further, the positioning mechanism comprises two groups of connecting rods, the two groups of connecting rods are respectively installed between the four groups of side rods, and the upper and lower surfaces of the two groups of connecting rods are both installed with L-shaped positioning frames.
[0010] Further, the collecting mechanism comprises two groups of side plates, the two groups of side plates are installed on the upper surfaces of the bottom end one group of first acrylic plates, and a collecting box is slidably connected between the two groups of side plates.
[0011] Further, the limiting mechanism comprises two groups of slide rods, the two groups of slide rods are both slidably connected between the two groups of side plates in a damping mode, and the upper surfaces of the two groups of slide rods are both installed with limiting rods.
[0012] Further, the storage mechanism comprises two groups of bottom rods, the two groups of bottom rods are respectively installed between the four groups of side rods, and the upper surfaces of the two groups of bottom rods are both installed with a plurality of L-shaped positioning plates.
[0013] The beneficial effects of the utility model are as follows:
[0014] 1.The utility model discloses a fixed assembly is spliced into a group of rectangular frames through two groups of first acrylic plates and four groups of second acrylic plates at the outer end, which helps to keep the stability of smoke concentration in the experiment process, and the spacious interior of the sealing mechanism can accommodate multiple mouse cages at the same time, thereby reducing the crowding and stress reaction of rats in the experiment process and improving the reliability of experimental data; the sealing mechanism is mainly composed of four groups of second acrylic plates, two groups of first acrylic plates and two groups of guide rails, which are common and low in cost, thereby avoiding the complex pipeline and control module in the traditional smoke exposure system, and thus the device is suitable for rapid construction and use in general laboratory environment, thereby improving the practicability of the device.
[0015] 2.The utility model discloses the position setting of the collecting box is at the positive lower end of the positioning mechanism, so that the surgical pad inside the collecting box collects the excrement spilt by the clamped mouse cage in the positioning mechanism during use, and the trapezoidal shape provided on the inner wall bottom of the collecting box makes the excrement spilt on the upper surface of the surgical pad slide to the central area of the surgical pad under the action of gravity, thereby making it difficult for the user to spatter the rat excrement accumulated on the upper surface of the surgical pad to the ground during the process of taking out the surgical pad to clean the excrement accumulated in the collecting mechanism, and thus improving the convenience and hygiene of the collecting mechanism during use. BRIEF DESCRIPTION OF DRAWINGS
[0016] Figure 1 It is the side surface structure schematic view of the utility model;
[0017] Figure 2 It is the top surface structure schematic view of the utility model;
[0018] Figure 3 It is the front surface structure schematic view of the utility model;
[0019] Figure 4 It is the utility model Figure 3 The enlarged view of A in the utility model.
[0020] Signs: 1, fixed assembly;101, top rod;102, side rod;103, fixed rod;2, sealing mechanism;201, first acrylic plate;202, second acrylic plate;203, guide rail;3, storage mechanism;301, bottom rod;302, L-shaped positioning plate;4, positioning mechanism;401, connecting rod;402, L-shaped positioning frame;5, collecting mechanism;501, side plate;502, collecting box;6, limiting mechanism;601, sliding rod;602, limiting rod. DETAILED DESCRIPTION
[0021] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. The components of the embodiments of this utility model described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.
[0022] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.
[0023] It should be noted that similar reference numerals and letters in the following figures indicate similar items; therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures. Furthermore, the terms "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.
[0024] In the description of the embodiments of this utility model, it should be noted that the terms "inner", "outer", "upper", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the utility model product is usually placed when in use. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.
[0025] like Figures 1 to 4 As shown, an experimental device for rat smoke exposure includes a fixing component 1, which includes four sets of side rods 102, two sets of top rods 101, and two sets of fixing rods 103. The two sets of top rods 101 and the two sets of fixing rods 103 are installed between the four sets of side rods 102. A sealing mechanism 2 for sealing the rat experimental space is installed at the outer end of the fixing component 1. A collection mechanism 5 for collecting rat feces is installed at the bottom of the inner wall of the sealing mechanism 2. A limiting mechanism 6 for restricting the movement of the rat cage is installed inside the collection mechanism 5. A storage mechanism 3 for storing and storing the rat cage is installed inside the fixing component 1. A positioning mechanism 4 for positioning the rat cage at the upper position of the collection mechanism 5 is installed between the four sets of side rods 102.
[0026] Specifically, by sealing mechanism 2 in the fixed assembly 1 outside the end splicing into a rectangular experimental space, so that the sealing mechanism 2 in the process of use to help keep the smoke concentration stable during the experiment, while the sealing mechanism 2 inside space, can accommodate multiple mouse cage at the same time, thereby reducing the rat in the experimental process crowded and stress reaction, thus improving the reliability of experimental data; by pushing the mouse cage mouse cage card to the inside of the positioning mechanism 4, so that the positioning mechanism 4 suspended inside the sealing mechanism 2, so as to avoid the mouse cage bottom and rat excrement contact and lead to the mouse cage surface contaminated.
[0027] As Figures 1 to 3 shown, the sealing mechanism 2 includes two groups of guide rail 203 and two groups of first acrylic plate 201, two groups of first acrylic plate 201 are respectively bonded between two groups of top rod 101 and two groups of fixed rod 103, four groups of second acrylic plate 202 are bonded on the outer end of four groups of side rod 102, two groups of guide rail 203 are respectively installed inside the front side of a group of top rod 101 and a group of fixed rod 103, the back of the front group of second acrylic plate 202 is installed on the front of the two groups of guide rail 203, the inside of the left and right groups of second acrylic plate 202 is respectively provided with 12 groups of through holes, the inside of the front and rear groups of second acrylic plate 202 is respectively provided with 22 groups of through holes, the inside of the two groups of first acrylic plate 201 is provided with 48 groups of through holes, with reference to Figure 2 ;
[0028] Specifically, by two groups of first acrylic plate 201 and four groups of second acrylic plate 202 in the fixed assembly 1 outside the end splicing into a rectangular frame, so that the sealing mechanism 2 in the process of use to help keep the smoke concentration stable during the experiment, while the sealing mechanism 2 inside space, can accommodate multiple mouse cage at the same time, thereby reducing the rat in the experimental process crowded and stress reaction, thus improving the reliability of experimental data; by sealing mechanism 2 mainly by four groups of second acrylic plate 202, two groups of first acrylic plate 201 and two groups of guide rail 203, which is common, and low cost, so as to avoid the complex pipeline and control module in the traditional smoke exposure system, and then suitable for rapid construction and use in general laboratory environment, thus improving the practicability of the device; by four groups of second acrylic plate 202 and two groups of first acrylic plate 201 inside the hole number is clear, and the assembly structure is intuitive, and then the four groups of second acrylic plate 202, two groups of first acrylic plate 201 and two groups of guide rail 203 can be fixed and installed by glue, screw and nut, which is simple to operate, so that the device can be completed in the process of installation and maintenance without depending on professional equipment and technical personnel, thus reducing the time spent in the production and maintenance process of the device;
[0029] Meanwhile, by pushing the front side a group of second acrylic plates 202 to drive the front side a group of sliding in the front end of the fixed assembly 1, so that the subsequent sealing mechanism 2 can be quickly opened and closed as needed, so that the staff can place or replace the rat cage, improve the experimental efficiency, adapt to different experimental process needs.
[0030] As shown in Figure 2 and Figure 3 , the positioning mechanism 4 includes two groups of connecting rods 401, which are respectively installed between the four groups of side rods 102, and the upper and lower surfaces of the two groups of connecting rods 401 are provided with L-shaped positioning frames 402; Specifically, by pushing the cage to clamp the cage top plate between the two L-shaped positioning frames 402, the cage can be placed in the sealing mechanism 2, so as to avoid the contact between the bottom of the cage and the rat excrement and cause the surface of the cage to be contaminated, thereby reducing the cleaning frequency of the staff regularly.
[0031] As shown in Figure 2 and Figure 4 , the collecting mechanism 5 includes two groups of side plates 501, which are installed on the upper surface of the bottom group of first acrylic plates 201, and the collecting box 502 is slidably connected between the two groups of side plates 501. The position of the collecting box 502 is located at the lower end of the positioning mechanism 4, and the inner wall bottom of the collecting box 502 is provided with a trapezoidal slope. The side of the two groups of side plates 501 close to the collecting box 502 is provided with a clamping groove, and the collecting box 502 is slidably connected in the clamping groove of the two groups of side plates 501. The inside of the collecting box 502 is paved with surgical pads; Specifically, by setting the position of the collecting box 502 at the lower end of the positioning mechanism 4, the surgical pads inside the collecting box 502 can collect the excrement falling from the clamped cage in the positioning mechanism 4 during use. The inner wall bottom of the collecting box 502 is provided with a trapezoidal shape, so that the excrement falling on the upper surface of the surgical pad can slide to the center area of the surgical pad under the action of gravity, thereby preventing the user from spilling the rat excrement accumulated on the upper surface of the surgical pad to the ground during the process of taking out the surgical pad to clean the excrement accumulated in the collecting mechanism 5, thereby improving the convenience and hygiene of the collecting mechanism 5 during use. By pulling the collecting box 502 to drive the collecting box 502 to slide in the clamping groove of the two groups of side plates 501, the staff can pull out the collecting box 502 from the side plate 501, so as to facilitate the staff to clean the collecting box 502 in depth; By abutting the front and rear sides of the collecting box 502 to the sides of the front and rear groups of second acrylic plates 202 close to the positioning mechanism 4, the front and rear groups of second acrylic plates 202 can limit the moving position of the collecting box 502 in the sealing mechanism 2, so as to avoid the collecting box 502 from sliding during use.
[0032] As shown in Figure 2 andFigure 4 As shown, the limiting mechanism 6 includes two groups of sliding rods 601, which are both slidingly connected between the two groups of side plates 501, and the upper surfaces of the two groups of sliding rods 601 are both provided with limiting rods 602, and the side of the two groups of side plates 501 close to the collection box 502 is provided with a sliding groove, and the two groups of sliding rods 601 are both slidingly connected in the sliding grooves of the two groups of side plates 501; Specifically, by pushing the two groups of sliding rods 601 to drive the two groups of limiting rods 602 to move, the two groups of limiting rods 602 are respectively abutted to the front and rear sides of the caged mouse inside the positioning mechanism 4, so that the limiting mechanism 6 limits the moving position of the caged mouse inside the positioning mechanism 4, thereby avoiding the shaking of the caged mouse inside the sealing mechanism 2 during the carrying and moving of the device by the staff, and thus improving the stability of the caged mouse during use.
[0033] As shown in Figure 1 and Figure 3 The storage mechanism 3 includes two groups of bottom rods 301, which are respectively installed between the four groups of side rods 102, and the upper surfaces of the two groups of bottom rods 301 are both provided with a plurality of L-shaped positioning plates 302, and the plurality of L-shaped positioning plates 302 are symmetrically installed on the upper surfaces of the two groups of bottom rods 301, and the spacing between the inner walls of the two groups of L-shaped positioning plates 302 is matched with the outer contour of the caged mouse; Specifically, by matching the spacing between the inner walls of the two groups of L-shaped positioning plates 302 with the outer contour of the caged mouse, the staff can clamp the caged mouse between the two groups of L-shaped positioning plates 302 during storage, so that the storage mechanism 3 can store the caged mouse, thereby facilitating the user to take it in time during the use of the caged mouse.
[0034] In summary: The two groups of first acrylic plates 201 and the four groups of second acrylic plates 202 are spliced into a rectangular frame at the outer end of the fixing assembly 1, so that the sealing mechanism 2 can help to keep the smoke concentration stable during the experiment, and the internal space of the sealing mechanism 2 is spacious, which can accommodate multiple caged mice at the same time, thereby reducing the crowding and stress reaction of rats during the experiment; By pushing the front group of second acrylic plates 202 to drive the front group of second acrylic plates 202 to slide at the front end of the fixing assembly 1, the subsequent sealing mechanism 2 can be quickly opened and closed according to the needs, thereby facilitating the staff to place or replace the rat cage, and improving the experimental efficiency.
[0035] Meanwhile, the mouse cage top plate is clamped between the two groups of L-shaped positioning frames 402 by pushing the mouse cage, so that the mouse cage can be suspended when placed inside the sealing mechanism 2; the collecting box 502 is arranged at the lower end of the positioning mechanism 4, so that the feces spilt from the clamped mouse cage in the positioning mechanism 4 can be collected in the collecting box 502 during use of the surgical pad, and the trapezoidal shape arranged on the inner wall bottom of the collecting box 502 enables the feces spilt on the upper surface of the surgical pad to slide to the center area of the surgical pad under the action of gravity, so that the user is less likely to spilt the rat feces accumulated on the upper surface of the surgical pad to the ground during the process of taking out the surgical pad to clean the feces accumulated in the collecting mechanism 5.
[0036] The basic principle, main features and advantages of the utility model are shown and described above. It should be understood by those skilled in the art that the utility model is not limited by the above-mentioned embodiments, and the above-mentioned embodiments and descriptions in the specification are only the principles of the utility model. Various changes and improvements can be made to the utility model without departing from the spirit and scope of the utility model, and these changes and improvements all fall within the scope of the utility model claimed. The protection scope required by the utility model is defined by the appended claims and their equivalents.
Claims
1. An experimental apparatus for rat smoke exposure, comprising a fixation component (1), characterized in that: The fixing component (1) includes four sets of side rods (102), two sets of top rods (101), and two sets of fixing rods (103). The two sets of top rods (101) and the two sets of fixing rods (103) are installed between the four sets of side rods (102). A sealing mechanism (2) for sealing the rat experimental space is installed at the outer end of the fixing component (1). A collection mechanism (5) for collecting rat feces is installed at the bottom of the inner wall of the sealing mechanism (2). A limiting mechanism (6) for restricting the movement of the rat cage is installed inside the collection mechanism (5). A storage mechanism (3) for storing and storing the rat cage is installed inside the fixing component (1). A positioning mechanism (4) for positioning the rat cage at the upper end of the collection mechanism (5) is installed between the four sets of side rods (102).
2. The experimental apparatus for rat smoke exposure according to claim 1, characterized in that: The sealing mechanism (2) includes two sets of guide rails (203) and two sets of first acrylic plates (201). The two sets of first acrylic plates (201) are respectively bonded between the two sets of top rods (101) and the two sets of fixing rods (103). The outer ends of the four sets of side rods (102) are bonded with four sets of second acrylic plates (202). The two sets of guide rails (203) are respectively installed inside the front set of top rods (101) and the front set of fixing rods (103). The back of the front set of second acrylic plates (202) is installed on the front of the two sets of guide rails (203).
3. The experimental apparatus for rat smoke exposure according to claim 1, characterized in that: The positioning mechanism (4) includes two sets of connecting rods (401), which are respectively installed between the four sets of side rods (102). L-shaped positioning frames (402) are installed on the upper and lower surfaces of the two sets of connecting rods (401).
4. The experimental apparatus for rat smoke exposure according to claim 2, characterized in that: The collection mechanism (5) includes two sets of side plates (501), which are mounted on the upper surface of the first acrylic plate (201) at the bottom, and a collection box (502) is slidably connected between the two sets of side plates (501).
5. The experimental apparatus for rat smoke exposure according to claim 4, characterized in that: The limiting mechanism (6) includes two sets of slide rods (601), both sets of slide rods (601) are damped and slidably connected between the two sets of side plates (501), and the upper surfaces of the two sets of slide rods (601) are equipped with limiting rods (602).
6. The experimental apparatus for rat smoke exposure according to claim 1, characterized in that: The storage mechanism (3) includes two sets of bottom rods (301), which are respectively installed between four sets of side rods (102). Multiple sets of L-shaped positioning plates (302) are installed on the upper surface of both sets of bottom rods (301).