Intelligent mouse cage for mouse chronic unpredictable stimulation model

Abstract

The utility model belongs to the technical field of animal experiment instruments, and relates to an intelligent mouse cage for a mouse chronic unpredictable stimulation model. The mouse cage comprises an upper-layer cage body and a base, the upper-layer cage body is composed of an upper cover, a lower wall and a side wall, a stimulation module is arranged in the mouse cage, the stimulation module comprises a temperature stimulation module, a humidity stimulation module, an acousto-optic stimulation module, an inclined vibration stimulation module, a water and grain control module and a space stimulation module, and the stimulation module is controlled by a central controller; the intelligent mouse cage is compact in structure, and stimulation conditions can be automatically controlled. Moreover, various unpredictable stimulation can be completed in a single device, the intelligent mouse cage is easy to maintain and clean, and whether modeling succeeds or not is conveniently checked, so that the mouse welfare is ensured, the accuracy and repeatability of experimental data are improved, and manpower and experimental expenditure are effectively saved.

Description

TECHNICAL FIELD

[0001] The utility model belongs to animal experiment instrument technical field relates to a kind of intelligent mouse cage for mouse chronic unpredictable stimulus model. BACKGROUND

[0002] Depression is a global common mental illness, with high relapse rate, seriously affecting the quality of life of human beings, and is the main cause of mental disability worldwide. In order to deeply study the mechanism of depression and develop effective treatment methods, scientists have developed various animal models, among which the CUMS model is widely used because it can better simulate the pathogenesis of human depression. By applying a series of unpredictable mild stressors to experimental animals, this model can induce behavioral and physiological changes similar to depression, thereby helping researchers better understand the pathogenesis of depression and evaluate the effectiveness of drug treatment. The stressors of CUMS model usually include various types of stimuli, such as food or water deprivation, cage humidity increase, noise exposure, temperature change, light cycle change, cage tilt or vibration, activity restriction. These stressors are randomly applied to experimental animals, making them in a state of continuous stress. This continuous and unpredictable stress is the core feature of CUMS model, which also makes it an effective tool for studying depression.

[0003] The existing CUMS experiment has high demand for manpower, space and cost, and has deficiencies in stimulus connection, animal escape prevention and control, and experimental accuracy. At the same time, the scattered use of different stimulus devices also leads to greater complexity in maintenance, cleaning and operation, increasing the error and time cost of the experimental process. Therefore, it is urgent to design an intelligent mouse cage for mouse chronic unpredictable stress model. UTILITY MODEL CONTENT

[0004] The utility model aims at overcoming the above-mentioned shortcomings of the prior art and proposes an intelligent mouse cage for mouse chronic unpredictable stimulus model.

[0005] To achieve the above-mentioned purpose, the utility model adopts the following technical solutions:

[0006] An intelligent mouse cage for mouse chronic unpredictable stimulus model, comprising a mouse cage, the mouse cage comprising an upper cage body and a base, the upper cage body consisting of an upper cover, a lower wall and a side wall, a stimulus module is provided in the mouse cage, the stimulus module comprising a temperature stimulus module, a humidity stimulus module, a sound and light stimulus module, a tilt and vibration stimulus module, a water and food control module, a space stimulus module, the stimulus module being controlled by a central controller;

[0007] The temperature stimulation module includes a heating element and a cooling element mounted on the top wall of the base. The heating element heats the inside of the cage, and the cooling element cools the inside of the cage. The humidity stimulation module includes a humidifier mounted on the outside of the cage to humidify the inside of the cage. The sound and light stimulation module includes a sound source mounted on the side wall of the cage to release noise. The sound and light stimulation module also includes a controllable light source mounted on the top cover to change the light intensity. The tilting and vibration stimulation module includes a vibrating tilting platform mounted on the base. The tilting or vibration of the platform is achieved by changing the angle and speed of the shaker motor output shaft. The water and food control module includes a food trough mounted below the top cover and a water bottle mounted outside the side wall of the cage. The space stimulation module includes a first enclosure and a second enclosure mounted opposite each other inside the cage. The size of the space is changed by changing the relative distance between the first enclosure and the second enclosure.

[0008] Furthermore, the base includes a base plate and a hinge joint disposed on the base. A connecting block is disposed on the top wall of the base, and the connecting block is hinged to the hinge joint. The tilting vibration stimulation module includes a shaking table motor located on the base plate. The shaking table motor is connected to the base plate through a shaking table. The left and right output ends of the shaking table motor are each provided with a first electric rod.

[0009] Furthermore, the vibration frequency, tilt angle, and switching time of the shaking table motor can all be adjusted according to the set program or random algorithm in the central control system.

[0010] Furthermore, the water and food control module includes a second electric rod disposed on the side wall, the output end of the second electric rod is connected to a connecting rod, the connecting rod is connected to a feeding trough rotating rod, and a feeding trough is sleeved on the feeding trough rotating rod.

[0011] Furthermore, the water and food control module includes a water bottle bracket disposed on the outer wall of the cage. The water bottle bracket includes a bracket rotating rod, a water bottle baffle is disposed on the bracket rotating rod, and a water bottle is disposed on the water bottle baffle. The water and food control module also includes a third electric rod, one end of which is connected to the bracket rotating rod, and the other end of which is connected to the side wall of the cage.

[0012] Furthermore, the spatial stimulation module includes a first motor disposed on the side wall, the output end of the first motor is connected to a frame rod, the frame rod is provided with threads, the first enclosure plate and the second enclosure plate are sleeved on the frame rod, and the first motor drives the frame rod to rotate, thereby driving the first enclosure plate and the second enclosure plate to move.

[0013] Furthermore, the base is provided with an inner cavity, and the temperature stimulation module includes a temperature control zone located in the inner cavity. The temperature control zone is located below the cage body, and a heating element and a cooling element are provided in the temperature control zone. A temperature sensor is provided in the cage body, and a temperature signal is sent to the central controller through the temperature sensor. The central controller controls the temperature control zone to achieve cooling or heating.

[0014] Furthermore, the temperature stimulation module includes a gas ventilation fan located on the upper cover, which is controlled by a central controller.

[0015] Furthermore, the humidity stimulation module includes a humidifier installed on the outer side of the side wall, and the activation of the humidifier is controlled by a central controller.

[0016] Furthermore, the sound and light stimulation module includes a sound source installed on the inner side of the side wall and a controllable light source installed on the top cover, wherein the sound source and the controllable light source are controlled by a central controller.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] This invention provides an intelligent mouse cage for a chronic unpredictable stimulation model in mice. The intelligent mouse cage has a compact structure and automatically controllable stimulation conditions. Furthermore, it can handle multiple unpredictable stimuli within a single device, is easy to maintain and clean, and facilitates verification of model success. This intelligent mouse cage ensures mouse welfare while improving the accuracy and reproducibility of experimental data, and effectively saves manpower and experimental costs. Attached Figure Description

[0019] The accompanying drawings are incorporated in and form part of this specification, and together with the description, serve to explain the principles of this invention.

[0020] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, for those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0022] Figure 2 This is an axial view of the overall structure of this utility model;

[0023] Figure 3 This is a cross-sectional view of the present invention;

[0024] Figure 4 This is a view of part I of the present invention;

[0025] Figure 5 This is a view of part II of the present invention;

[0026] Figure 6 This is a schematic diagram of the heating element of this utility model;

[0027] Figure 7 This is a side view of the present invention;

[0028] Figure 8 This is a schematic diagram of the water bottle baffle of this utility model.

[0029] Wherein: 1 is the side wall; 2 is the lower wall; 201 is the upper electric column slot; 3 is the base plate; 301 is the shaking table column; 4 is the top wall of the base; 401 is the lower electric column; 5 is the shaking table motor; 6 is the first electric rod; 7 is the shaking table base; 8 is the upper and lower connecting buckle; 9 is the buckle slot; 10 is the observation window cover; 11 is the heating element; 12 is the cooling element; 13 is the movable rod; 14-1 is the first enclosure panel; 14-2 is the second enclosure panel; 15 is the frame rod; 16 17 is the first motor; 18 is the feeding trough; 19 is the second electric rod; 20 is the feeding trough cover; 21 is the sound source; 22 is the humidifier; 23 is the ventilation device frame; 24 is the control panel; 25 is the heater; 26 is the gas ventilation fan; 27 is the air filter; 28 is the ventilation fan cover; 29 is the third electric rod; 30 is the water bottle; 31 is the water bottle bracket; 32 is the water bottle baffle; 33 is the feeding trough rotating rod; 34 is the controllable light source; 35 is the bracket rotating rod. Detailed Implementation

[0030] Exemplary embodiments will be described in detail below. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with this invention. Rather, they are merely examples consistent with some aspects of this invention as detailed in the appended claims.

[0031] To enable those skilled in the art to better understand the technical solution of this utility model, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments.

[0032] Example

[0033] like Figures 1-2 As shown, an intelligent mouse cage for a chronic unpredictable stimulation model in mice includes a mouse cage, which comprises an upper cage body and a base. The upper cage body consists of an upper cover, a lower wall 2, and a side wall 1. The mouse cage is equipped with stimulation modules, which include a temperature stimulation module, a humidity stimulation module, an audio-visual stimulation module, a tilt and vibration stimulation module, a water and food control module, and a spatial stimulation module. The stimulation modules are controlled by a central controller.

[0034] The temperature stimulation module includes a heating element 11 and a cooling element 12. The heating element 11 heats the inside of the cage, and the cooling element 12 cools the inside of the cage. The humidity stimulation module includes a humidifier 21 located outside the cage, which humidifies the inside of the cage. The sound and light stimulation module includes a sound source 20 installed on the side wall of the cage, which releases noise. The sound and light stimulation module also includes a controllable light source 33 located on the top cover, which changes the light intensity. The tilting and vibration stimulation module includes a vibrating tilting platform located on the base. The tilting or vibration of the vibrating tilting platform is achieved by changing the angle and speed of the output shaft of the shaker motor 5. The water and food control module includes a food trough 17 located below the top cover and a water bottle 29 located outside the side wall of the cage. The space stimulation module includes a first enclosure 14-1 and a second enclosure 14-2 located opposite each other inside the cage. The size of the space is changed by changing the relative distance between the first enclosure 14-1 and the second enclosure 14-2.

[0035] In this embodiment: the intelligent mouse cage includes at least the following parts:

[0036] Cage structure: The overall structure is cubic or cuboid, consisting of an upper cage and a base, providing internal space for the mouse to move around, such as... Figure 5 As shown, a ventilation device frame 22 is installed on the top of the upper cage. The ventilation device frame 22 consists of a control panel 23 and a gas ventilation device, which is composed of a gas ventilation fan 25, an air filter 26, and a fan cover 27. The control panel 23 is also installed on the ventilation device frame 22, and a heater 22 is installed at the bottom of the ventilation device frame 22. The base and the cage are connected by upper and lower layer connecting buckles 8 and buckle grooves 9. The side wall 1 of the cage is made of opaque material to facilitate the control of the light cycle. An observation window cover 10 is installed on the side wall 1 to observe the activity of the mouse. The upper cover is equipped with a gas ventilation fan and an air filter to maintain air circulation and meet the needs of hot air stimulation.

[0037] Multifunctional programmable stimulation component:

[0038] (1) Temperature stimulation module: A controllable cold and hot module is integrated in the base. The temperature inside the cage is monitored and adjusted in real time through temperature sensors and a central control system. The cold / hot stimulation can be automatically switched according to random or preset programs.

[0039] (2) Humidity / immersion stimulation module: A water tank is reserved on the outside of the side wall to humidify the area inside the cage during a specified period of time to create a humid environment.

[0040] (3) Sound and light stimulation module: Programmable sound source and controllable light source are installed on the side wall and top cover of the cage respectively. Sound and light stimulation of different frequencies and intensities are generated by external random program or preset program, and the light rhythm is changed.

[0041] (4) Vibration / Tilting Platform Module: A micro platform that can vibrate or tilt is set on the base of the mouse cage. It is driven by a motor and can change the tilt angle or vibration frequency to generate mechanical stimulation.

[0042] (5) Spatial stimulation module: The mouse activity space is temporarily separated by setting a movable first enclosure 14-1 and a second enclosure 14-2 inside the mouse cage, so as to restrict the activity or change the living space environment.

[0043] (6) Water and food control module: By setting up a rotatable feeding trough 17 and a water bottle 29, the system can achieve unmanned operation of water and food restriction. At the same time, the setting of two water bottles 29 can facilitate testing during sugar water experiments, and the mechanical feeding and dispensing can also greatly reduce the error of manual operation.

[0044] (7) Sensors and monitoring system: including various sensors such as temperature, humidity, light intensity, noise and real-time video monitoring; data can be read by the sensors and transmitted to the operation panel of the top cover control system so as to adjust the stimulation mode and record experimental data in real time.

[0045] (8) Central control system: Configured with a programmable controller (such as an embedded processor or microcontroller) and a random algorithm module to achieve the following functions:

[0046] a. Automatic arrangement of unpredictable stimuli: Automatically switch the working status and intensity of various stimulus units according to the set time period, random algorithm or custom program;

[0047] b. Data recording and remote monitoring: Real-time recording of temperature, humidity, sound and light environment, vibration frequency and mouse behavior; can be linked with a computer or mobile terminal via wired or wireless means to achieve remote monitoring and parameter adjustment;

[0048] c. Safety protection mechanism: The stimulation mode is automatically stopped or switched when sensor abnormalities or system failures occur to protect the experimental animals and avoid data distortion.

[0049] (9) The base integrates storage and connection to the power pole:

[0050] Modular design: The power supply, tilting vibration stimulation module, etc. are uniformly stored inside the base, and a detachable structure is set for easy maintenance and repair; it is connected to the upper layer via an electric pole for quick use.

[0051] Through the above structural and functional integration, the intelligent mouse cage of the present invention realizes the automated integrated control of multiple stressors, overcoming the shortcomings of existing CUMS experimental equipment in terms of cumbersome operation, animal escape, inconsistent stimulus connection and high maintenance cost.

[0052] In summary, the purpose of this invention is to provide an intelligent mouse cage that is compact in structure, automatically controls the stimulation conditions, can complete multiple unpredictable stimuli in a single device, is easy to maintain and clean, and facilitates the verification of modeling success. This will ensure mouse welfare, improve the accuracy and repeatability of experimental data, and effectively save manpower and experimental costs.

[0053] Furthermore, such as Figures 3-4 As shown, the base includes a base plate 3 and a hinge joint mounted on the base 3. A connecting block is provided on the top wall 4 of the base, and the connecting block is hinged to the hinge joint. The tilting vibration stimulation module includes a rocking table motor 5 located on the base plate 3. The rocking table motor 5 is connected to the base plate via a rocking table seat 7. First electric rods 6 are provided on both the left and right output ends of the rocking table motor 5. A lower electric post 401 is provided on the top wall 4 of the base, and the lower electric post 401 cooperates with the upper electric post slot 401 on the lower wall 2. The function of the lower electric post 401 is to supply power to the central control system and all modules.

[0054] Furthermore, the vibration frequency, tilt angle, and switching time of the shaking table motor 5 can all be adjusted according to the set program or random algorithm in the central control system.

[0055] In this embodiment, the vibration / tilting platform in the base is driven by the shaking table motor 5, and tilting or vibration is achieved by changing the angle and speed of the output shaft.

[0056] When the system enters the vibration stimulation mode, the shaker motor 5, combined with the first electric rod 6, will vibrate at a predetermined or random frequency and amplitude; if it enters the tilt mode, the platform will slowly or quickly change the tilt angle, putting the mouse in an unstable environment.

[0057] The vibration frequency, tilt angle, and switching time can be adjusted in real time according to the set program or random algorithm in the central control system to ensure that the CUMS experiment meets the requirements of unpredictability.

[0058] If the tilt is too large or the vibration is too strong, the central controller will automatically limit the amplitude or issue a warning to prevent excessive stress or harm to the experimental animals.

[0059] Furthermore, the water and food control module includes a second electric rod 18 disposed on the side wall 1. The output end of the second electric rod 18 is connected to a connecting rod, which is connected to a feeding trough rotating rod 32. A feeding trough 17 is sleeved on the feeding trough rotating rod 32, and a feeding trough cover 19 is disposed on the feeding trough 17.

[0060] Furthermore, such as Figures 7-8 As shown, the water and food control module includes a water bottle bracket 30 disposed on the outer wall of the cage. The water bottle bracket 30 includes a bracket rotating rod 34, a water bottle baffle 31 disposed on the bracket rotating rod 34, and a water bottle 29 disposed on the water bottle baffle 31. The water and food control module also includes a third electric rod 28, one end of which is connected to the bracket rotating rod, and the other end of which is connected to the side wall of the cage.

[0061] In this embodiment, the food trough 17 and water bottle 29 in the rat cage can be opened or closed by a motor or mechanical switch to achieve unmanned operation of water and food restriction.

[0062] The central control module shuts down the feed trough 17 at regular or random intervals according to experimental requirements and random procedures to simulate stress states of water and food shortage.

[0063] Sugar water test

[0064] When a sucrose experiment is needed to assess the success of the model, two water bottles can be placed in the cage, one containing pure water and the other containing sucrose. The mice's water intake and preferences are recorded using sensors.

[0065] Mechanical insertion or removal of water bottles can reduce human intervention and improve the accuracy of monitoring mouse ingestion behavior.

[0066] Furthermore, the spatial stimulation module includes a first motor 16 disposed on the side wall, the output end of the first motor is connected to a support rod 15, the support rod 15 is provided with threads, the first enclosure plate and the second enclosure plate are sleeved on the support rod 15, and the first motor 16 drives the support rod 15 to rotate, thereby driving the first enclosure plate 14-1 and the second enclosure plate 14-2 to move.

[0067] In this embodiment, the mouse cage is equipped with movable first and second enclosure panels 14-1 and 14-2, support rods 15, etc., to restrict the mouse's activity space. The two enclosure panels can be moved to designated positions manually or automatically by a small motor. To maintain the stability of the first and second enclosure panels 14-1 and 14-2, cross-arranged movable rods 13 are installed on one side of the first and second enclosure panels 14-1 and 14-2, respectively. The movable rods 13 can be extended and retracted through the cross structure, and one end of the movable rods 13 is fixed to the lower and side walls of the upper cage.

[0068] The two enclosures can be used in conjunction with other stimuli (such as humidity or noise) to create different stimuli in the same space, thus providing multiple stresses to the mice.

[0069] Furthermore, the base is provided with an inner cavity, and the temperature stimulation module includes a temperature control zone located within the inner cavity, the temperature control zone being located below the cage body, such as... Figure 6 As shown, the temperature control zone is equipped with a heating element 11 and a cooling element 12. A temperature sensor is installed inside the cage. The temperature sensor sends a temperature signal to the central controller, which then controls the temperature control zone to achieve cooling or heating.

[0070] Furthermore, the temperature stimulation module includes a gas ventilation fan 25 located on the upper cover, which is controlled by a central controller.

[0071] Furthermore, the humidity stimulation module includes a humidifier 21 installed on the outer side of the side wall, and the activation of the humidifier 21 is controlled by a central controller.

[0072] In this embodiment, temperature and humidity sensors are distributed within the cage, feeding back the detection signals to the central control system in real time. The control system dynamically adjusts the stimulation program based on the sensor data. For example, if the humidity exceeds a safe threshold, humidification is immediately stopped and ventilation / drying is initiated; if the temperature continues to rise, heating is reduced and cooling is activated.

[0073] Furthermore, the sound and light stimulation module includes a sound source 20 installed on the inner side of the side wall and a controllable light source 33 installed on the top cover. The sound source 20 and the controllable light source 33 are controlled by a central controller.

[0074] In this embodiment, the upper cover is equipped with a controllable light source, capable of providing stimuli such as flashes, sudden bright lights, and changes in light cycle, as well as simulating circadian rhythms. The central controller can set or randomly change the brightness and switching frequency of the light source and record the light intensity for subsequent analysis. The intensity of noise and light stimulation can be monitored by built-in sensors and fed back to the central controller for timely adjustment of output parameters or triggering of other related stimuli.

[0075] The sound source installed on the side wall 1 can output noise (such as white noise, noise, etc.) of different intensities, frequencies or intermittent modes within a specified period of time to create an unpredictable sound stimulation environment.

[0076] The central controller automatically controls the duration, loudness, and repetition frequency of noise using a random algorithm to ensure that the mice cannot predict the occurrence of the sound stimulus.

[0077] The above description is merely a specific embodiment of this utility model, enabling those skilled in the art to understand or implement it. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of this utility model.

[0078] It should be understood that this utility model is not limited to the content already described above, and various modifications and changes can be made without departing from its scope. The scope of this utility model is limited only by the appended claims.

Claims

1. A smart mouse cage for a mouse model of chronic unpredictable stimulation, characterized in that, The cage includes a rat cage, which includes an upper cage body and a base. The upper cage body is composed of an upper cover, a lower wall (2) and a side wall (1). The rat cage is equipped with a stimulation module, which includes a temperature stimulation module, a humidity stimulation module, an audio-visual stimulation module, a tilt vibration stimulation module, a water and food control module, and a space stimulation module. The stimulation module is controlled by a central controller. The temperature stimulation module includes a heating element (11) and a cooling element (12) disposed on the top wall (4) of the base. The heating element (11) heats the inside of the cage, and the cooling element (12) cools the inside of the cage. The humidity stimulation module includes a humidifier (21) disposed on the outside of the cage, which humidifies the inside of the cage. The sound and light stimulation module includes a sound source (20) installed on the side wall of the cage, which releases noise. The sound and light stimulation module also includes a controllable light source (33) disposed on the top cover, which releases noise. The light changes are achieved; the tilting vibration stimulation module includes a vibration tilting platform set on the base, which tilts or vibrates by changing the angle and speed of the output shaft of the shaker motor (5); the water and food control module includes a feeding trough (17) set below the top cover and a water bottle (29) set outside the side wall of the cage; the space stimulation module includes a first enclosure (14-1) and a second enclosure (14-2) set opposite to each other inside the cage, which change the size of the space by changing the relative distance between the first enclosure (14-1) and the second enclosure (14-2).

2. The intelligent mouse cage for a mouse chronic unpredictable stimulation model according to claim 1, characterized in that, The base includes a base plate (3) and a hinge joint (301) disposed on the base plate (3). A connecting block (402) is provided on the top wall (4) of the base. The connecting block (402) is hinged to the hinge joint (301). The tilting vibration stimulation module includes a rocking table motor (5) located on the base plate (3). The rocking table motor (5) is connected to the base plate through a rocking table seat (7). The left and right output ends of the rocking table motor (5) are each provided with a first electric rod (6).

3. The intelligent mouse cage for a mouse model of chronic unpredictable stimulation according to claim 2, characterized in that, The vibration frequency, tilt angle, and switching time of the shaking table motor (5) can all be adjusted according to the set program or random algorithm in the central control system.

4. The intelligent mouse cage for a mouse model of chronic unpredictable stimulation according to claim 1, characterized in that, The water and food control module includes a second electric rod (18) disposed on the side wall (1). The output end of the second electric rod (18) is connected to a connecting rod, which is connected to a feeding trough rotating rod (32). A feeding trough (17) is sleeved on the feeding trough rotating rod (32).

5. The intelligent mouse cage for a mouse model of chronic unpredictable stimulation according to claim 1, characterized in that, The water and food control module includes a water bottle bracket (30) installed on the outer wall of the cage. The water bottle bracket (30) includes a bracket rotating rod (34), a water bottle baffle (31) is installed on the bracket rotating rod (34), and a water bottle (29) is installed on the water bottle baffle (31). The water and food control module also includes a third electric rod (28), one end of which is connected to the bracket rotating rod, and the other end of which is connected to the side wall of the cage.

6. The intelligent mouse cage for a mouse chronic unpredictable stimulation model according to claim 1, characterized in that, The spatial stimulation module includes a first motor (16) disposed on the side wall. The output end of the first motor is connected to a frame rod (15). The frame rod (15) is provided with threads. The first enclosure plate and the second enclosure plate are sleeved on the frame rod (15). The first motor (16) drives the frame rod (15) to rotate, thereby driving the first enclosure plate (14-1) and the second enclosure plate (14-2) to move.

7. The intelligent mouse cage for a mouse chronic unpredictable stimulation model according to claim 1, characterized in that, The base is provided with an inner cavity, and the temperature stimulation module includes a temperature control zone located in the inner cavity. The temperature control zone is located below the cage body. A heating element (11) and a cooling element (12) are provided in the temperature control zone. A temperature sensor is provided in the cage body. The temperature sensor sends a temperature signal to the central controller, and the central controller controls the temperature control zone to achieve cooling or heating.

8. The intelligent mouse cage for a mouse model of chronic unpredictable stimulation according to claim 7, characterized in that, The temperature stimulation module includes a gas ventilation fan (25) located on the upper cover, which is controlled by a central controller.

9. The intelligent mouse cage for a mouse model of chronic unpredictable stimulation according to claim 1, characterized in that, The humidity stimulation module includes a humidifier (21) installed on the outer side of the side wall, and the activation of the humidifier (21) is controlled by a central controller.

10. The intelligent mouse cage for a mouse model of chronic unpredictable stimulation according to claim 1, characterized in that, The sound and light stimulation module includes a sound source (20) installed on the inner side of the side wall and a controllable light source (33) installed on the top cover. The sound source (20) and the controllable light source (33) are controlled by a central controller.

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