Transfer box for cfDNA samples

Abstract

The utility model discloses a transfer box for cfDNA samples, which comprises a hollow box body and an upper cover covering the upper end of the box body, a locking fastener is connected between the box body and the upper cover, the periphery of the bottom of the box body is connected with a vibration reduction part, the bottom of the inner cavity of the box body is provided with a refrigeration cavity and a cold air screen plate located above the refrigeration cavity, and the cold air screen plate is provided with a cold air outlet. A plurality of vibration reduction partition plates are arranged above the cold air screen plate, the vibration reduction partition plates divide an inner cavity of the box body into a plurality of containing cavities containing sample containers, vibration reduction screen pads which are located on the top of the cold air screen plate and matched with the bottoms of the sample containers are arranged below the sample containers, and a plurality of fixing pressing pads corresponding to the sample containers are arranged on the lower portion of the upper cover. According to the utility model, the vibration damping part can be used for damping the periphery outside the box body, reducing the impact force on the box body during collision, effectively fixing the sample container, reducing the adverse effect of vibration on the sample container, improving the vibration damping effect on the sample container, effectively reducing the adverse effect of vibration on a sample, and improving the quality of the sample container. The safe transfer of the cfDNA sample is ensured.

Description

TECHNICAL FIELD

[0001] The utility model relates to sample transfer case technical field especially, it is a kind of for cfDNA sample's transfer case. BACKGROUND

[0002] Cell-free DNA (cfDNA) is the DNA fragment free in extracellular, usually comes from cell apoptosis, necrosis or active release, widely exists in human body blood, urine, cerebrospinal fluid, pleural effusion, follicular fluid, saliva and various body fluids etc..Since cfDNA is relatively stable in body fluid and carries rich genetic and epigenetic information, body fluid sample is easy to collect, therefore cfDNA is considered as ideal biomarker for disease prevention, diagnosis, treatment and prognosis.CfDNA has extensive research or application in non-invasive prenatal testing, cancer, diabetes, cardiovascular disease, organ transplantation, autoimmune disease and sepsis etc..During cfDNA sample transportation, obvious or long time vibration should be avoided to maintain the stability and safety of sample during transportation.

[0003] CfDNA sample generally uses transfer case to transport sample, multiple sampling completed sample tubes are placed into sample container, and sample container is placed into transfer case for transfer.However, vibration inevitably occurs during transportation, to ensure the stability and safety of sample during transportation, transfer case and sample container need to be damped, existing transfer case generally sets sponge pad or foam in box to damp sample container, but its damping effect is poor, cannot effectively reduce the adverse effects of vibration on sample, and when violent vibration and long time vibration occur, it can cause hemolysis of blood sample, cause release of cell metabolites, cause sample failure. UTILITY MODEL CONTENT

[0004] To solve the technical problems that the damping effect of existing transfer case is poor in prior art, cannot effectively reduce the adverse effects of vibration on sample, and when violent vibration and long time vibration occur, it can cause hemolysis of blood sample, cause release of cell metabolites, cause sample failure, the utility model provides the following technical scheme.

[0005] This utility model discloses a transport box for cfDNA samples, comprising a hollow box body and a top cover that fits over the upper part of the box body. A locking fastener connects the box body and the top cover. Vibration damping components are connected around the bottom of the box body. A cooling chamber is provided at the bottom of the inner cavity of the box body, and a cooling air mesh plate is located above the cooling chamber. Several vibration damping baffles are provided above the cooling air mesh plate, which divide the inner cavity of the box body into several receiving chambers for accommodating sample containers. A vibration damping mesh pad matching the bottom of the sample container is provided below the sample container and located on the top of the cooling air mesh plate. Several fixing pads corresponding to the sample containers are provided on the lower part of the top cover.

[0006] As a further technical solution, the vibration damping component includes vibration damping corner pads fixed to the four corners of the outer side of the housing and vibration damping plates connected to adjacent vibration damping corner pads.

[0007] As a further technical solution, the locking component includes a locking tongue connected to the housing and a locking buckle connected to the top cover.

[0008] As a further technical solution, the cooling cavity is provided with a semiconductor cooling chip and a battery pack located at the bottom of the inner cavity of the box. The cooling surface of the semiconductor cooling chip is located inside the cooling cavity, and the heat dissipation surface of the semiconductor cooling chip faces the outside of the box.

[0009] As a further technical solution, a vibration sensor is provided in the inner cavity of the box, and the vibration sensor is connected to a wireless transmission module.

[0010] As a further technical solution, the inner cavity of the box is equipped with a desiccant mesh bag.

[0011] The beneficial effects of this invention are as follows: Vibration damping components are installed around the exterior of the box, reducing vibrations around the exterior and minimizing impact forces during collisions. The internal cavity of the box is divided into multiple receiving chambers by several vibration-damping partitions. Each receiving chamber contains a sample container elastically held against it from the left and right sides. The sample container has fixing pads and vibration-damping mesh pads at its top and bottom ends, further absorbing vibration energy. This effectively secures the sample container while reducing the adverse effects of vibration, improving vibration damping and ensuring the safe transport of cfDNA samples. The box also contains a vibration sensor connected to a wireless transmission module, allowing for real-time monitoring of vibrations within the box and facilitating timely observation of the transport status by transport personnel. Attached Figure Description

[0012] Figure 1 This utility model provides a schematic diagram of the external structure of a transport box for cfDNA samples.

[0013] Figure 2 The utility model is used to the box body internal structure schematic drawing of cfDNA sample's transport case,

[0014] Figure 3 The utility model is used to the box body cutaway schematic drawing of cfDNA sample's transport case,

[0015] Figure 4 The utility model is used to the sample container below structure's decomposition schematic drawing of cfDNA sample's transport case,

[0016] Figure 5 The utility model is used to the structure schematic drawing of cfDNA sample's transport case's damping part,

[0017] In the drawing: 1-box body;101-inclined cross buckle;102-damping partition;103-housing cavity;104-refrigeration cavity;2-upper cover;201-fixed pressure pad;3-locking part;301-locking tongue;302-locking buckle;4-damping part;401-damping angle pad;402-damping plate;5-sample container;6-cold air net plate;7-damping net pad;8-semiconductor refrigeration sheet;9-battery pack;10-vibration sensor;11-dryer net bag. DETAILED DESCRIPTION

[0018] In order to make the utility model's purpose, technical scheme and advantage more clearly clear, following combining with the drawing and example, this utility model is further detailedly explained.Should understand, the specific example described here is only used to explain the utility model, and is not used to limit the utility model.It is stated that in the case where there is no conflict, the example in the utility model and the feature in the example can be combined mutually.

[0019] In the description of the utility model, need understanding is, the term '' upper '' '' below '' based on the orientation or position relation shown in the drawing, only for the convenience of describing the utility model and simplifying the description, and is not the device or element indicated or implied must have the specific orientation, with specific orientation construction and operation, therefore can not be understood as the restriction of the utility model.In addition, the term '' first '' '' second '' etc. are only used for the description purpose, and can not be understood as indicating or implied relative importance or impliedly indicate the number of the technical features indicated.In the description of the utility model, unless otherwise specified, the meaning of '' multiple '' is two or two or more.

[0020] As Figure 1 And Figure 2As shown, the utility model relates to a kind of transport box for cfDNA sample, including hollow box 1 and the upper cover 2 of the upper end of box 1 is covered in box 1.Box 1 and upper cover 2 use good toughness and impact-resistant polycarbonate or ABS plastic, so that box 1 has good toughness and durability.Box 1 top is provided with handle, and the two sides of box 1 are respectively provided with oblique cross buckle 101, can be used for the carrying and transport of box 1 with cross belt.Box 1 and upper cover 2 are connected with lock catch 3, and lock catch 3 includes lock tongue 301 connected with box 1 and lock catch 302 connected with upper cover 2, after cfDNA sample is placed with sample container 5 in box 1, upper cover 2 can be covered in the upper end of box 1, and after lock tongue 301 and lock catch 302 are locked, it can be transported.

[0021] As Figure 3 And Figure 4 As shown in the preferred embodiment, the bottom of the inner cavity of box 1 is provided with a refrigeration cavity 104 and a cold air mesh plate 6 located above the refrigeration cavity 104. According to different cfDNA sample detection projects, the transport temperature of cfDNA is generally between 4℃-30℃, and the refrigeration cavity 104 can create a low-temperature environment in the box 1 to ensure that the sample is transported within a safe temperature range. The refrigeration mode of the refrigeration cavity 104 can be various, and in this embodiment, a semiconductor refrigeration sheet 8 located at the bottom of the inner cavity of the box 1 and a battery pack 9 are provided in the refrigeration cavity 104. The battery pack 9 is a storage battery used to provide power for the semiconductor refrigeration sheet 8. The refrigeration surface of the semiconductor refrigeration sheet 8 is located in the refrigeration cavity 104, and the heat dissipation surface of the semiconductor refrigeration sheet 8 faces the outside of the box 1. The low-temperature environment generated by the semiconductor refrigeration sheet 8 can be transmitted upwards from the refrigeration cavity 104 and the cold air mesh plate 6 to provide a low-temperature environment for the cfDNA sample in the box 1.

[0022] In the preferred embodiment, a shock-absorbing foam layer is provided on the inner wall of the box 1, and a plurality of shock-absorbing partitions 102 are provided above the cold air mesh plate 6. The shock-absorbing partitions 102 divide the inner cavity of the box 1 into a plurality of containing cavities 103, and each containing cavity 103 contains a sample container 5. The sample container 5 is used to store samples of different specifications. The shock-absorbing partitions 102 are made of rubber material, and the shock-absorbing partitions 102 are filled with high-density foam, so that the shock-absorbing partitions 102 have good elasticity and shock-absorbing capacity. At this time, part of the sample containers 5 are tightly pressed between two shock-absorbing partitions 102, and part of the sample containers 5 are tightly pressed between the shock-absorbing partitions 102 and the inner wall of the box 1, so that the sample containers 5 are elastically clamped in multiple directions, which can prevent the adverse effects of vibration on the sample containers 5.

[0023] In a preferred embodiment, a shock-absorbing mesh pad 7 matching the bottom of the sample container 5 is arranged on the top of the cold air mesh plate 6 below the sample container 5, the shock-absorbing mesh pad 7 is made of mesh-shaped rubber material, which can effectively bear the sample container 5 and ensure the stability of the sample container 5. Meanwhile, a plurality of fixed pressing pads 201 corresponding to the sample container 5 are arranged on the lower part of the upper cover 2, the fixed pressing pads 201 can be high-density sponge pads, which can press the sample container 5 tightly and reduce the adverse effects of vibration on the sample container 5.

[0024] The inner cavity of the box body 1 is provided with a vibration sensor 10, which can monitor the vibration in the box body 1 in real time. The vibration sensor 10 is connected with a wireless transmission module, which can be connected to the Bluetooth of the mobile phone of the transportation personnel. In this way, the wireless transmission module can transmit the vibration signal of the vibration sensor 10 to the control terminal of the transportation personnel, so as to facilitate the transportation personnel to observe the vibration intensity in the box body 1 in time. The inner cavity of the box body 1 can also be provided with a drying agent mesh bag 11 to prevent the air humidity in the box body 1 from being too large during refrigeration.

[0025] As shown in Figure 5 In a preferred embodiment, the bottom of the box body 1 is connected with a vibration reduction piece 4, which is used to reduce the vibration of the box body 1 when colliding. Specifically, the vibration reduction piece 4 includes a vibration reduction corner pad 401 fixed on the corners of the outer part of the box body 1 and a vibration reduction plate 402 connected to adjacent vibration reduction corner pads 401. The vibration reduction corner pad 401 is made of rubber or silicone material, which can absorb vibration and reduce the influence of vibration on the box body 1. The vibration reduction corner pad 401 is bonded to the corners of the box body 1. The vibration reduction plate 402 connects adjacent vibration reduction corner pads 401. When one vibration reduction corner pad 401 collides and vibrates, the vibration is transmitted to the adjacent vibration reduction corner pad 401 through the vibration reduction plate 402, and the vibration is dispersed to the surrounding area, which can effectively reduce the adverse effects on the sample container 5 in the box body 1 and ensure the safe transportation of the sample.

[0026] The preferred specific embodiments and examples of the present application are described in detail above in combination with the drawings, but the present application is not limited to the above-mentioned embodiments and examples. Within the scope of knowledge possessed by those skilled in the art, various changes or equivalent replacements can be made without departing from the concept of the present application. Therefore, the present application is not limited to the specific embodiments disclosed herein, and all embodiments falling within the scope of the claims of the present application belong to the scope of protection of the present application.

Claims

1. A transport case for cfDNA samples, comprising a hollow case body (1) and an upper cover (2) covering the upper end of the case body (1), a lock catch (3) being connected between the case body (1) and the upper cover (2), characterized in that: The bottom of the box (1) is connected with a damping member (4), the inner cavity of the box (1) is provided with a refrigeration cavity (104) and a cold air mesh plate (6) above the refrigeration cavity (104), a plurality of damping partitions (102) are arranged above the cold air mesh plate (6), the damping partitions (102) divide the inner cavity of the box (1) into a plurality of containing cavities (103) containing sample containers (5), the sample containers (5) are provided below with damping mesh pads (7) on the top of the cold air mesh plate (6) and matched with the bottoms of the sample containers (5), and the upper cover (2) is provided at the lower part with a plurality of fixed pressing pads (201) corresponding to the sample containers (5).

2. The transport box for cfDNA samples of claim 1, wherein: The damping member (4) comprises damping corner pads (401) fixed on the corners of the outer part of the box (1) and damping plates (402) connected with adjacent damping corner pads (401).

3. The transport box for cfDNA samples of claim 1, wherein: The locking member (3) comprises a locking tongue (301) connected with the box (1) and a lock catch (302) connected with the upper cover (2).

4. The transport box for cfDNA samples of claim 1, wherein: The refrigeration cavity (104) is provided with a semiconductor refrigeration sheet (8) and a battery pack (9) on the bottom of the inner cavity of the box (1), the refrigeration surface of the semiconductor refrigeration sheet (8) is located in the refrigeration cavity (104), and the heat dissipation surface of the semiconductor refrigeration sheet (8) faces the outside of the box (1).

5. The shipping box for cfDNA samples of claim 1, wherein: The inner cavity of the box (1) is provided with a vibration sensor (10), and the vibration sensor (10) is connected with a wireless transmission module.

6. The shipping box for cfDNA samples of claim 1, wherein: The inner cavity of the box (1) is provided with a desiccant mesh bag (11).

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