Bio-enzyme catalysis constant-temperature and constant-pressure control device

Abstract

The utility model discloses a constant-temperature and constant-pressure control device for biological enzyme catalysis, and relates to the field of medical intermediates. A biological enzyme catalysis constant-temperature and constant-pressure control device comprises a reaction kettle, the upper end of the reaction kettle is communicated with a biological enzyme adding pipe, a substrate adding pipe, a manhole pipe and an exhaust pipe, the bottom of the reaction kettle is communicated with a discharging pipe, and the biological enzyme catalysis constant-temperature and constant-pressure control device further comprises a gas storage box fixedly installed on the reaction kettle; compared with a traditional temperature control mode, the temperature control device not only can quickly and uniformly control the temperature of reactants and bio-enzyme and reduce the temperature difference inside and outside the reactants and the bio-enzyme, but also can monitor and accurately adjust the pressure in the reaction kettle in real time, realize constant-pressure control and ensure that the bio-enzyme catalytic reaction is carried out under a stable pressure condition; the adverse effect on the reaction due to pressure fluctuation is avoided, the reactant and the biological enzyme are mixed more sufficiently due to the disturbance effect of the gas on the reactant, the reaction efficiency is remarkably improved, and the yield and quality of the catalytic reaction of the biological enzyme are improved.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of pharmaceutical intermediates, more particularly to a kind of biological enzyme catalysis constant temperature constant pressure control device. BACKGROUND

[0002] In the field of pharmaceutical intermediates, biological enzyme catalytic reaction is widely used in many industries such as biological pharmaceuticals, food fermentation and bioenergy due to its advantages of high efficiency, specificity and mild reaction conditions. During the biological enzyme catalytic reaction process, accurate temperature and pressure control are crucial for ensuring the smooth progress of the reaction, improving reaction efficiency and ensuring product quality.

[0003] At present, the existing biological enzyme catalytic constant temperature constant pressure control device mostly sets a jacket on the reaction kettle in terms of temperature control, and realizes temperature control by heating or refrigerating water or heat-conducting oil. In terms of pressure control, the existing device mostly realizes it by simply venting or exhausting the reaction kettle.

[0004] However, during temperature control, heat-conducting oil or water will first heat the reactants located on the outside, resulting in a certain temperature difference between the reactants inside and outside, making it difficult to achieve rapid and uniform temperature control. This may affect the activity of biological enzymes and the consistency and stability of the reaction. Therefore, the present utility model is proposed. UTILITY MODEL CONTENT

[0005] The technical problem to be solved by the utility model is to overcome the shortcomings of the prior art and provide a biological enzyme catalytic constant temperature constant pressure control device that can overcome the above problems or at least partially solve the above problems.

[0006] The utility model discloses a biological enzyme catalysis constant temperature and constant pressure control device, including the reaction kettle, the upper end of reaction kettle is connected with biological enzyme adding pipe, substrate adding pipe, manhole pipe and exhaust pipe, the bottom of reaction kettle is connected with the discharge pipe, still include: gas storage tank, fixed mounting on the reaction kettle, jet box, fixed mounting on the reaction kettle, and located the below of gas storage tank, first gas pump, fixed mounting on the gas storage tank, the air outlet of first gas pump is connected with the gas outlet of gas storage tank, and the air outlet of first gas pump is connected with the air inlet of jet box, electric heating pipe, fixed mounting in the jet box, the jet head is in the inside of jet box and is connected in the circumference equidistance, and the jet end of jet head extends into the reaction kettle, second gas pump, fixed mounting on the gas storage tank, and the air outlet of second gas pump is connected with exhaust pipe through the air pipe, and the air outlet of second gas pump is connected with the back gas port of gas storage tank, the gas inlet and outlet of gas storage tank are all provided with pressure valve, and the temperature table and pressure table are installed on the reaction kettle, and the detection end of temperature table and pressure table all extends into the reaction kettle.

[0007] In order to facilitate the gas jet head to be ejected can be located at the bottom of the substrate impact, so that it can roll, further improve the uniformity of biological enzyme and substrate mixing, further, the jet head is inclined downward setting.

[0008] In order to facilitate the substrate can be rotated under the impact of the gas jet head, so that the stirring rod can simulate the effect of stirring the substrate and biological enzyme, more further, the jet head is inclined to one side.

[0009] In order to facilitate the substrate can be intercepted in the reaction kettle, further, the reaction kettle is fixedly installed with microporous membrane at the position of exhaust pipe.

[0010] In order to facilitate the substrate will be along the arc-shaped microporous membrane to the middle, so that the gas can be smooth for a long time, more further, the microporous membrane is arranged in arc shape.

[0011] In order to facilitate the reduction of the influence on biological enzyme and reactant, further, the gas stored in the gas storage tank is inert gas.

[0012] After adopting the above technical scheme, the utility model discloses the following beneficial effects compared with the prior art: compared with the traditional temperature control mode, the device can quickly and uniformly control the temperature of the reactant and biological enzyme, reduces the temperature difference between the inside and outside of the reactant and biological enzyme, provides a more stable and uniform temperature environment for biological enzyme catalytic reaction, and is beneficial to improve the consistency and stability of the reaction.

[0013] Through the cooperation of the pressure valve, the pressure gauge and the second air pump, the pressure in the reaction kettle can be monitored and accurately adjusted in real time, constant pressure control is realized, the biological enzyme catalytic reaction is ensured to be carried out under stable pressure conditions, and the adverse effects of pressure fluctuation on the reaction are avoided.

[0014] The disturbance of the gas to the reactants makes the reactants and the biological enzymes mix more fully, significantly improves the reaction efficiency, helps to improve the yield and quality of the biological enzyme catalytic reaction, and has good application value and economic benefits.

[0015] The specific embodiments of the utility model will be described in further detail below with reference to the drawings. BRIEF DESCRIPTION OF DRAWINGS

[0016] In the drawings:

[0017] Figure 1 The structure diagram of the utility model Figure 1 ;

[0018] Figure 2 The structure diagram of the utility model Figure 2 ;

[0019] Figure 3 The structure diagram of the utility model reaction kettle and jet box inside.

[0020] In the drawing: 1, reaction kettle; 101, biological enzyme adding pipe; 102, substrate adding pipe; 103, manhole pipe; 104, exhaust pipe; 105, discharge pipe; 106, temperature gauge; 107, pressure gauge; 108, microporous membrane; 2, gas storage tank; 201, jet box; 202, first air pump; 203, second air pump; 204, air extraction pipe; 205, electric heating pipe; 206, jet head. DETAILED DESCRIPTION

[0021] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the technical scheme in the embodiments will be described clearly and completely below with reference to the drawings in the embodiments of the utility model, and the following embodiments are used to illustrate the utility model, but not to limit the scope of the utility model.

[0022] Embodiment 1:

[0023] Refer to Figures 1-3The utility model provides a kind of biological enzyme catalysis thermostatic constant pressure control device, including reaction kettle 1, the upper end of reaction kettle 1 is connected with biological enzyme adding pipe 101, substrate adding pipe 102, manhole pipe 103 and exhaust pipe 104, reaction kettle 1 bottom is connected with discharge pipe 105, further including: gas storage tank 2, fixedly installed on reaction kettle 1;Jet tank 201, fixedly installed on reaction kettle 1, and located below gas storage tank 2;First air pump 202, fixedly installed on gas storage tank 2, the air inlet of first air pump 202 is connected with the air outlet of gas storage tank 2, the air outlet of first air pump 202 is connected with the air inlet of jet tank 201;Electric heating pipe 205, fixedly installed in jet tank 201;Jet head 206, it is connected in the inside of jet tank 201 in circumferential equidistance, and the jet end of jet head 206 extends into reaction kettle 1;Second air pump 203, fixedly installed on gas storage tank 2, and the air inlet of second air pump 203 is connected between exhaust pipe 104 by air extraction pipe 204, and the air outlet of second air pump 203 is connected with the air return of gas storage tank 2;The air inlet and air outlet of gas storage tank 2 are all provided with pressure valve;Reaction kettle 1 is installed with temperature table 106 and pressure gauge 107, and the detection end of temperature table 106 and pressure gauge 107 all extends into reaction kettle 1.

[0024] The existing biological enzyme catalysis thermostatic constant pressure control device is controlled by the water or heat-conducting oil in the jacket of reaction kettle 1, which is not conducive to fast and uniform temperature control because the heat-conducting medium first acts on the outside reactant and causes temperature difference between the inside and outside reactants. The device realizes temperature control through the cooperative work of gas storage tank 2, first air pump 202, jet tank 201, electric heating pipe 205 and jet head 206. The electric heating pipe 205 is used to heat the gas in jet tank 201 to a specified temperature. The first air pump 202 pumps the gas in gas storage tank 2 into jet tank 201 after heating, and then the gas is sprayed into reaction kettle 1 through the circumferentially equidistantly distributed jet head 206. The gas flows from bottom to top and fully exchanges heat with the reactant, realizing fast and uniform temperature control.

[0025] The common pressure control method is to let air in and out of reaction kettle 1. In the device, the pressure in reaction kettle 1 changes as the gas at the specified temperature continuously enters reaction kettle 1. The pressure can be monitored in real time through the pressure gauge 107 installed on reaction kettle 1. When the pressure in reaction kettle 1 is relatively large, the second air pump 203 is started to pump the gas in reaction kettle 1 back to gas storage tank 2 through air extraction pipe 204, so as to reduce the pressure in reaction kettle 1 and maintain the constant pressure in reaction kettle 1.

[0026] The gas entering reaction kettle 1 is not only used for temperature control, but also plays a role in disturbing the reactant. When the gas flows in reaction kettle 1, it pushes the reactant to move, so that the reactant and biological enzyme are more uniformly mixed, the contact area between the reactant and biological enzyme is increased, the reaction rate is accelerated, and the efficiency of biological enzyme catalytic reaction is further improved.

[0027] Compared with the traditional temperature control mode, the device can quickly and uniformly control the temperature of the reactants and biological enzymes, reduce the temperature difference inside and outside the reactants and biological enzymes, provide a more stable and uniform temperature environment for biological enzyme catalytic reaction, and is conducive to improving the consistency and stability of the reaction.

[0028] Through the cooperation of the pressure valve, the pressure gauge 107 and the second air pump 203, the pressure in the reaction kettle 1 can be monitored and accurately adjusted in real time, constant pressure control is realized, the biological enzyme catalytic reaction is ensured to be carried out under stable pressure conditions, and adverse effects on the reaction caused by pressure fluctuation are avoided.

[0029] The disturbance effect of the gas on the reactants makes the mixing of the reactants and biological enzymes more sufficient, significantly improves the reaction efficiency, helps to improve the yield and quality of the biological enzyme catalytic reaction, and has good application value and economic benefits.

[0030] Example 2:

[0031] Referring to Figure 3 A biological enzyme catalytic constant temperature and pressure control device, which is basically the same as example 1, and further has: the air jet head 206 is inclined downward, by designing the air jet head 206 to be inclined downward, when the air jet head 206 sprays gas into the substrate, the gas sprayed by the air jet head 206 can impact the substrate located at the bottom, so that it can roll, further improving the uniformity of mixing between the biological enzyme and the substrate, and effectively improving the catalytic efficiency.

[0032] The air jet head 206 is inclined to one side, by making the plurality of air jet heads 206 inclined to one side, when the air jet head 206 delivers the heated gas into the substrate in the reaction kettle 1, the substrate can rotate under the impact of the gas sprayed by the air jet head 206, so that the effect of the stirring rod stirring the substrate and the biological enzyme can be simulated, further improving the uniformity of mixing between the substrate and the biological enzyme.

[0033] Example 3:

[0034] Referring to Figures 1-3 A biological enzyme catalytic constant temperature and pressure control device, which is basically the same as example 2, and further has: a microporous membrane 108 is fixedly installed at the position of the exhaust pipe 104 in the reaction kettle 1, by the setting of the microporous membrane 108, when the gas carries part of the substrate upwards, the microporous membrane 108 can intercept it, only allowing the gas to pass through, avoiding that the gas carries part of the substrate out of the reaction kettle 1 when it is excluded from the reaction kettle 1, causing waste of the substrate.

[0035] The microporous membrane 108 is arranged in an arc shape, such as Figure 3As shown, by arranging the microporous membrane 108 in an arc shape, when the gas-carrying part of the substrate rises, the microporous membrane 108 can intercept it, only allowing the gas to pass through, and the substrate will approach the middle along the arc-shaped microporous membrane 108, so that the microporous membrane 108 can be used stably for a long time, and the interception effect on the substrate is guaranteed.

[0036] Embodiment 4:

[0037] With reference to Figures 1-3 The biological enzyme catalysis constant-temperature and constant-pressure control device is basically the same as that in Embodiment 3, and further, the gas stored in the gas storage tank 2 is inert gas, and the gas stored in the gas storage tank 2 can be helium, argon or other inert gas with high chemical stability. In some biological enzyme catalysis reactions with extremely high requirements for gas purity and stability, helium can be used. In some biological enzyme catalysis reactions that require a strictly oxygen-free or active gas-free environment, argon can be used.

[0038] The above merely describes preferred embodiments of the present application and is not intended to limit the present application in any form. Although the present application has been disclosed with reference to the preferred embodiments, it is not intended to limit the present application.

Claims

1. A biocatalyst constant temperature and constant pressure control device, characterized by, The utility model provides a kind of biocatalysis reaction device, including reaction kettle (1), the upper end of the reaction kettle (1) is connected with biological enzyme adding pipe (101), substrate adding pipe (102), manhole pipe (103) and exhaust pipe (104), the bottom of the reaction kettle (1) is connected with discharge pipe (105), further including: gas storage tank (2), fixedly installed on the reaction kettle (1);Jet tank (201) is fixedly installed on the reaction kettle (1), and located below the gas storage tank (2);First air pump (202) is fixedly installed on the gas storage tank (2), the air outlet of the first air pump (202) is connected with the gas outlet of gas storage tank (2), the air outlet of the first air pump (202) is connected with the air inlet of jet tank (201);Electric heating pipe (205) is fixedly installed in the jet tank (201);Jet head (206) is circumferentially equidistantly connected in the inside of the jet tank (201), and the jet end of the jet head (206) extends into reaction kettle (1);Second air pump (203) is fixedly installed on the gas storage tank (2), and the air outlet of the second air pump (203) is connected with exhaust pipe (104) by air suction pipe (204), the air outlet of the second air pump (203) is connected with the air return of gas storage tank (2);The inlet and outlet of the gas storage tank (2) are provided with pressure valve;Reaction kettle (1) is provided with temperature table (106) and pressure gauge (107), and the detection end of temperature table (106) and pressure gauge (107) extends into reaction kettle (1);The jet head (206) is obliquely downwardly arranged;The jet head (206) is obliquely arranged to one side;The micro-porous membrane (108) is fixedly installed in the reaction kettle (1) at the position of exhaust pipe (104).

2. The constant temperature and constant pressure control device of claim 1, wherein the constant temperature and constant pressure control device is a bio-enzyme catalytic constant temperature and constant pressure control device. The micro-porous membrane (108) is arranged in arc shape.

3. The constant temperature and constant pressure control device of claim 1, wherein the constant temperature and constant pressure control device is a bio-enzyme catalytic constant temperature and constant pressure control device. The gas stored in the gas storage tank (2) is inert gas.

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