Sample movement device for living cell imager

Abstract

The utility model relates to the technical field of living cell observation, in particular to a sample moving device for a living cell imager. A sample movement device for a living cell imager comprises a movement base table which is detachably connected to the surface of an objective table; comprising an X-axis linear motion assembly used for driving the sample clamp to move in the X-axis direction and a Y-axis linear motion assembly used for driving the X-axis linear motion assembly to move in the Y-axis direction. The Y-axis linear motion assembly is fixed on the motion base station; the moving base station comprises a base station body and an adaptive part connected with the base station body, the adaptive part can be adjusted in the length direction of the base station body, the base station body is located on the upper surface of the objective table, the adaptive part comprises a fastening structure, and the moving base station is installed on the objective table through the fastening structure. The sample moving device is adaptive to a microscope objective table, can be quickly mounted and dismounted, and can realize accurate movement of different samples.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of living cell observation, specifically relates to a sample motion device for living cell imaging instrument. BACKGROUND

[0002] In the field of living cell observation, the living cell imaging instrument is one of the commonly used equipment, which is used for real-time observation and recording of the morphology, structure and physiological activity of living cells. However, the existing fixed stage living cell imaging instrument has certain limitations, especially in the sample movement: first, the fixed stage equipment depends on manual direct movement of the sample, which is difficult to align and easy to cause millimeter level displacement deviation, and it is difficult to meet the high precision movement requirement, and there are problems such as loss of microscopic field of view or image sequence misalignment; second, the conventional modification scheme needs to cut the microscope platform and install the electric displacement table, which destroys the original equipment airtightness and is high in cost; third, the general type microscope displacement table on the market will block the light path of the condenser lens, and the table surface has a centimeter level thickness, which exceeds the millimeter level focal length of the living cell imaging instrument, and cannot be adapted.

[0003] And the existing external motion device is fixed at a single point, which is easy to vibrate and deviate during movement, resulting in sample defocusing or imaging blur. At the same time, the size of different microscope stages is quite different, and the existing motion device is difficult to quickly adapt.

[0004] Therefore, a sample movement device is needed, which does not need to change the appearance of the living cell imaging instrument, is convenient to install and disassemble, and can also ensure the accurate movement of the sample. UTILITY MODEL CONTENTS

[0005] The utility model provides a sample motion device for living cell imaging instrument in view of the technical problems existing in prior art, which is adapted to the microscope stage, convenient to install, and can realize the accurate movement of the sample.

[0006] The technical scheme for solving the above technical problems is as follows: a sample motion device for living cell imaging instrument, comprising,

[0007] The motion base is detachably connected to the surface of the stage;

[0008] The motion base comprises a base body and an adapter connected thereto, the adapter is adjustable along the length direction of the base body, the base body is located on the upper surface of the stage, the adapter comprises a fastening structure, and the motion base is installed on the stage through the fastening structure.

[0009] On the basis of the above technical scheme, the utility model can also be improved as follows.

[0010] Further, the base body is provided with a through groove along the length direction thereof, the adapter includes a transverse connecting rod and a longitudinal adapter part, the adapter part is located on the side of the object table, and the adapter part is provided with a fastening structure, the connecting rod is inserted into the through groove, and a plurality of screws are arranged outside the through groove to fasten the connecting rod.

[0011] Further, the base body is arranged horizontally along the X-axis direction, the base body extends out a Y-axis base away from the adapter part along the Y-axis direction, the Y-axis base is provided with a positioning structure, the positioning structure is connected with the side of the object table, the other side of the object table is connected with the adapter part, and the X-axis is perpendicular to the Y-axis.

[0012] Further, the fastening structure includes a nylon clamping sheet and an adjusting clamping screw, the nylon clamping sheet is located on the side of the adapter part facing the object table, and the adjusting clamping screw is arranged on the other side of the object table.

[0013] Further, the positioning structure includes a square groove and a positioning sheet, the square groove is arranged on the surface of the Y-axis base, the square groove is open towards the side of the object table, and the positioning sheet is located in the square groove and can extend out of the square groove to be connected with the side of the object table; the positioning sheet is provided with a transverse groove, and a plurality of screws are connected with the square groove through the transverse groove.

[0014] Further, the X-axis linear motion assembly is further arranged to drive the sample clamp to move along the X-axis direction.

[0015] The Y-axis linear motion assembly is arranged to drive the X-axis motion assembly to move along the Y-axis direction.

[0016] The Y-axis linear motion assembly is fixed to the motion base.

[0017] The X-axis linear motion assembly is rigidly connected with the slider of the Y-axis linear motion assembly through the mounting seat, and the two assemblies are arranged in an orthogonal and laminated mode.

[0018] One end of the mounting seat is fixed to the slider of the Y-axis linear motion assembly, and the other end is connected with the external object table through the adjustable support assembly.

[0019] Further, the adjustable support assembly includes a limiting screw, a ball pulley, a gasket and a mounting bracket.

[0020] The mounting bracket is connected to one end of the mounting seat and is internally provided with a screw hole.

[0021] The limiting screw is connected with the mounting bracket through the screw hole at the upper end, and is provided with a limiting hole at the lower end.

[0022] The ball pulley is installed in the limiting hole and can rotate freely, and the lower end of the ball pulley is in contact with the external carrier.

[0023] The gasket is located between the limiting screw and the screw hole.

[0024] Further, the mounting seat comprises a U-shaped mounting frame and an L-shaped mounting frame, the U-shaped mounting frame is composed of a bottom plate and two side plates, and the two ends of the bottom plate are respectively connected with a side plate vertically; the L-shaped mounting frame is composed of a horizontal plate and a longitudinal plate connected with each other vertically, the upper end of the longitudinal plate is connected with the lower end of the U-shaped mounting frame, and the lower end is connected with the horizontal plate.

[0025] Further, the X-axis linear motion assembly comprises a lead screw, a first guide rail and a first hand wheel.

[0026] The first guide rail is horizontally installed on the bottom plate, the lead screw is connected with the two side plates of the mounting seat through bearings at the two axial ends, a nut seat is threadedly connected with the lead screw, a sliding groove matched with the first guide rail is formed in the lower end of the nut seat and is in sliding connection with the first guide rail, the nut seat is connected with a sample clamp through a connecting piece, and the first hand wheel is located on one side of the mounting seat and is fixedly connected with the lead screw to drive the rotation of the lead screw. The height of the X-axis linear motion assembly can be set according to the height of the microscope lens from the carrier.

[0027] The X-axis linear motion assembly further comprises a protective cover, and the surface of the protective cover is provided with a scale.

[0028] Further, the Y-axis linear motion assembly comprises an inclined rack, an inclined gear, a second hand wheel, a second guide rail, a sliding block and a mounting plate.

[0029] The second guide rail is installed on the surface of the mounting plate, the inclined rack is installed on the surface of the second guide rail, the inclined gear is engaged with the inclined rack, the sliding block is provided with a sliding groove matched with the second guide rail and is in sliding connection with the second guide rail, the sliding block is provided with a through hole, the second hand wheel is connected with the inclined gear through a set screw passing through the through hole and drives the rotation of the inclined gear; the sliding block is installed on the upper surface of the horizontal plate, the second guide rail is installed on the lower surface of the mounting plate, the sliding block is in sliding connection with the second guide rail, and the upper surface of the mounting plate is fixedly connected with the lower surface of the Y-axis base.

[0030] The material of the inclined rack is copper or stainless steel, the modulus of the inclined rack and the inclined gear is 0.5 module, and the number of teeth of the inclined gear is 15-17 teeth; an adjustable gap adjusting gasket is arranged between the contact surfaces of the inclined gear and the second hand wheel.

[0031] Further, the stroke ratio of the Y-axis linear motion assembly and the X-axis linear motion assembly is set to 1:1 to 1:2, the maximum stroke range of the X-axis is 140-160 mm, and the maximum stroke range of the Y-axis is 80-160 mm.

[0032] Further, the sample clamp comprises a positioning frame and a transition groove which is detachably installed in the positioning frame, and a connecting plate is used to rigidly connect the clamp and the motion assembly.

[0033] The positioning frame is provided with a clamping mechanism around the upper right corner, the clamping mechanism is a rotatable spring clamp, the rotation axis of the spring clamp is perpendicular to the bottom of the positioning frame, the end of the spring clamp is provided with a buffer pad, and the spring clamp generates a diagonal direction thrust through rotation, so that the multi-well plate or the transition groove is tightly attached to the inner side of the positioning frame opposite to the spring clamp.

[0034] The positioning frame is provided with a clamping mechanism around the upper right corner, the clamping mechanism is a rotatable spring clamp, the rotation axis of the spring clamp is perpendicular to the bottom of the positioning frame, the end of the spring clamp is provided with a buffer pad, and the spring clamp generates a diagonal direction thrust through rotation, so that the multi-well plate or the transition groove is tightly attached to the inner side of the positioning frame opposite to the spring clamp.

[0035] Further, the middle part of the transition groove is hollow, a sliding tab which is in sliding connection with the transition groove is arranged in the transition groove, the sliding tab moves along the length direction of the transition groove, the sliding tab and one side of the width of the transition groove form a clamping area, and the clamping area is used for clamping a glass slide or a culture dish.

[0036] The edge of the side of the sliding tab facing the clamping area is in arc shape and opens towards the clamping area, a square platform which is matched with the shape of one end of the glass slide is arranged at the middle segment of the arc, and the shape of the side edge of the transition groove opposite to the clamping area is centrally symmetrical to the shape of the edge of the side of the sliding tab facing the clamping area.

[0037] The transition groove is provided with two sliding grooves which are parallel to each other, sliding blocks which are in sliding connection with the sliding grooves are arranged in the sliding grooves, the two ends of the sliding tab are respectively provided with an opening, and a screw rod is arranged, one end of the screw rod penetrates through the opening and is connected with the sliding blocks.

[0038] Further, an annular platform is arranged on the inner wall of the positioning frame, the annular platform and the inner wall of the positioning frame jointly form a positioning area, the outer edge of the multi-well plate is in clearance fit with the positioning area, and the outer edge of the transition groove is the same as the outer edge of the multi-well plate in shape and size.

[0039] The utility model discloses the beneficial effect is:

[0040] 1. The utility model discloses a through groove and connecting rod cooperation design realizes the adjustability of adapter, can adapt to different width's object table. The device is fastened and installed in object table one side through the adaptation department, and is connected object table another table through the positioning structure, and the positioning structure plays the supporting effect, and the accurate control of clamping force is realized through screw adjustment, ensures realizing quick installation and installation stability, and is convenient for quick adjustment and dismounting simultaneously.

[0041] 2. The utility model discloses through the orthogonal lamination setting of X axis linear motion subassembly and Y axis linear motion subassembly and simply supported beam design, cooperation screw guide rail drive and gear rack drive, realize accurate positioning under the manual drive while guaranteeing stability, adapt living cell imaging appearance.

[0042] 3. The utility model discloses a sample clamp through the combination design of positioning frame and detachable transition groove, and the clamping of multi -well plate, glass slide and petri dish is compatible, and adjustable clamping area is formed to the slide piece, and different size sample is adapted, and hollow structure ensures that sample and object table are directly contacted, and defocus is avoided. BRIEF DESCRIPTION OF DRAWINGS

[0043] Figure 1 The structure schematic drawing of sample motion device clamping multi -well plate for the utility model embodiment is described;

[0044] Figure 2 The structure schematic drawing of X axis linear motion subassembly for the utility model embodiment is described;

[0045] Figure 3 The structure schematic drawing of Y axis linear motion subassembly for the utility model embodiment is described;

[0046] Figure 4 The structure schematic drawing of motion base station for the utility model embodiment is described;

[0047] Figure 5 The structure schematic drawing of adaptation department for the utility model embodiment is described;

[0048] Figure 6 The structure schematic drawing of sample clamp for the utility model embodiment is described;

[0049] In the drawing, the component list that each sign represents is as follows:

[0050] 1. A motion base, 11. Base body, 12. Y-axis base, 13. Through slot, 14. Adaptation part, 15. Adjusting clamping screw, 16. Nylon clamping piece, 17. Screw, 18. Square groove, 181. Horizontal groove, 182. Positioning piece, 19. Connecting rod, 2. Y-axis linear motion assembly, 21. Slider, 22. Bevel gear rack, 23. Mounting plate, 24. Gap adjusting washer, 25. Second hand wheel, 26. Second guide rail, 3. X-axis linear motion assembly, 31. Screw rod, 32. Nut seat, 33. First guide rail, 34. Bearing, 35. First hand wheel, 36. Mounting bracket, 361. Bottom plate, 362. Side plate, 363. Horizontal plate, 364. Longitudinal plate, 365. Scale, 366. Protective cover, 37. Mounting support, 38. Washer, 39. Limiting screw, 4. Sample clamp, 41. Positioning frame, 42. Connecting plate, 411. Spring clip, 412. Transition groove, 413. Sliding tab, 414. Screw, 415. Slide groove, 416. Clamping area. DETAILED DESCRIPTION

[0051] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0052] In the description of the present application, the terms "first", "second" are used only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first", "second" can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "multiple" is two or more, unless otherwise specifically limited.

[0053] In the description of the present application, the term "for example" is used to indicate "as an example, illustration or explanation". Any embodiment described as "for example" in the present application is not necessarily interpreted as more preferred or more advantageous than other embodiments. The following description is given in order to enable any person skilled in the art to implement and use the present application. In the following description, details are listed for the purpose of explanation. It should be understood that those skilled in the art can realize the present application without using these specific details. In other examples, well-known structures and processes will not be described in detail to avoid unnecessary details making the description of the present application obscure. Therefore, the present application is not intended to be limited to the shown embodiments, but is consistent with the broadest scope of principles and features disclosed in the present application.

[0054] EMBODIMENT

[0055] As shown in Figure 1 , Figure 4 and Figure 5 , a sample movement device for live cell imager, comprising a movement base 1, which is detachably connected to the surface of the stage; comprising an X-axis linear movement assembly 3 for driving the sample clamp 4 to move along the X-axis direction and a Y-axis linear movement assembly 2 for driving the X-axis movement assembly 3 to move along the Y-axis direction; the Y-axis linear movement assembly 2 is fixed to the movement base 1; the movement base 1 comprises a base body 11 and an adapter connected thereto, the adapter is adjustable along the length direction of the base body 11, the base body 11 is located on the upper surface of the stage, and the adapter comprises a fastening structure, and the movement base 1 is installed on the stage through the fastening structure. Through the detachable movement base 1, quick installation is realized without the need to modify the original structure of the microscope.

[0056] Among them, the base body 11 is provided with a through groove 13 along the length direction thereof, the adapter comprises a transverse connecting rod 19 and a longitudinal adapter part 14, the adapter part 14 is located on the side of the stage, and the adapter part 14 is provided with a fastening structure, the connecting rod 19 is inserted into the through groove 13, a plurality of screws 17 are provided outside the through groove 13, and the screws 17 pass through the base body 11 into the through groove 13 to fasten the connecting rod 19. The cooperation of the through groove 13 and the connecting rod 19 realizes the adjustability of the adapter, which can adapt to stages of different widths.

[0057] In a preferred embodiment, the base body 11 is arranged horizontally along the X direction, one end of the base body 11 away from the adapter part 14 extends along the Y-axis direction to form a Y-axis base 12, the Y-axis base 12 is provided with a positioning structure, the positioning structure is connected with the side of the stage, and the other side of the stage is connected with the adapter part 14. The positioning structure comprises a square groove 18 and a positioning sheet 182, the surface of the Y-axis base 12 is provided with the square groove 18, the square groove 18 has an opening facing the side of the stage, and the positioning sheet 182 is located in the square groove 18 and can extend out of the square groove 18 to connect with the side of the stage; the positioning sheet 182 is provided with a transverse groove 181, and a plurality of screws 17 are connected with the square groove 18 through the transverse groove 181. The positioning structure provides a support point, and the installation is more stable.

[0058] Among them, the fastening structure comprises a nylon clamping sheet 16 and an adjusting clamping screw 15, the nylon clamping sheet 16 is located on the side of the adapter part 14 facing the stage, and the adjusting clamping screw 15 is installed on the other side of the stage. The nylon clamping sheet 16 can internally offset the torque generated by the adjusting clamping screw 15, so that the clamping force is perpendicular to the side of the live cell imager, thereby improving the installation accuracy.

[0059] AsFigures 1-3 As shown in a preferred embodiment,

[0060] The X-axis linear motion assembly 3 is connected with the sliding block 21 of the Y-axis linear motion assembly 2 through a mounting seat 36, and the two assemblies are orthogonally stacked to realize the movement of the sample in a two-dimensional plane; one end of the mounting seat 36 is fixed to the sliding block 21 of the Y-axis linear motion assembly 2, and the other end is in contact with the external stage through an adjustable support assembly, forming a simply supported beam structure with rigid support at both ends, which is used to avoid the loss of movement precision caused by cantilever deformation, and the adjustable support assembly eliminates the cantilever deformation to ensure the stability of the movement.

[0061] Specifically, the adjustable support assembly includes a limiting screw 39, a ball pulley, a gasket 38, and a mounting bracket 37; the mounting bracket 37 is connected to one end of the mounting seat 36 and has a screw hole inside; the limiting screw 39 is connected to the mounting bracket 37 through the screw hole at the upper end and has a limiting hole at the lower end; the ball pulley is installed in the limiting hole and can rotate freely, and the lower end of the ball pulley is in contact with the external stage; the gasket 38 is located between the limiting screw 39 and the screw hole. A certain number of gaskets 38 with a thickness of 0.1 mm are used to adjust the parallelism between the X-axis linear motion assembly 3 and the stage, and the sample holder 4 is suspended, keeping the distance between the sample holder 4 and the stage at 1-2 mm; the simply supported beam structure can avoid the center of gravity deviation caused by sample movement under the cantilever beam structure, which causes the X-axis linear motion assembly 3 to bend slightly, thereby avoiding the collision between the sample holder 4 and the stage and the change in focal length.

[0062] In a preferred embodiment, the mounting seat 36 includes a U-shaped mounting frame and an L-shaped mounting frame; the U-shaped mounting frame is composed of a bottom plate 361 and two side plates 362, and the two ends of the bottom plate 361 are respectively connected perpendicularly to a side plate 362; the L-shaped mounting frame is composed of a horizontal plate 363 and a longitudinal plate 364 connected perpendicularly to each other, and the upper end of the longitudinal plate 364 is connected to the lower end of the U-shaped mounting frame, and the lower end is connected to the horizontal plate 363.

[0063] In a preferred embodiment, the X-axis linear motion assembly 3 comprises a lead screw 31, a first guide rail 33, a first hand wheel 35, a nut seat 32 and a protective cover 366; the first guide rail 33 is horizontally mounted on the bottom plate 361; the lead screw 31 is connected to the two side plates 362 of the mounting seat 36 through bearings 34 at both axial ends; the nut seat 32 is threadedly connected to the lead screw 31; a sliding groove matched with the first guide rail 33 is formed in the lower end of the nut seat 32 and the nut seat 32 is slidably connected to the first guide rail 33; the nut seat 32 is connected to the sample clamp 4 through a connecting piece; the first hand wheel 35 is located on one side of the mounting seat 36 and is fixedly connected to the lead screw 31 to drive the lead screw 31 to rotate; and the surface of the protective cover 366 is provided with a scale 365. The lead screw guide rail transmission mechanism provides high-precision linear movement, the first hand wheel 35 is convenient for fine adjustment, and the first guide rail 33 provides a guide for the nut seat 32. Rotating the first hand wheel 35 drives the sample clamp 4 to move along the X-axis direction.

[0064] In a preferred embodiment, the Y-axis linear motion assembly 2 comprises an inclined rack 22, an inclined gear, a second hand wheel 25, a second guide rail 26, a sliding block 21 and a mounting plate 23; the second guide rail 26 is mounted on the surface of the mounting plate 23; the inclined rack 22 is mounted on the surface of the second guide rail 26; the inclined gear is engaged with the inclined rack 22; the sliding block 21 is provided with a sliding groove matched with the second guide rail 26 and is slidably connected to the second guide rail 26; the sliding block 21 is provided with a through hole; and the second hand wheel 25 is connected to the inclined gear through the through hole and drives the inclined gear to rotate. The gear and rack transmission mechanism realizes high-precision linear movement, and rotating the second hand wheel 25 drives the sliding block 21 to move along the Y-axis direction. The X-axis linear motion assembly 3 is connected to the sliding block 21 of the Y-axis linear motion assembly 2 through the mounting seat 36, and the movement of the sliding block 21 drives the Y-axis linear motion assembly 2 to move.

[0065] In a preferred embodiment, the Y-axis linear motion assembly 2 comprises an inclined rack 22, an inclined gear, a second hand wheel 25, a second guide rail 26, a sliding block 21 and a mounting plate 23; the second guide rail 26 is mounted on the surface of the mounting plate 23; the inclined rack 22 is mounted on the surface of the second guide rail 26; the inclined gear is engaged with the inclined rack 22; the sliding block 21 is provided with a sliding groove matched with the second guide rail 26 and is slidably connected to the second guide rail 26; the sliding block 21 is provided with a through hole; and the second hand wheel 25 is connected to the inclined gear through the through hole and drives the inclined gear to rotate. The gear and rack transmission mechanism realizes high-precision linear movement, and rotating the second hand wheel 25 drives the sliding block 21 to move along the Y-axis direction. The X-axis linear motion assembly 3 is connected to the sliding block 21 of the Y-axis linear motion assembly 2 through the mounting seat 36, and the movement of the sliding block 21 drives the Y-axis linear motion assembly 2 to move.

[0066] Specifically, the material of the inclined rack 22 is copper, which is not easy to corrode.

[0067] Specifically, the modulus of the inclined rack 22 and the inclined gear is 0.5 module, and the number of teeth of the inclined gear is 15-17 teeth.

[0068] Specifically, an adjustable gap adjusting washer 24 is arranged between the contact surface of the bevel gear and the second hand wheel 25.

[0069] As shown in the preferred embodiment, Figure 6

[0070] The sample clamp 4 includes a positioning frame 41 and a transition groove 412 which is detachably mounted in the positioning frame 41. The positioning frame 41 is connected to a connecting plate 42 at one corner, and the connecting plate 42 is rigidly connected to the connecting member of the nut seat 32 to ensure the transmission of movement accuracy to the sample. A clamping mechanism is provided around the upper right corner of the positioning frame 41. The clamping mechanism is a rotatable spring clamp 411, and the rotation axis of the spring clamp 411 is perpendicular to the bottom surface of the positioning frame 41. The end of the spring clamp 411 is provided with a buffer pad. The spring clamp 411 generates a diagonal pushing force by rotating, so that the multi-well plate or the transition groove 412 is tightly attached to the inner side of the positioning frame 41 opposite to the spring clamp 411, thereby achieving rapid fixation and release and reducing manual intervention errors. The multi-well plate or the transition groove 412 can be selected for use through the clamping mechanism, which is suitable for different samples.

[0071] The surface of the positioning frame 41 is treated by fluorine plating or sand blasting to form a friction-reducing layer, which reduces the friction between the positioning frame 41 and the multi-well plate or the transition groove 412, facilitates placement and removal, and avoids scratching.

[0072] In a preferred embodiment, the transition groove 412 is hollow in the middle, and a sliding tab 413 is arranged in the transition groove 412 and is slidably connected thereto. The sliding tab 413 moves along the length direction of the transition groove 412, and the sliding tab 413 and one side of the transition groove 412 form a clamping area 416. The clamping area 416 is used for clamping a glass slide or a culture dish.

[0073] The edge of the side of the sliding tab 413 facing the clamping area 416 is in the form of a circular arc and opens towards the clamping area 416. A square platform matching the shape of one end of the glass slide is arranged in the middle of the circular arc. The shape of the edge of the side of the transition groove 412 facing the clamping area 416 is centrally symmetrical to the shape of the edge of the side of the sliding tab 413 facing the clamping area 416. The circular arc edge is suitable for the shape of the culture dish, and the square platform is suitable for the glass slide.

[0074] ​The transition groove 412 is provided with two parallel upper and lower sliding grooves 415, the sliding grooves 415 are provided with sliding blocks connected with the sliding grooves 415, the sliding push piece 413 is provided with an opening at each end, and the screw rod 414 is connected with the sliding blocks through the openings.

[0075] In a preferred scheme, the inner wall of the positioning frame 41 is provided with an annular platform, the annular platform and the inner wall of the positioning frame 41 jointly form a positioning area, the outer edge of the multi-well plate is in clearance fit with the positioning area, and the outer edge of the transition groove 412 is the same in shape and size as the outer edge of the multi-well plate.

[0076] In summary, the utility model discloses a quick installation of the object table through the motion base 1;Through the orthogonal superposition of X-axis linear motion assembly 3 and Y-axis linear motion assembly 2 and simply supported beam design, cooperate with screw rod guide rail transmission and rack and pinion transmission, realize the accurate positioning of sample under manual drive;Through the design of sample clamp 4, different samples are adapted.

[0077] Although the embodiments or examples of the present disclosure have been described with reference to the drawings, it should be understood that the above-mentioned methods, systems and devices are only exemplary embodiments or examples, and the scope of the utility model is not limited by these embodiments or examples, but only by the granted claims and their equivalent scope. Various elements in the embodiments or examples can be omitted or replaced by equivalent elements. In addition, each step can be performed in an order different from that described in the present disclosure. Further, various elements in the embodiments or examples can be combined in various ways. What is important is that as technology evolves, many elements described herein can be replaced by equivalent elements that appear after the present disclosure.

Claims

1. A sample motion device for a live-cell imaging system, characterized in that, include The motion base is detachably connected to the surface of the platform; The motion base includes a base body and an adapter connected thereto. The adapter is adjustable along the length of the base body. The base body is located on the upper surface of the platform. The adapter includes a fastening structure. The motion base is mounted on the platform through the fastening structure.

2. The sample motion device for a live-cell imaging system according to claim 1, characterized in that, The base body has a through groove along its length. The adapter includes a transverse connecting rod and a longitudinal adapter part. The adapter part is located on the side of the platform and has a fastening structure. The connecting rod is inserted into the through groove. Multiple screws are provided outside the through groove. The screws pass through the base body and enter the through groove to fasten the connecting rod.

3. The sample motion device for a live-cell imaging system according to claim 2, characterized in that... The base body is arranged horizontally along the X-axis direction. The end of the base body away from the adapter extends into a Y-axis base along the Y-axis direction. The Y-axis base is provided with a positioning structure. The positioning structure is connected to the side of the platform. The other side of the platform is connected to the adapter. The X-axis is orthogonal to the Y-axis.

4. The sample motion device for a live-cell imaging system according to claim 3, characterized in that, The fastening structure includes a nylon clamping plate and an adjusting clamping screw. The nylon clamping plate is located on one side of the adapter facing the stage, and the adjusting clamping screw is installed on the other side of the stage.

5. The sample motion device for a live-cell imaging system according to claim 4, characterized in that, The positioning structure includes a square groove and a positioning piece. The square groove is provided on the surface of the Y-axis base. The opening of the square groove faces the side of the platform. The positioning piece is located in the square groove and can extend out of the square groove to connect with the side of the platform. The positioning piece is provided with a horizontal groove, and several screws are connected to the square groove through the horizontal groove.

6. The sample motion device for a live-cell imaging system according to claim 3, characterized in that, It also includes an X-axis linear motion component for driving the sample holder to move along the X-axis direction; The Y-axis linear motion component is used to drive the X-axis motion component to move along the Y-axis direction; The Y-axis linear motion component is fixed to the motion base; The X-axis linear motion component is rigidly connected to the slider of the Y-axis linear motion component via a mounting base, and the two components are orthogonally stacked. One end of the mounting base is fixed to the slider of the Y-axis linear motion component, and the other end is in contact with the external stage through an adjustable support component.

7. The sample motion device for a live-cell imaging system according to claim 6, characterized in that, The adjustable support assembly includes a limit screw, a ball pulley, a washer, and a mounting bracket; The mounting bracket is connected to one end of the mounting base and has screw holes inside; The upper end of the limiting screw passes through the screw hole and connects to the mounting bracket, and the lower end is provided with a limiting hole; The ball pulley is installed in the limiting hole and can rotate freely, with the lower end of the ball pulley in contact with the external platform; The gasket is located between the limiting screw and the screw hole.

8. The sample motion device for a live-cell imaging system according to claim 6, characterized in that, The mounting base includes a U-shaped mounting bracket and an L-shaped mounting bracket. The U-shaped mounting bracket consists of a base plate and two side plates, with one side plate perpendicularly connected to both ends of the base plate. The L-shaped mounting bracket consists of a horizontal plate and a vertical plate that are perpendicularly connected to each other. The upper end of the vertical plate is connected to the lower end of the U-shaped mounting bracket, and the lower end is connected to the horizontal plate.

9. The sample motion device for a live-cell imaging system according to claim 8, characterized in that, The X-axis linear motion component includes a lead screw, a first guide rail, and a first handwheel; A first guide rail is horizontally mounted on the base plate. The two ends of the lead screw are respectively connected to the two side plates of the mounting base through bearings. The nut seat is threaded to the lead screw. The lower end of the nut seat has a sliding groove that matches the first guide rail and is slidably connected to it. The nut seat is connected to the sample clamp through a connector. The first handwheel is located on one side of the mounting base and is fixedly connected to the lead screw to drive the lead screw to rotate.

10. The sample motion device for a live-cell imaging system according to claim 8, characterized in that, The Y-axis linear motion assembly includes a helical rack, a helical gear, a second handwheel, a second guide rail, a slider, and a mounting plate; A second guide rail is mounted on the surface of the mounting plate, and a helical rack is mounted on the surface of the second guide rail. The helical gear meshes with the helical rack. The slider has a groove that matches the second guide rail and is slidably connected to it. The slider has a through hole, and the second handwheel is connected to the helical gear through the through hole via a set screw and drives it to rotate. The slider is mounted on the upper surface of the horizontal plate, and the second guide rail is mounted on the lower surface of the mounting plate. The slider is slidably connected to the second guide rail, and the upper surface of the mounting plate is fixedly connected to the lower surface of the Y-axis base.

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