Laboratory mouse fixing device

Abstract

The utility model discloses a laboratory mouse fixing device which comprises a cylinder body and a stopping piece, the cylinder body is a conical cylinder bent towards one side, the narrow end of the cylinder body is closed, the other end of the cylinder body forms an inlet of the cylinder body, the inner side of the cylinder body forms a first side wall of the cylinder body, the outer side of the cylinder body forms a second side wall of the cylinder body, and a guide groove hole is formed in a first center line; the laboratory mouse fixing device has the advantages that the laboratory mouse fixing device is simple in structure and low in cost, the laboratory mouse fixing process is simplified, the laboratory mouse fixing device is suitable for fixing various laboratory mice with different sizes, and the laboratory mouse fixing device is convenient to use and high in practicability. The posture of the laboratory mouse in the cylinder is fixed, the laboratory mouse is not prone to rolling in the inner cavity of the cylinder, the obvious degree of veins on the two sides of the mouse tail can be observed by turning over the cylinder, puncture points are selected, and experiment operation is convenient.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and more specifically, to a mouse restraint device. Background Technology

[0002] Tail vein injection in laboratory mice is a commonly used drug administration method in biological, medical, and pharmaceutical experiments. However, mice are difficult to control during tail vein injection, requiring immobilization. Current immobilization devices are only suitable for mice of a single size. For mice of different sizes and weights, multiple immobilization devices are needed, impacting experimental efficiency. Furthermore, the process of immobilizing mice is complex and difficult, and the immobilization device cannot be adjusted in real-time, affecting the accuracy of injection at the puncture point in the tail vein during the experimental procedure. Utility Model Content

[0003] This invention aims to solve at least one of the technical problems existing in the prior art. To this end, this invention proposes a mouse restraint device. This device has a simple structure, low cost, simplifies the mouse restraint process, and is suitable for restraining mice of various sizes. The mouse's posture is fixed inside the cylinder, preventing it from rolling around inside. Turning the cylinder allows observation of the prominence of the veins on both sides of the mouse's tail, facilitating the selection of puncture points and simplifying experimental procedures.

[0004] To achieve the above objectives, an experimental mouse restraint device is proposed according to an embodiment of the present invention. The experimental mouse restraint device includes: a cylindrical body, which is formed as a conical cylinder bent to one side, with the narrow end of the cylindrical body closed and the other end forming the inlet of the cylindrical body, a guide groove hole being provided at the first center line inside the cylindrical body, and a mouse tail groove hole being provided at the second center line outside the cylindrical body.

[0005] A stop member is provided movably in the inner cavity of the cylinder through the inlet along the guide slot, and at least a portion of the stop member engages with the guide slot.

[0006] The experimental mouse fixation device according to the present invention has a simple structure, low cost, simplifies the experimental mouse fixation process, and is suitable for fixing experimental mice of various sizes. The experimental mouse posture is fixed inside the cylinder, and the experimental mouse is not easy to roll around in the inner cavity of the cylinder. The obviousness of the veins on both sides of the mouse tail can be observed by turning the cylinder, and the puncture point can be selected, which facilitates the experimental operation.

[0007] In addition, the experimental mouse restraint device according to the above embodiments of this utility model may also have the following additional technical features:

[0008] According to one embodiment of the present invention, the stop member includes:

[0009] A baffle is provided in the inner cavity and divides the inner cavity of the cylinder into a first space and a second space. The first space is located on the side of the baffle facing away from the inlet and is used to store laboratory mice.

[0010] A connecting part is connected to the baffle and mates with the guide slot, and the connecting part extends to the outside of the inner cavity.

[0011] According to one embodiment of the present invention, the stop member further includes:

[0012] A limiting member, which is rotatably connected to the connecting portion between a locked position and an unlocked position;

[0013] A reset member, which is connected to the limiting member, is used to drive the limiting member to move toward the locking position;

[0014] The limiting member is provided with a limiting part, and multiple limiting mating parts are provided on the outer surface of the cylinder near the edge of the guide groove. The multiple limiting mating parts are arranged sequentially along the extension direction of the guide groove. In the locked position, the limiting part is adapted to cooperate with any one of the limiting mating parts to fix the baffle to different depth positions in the inner cavity of the cylinder.

[0015] According to one embodiment of the present invention, the limiting portion forms a limiting protrusion, and the limiting mating portion forms a limiting recess, wherein the limiting protrusion has a limiting surface and a guiding surface, and the limiting surface and the guiding surface are arranged opposite to each other in the extending direction of the guide slot.

[0016] Wherein, the angle between the limiting surface and the extending direction of the guide slot is greater than the angle between the guiding surface and the extending direction of the guide slot.

[0017] According to one embodiment of the present invention, the first centerline is formed as a first arc segment, which is a part of a first circle with O1 as the center and R1 as the radius.

[0018] According to one embodiment of the present invention, the experimental mouse restraint device further includes a support arm, the support arm being connected to the first sidewall, and the stop member being rotatably connected to the support arm through the guide slot.

[0019] The rotation center of the stop is located at O1.

[0020] According to one embodiment of the present invention, the experimental mouse fixing device further includes: an auxiliary fixing component, the auxiliary fixing component including a base and a fixing rod, the fixing rod extending vertically and its bottom connected to the base, the fixing rod engaging with the support arm and the cylinder at an angle.

[0021] According to one embodiment of the present invention, the second centerline is formed as a second arc segment, which is a part of a second circle with O2 as the center and R2 as the radius, and the first circle and the second circle are located in the same plane.

[0022] According to one embodiment of the present invention, the radius of the first circle is R1, 15mm≤R1≤100mm, and the radius of the second circle is R2, 25mm≤R2≤200mm.

[0023] According to one embodiment of the present invention, O1 is located in a first direction of O2, and the distance between O1 and O2 is L, where 0mm≤L≤180mm;

[0024] And / or, the inlet is located on the plane containing O1 and O2.

[0025] According to one embodiment of the present invention, the cylinder body has a plurality of ventilation holes on the side near the narrow end.

[0026] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0027] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0028] Figure 1 This is a schematic diagram of the structure of the experimental mouse restraint device according to an embodiment of the present invention;

[0029] Figure 2 This is a schematic diagram of the structure of the experimental mouse restraint device according to an embodiment of the present invention;

[0030] Figure 3 This is a cross-sectional view of the experimental mouse restraint device according to an embodiment of the present invention;

[0031] Figure 4 This is a cross-sectional view of the experimental mouse restraint device according to an embodiment of the present invention;

[0032] Figure 5 yes Figure 4 A magnified view of the area at point C;

[0033] Figure 6 This is a structural schematic diagram of the limiting member according to an embodiment of the present utility model;

[0034] Figure 7 This is a partial structural diagram of the cylinder at the guide slot according to an embodiment of the present utility model.

[0035] Figure label:

[0036] Laboratory mouse restraint device 100,

[0037] Cylinder body 1, first side wall 11, guide groove 111, mating protrusion 112, second side wall 12, rat tail groove 121, inlet 13, vent 14.

[0038] Stop 2, baffle 21, connecting part 22, limiting part 23, limiting part 231, limiting surface 2311, guide surface 1312.

[0039] Support arm 3, auxiliary fixing component 4, base 41, fixing rod 42.

[0040] The first circle is 5, the second circle is 6. Detailed Implementation

[0041] This application is based on the inventor's discoveries and understanding of the following facts and problems:

[0042] Tail vein injection in laboratory mice is a commonly used drug administration method in biological, medical, and pharmaceutical experiments. However, mice are difficult to control during tail vein injection, requiring immobilization. Current immobilization devices are only suitable for mice of a single size. For mice of different sizes and weights, multiple immobilization devices are needed, impacting experimental efficiency. Furthermore, the process of immobilizing mice is complex and difficult, and the immobilization device cannot be adjusted in real-time, affecting the accuracy of injection at the puncture point in the tail vein during the experimental procedure.

[0043] Therefore, this utility model embodiment designs a laboratory mouse fixation device 100 including a curved conical tube to utilize the laboratory mouse's burrowing instinct to fix the laboratory mouse, simplifying the laboratory mouse fixation process. Furthermore, since the conical tube gradually narrows from the outside to the inside, laboratory mice of different sizes and weights will burrow to different positions, making it suitable for fixing laboratory mice of various sizes. Moreover, because the tube 1 is curved, the posture of the laboratory mouse burrowing into the tube 1 is fixed, and the laboratory mouse burrowing into the tube 1 is less likely to roll over in the inner cavity of the tube 1, which is more conducive to experimental operation. Before intravenous injection into the laboratory mouse's tail, the visibility of the veins on both sides of the tail can be observed by flipping the tube 1 to select the puncture point, which facilitates the experimental operation.

[0044] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0045] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "transverse," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential," etc., indicating the orientation or positional relationship shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, features defined with "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0046] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0047] The experimental mouse restraint device 100 according to an embodiment of the present invention is described below with reference to the accompanying drawings.

[0048] like Figures 1-7 As shown, the experimental mouse restraint device 100 according to an embodiment of the present invention includes: a cylinder 1 and a stop 2.

[0049] The cylinder 1 is formed as a conical cylinder that bends to one side, with the bent side being the inner side and the other side being the outer side. The narrow end of the cylinder 1 is closed, and the other end is formed as the inlet 13 of the cylinder 1. A rat-tail groove 121 is provided at the second centerline on the outer side of the cylinder 1.

[0050] When the experimental mouse is fixed by the experimental mouse fixing device 100, the experimenter can lift the experimental mouse by the tail and bring the head of the experimental mouse close to the inlet 13 of the cylinder 1. Due to the experimental mouse's burrowing nature, the experimental mouse will enter the inner cavity of the cylinder 1 through the inlet 13. During the process of the experimental mouse burrowing inward, the experimenter will lead the experimental mouse's tail out of the cylinder 1 through the tail slot 121.

[0051] After the experimental mouse burrows into the cylinder 1, a stop 2 is installed on the rear side of the experimental mouse to prevent it from retreating. The stop 2 can restrict the movement of the experimental mouse.

[0052] A guide slot 111 is provided at the first centerline of the inner side of the cylinder 1. The stop 2 is movably disposed in the inner cavity of the cylinder 1 through the inlet 13 along the extension direction of the guide slot 111. At least a part of the stop 2 cooperates with the guide slot 111. The guide slot 111 can guide the movement of the stop 2 to ensure the stability of the movement of the stop 2. Furthermore, at least a part of the stop 2 can pass through the guide slot 111. This part of the stop 2 is located on the outside of the cylinder 1. The experimenter can change the position of the stop 2 by driving the stop 2 on the outside of the cylinder 1 to ensure that the stop 2 can be limited to the rear of the experimental mouse to prevent the experimental mouse from running around.

[0053] When the guide slot 111 is open to the side facing the opening, and the stop 2 is located outside the cylinder 1, the stop 2 does not cooperate with the guide slot 111. When at least part of the structure of the stop 2 enters the inner cavity of the cylinder 1 through the inlet 13, a part of the stop 2 enters the guide slot 111 through the open side of the guide slot 111 and cooperates with the guide slot 111. Under the guidance of the guide slot 111, it moves stably towards the narrow end of the cylinder 1.

[0054] Therefore, the experimental mouse fixation device 100 utilizes the burrowing nature of experimental mice to fix them, simplifying the fixation process. Furthermore, since the conical tube gradually narrows from the outside to the inside, experimental mice of different sizes and weights will burrow to different positions, making it suitable for fixing experimental mice of various sizes. Also, because the tube 1 is curved, the posture of the experimental mice burrowing into the tube 1 is fixed, and the experimental mice burrowing into the tube 1 are less likely to roll around inside the tube 1, which is more conducive to experimental operation. Before intravenous injection into the experimental mouse's tail, the distribution of veins at various angles of the tail can be observed by flipping the tube 1 to select the puncture point, which facilitates the injection into the experimental mouse's tail vein during the experimental operation.

[0055] According to the embodiment of the present invention, the experimental mouse fixation device 100 has a simple structure, low cost, simplifies the experimental mouse fixation process, is suitable for fixing experimental mice of various sizes, fixes the posture of the experimental mouse in the cylinder, makes it difficult for the experimental mouse to roll around in the inner cavity of the cylinder 1, and allows the cylinder 1 to be turned over to observe the degree of prominence of the veins on both sides of the mouse tail, select the puncture point, and facilitate experimental operation.

[0056] Reference Figures 1-4 Multiple ventilation holes 14 are provided on the side of the cylinder 1 near the narrow end. After the experimental mouse is fixed in the inner cavity of the cylinder 1, the mouse head is located at the narrow end of the cylinder 1. Multiple ventilation holes 14 are provided on the side of the cylinder 1 near the narrow end to ensure that the inside of the cylinder 1 is breathable and that the experimental mouse can breathe normally in the inner cavity of the cylinder 1, thus avoiding the experimental mouse from suffocating in the cylinder 1.

[0057] like Figures 1-4 As shown, the stop 2 includes a baffle 21 and a connecting part 22. The baffle 21 is disposed in the inner cavity and divides the inner cavity of the cylinder 1 into a first space and a second space. The first space is located on the side of the baffle 21 facing away from the inlet 13. The first space can be used to store laboratory mice. The larger the weight of the laboratory mouse stored and fixed inside the laboratory mouse fixing device 100, the larger the space it occupies after entering the inner cavity of the cylinder 1. The closer the baffle 21 is to the inlet 13 inside the cylinder 1, the smaller the weight of the laboratory mouse stored and fixed inside the laboratory mouse fixing device 100, the smaller the space it occupies after entering the inner cavity of the cylinder 1. The further the baffle 21 is from the inlet 13 inside the cylinder 1, the better. Thus, laboratory mice of different sizes and weights can be fixed, improving the practicality of the laboratory mouse fixing device 100.

[0058] The connecting part 22 is connected to the baffle 21 and cooperates with the guide slot 111. The connecting part 22 extends to the outside of the inner cavity. The cooperation between the guide slot 111 and the connecting part 22 can guide the movement of the stop 2, ensuring the stability of the stop 2 during movement. Furthermore, the part of the connecting part 22 extending to the outside of the inner cavity is located on the outside of the cylinder 1. The experimenter can change the position of the stop 2 by driving the connecting part 22 on the outside of the cylinder 1, ensuring that the stop 2 can be limited to the rear of the experimental mouse to prevent the experimental mouse from running around.

[0059] Reference Figures 1-4 The stop member 2 also includes a limiting member 23 and a resetting member. The limiting member 23 is rotatably connected to the connecting part 22 between the locked position and the unlocked position. In the locked position, the limiting member 23 can limit and fix the stop member 2 on the cylinder 1. At this time, the position of the baffle 21 of the stop member 2 is fixed. The baffle 21 provided in the inner cavity of the cylinder 1 can restrict the movement of the experimental mouse from the rear side. When the experimental mouse tries to retreat during the experiment, the movement of the experimental mouse is restricted due to the setting of the baffle 21, thus fixing the experimental mouse.

[0060] In the unlocked position, there is no connection or engagement between the limiting member 23 and the cylinder 1. The stop member 2 can move along the extension direction of the guide slot 111 under the guidance of the guide slot 111. By moving the position of the stop member 2, the position of the baffle 21 located in the inner cavity of the cylinder 1 can be moved. By controlling the position of the baffle 21, the size of the first space can be controlled. When the experimental mouse is a large rat, the stop member 2 moves a shorter distance along the guide slot 111 towards the narrow end of the cylinder 1 to make the first space larger. When the experimental mouse is a small mouse, the stop member 2 moves a longer distance along the guide slot 111 towards the narrow end of the cylinder 1 to make the first space larger.

[0061] The reset member is connected to the limiting member 23 and is used to drive the limiting member 23 to move toward the locked position. Thus, when the stop member 2 is moved, the reset member can be controlled to move toward the unlocked position until it moves to the appropriate position. Then the limiting member 23 is released, and the limiting member 23 returns to the locked position under the drive of the reset member, thus fixing the baffle 21.

[0062] The limiting member 23 is provided with a limiting part 231. Multiple limiting mating parts are provided on the outer surface of the cylinder 1 near the edge of the guide slot 111. These multiple limiting mating parts are arranged sequentially along the extension direction of the guide slot 111. In the locked position, the limiting part 231 is adapted to engage with any one of the limiting mating parts to hold the plate-shaped cylinder 1 at different depths. The heavier the experimental mouse being fixed inside the experimental mouse fixing device 100, the larger the space it occupies after entering the cylinder 1, and the closer the baffle 21 is to the inlet 13 inside the cylinder 1. In this case, the limiting part 231 is adapted to engage with the limiting mating part closest to the open side of the guide slot 111 among the multiple limiting mating parts.

[0063] The smaller the weight of the experimental mouse that is fixed inside the experimental mouse restraint device 100, the less space it occupies after crawling into the inner cavity of the cylinder 1, and the further away the baffle 21 is from the inlet 13 inside the cylinder 1.

[0064] Therefore, laboratory mice of different sizes and weights can be secured, improving the practicality of the laboratory mouse restraint device 100. Thus, the baffle 21 can be fixed at different depths, suitable for laboratory mice of different sizes.

[0065] The limiting protrusion has a limiting surface 2311 and a guide surface 2312, which are arranged opposite to each other in the extension direction of the guide slot 111. The angle between the limiting surface 2311 and the extension direction of the guide slot 111 is greater than the angle between the guide surface 2312 and the extension direction of the guide slot 111.

[0066] The limiting protrusion has a limiting surface 2311 and a guide surface 2312. During the process of the baffle 21 moving from the open side to the narrow side of the cylinder 1, the guide surface 2312 of the limiting protrusion cooperates with the limiting recess. The guide surface 2312 of the limiting protrusion guides the movement of the limiting protrusion and the limiting member 23, so that the limiting protrusion moves away from the cylinder 1. This causes the limiting member 23 to disengage from the limiting formed by the cooperation of the limiting protrusion and the limiting recess. The stop member 2 and the cylinder 1 can continue to move relative to each other until the limiting protrusion cooperates with the next limiting recess. The guide surface 2312 of the limiting protrusion cooperates with the next limiting recess to continue to allow the limiting part 231 and the cylinder 1 to move relative to each other, and continue to move until the stop member 2 reaches the appropriate position.

[0067] Furthermore, the limiting surface 2311 can mate with any limiting recess to fix the position of the limiting member 23 relative to the cylinder 1, that is, the stop member 2 will not move relative to the cylinder 1 towards the opening, so that the stop member 2 is limited after it moves to a sufficient depth. The limiting surface 2311 and the guide surface 2312 are arranged opposite to each other in the extension direction of the guide slot 111, and the included angle between the limiting surface 2311 and the extension direction of the guide slot 111 is greater than the included angle between the guide surface 2312 and the extension direction of the guide slot 111, so that the guide surface 2312 has a guiding effect and the limiting surface 2311 has a limiting effect.

[0068] Reference Figure 5 The limiting part 231 forms a limiting protrusion, and the limiting mating part forms a limiting recess. Specifically, mating protrusions 112 are provided on both sides of the guide slot 111, and a limiting recess is defined between two adjacent protrusions. The limiting protrusion is suitable for engaging with any one of the multiple limiting recesses to fix the baffle 21 at different depths inside the cylinder 1. Through the engagement of the limiting protrusion and the limiting recess, the cylinder 1 and the stop member 2 can be stably fixed together, and the structure of the experimental mouse fixing device 100 is made simpler, further reducing production costs.

[0069] Reference Figure 4 The first centerline is formed as a first arc segment, which is part of a first circle 5 with O1 as the center and R1 as the radius. The experimental mouse fixing device 100 also includes a support arm 3, which is connected to the first side wall 11. The stop member 2 is rotatably connected to the support arm 3 through the guide slot 111, wherein the rotation center of the stop member 2 is located at O1.

[0070] Since the support arm 3 is fixedly connected to the cylinder 1, the experimenter can adjust the position and change the angle of the entire experimental mouse fixing device 100 by moving the support arm 3 throughout the experiment, thus improving the convenience of the experimental operation.

[0071] The support arm 3 can also provide an installation position for the stop 2. The stop 2 is rotatably connected to the support arm 3, which limits the position and direction of movement of the stop 2, ensuring the stability of the stop 2 and preventing the loss of the stop 2 from affecting the use of the experimental mouse fixing device 100.

[0072] Since the first centerline is formed as the first arc segment, and the first arc segment is part of the first circle 5 with O1 as the center, it is only necessary to control the distance between the baffle 21 and the center O1 to be greater than R1, and make the rotation center of the stop 2 located at O1, so as to ensure the stability of the posture of the stop 2 during rotation, and the baffle 21 will not collide with the cylinder 1 during rotation, thus affecting the control effect of the stop 2 on the experimental mouse.

[0073] According to one embodiment of the present invention, the experimental mouse restraint device 100 further includes an auxiliary fixing component 4, which includes a base 41 and a fixing rod 42. The fixing rod 42 extends vertically and its bottom is connected to the base 41. The fixing rod 42 is angled with the support arm 3 and the cylinder 1. The base 41 can be placed on a stable desktop or horizontal surface. The auxiliary fixing component 4 is set up stably. The angled cooperation between the fixing rod 42 and the support arm 3 and the cylinder 1 can limit the cylinder 1 of the experimental mouse restraint device 100, fixing it together on the desktop or other horizontal platform surface, avoiding dangerous situations such as the experimental mouse restraint device 100 with the experimental mouse being restrained falling from a height, and ensuring the stability of the cylinder 1 during the injection process, ensuring that the experimenter can inject the experimental mouse stably and safely.

[0074] Furthermore, the second centerline is formed into a second arc segment, which is part of a second circle 6 with O2 as the center and R2 as the radius. The first circle 5 and the second circle 6 are located in the same plane, thereby causing the cylinder 1 to bend to one side.

[0075] The radius of the first circle 5 is R1, 15mm≤R1≤100mm, and the radius of the second circle 6 is R2, 25mm≤R2≤200mm.

[0076] For example, in some embodiments, the radius R1 of the first circle 5 is 15 mm and the radius R2 of the second circle 6 is 25 mm. A mouse restraint device 100 of this size can be used for adult mice weighing 18 g to 50 g. For example, in other embodiments, the radius R1 of the first circle 5 is 100 mm and the radius of the second circle 6 is 200 mm. A mouse restraint device 100 of this size can be used for adult rats weighing 300 g to 600 g. The dimensions of the cylinder 1 can also be in other different combinations, which are not limited here.

[0077] Furthermore, refer to Figure 4 O1 is located in the first direction of O2 [e.g.] Figure 3and Figure 4 [As shown in the OA direction], the distance between O1 and O2 is L, where L ≤ 180mm. When the distance between O1 and O2 is not 0, the cylinder 1 is formed as a conical cylinder. The greater the distance between O1 and O2, the greater the dimensional change between the opening and the narrow end of the cylinder 1. Because the conical cylinder gradually narrows from the outside to the inside, experimental mice of different sizes and weights can crawl into different positions, which is suitable for fixing experimental mice of various sizes. Furthermore, because the cylinder 1 is curved, the posture of the experimental mice inside the cylinder 1 is fixed, and the experimental mice inside the cylinder 1 are less likely to roll around in the inner cavity of the cylinder 1, which is more conducive to experimental operation.

[0078] like Figure 4 As shown, inlet 13 is located on the plane containing O1 and O2, so that inlet 13 can be opened large enough to facilitate the laboratory mouse to crawl inside. The sidewall located on the side of the opening in the first direction is the first sidewall 11 of the cylinder 1, which is the inner sidewall of the cylinder 1, located in the second direction opposite to the opening in the first direction [e.g. Figure 3 and Figure 4 The side wall on one side of the OB direction shown is the second side wall 12, which is the outer side wall of the cylinder 1.

[0079] An embodiment of the present invention will now be described with reference to the accompanying drawings.

[0080] Reference Figures 1-6 1. Cylinder body, 2. Stop, 3. Support arm, and 4. Auxiliary fixing parts.

[0081] The cylinder 1 is formed as a conical cylinder that bends to one side, with the bent side being the inner side and the other side being the outer side. The narrow end of the cylinder 1 is closed, and the other end forms the inlet 13 of the cylinder 1. A rat-tail groove 121 is provided at the second centerline on the outer side of the cylinder 1, and the side of the rat-tail groove 121 that is open is open near the opening. A guide groove 111 is provided at the first centerline on the inner side of the cylinder 1, and the guide groove 111 is open towards the opening.

[0082] The stop member 2 includes a baffle 21, a connecting part 22, a limiting member 23, and a resetting member. The baffle 21 is disposed in the inner cavity and divides the inner cavity of the cylinder 1 into a first space and a second space. The first space is located on the side of the baffle 21 facing away from the inlet 13, and the interior of the first space can be used to store laboratory mice. The connecting part 22 is connected to the baffle 21 and cooperates with the guide slot 111. The connecting part 22 extends to the outside of the inner cavity. The limiting member 23 is rotatably connected to the connecting part 22 between the locked position and the unlocked position. The resetting member is connected to the limiting member 23 and is used to drive the limiting member 23 to move toward the locked position.

[0083] The limiting member 23 is provided with a limiting part 231. Multiple limiting mating parts are provided on the outer surface of the cylinder 1 near the edge of the guide groove hole 111. The multiple limiting mating parts are arranged in sequence along the extension direction of the guide groove hole 111. In the locked position, the limiting part 231 is suitable to cooperate with any one of the limiting mating parts to position the plate part cylinder 1 at different depths.

[0084] The first centerline is formed as a first arc segment, which is part of a first circle 5 with O1 as the center and R1 as the radius. The experimental mouse fixing device 100 also includes a support arm 3, which is connected to the first side wall 11. The stop member 2 is rotatably connected to the support arm 3 through the guide slot 111, wherein the rotation center of the stop member 2 is located at O1.

[0085] When securing the experimental mouse with the mouse restraint device 100, first rotate the stop 2 to move it from the inner cavity of the cylinder 1 to the outside of the cylinder 1. The experimenter can hold the support arm 3 of the cylinder 1 of the mouse restraint device 100 with one hand, so that the inner side of the cylinder 1 faces upward, and lift the tail of the experimental mouse with the other hand, bringing the head of the experimental mouse close to the inlet 13 of the cylinder 1. Due to the experimental mouse's burrowing instinct, the experimental mouse will enter the inner cavity of the cylinder 1 through the inlet 13. As the experimental mouse burrows inward, the experimenter guides the tail of the experimental mouse out of the cylinder 1 through the open end of the tail slot 121 on the open side. At this time, the head of the experimental mouse is located at the narrow end of the cylinder 1, the abdomen of the experimental mouse faces the outside of the cylinder 1, and the back faces the inside of the cylinder 1.

[0086] After the experimental mouse burrows into the cylinder 1, the stop 2 is rotated, causing it to rotate from the outside of the cylinder 1 into the inner cavity of the cylinder 1. This continues until the baffle 21 is located behind the experimental mouse, preventing the mouse from retreating and restricting its movement.

[0087] Multiple ventilation holes 14 are provided on the side of the cylinder 1 near the narrow end. After the experimental mouse is fixed in the inner cavity of the cylinder 1, the mouse head is located at the narrow end of the cylinder 1. The multiple ventilation holes 14 provided on the side of the cylinder 1 near the narrow end can ensure that the inside of the cylinder 1 is breathable and that the experimental mouse can breathe normally in the inner cavity of the cylinder 1, and avoid the experimental mouse being stimulated and struggling, which would affect the experimental operation.

[0088] The auxiliary fixing component 4 includes a base 41 and a fixing rod 42. The fixing rod 42 extends vertically and its bottom is connected to the base 41. The fixing rod 42 is engaged with the support arm 3 and the cylinder 1 at an angle. The base 41 can be placed on a stable table or horizontal surface. The auxiliary fixing component 4 is set up stably. The engagement between the fixing rod 42 and the support arm 3 and the cylinder 1 can limit the cylinder 1 of the experimental mouse fixing device 100, fixing it together on the table or other horizontal platform surface, avoiding dangerous situations such as the experimental mouse fixing device 100 with the experimental mouse being fixed falling from a height, and ensuring the stability of the cylinder 1 during the injection process, ensuring that the experimenter can inject the experimental mouse stably and safely.

[0089] Therefore, the experimental mouse fixation device 100 utilizes the burrowing nature of experimental mice to fix them, simplifying the fixation process. Furthermore, since the conical tube gradually narrows from the outside to the inside, experimental mice of different sizes and weights will burrow to different positions, making it suitable for fixing experimental mice of various sizes. Also, because the tube 1 is curved, the posture of the experimental mice burrowing into the tube 1 is fixed, and the experimental mice burrowing into the tube 1 are less likely to roll around inside the tube 1, which is more conducive to experimental operation. Before intravenous injection into the tail of the experimental mouse, the visibility of the veins on both sides of the tail can be observed by flipping the tube 1 to select the puncture point, which facilitates the experimental operation.

[0090] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0091] Although embodiments of the present invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the claims and their equivalents.

Claims

1. An experimental mouse fixing device, characterized by, The experimental mouse fixing device comprises: a barrel formed as a conical barrel bent to one side, a narrow end of the barrel being closed and the other end being formed as an inlet of the barrel, a guide slot hole being formed at a first middle line inside the barrel, and a mouse tail slot hole being formed at a second middle line outside the barrel; a stopper movably arranged in the inner cavity of the barrel along the guide slot hole through the inlet, at least a part of the stopper being matched with the guide slot hole.

2. The experimental mouse immobilization device of claim 1, wherein, The stopper comprises: a baffle arranged in the inner cavity and dividing the inner cavity of the barrel into a first space and a second space, the first space being located on a side of the baffle away from the inlet and being used for accommodating an experimental mouse; a connecting part connected with the baffle and matched with the guide slot hole, the connecting part extending out of the inner cavity.

3. The experimental mouse immobilization device of claim 2, wherein, The stopper further comprises: a limiting part rotatably connected with the connecting part between a locking position and an unlocking position; a reset part connected with the limiting part and used for driving the limiting part to move towards the locking position; wherein the limiting part is provided with a limiting portion, a plurality of limiting matching portions are arranged on the outer surface of the barrel close to the edge of the guide slot hole and sequentially arranged along the extension direction of the guide slot hole, and in the locking position, the limiting portion is adapted to be matched with any one of the limiting matching portions to fix the baffle to different depth positions in the inner cavity of the barrel.

4. The experimental mouse immobilization device of claim 3, wherein, The limiting portion forms a limiting convex part, and the limiting matching portion forms a limiting concave part, wherein the limiting convex part is provided with a limiting surface and a guide surface, and the limiting surface and the guide surface are oppositely arranged along the extension direction of the guide slot hole, wherein the included angle between the limiting surface and the extension direction of the guide slot hole is greater than the included angle between the guide surface and the extension direction of the guide slot hole.

5. The apparatus of claim 1 wherein, The first middle line is formed as a first arc segment, and the first arc segment is formed as a part of a first circle with O1 as the center and R1 as the radius; the experimental mouse fixing device further comprises a support arm connected with the barrel, and the stopper is rotatably connected with the support arm through the guide slot hole, wherein the rotation center of the stopper is located at O1.

6. The experimental mouse immobilization device of claim 5, wherein, Further comprising: an auxiliary fixing part comprising a base and a fixing rod, the fixing rod vertically extending and the bottom of the fixing rod being connected with the base, and the fixing rod being matched with the included angle between the support arm and the barrel.

7. The experimental mouse immobilization device of claim 5, wherein, The second middle line is formed as a second arc segment, and the second arc segment is formed as a part of a second circle with O2 as the center and R2 as the radius, and the first circle and the second circle are located on the same plane.

8. The experimental mouse immobilization device of claim 7, wherein, The radius of the first circle is R1, and 15mm≤R1≤100mm, and the radius of the second circle is R2, and 25mm≤R2≤200mm.

9. The experimental mouse immobilization device of claim 8, wherein, O1 is located in the first direction of O2, the distance between O1 and O2 is L, and 0mm≤L≤180mm; and / or, the inlet is located on the plane where O1 and O2 are located.

10. The experimental mouse immobilization device of claim 1, wherein, A plurality of air holes are formed on the side of the barrel close to the narrow end.

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