Breast cancer circulating tumor cell remote metastasis model
By designing the squeeze rod and collection box structure in the distant metastasis model of circulating tumor cells in breast cancer, the problem of water dripping when the ball is removed was solved, ensuring the transparency of the model and the cleanliness of the environment, extending the service life of the filter plate, and improving the stability of the model.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-21
- Publication Date
- 2026-03-31
AI Technical Summary
Existing breast cancer circulating tumor cell distant metastasis models cause water droplets to fall when the microspheres are removed after simulating tumor cell metastasis, affecting the transparency of the organ model and the cleanliness of the placement environment.
A distant metastasis model of circulating tumor cells in breast cancer was designed. By using a squeezing rod, a moving plate, and a collection box in combination, the small ball is left in the collection box when it is removed, and the water is kept in the collection box to prevent dripping. Impurities on the filter plate are cleaned by a round rod and a cleaning plate to prevent the filter holes from becoming clogged.
It enables quick removal of the ball and maintains the transparency of the model, avoiding watermarks, ensuring the transparency of the model and the cleanliness of the placement environment, while extending the service life of the filter plate and improving the stability of the model.
Smart Images
Figure CN224067326U_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of tumor cell metastasis model technology, and in particular to a distant metastasis model of circulating tumor cells in breast cancer. Background Technology
[0002] Tumor metastasis refers to the phenomenon where tumor cells spread from one part of the body to other distant tissues and organs and continue to proliferate. In order to study tumor metastasis, scientists have proposed a variety of metastasis models. Studying tumor cell metastasis models helps to reveal the molecular mechanisms of cancer metastasis, find new therapeutic targets, develop new anti-metastasis drugs, and provide a basis for clinical research.
[0003] Existing breast cancer circulating tumor cell distant metastasis models simulate tumor cell metastasis in the human body by moving different colored balls with water. However, after the simulation is completed, the balls need to be removed from the transparent organ models. This process causes water droplets to fall onto the workbench and other organ models. Over time, this leads to a large amount of scale buildup on the organ models, affecting their transparency and making it difficult for viewers to see clearly. It also affects the cleanliness of the placement environment. Utility Model Content
[0004] The purpose of this invention is to address the following shortcomings in the existing technology: Existing breast cancer circulating tumor cell distant metastasis models simulate tumor cell metastasis in the human body by moving different colored balls with water. However, after the simulation is complete, the balls need to be removed from each transparent organ model. Removing the balls causes water droplets to fall onto the workbench and other organ models. Long-term use leads to a large amount of scale buildup on the organ models, affecting their transparency and making it difficult for viewers to see clearly. It also affects the cleanliness of the placement environment. Therefore, this proposed breast cancer circulating tumor cell distant metastasis model addresses these issues.
[0005] To achieve the above objectives, the present invention adopts the following technical solution:
[0006] A breast cancer circulating tumor cell distant metastasis model includes a base and a fixing rod, wherein the fixing rod is fixedly connected to the base and a brain metastasis model is fixedly connected to the fixing rod;
[0007] The brain transfer model is equipped with a placement component, which includes an inclined plate, a fixed plate, a movable plate, a pressure plate, a straight spring, and a collection box. The inclined plate is fixedly connected inside the brain transfer model, and the fixed plate is fixedly connected to the inner wall of the brain transfer model. The fixed plate has a square through hole, and the movable plate is slidably connected inside the square through hole. Both pressure plates are fixedly connected to the fixed plate, and the straight spring is fixedly connected between the pressure plate and the movable plate. The collection box is fixedly connected to the inner wall of the brain transfer model, and a locking plate is slidably connected inside the collection box. The locking plate has a locking groove, and one end of the locking plate has a handle. The locking plate is slidably connected to the collection box.
[0008] Preferably, a filter plate is fixedly connected inside the brain transfer model, a cleaning plate is slidably connected to the outer surface of the filter plate, and a cylinder is fixedly connected to the inner wall of the brain transfer model.
[0009] Preferably, a square rod is slidably connected inside the cylinder, and the end of the square rod away from the cylinder is fixedly connected to the cleaning plate. A squeezing rod is slidably connected inside the brain transfer model, and the squeezing rod passes through the brain transfer model and is fixedly connected to the moving plate.
[0010] Preferably, a round rod is slidably connected inside the brain transfer model, the round rod passes through the brain transfer model and is fixedly connected to the cleaning plate, and a straight plate is provided between the round rod and the extrusion rod.
[0011] Preferably, a breast model is fixedly connected to the fixing rod, and multiple red balls, multiple yellow balls, and multiple blue balls are slidably connected inside the breast model. A lung transfer model and a bone transfer model are fixedly connected to the fixing rod. A water storage box is fixedly connected to the base, and a water outlet pipe is fixedly connected inside the bone transfer model.
[0012] Preferably, the breast model is connected to the brain transfer model, the brain transfer model is connected to the lung transfer model, the lung transfer model is connected to the bone transfer model, a circulation pump is fixedly connected to the base, a water pump is provided between the circulation pump and the water storage box, the water storage box is connected to the circulation pump through the water pump, and the circulation pump is connected to the breast model through a water delivery pipe.
[0013] Compared with the prior art, the beneficial effects of this utility model are:
[0014] 1. The combination of components such as the squeezing rod, the moving plate, and the collection box allows the clamping plate to hold the small balls of different colors. Pulling the clamping plate removes the small balls, and the residual water will remain in the collection box, thus enabling the quick removal of the small balls. At the same time, no water will drip onto the outer surface of the model, avoiding watermarks on the outer surface of the model that would affect the transparency of the model and ensuring the transparency of the organ model and the cleanliness of the placement environment.
[0015] 2. The cleaning plate acts on the filter plate through the cooperation of parts such as round rods, cylinders, and square rods, hanging the residual impurities on the filter plate and preventing the accumulation of impurities in the water due to long-term water flow, which would cause the filter holes on the filter plate to become clogged and lose its screening function for balls of different radii. This improves the service life of the filter plate and also improves the overall stability of the model, preventing clogging.
[0016] 3. By combining components such as breast cancer models, brain metastasis models, lung metastasis models, and bone metastasis models, the process of tumor cell metastasis can be presented, which helps to reveal the molecular mechanism of cancer metastasis and provides a basis for clinical research. Attached Figure Description
[0017] Figure 1 This is a frontal structural diagram of the breast cancer circulating tumor cell distant metastasis model proposed in this utility model;
[0018] Figure 2 This is a schematic diagram of the brain metastasis model of the distant metastasis model of circulating tumor cells in breast cancer proposed in this utility model.
[0019] Figure 3 This is a schematic diagram of the collection box structure for the breast cancer circulating tumor cell distant metastasis model proposed in this utility model.
[0020] Figure 4 This is a schematic diagram of the breast model structure for the distant metastasis model of circulating tumor cells in breast cancer proposed in this invention.
[0021] In the diagram: 1. Base, 2. Fixing rod, 3. Breast model, 4. Brain metastasis model, 5. Lung metastasis model, 6. Bone metastasis model, 7. Water storage box, 8. Circulation pump, 9. Water supply pipe, 10. Water outlet pipe, 11. Inclined plate, 12. Fixing plate, 13. Moving plate, 14. Pressure plate, 15. Straight spring, 16. Collection box, 17. Clamping plate, 18. Filter plate, 19. Cleaning plate, 20. Cylinder, 21. Square rod, 22. Squeezing rod, 23. Round rod, 24. Red ball, 25. Yellow ball, 26. Blue ball. Detailed Implementation
[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.
[0023] The terms used in this utility model, such as "upper", "lower", "left", "right", "middle" and "one", are only for clarity of description and are not intended to limit the scope of implementation of this utility model. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered as within the scope of implementation of this utility model.
[0024] Reference Figures 1-4 A breast cancer circulating tumor cell distant metastasis model includes a base 1 and a fixing rod 2. The fixing rod 2 is fixedly connected to the base 1, and a brain metastasis model 4 is fixedly connected to the fixing rod 2.
[0025] The brain transfer model 4 is equipped with placement components, including an inclined plate 11, a fixed plate 12, a movable plate 13, a pressure plate 14, a straight spring 15, and a collection box 16. The inclined plate 11 is fixedly connected inside the brain transfer model 4, and its function is to facilitate the flow of water to the filter plate 18. The fixed plate 12 is fixedly connected to the inner wall of the brain transfer model 4, and the fixed plate 12 has a square through hole. The movable plate 13 is slidably connected inside the square through hole. Both pressure plates 14 are fixedly connected to the fixed plate 12. The straight spring 15 is fixedly connected between the pressure plate 14 and the movable plate 13. The collection box 16 is fixedly connected to the inner wall of the brain transfer model 4. A locking plate 17 is slidably connected inside the collection box 16. The locking plate 17 has a locking groove, the diameter of which is larger than the diameter of the small balls of different colors, so as to facilitate locking the small balls. One end of the locking plate 17 has a handle, and the locking plate 17 is slidably connected to the collection box 16.
[0026] A filter plate 18 is fixedly connected inside the brain transfer model 4. The brain transfer model 4 is made of transparent glass for easy viewing. A cleaning plate 19 is slidably connected to the outer surface of the filter plate 18. A cylinder 20 is fixedly connected to the inner wall of the brain transfer model 4. A square rod 21 is slidably connected inside the cylinder 20. A return spring is provided between the square rod 21 and the bottom wall of the cylinder 20. The end of the square rod 21 away from the cylinder 20 is fixedly connected to the cleaning plate 19. A compression rod 22 is slidably connected inside the brain transfer model 4. The compression rod 22 passes through the brain transfer model 4 and is fixedly connected to the moving plate 13. A round rod 23 is slidably connected inside the brain transfer model 4. The round rod 23 passes through the brain transfer plate 13. Model 4 is fixedly connected to the cleaning plate 19. A straight plate is provided between the round rod 23 and the extrusion rod 22. A breast model 3 is fixedly connected to the fixing rod 2. Multiple red balls 24, multiple yellow balls 25, and multiple blue balls 26 are slidably connected inside the breast model 3. The radius of the red balls 24 is larger than the radius of the blue balls 26, and the radius of the blue balls 26 is larger than the radius of the yellow balls 25. The breast model 3 has a placement opening for placing some props. The filter hole radius of the filter plate 18 inside the brain transfer model 4 is larger than the yellow balls 25 and blue balls 26, but smaller than the red balls 24, which will block the red balls 24 inside the brain transfer model 4. A lung transfer model 5 is fixedly connected to the fixed rod 2. The lung transfer model 5 also contains the same placement component. The lung transfer model 5 has filter plates 18 with different filter hole radii. The filter hole radius of this filter plate 18 is slightly larger than that of the yellow ball 25 but smaller than that of the blue ball 26, thus blocking the blue ball 26 inside the lung transfer model 5. A bone transfer model 6 is fixedly connected to the fixed rod 2. Both the lung transfer model 5 and the bone transfer model 6 are made of transparent glass. The bone transfer model 6 has the same placement component installed inside. The bone transfer model 6 also contains filter plates 18 with different filter hole radii. The filter hole radius of this filter plate 18 is slightly smaller than that of the yellow ball 25, thus… The yellow ball 25 will be blocked inside the bone transfer model 6. A water storage box 7 is fixedly connected to the base 1. A water outlet pipe 10 is fixedly connected inside the bone transfer model 6. The water outlet pipe 10 is used to drain the water flowing into the entire model. The breast model 3 is connected to the brain transfer model 4. The brain transfer model 4 is connected to the lung transfer model 5. The lung transfer model 5 is connected to the bone transfer model 6. A circulation pump 8 is fixedly connected to the base 1. The circulation pump 8 is existing technology. Its working principle is similar to that of water pumps in existing technology. A water suction pipe is provided between the circulation pump 8 and the water storage box 7. The water storage box 7 is connected to the circulation pump 8 through the water suction pipe. The circulation pump 8 is connected to the breast model 3 through the water delivery pipe 9.
[0027] In this invention, multiple red balls 24, yellow balls 25, and blue balls 26 are first placed into a breast model 3. The circulation pump 8 is activated to draw water from the water storage box 7 into the breast model 3. The switch inside the breast model 3 is then turned on, allowing the water, carrying the red balls 24, yellow balls 25, and blue balls 26, to enter the brain transfer model 4. Under the action of the inclined plate 11, the water containing the various colors acts on the filter plate 18. The filter holes on the filter plate 18 block the red balls 24. The red ball 24 will stop on the fixed plate 12. As the water continues to move, the water carries the other two colored balls into the lung metastasis model 5. The filter plate 18 in the lung metastasis model 5 will block the blue ball 26, so the yellow ball 25 and the rest of the water will pass through the filter plate 18 into the bone metastasis model 6. The filter plate 18 in the bone metastasis model 6 will block the yellow ball 25. The remaining water will return to the water storage box 7 through the water outlet pipe 10, completing the entire simulated tumor cell metastasis process.
[0028] When it is necessary to remove the red ball 24, yellow ball 25, and blue ball 26 from their respective models, pressing the straight plate between the extrusion rod 22 and the round rod 23 causes the straight plate to move the extrusion rod 22 and the round rod 23. The extrusion rod 22 pushes the moving plate 13 downward, exposing the square through hole on the fixed plate 12. This allows the small balls on the fixed plate 12 and some residual water to fall into the collection box 16. The locking plate 17 inside the collection box 16 will hold these small balls in place, preventing them from falling onto the bottom wall of the collection box 16. The residual water will fall onto the bottom wall of the collection box 16, thus separating the small balls from the water. Then, pulling the handle on one side of the locking plate 17 will remove the locking plate 17 from the collection box 16 and the model, thereby achieving the removal of the small balls from the model. The small balls are quickly removed without water dripping onto the outer surface of the model, preventing watermarks that could affect the model's transparency and ensuring the clarity of the organ model and the cleanliness of its placement environment. The cleaning plate 19 moves along with the circular rod 23, removing residual impurities from the filter plate 18. This prevents impurities from accumulating on the filter plate 18 due to prolonged water flow, which could clog the filter holes and impair its ability to filter balls of different radii. This extends the lifespan of the filter plate 18 and improves the overall stability of the model, preventing clogging. The scraped-off impurities eventually enter the water storage box 7 with the water flow, preventing their accumulation inside the model.
[0029] In this utility model, unless otherwise explicitly specified and limited, the terms "installation", "connection", "linking", "fixing", etc., should be interpreted broadly.
[0030] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.
Claims
1. A model for distant metastasis of circulating tumor cells of breast cancer, comprising a base (1) and a fixing rod (2), characterized in that, The fixed rod (2) is fixedly connected to the base (1), and the fixed rod (2) is fixedly connected with a brain metastasis model (4); The brain metastasis model (4) is provided with a placing component, the placing component comprises an inclined plate (11), a fixed plate (12), a moving plate (13), a pressure plate (14), a straight spring (15), a collecting box (16), the inclined plate (11) is fixedly connected in the brain metastasis model (4), the fixed plate (12) is fixedly connected to the inner wall of the brain metastasis model (4), the fixed plate (12) is provided with a square through hole, the moving plate (13) is slidably connected in the square through hole, two pressure plates (14) are fixedly connected to the fixed plate (12), the straight spring (15) is fixedly connected between the pressure plate (14) and the moving plate (13), the collecting box (16) is fixedly connected to the inner wall of the brain metastasis model (4), the collecting box (16) is slidably connected with a clamping plate (17), the clamping plate (17) is provided with a clamping groove, one end of the clamping plate (17) is provided with a handle, and the clamping plate (17) is slidably connected with the collecting box (16).
2. The breast cancer circulating tumor cell metastasis model of claim 1, wherein, The brain metastasis model (4) is fixedly connected with a filter plate (18), the filter plate (18) is slidably connected with a cleaning plate (19), and the brain metastasis model (4) is fixedly connected with a cylinder (20).
3. The breast cancer circulating tumor cell metastasis model of claim 2, wherein, The cylinder (20) is slidably connected with a square rod (21), one end of the square rod (21) away from the cylinder (20) is fixedly connected with the cleaning plate (19), the brain metastasis model (4) is slidably connected with an extrusion rod (22), and the extrusion rod (22) is fixedly connected with the moving plate (13) and passes through the brain metastasis model (4).
4. The breast cancer circulating tumor cell metastasis model of claim 3, wherein, The brain metastasis model (4) is slidably connected with a round rod (23), the round rod (23) is fixedly connected with the cleaning plate (19) and passes through the brain metastasis model (4), and a straight plate is arranged between the round rod (23) and the extrusion rod (22).
5. The breast cancer circulating tumor cell metastasis model of claim 1, wherein, The fixed rod (2) is fixedly connected with a breast model (3), the breast model (3) is slidably connected with a plurality of red balls (24), the breast model (3) is slidably connected with a plurality of yellow balls (25), the breast model (3) is slidably connected with a plurality of blue balls (26), the fixed rod (2) is fixedly connected with a lung metastasis model (5), the fixed rod (2) is fixedly connected with a bone metastasis model (6), the base (1) is fixedly connected with a water storage box (7), and the bone metastasis model (6) is fixedly connected with a water outlet pipe (10).
6. The breast cancer circulating tumor cell metastasis model of claim 5, wherein, The breast model (3) is communicated with the brain metastasis model (4), the brain metastasis model (4) is communicated with the lung metastasis model (5), the lung metastasis model (5) is communicated with the bone metastasis model (6), the base (1) is fixedly connected with circulating pump (8), circulating pump (8) and the water pump between the water storage box (7) are equipped with, the water storage box (7) is communicated with circulating pump (8) through the water pump, circulating pump (8) is communicated with the breast model (3) through water pipe (9).