Molecular sieve device for detecting blood type irregular antibody

Abstract

The utility model relates to the technical field of medical equipment, and discloses a molecular sieve device for detecting irregular blood antibodies, which comprises a microcolumn single card, a plurality of microcolumn gel tubes are mounted on the inner wall of the top of the microcolumn single card, a sealing mechanism is arranged at the top of the microcolumn single card, a supporting mechanism is arranged at the bottom of the microcolumn single card, and the microcolumn gel tubes are arranged on the supporting mechanism. The sealing mechanism comprises a rotating cover, the bottom of the rotating cover is rotationally connected to the top of the micro-column single clamp, extension blocks are fixedly connected to the two sides of the bottom of the rotating cover, first springs are fixedly connected to the inner walls of the extension blocks, and the other ends of the first springs are fixedly connected with moving blocks; and the other end of the moving block is fixedly connected with a clamping block. According to the utility model, the circular bead design of the clamping block is in good contact with the inner wall of the micro-column single card, the sealing ring is combined to form a sealing effect, the state of a sample is reserved to the maximum extent, and the application of the spring enables the clamping block to quickly restore the position when the micro-column single card is attached to the rotating cover.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a molecular sieve device for detecting irregular blood type antibodies. Background Technology

[0002] Irregular antibody testing for blood types is an important test in transfusion medicine and immunology. It is used to identify atypical antibodies that may be present in the blood. These antibodies can affect blood transfusions and pregnancy, so timely and accurate detection is crucial. Molecular sieve materials can selectively allow certain molecules to pass through while blocking others, thereby achieving separation. They are often used to separate antibodies, antigens, and other blood components, ensuring sample purity and reducing interference.

[0003] A search revealed a Chinese publication (CN203310840U) disclosing a microcolumn gel card, comprising a card body and eight microcolumn gel tubes. The eight microcolumn gel tubes are evenly arranged within the card body. Each microcolumn gel tube includes a large upper column, a reaction chamber, and a small lower column. The large upper column is positioned above the small lower column, and the reaction chamber connects the large upper column and the small lower column. The small lower column has a flattened inner cavity. The distance between any two adjacent microcolumn gel tubes is 8.5 mm. The cross-section of the inner cavity of the small lower column is rectangular or elliptical. This invention, with equal cross-sectional areas of the inner cavity of the small lower column, can increase the pore width, making experimental results clearer and reducing the probability of misinterpretation. With the same pore width of the inner cavity of the small lower column, it can reduce the amount of antibodies and gel used in producing the gel card, lowering production costs. The flattened external structure of the small lower column also facilitates operation and machine installation.

[0004] While the aforementioned patent can reduce the probability of misjudgment during use, the top of the gel tube is exposed to air during use, which poses a risk of contamination during the detection process and affects the final detection structure. Therefore, a molecular sieve device for detecting irregular antibodies in blood types is proposed to solve the above problems. Utility Model Content

[0005] To overcome the above shortcomings, this invention provides a molecular sieve device for detecting irregular blood type antibodies, aiming to improve the problem in the prior art where the top of the gel tube is exposed to air, which poses a risk of contamination during the detection process.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A molecular sieve device for detecting irregular blood type antibodies includes a microcolumn single card, wherein a plurality of microcolumn gel tubes are installed on the top inner wall of the microcolumn single card, a sealing mechanism is provided at the top of the microcolumn single card, and a support mechanism is provided at the bottom of the microcolumn single card.

[0008] The sealing mechanism includes a rotating cover, the bottom of which is rotatably connected to the top of the micro-pillar card. Extension blocks are fixedly connected to both sides of the bottom of the rotating cover. A spring is fixedly connected to the inner wall of the extension block. A moving block is fixedly connected to the other end of the spring. A locking block is fixedly connected to the other end of the moving block. A pushing component is slidably connected to the front end of the micro-pillar card. Multiple sealing rings are fixedly connected to the bottom of the rotating cover.

[0009] The above technical solution allows for easy opening and closing of the rotating cap. When closed, the locking block and the moving block cooperate to prevent accidental opening and enhance sealing. The micropillar gel tube at the top of the micropillar single card provides a favorable environment for antibody-sample reaction, promoting antibody aggregation, improving detection accuracy, and simplifying operation. This makes sample addition and subsequent detection processes smooth, thereby ensuring the reliability and efficiency of the detection results.

[0010] As a further description of the above technical solution:

[0011] The pushing assembly includes two pushing rods, which are slidably connected to the front end of the micro-column single card. A limiting block is fixedly connected to the bottom of the pushing rod, and a spring is fixedly connected to one side of the limiting block.

[0012] With the above technical solution, when the operator pushes the lever, the limiting block will move, and the second spring provides support force to ensure the smoothness of the operation and help to easily open the rotating cover of the micro-column single card, thereby facilitating the addition of samples.

[0013] As a further description of the above technical solution:

[0014] A push block is fixedly connected to one side of the push rod, and the other end of the spring is fixedly connected to the inner wall of the micro-column single card;

[0015] The above technical solution enables the push rod to be reset via the second spring.

[0016] As a further description of the above technical solution:

[0017] One side of the push rod contacts one side of the locking block, and the outer side of the moving block is slidably connected to the inner wall of the extension block;

[0018] The above technical solution uses a push rod and a locking block as a base, enabling the push rod to move the locking block, while the extension block restricts the movement of the moving block.

[0019] As a further description of the above technical solution:

[0020] The support mechanism includes two fixed columns. The top of the fixed columns is fixedly connected to the bottom of the micro-column single card. A sliding ring is slidably connected to the outside of the fixed columns. Support rods are rotatably connected to both sides of the sliding ring. A connecting rod is fixedly connected to the bottom of the fixed columns. Fixing blocks are rotatably connected to both sides of the connecting rod. The other end of the fixing block is rotatably connected to one side of the support rod.

[0021] Through the above technical solution, the support rod is rotatably connected to both sides of the sliding ring, ensuring the flexibility of the support. The fixing block at the bottom of the connecting rod further enhances the stability of the overall structure, ensuring that the microcolumn single clamp remains stable during operation, facilitating reliable experimental operation. This structural design improves the safety and effectiveness of the equipment.

[0022] As a further description of the above technical solution:

[0023] The bottom of the sealing ring contacts the top of the micro-pillar card, and the outside of the card block engages with the slot of the micro-pillar card.

[0024] Through the above technical solution, when the rotating cover is closed, the locking block engages with the slot of the micro-column single-clamp, ensuring the rotating cover is firmly fixed and further enhancing the sealing performance. This design guarantees the stability of the internal reaction environment and improves the accuracy and reliability of the detection.

[0025] As a further description of the above technical solution:

[0026] The microcolumn gel tube includes multiple reaction layers, which are placed on top of the microcolumn single card. A filter layer is fixedly connected to the bottom of the reaction layer, and a detection layer is fixedly connected to the bottom of the filter layer.

[0027] With the above technical solution, a filter layer is fixed at the bottom of the reaction layer to remove impurities and ensure the purity of the sample. The detection layer is fixed below the filter layer to detect and analyze the reaction results. This structure ensures the efficiency and accuracy of the detection process and improves the reliability of the experiment.

[0028] As a further description of the above technical solution:

[0029] The limiting block is externally slidably connected to the inner wall of the micro-pillar card, and the top two sides of the micro-pillar card are provided with through holes larger than the extension block.

[0030] The above technical solution allows the micro-pillar card to restrict the limiting block, while the through hole allows the extension block to enter the interior of the micro-pillar card.

[0031] This utility model has the following beneficial effects:

[0032] 1. In this utility model, the rounded corner design of the locking block ensures good contact with the inner wall of the micropillar card, forming a sealing effect in conjunction with the sealing ring, thus preserving the sample's state to the greatest extent. The application of the spring allows the locking block to quickly return to its position when the micropillar card and the rotating cover are in contact, ensuring the stability of the sealing performance. Simultaneously, the opening process is simple, and the push block design ensures that the user can easily unlock the rotating cover, improving the overall ease and reliability of operation. This design greatly enhances the practicality and sealing effect of the micropillar card.

[0033] 2. In this invention, the stabilization process of the micro-column single card is simplified by the operation of the sliding ring. The rotation of the support rod effectively supports the card body, avoiding the complexity of the card holder required by traditional single cards, thereby improving operational convenience. In addition, the collaborative mechanism between the support rod and the connecting rod allows for a compact design during storage, saving space and facilitating carrying and storage. This improvement not only enhances the user experience but also reduces the risk of operational errors, improving the efficiency and accuracy of experiments. Attached Figure Description

[0034] Figure 1 This is a three-dimensional schematic diagram of a molecular sieve device for detecting irregular antibodies in blood type proposed in this utility model;

[0035] Figure 2 This is a schematic diagram of the sealing ring of a molecular sieve device for detecting irregular antibodies in blood types, as proposed in this utility model.

[0036] Figure 3 for Figure 2 Enlarged view of point A in the middle;

[0037] Figure 4 for Figure 2 Enlarged view of point B in the middle.

[0038] Legend:

[0039] 1. Microcolumn single card; 2. Microcolumn gel tube; 21. Reaction layer; 22. Filter layer; 23. Detection layer; 3. Sealing mechanism; 301. Rotating cap; 302. Extension block; 303. Spring one; 304. Moving block; 305. Locking block; 306. Pushing assembly; 3061. Pushing rod; 3062. Restricting block; 3063. Spring two; 3064. Pushing block; 307. Sealing ring; 4. Support mechanism; 41. Fixed column; 42. Sliding ring; 43. Support rod; 44. Connecting rod; 45. Fixed block. Detailed Implementation

[0040] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0041] Reference Figure 2 and Figure 3 The present invention provides an embodiment of a molecular sieve device for detecting irregular blood type antibodies, comprising a microcolumn single card 1, wherein multiple microcolumn gel tubes 2 are installed on the inner wall of the top of the microcolumn single card 1, which enable the sample to react fully within the microcolumn, thereby improving the sensitivity and accuracy of the detection. A sealing mechanism 3 is provided at the top of the microcolumn single card 1 to prevent the sample from leaking during the detection process, thereby ensuring the reliability of the detection results. A support mechanism 4 is provided at the bottom of the microcolumn single card 1. This design not only provides the necessary stability, but also facilitates the placement of the microcolumn single card 1 in different environments.

[0042] The microcolumn gel tube 2 includes multiple reaction layers 21, which are placed on top of the microcolumn single card 1 to effectively increase the contact area with the sample, thereby improving the reaction efficiency. A filter layer 22 is fixedly connected to the bottom of the reaction layer 21, and a detection layer 23 is fixedly connected to the bottom of the filter layer 22. This structural design allows the sample after the reaction to undergo three-stage filtration, ensuring that the final detection result is pure and not affected by other factors. The sealing mechanism 3 includes a rotating cover 301, whose sealing effect ensures that the internal environment is not contaminated by the outside, thus improving the accuracy of the experiment.

[0043] The bottom of the rotating cover 301 is rotatably connected to the top of the micro-pillar single card 1, making it easy for operators to open and close during use. Extension blocks 302 are fixedly connected to both sides of the bottom of the rotating cover 301. Spring 303 is fixedly connected to the inner wall of the extension block 302. When the rotating cover 301 is closed, spring 303 provides the necessary pressure to enhance the sealing effect. The other end of spring 303 is fixedly connected to a moving block 304. The other end of the moving block 304 is fixedly connected to a locking block 305. The locking block 305 engages with the slot of the micro-pillar single card 1 to prevent the rotating cover 301 from opening accidentally, thereby ensuring the safety of operation.

[0044] Specifically, when using the microcolumn single card 1, the sample is first injected. The irregular antibodies in the sample bind to the anti-human globulin reagent in the reaction layer 21, forming agglomerates. The specific gel particles inside the microcolumn gel tube 2 provide an ideal reaction environment for this, effectively promoting antibody aggregation. After the reaction, the sample flows through the filter layer 22. The design of the filter layer 22 ensures that impurities and unbound substances are removed. Finally, the filtered sample passes through the detection layer 23. This layer makes the final data purer and more reliable, thereby improving the accuracy of the detection results. Furthermore, the sealing design of the rotating cover 301 ensures that the internal environment is not contaminated by the outside world throughout the process, avoiding possible errors during the experiment. During operation, the rotating cover 301 can be easily opened and closed, thanks to its rotating connection design with the top of the microcolumn single card 1. When the rotating cover 301 is closed, the spring 303 will apply pressure to further enhance the sealing effect, ensuring that the sample does not leak during the reaction process, thereby improving the safety and reliability of the experiment. Ultimately, the combination of this series of designs and operations makes the detection process of irregular blood type antibodies efficient and accurate.

[0045] refer to Figure 3 and Figure 4 The front end of the micro-pillar single card 1 is slidably connected to a pushing component 306. The design of the pushing component 306 makes operation simpler; the operator only needs to push gently to open the cover. The pushing component 306 includes two pushing rods 3061, which are slidably connected to the front end of the micro-pillar single card 1, effectively reducing force consumption. A limiting block 3062 is fixedly connected to the bottom of the pushing rod 3061. During the pushing operation, the limiting block 3062 prevents accidental contact, giving the user greater peace of mind. A second spring 3063 is fixedly connected to one side of the limiting block 3062. The second spring 3063 provides support force when the pushing component 306 is in operation, ensuring stability during pushing.

[0046] A push block 3064 is fixedly connected to one side of the push rod 3061. The push block 3064 is structurally designed so that the rotating cover 301 can be opened with a simple push. The other end of the spring 3063 is fixedly connected to the inner wall of the micro-pillar single card 1. This structure allows for quick return when needed, providing users with a smoother operating experience. One side of the push rod 3061 contacts one side of the card block 305, reducing starting resistance and making the overall operation easier.

[0047] The external sliding connection of the movable block 304 to the inner wall of the extension block 302 facilitates smooth operation between components. The external sliding connection of the limiting block 3062 to the inner wall of the micropillar single card 1 further improves the stability of the overall structure. The top two sides of the micropillar single card 1 are provided with through holes larger than those of the extension block 302. This design not only enhances airflow but also helps control sample flow during the detection process.

[0048] Specifically, the operator only needs to gently push the push rod 3061. The sliding connection design of the rod reduces the required force, making the entire operation more convenient. The bottom of the push rod 3061 is connected to a limiting block 3062, which prevents accidental contact and ensures user safety. During the pushing process, the spring 3063 provides the necessary support force to ensure the smoothness of the pushing process and quickly returns to its original position after release, thereby enhancing the smoothness of operation. The contact design between the push block 3064 and the rotating cover 301 is reasonable, allowing the rotating cover 301 to be easily opened when pushed. The sliding connection between the moving block 304 and the extension block 302 promotes the coordinated operation between the components and improves the overall stability of the system. In addition, the through-hole design at the top of the micro-column single card 1 promotes smooth airflow and helps control the flow of the sample during the reaction process. This series of designs and functions makes the detection operation more efficient and smooth.

[0049] refer to Figure 1 The support mechanism 4 includes two fixed columns 41, the tops of which are fixedly connected to the bottom of the micro-column single card 1, ensuring the stability of the entire device during use. A sliding ring 42 is slidably connected to the outside of the fixed columns 41, allowing the sliding ring 42 to move freely within the support mechanism 4, thus providing better flexibility and adaptability. Support rods 43 are rotatably connected to both sides of the sliding ring 42. Through this support structure, the angle adjustment of the support rods 43 can effectively adapt to different platform or space requirements.

[0050] A connecting rod 44 is fixedly connected to the bottom of the fixed column 41, and fixing blocks 45 are rotatably connected to both sides of the connecting rod 44, ensuring the stability and durability of the support mechanism 4, so that the micro-column single card 1 can remain vertical even on uneven surfaces. This design not only improves the practicality of the equipment, but also effectively extends its service life, providing the laboratory with a more reliable testing tool;

[0051] Specifically, the working principle of the support mechanism 4 is mainly reflected in its design structure, ensuring the stability and flexibility of the micro-column single card 1 in various environments. The top of the fixed column 41 is firmly connected to the bottom of the micro-column single card 1, providing a strong support foundation for the entire device. On this basis, the externally sliding ring 42 can move freely, allowing the support mechanism 4 to adapt to different usage scenarios. The rotational connection between the support rod 43 and the sliding ring 42 allows users to adjust according to the height and angle of the platform, ensuring that the micro-column single card 1 remains vertical on uneven or inclined surfaces, improving the applicability and stability of the device. At the same time, the combination of the connecting rod 44 and the fixing block 45 enhances the durability of the support mechanism 4, enabling it to maintain good performance even after long-term use. This design flexibility not only optimizes the convenience of operation but also effectively extends the service life of the device, providing the laboratory with a more reliable and stable testing tool, thereby improving the accuracy and efficiency of blood type irregular antibody detection.

[0052] Working principle: When microcolumn single card 1 is needed, the anti-human globulin reagent in the reaction layer 21 combines with the irregular antibodies in the sample to form agglomerates. After passing through the filter layer 22, the sample is finally collected through the detection layer 23. The microcolumn gel tube 2 is filled with specific gel particles, which enables efficient and accurate detection.

[0053] By sliding the sliding ring 42, the support rod 43 can be rotated. The rotation of the support rod 43 can drive the connecting rod 44 to rotate, and finally the support rod 43 touches the ground, thus stabilizing the micro-column single card 1. Compared with the traditional single card, it is more convenient to use, and no card seat is needed. By pushing the sliding ring 42 upward, the sliding ring 42 drives the support rod 43 to rotate, which controls the rotation of the connecting rod 44. The support rod 43 and the connecting rod 44 can be stored in the groove of the micro-column single card 1 in a nearly parallel manner.

[0054] Finally, during the use of the micro-pillar single card 1, rotating the rotating cover 301 can drive the extension block 302 to rotate. At this time, the card block 305 will contact the inner wall of the micro-pillar single card 1. The bottom of the card block 305 is provided with rounded corners, which will cause the card block 305 to be squeezed. At this time, the card block 305 will move. The movement of the card block 305 pushes the moving block 304 to compress the spring 303, so that the card block 305 can retract into the interior of the extension block 302. When the micro-pillar single card 1 is in contact with the rotating cover 301, the spring 303 will release elastic potential energy to push the moving block 304 to drive the card block 305 to move, so that the card block... The 305 movement resets and engages with the inner wall of the micropillar single card 1. During the engagement process, the sealing ring 307 abuts against the micropillar single card 1 to achieve a seal on the micropillar gel tube 2. When it is necessary to open the rotating cover 301, simply push the push block 3064. Under the push of the push block 3064, the push rod 3061 moves. At this time, the push rod 3061 contacts the card block 305, so that the card block 305 can retract, thereby allowing the rotating cover 301 to open. The movement of the push rod 3061 will cause the limiting block 3062 to compress the spring 3063, thereby allowing the push rod 3061 to reset.

[0055] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A molecular sieve device for detecting blood group irregular antibodies, comprising a microcolumn single card (1), characterized in that: The micropillar single card (1) has multiple micropillar gel tubes (2) installed on the top inner wall, a sealing mechanism (3) is provided on the top of the micropillar single card (1), and a support mechanism (4) is provided on the bottom of the micropillar single card (1). The sealing mechanism (3) includes a rotating cover (301), the bottom of which is rotatably connected to the top of the micro-pillar single card (1). Extension blocks (302) are fixedly connected to both sides of the bottom of the rotating cover (301). A spring (303) is fixedly connected to the inner wall of the extension block (302). A moving block (304) is fixedly connected to the other end of the spring (303). A card block (305) is fixedly connected to the other end of the moving block (304). A pushing component (306) is slidably connected to the front end of the micro-pillar single card (1). Multiple sealing rings (307) are fixedly connected to the bottom of the rotating cover (301).

2. The molecular sieve device for detecting irregular antibodies in blood types according to claim 1, characterized in that: The pushing assembly (306) includes two pushing rods (3061), which are slidably connected to the front end of the micro-pillar single card (1). A limiting block (3062) is fixedly connected to the bottom of the pushing rod (3061), and a spring (3063) is fixedly connected to one side of the limiting block (3062).

3. The molecular sieve device for detecting blood group irregular antibodies according to claim 2, characterized in that: A push block (3064) is fixedly connected to one side of the push rod (3061), and the other end of the spring (3063) is fixedly connected to the inner wall of the micro-column single card (1).

4. The molecular sieve device for detecting blood group irregular antibody according to claim 2, characterized in that: One side of the push rod (3061) is in contact with one side of the locking block (305), and the outside of the moving block (304) is slidably connected to the inner wall of the extension block (302).

5. The molecular sieve device for detecting blood group irregular antibody according to claim 1, characterized in that: The support mechanism (4) includes two fixed columns (41). The top of the fixed column (41) is fixedly connected to the bottom of the micro-column single card (1). A sliding ring (42) is slidably connected to the outside of the fixed column (41). Support rods (43) are rotatably connected to both sides of the sliding ring (42). A connecting rod (44) is fixedly connected to the bottom of the fixed column (41). Fixing blocks (45) are rotatably connected to both sides of the connecting rod (44). The other end of the fixing block (45) is rotatably connected to one side of the support rod (43).

6. The molecular sieve device for detecting blood group irregular antibody according to claim 1, characterized in that: The bottom of the sealing ring (307) is in contact with the top of the micro-pillar card (1), and the outside of the card block (305) is engaged with the slot of the micro-pillar card (1).

7. The molecular sieve device for detecting irregular antibodies in blood types according to claim 1, characterized in that: The microcolumn gel tube (2) includes multiple reaction layers (21), which are placed on top of the microcolumn single card (1). A filter layer (22) is fixedly connected to the bottom of the reaction layer (21), and a detection layer (23) is fixedly connected to the bottom of the filter layer (22).

8. The molecular sieve device for detecting blood group irregular antibody according to claim 2, characterized in that: The limiting block (3062) is externally slidably connected to the inner wall of the micro-pillar card (1), and the top two sides of the micro-pillar card (1) are provided with through holes larger than the extension block (302).

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