Pressure maintaining type virus removal filter

Abstract

The utility model provides a pressure maintaining type virus removal filter which is characterized in that elastic membrane mounting seats are connected in a liquid inlet pipe and a liquid outlet pipe of the filter in a sealing manner, elastic membranes are assembled on the elastic membrane mounting seats, and cross-shaped openings are formed in the elastic membranes; the elastic membrane comprises an extrusion part, a connecting part and a convex part, an annular clamping groove is formed in the elastic membrane mounting seat, the extrusion part is tightly clamped in the annular clamping groove, the cross-shaped opening is formed in the convex part, the convex part protrudes towards the direction of the filter, and the opening and closing of the cross-shaped opening are controlled through the internal and external pressure difference of the elastic membrane so as to ensure the internal pressure of the filter. According to the pressure maintaining type virus removal filter, the elastic membranes are arranged in the liquid inlet pipe and the liquid outlet pipe, opening and closing of the cross-shaped opening are controlled through the internal and external pressure difference of the elastic membranes, when the pressure is interrupted, the cross-shaped opening of the elastic membranes is closed, liquid cannot pass through the cross-shaped opening, and certain pressure is kept in the filter; therefore, the virus penetration risk caused by pressure interruption is reduced.

Description

Technical Field

[0001] This utility model relates to the field of filter technology, and in particular to a pressure-holding virus removal filter. Background Technology

[0002] In the viral clearance process of biopharmaceuticals, viral filtration is a core step in ensuring the safety of drugs against viruses. Current mainstream viral filtration membranes (such as...) DV20 PRO (Proteinized Interference Membrane) and other membrane technologies achieve virus retention based on size exclusion and adsorption mechanisms. Their designs typically include multi-layered asymmetric membrane structures (pre-filter layer + precision retention layer) and rigid sealing components. However, pressure release phenomena (such as buffer switching, sudden pump rate changes, or transient pressure drops caused by peristaltic pump pulsation) can trigger abnormal membrane dynamics, leading to viral penetration. Specifically, this manifests as follows:

[0003] 1. Changes in viral migration pathways: A sudden drop in pressure weakens convection, allowing viral particles that were originally trapped on the membrane surface or in small pores to escape into the macroporous region and penetrate. Experiments show that the LRV value can decrease by 1-3 logarithmic orders.

[0004] 2. Disruption of adsorption equilibrium: Pressure release disrupts the dynamic balance between the virus and the membrane surface charge / hydrophobic interactions, leading to viral desorption and diffusion.

[0005] Current industry standards (such as ASTM F838 and PDA TR26) require integrity testing, but do not provide preventative design specifications for pressure interruption scenarios. Therefore, this invention provides a pressure-maintaining virus removal filter to address the aforementioned technical problems. Utility Model Content

[0006] The purpose of this utility model is to disclose a pressure-maintaining virus removal filter, which has an elastic diaphragm in the inlet and outlet pipes. The opening and closing of the cross opening is controlled by the pressure difference between the inside and outside of the elastic diaphragm. When the pressure is interrupted, the cross opening of the elastic diaphragm closes, and the liquid cannot pass through. The filter maintains a certain pressure, thereby reducing the risk of virus penetration caused by pressure interruption.

[0007] To achieve the above objectives, this utility model provides a pressure-holding virus removal filter. Both the inlet and outlet pipes of the filter are sealed with elastic diaphragm mounting seats. An elastic diaphragm is mounted on the elastic diaphragm mounting seat. The elastic diaphragm has a cross opening. The opening and closing of the cross opening is controlled by the pressure difference between the inside and outside of the elastic diaphragm to control the flow of the liquid.

[0008] In some embodiments, the elastic diaphragm includes a compression portion, a connecting portion, and a protrusion portion. The elastic diaphragm mounting base is provided with an annular groove, the compression portion is tightly held in the annular groove, the cross opening is opened on the protrusion portion, the protrusion portion protrudes towards the filter, and the connecting portion 422 is trumpet-shaped.

[0009] In some embodiments, the protrusion has an arc-shaped cross-section.

[0010] In some embodiments, the cross-shaped opening is located at the apex of the protrusion.

[0011] In some embodiments, the elastic diaphragm mounting base is provided with a through hole, and the elastic diaphragm is installed in the through hole.

[0012] In some embodiments, the filter contains a plurality of welded and stacked filter membranes.

[0013] In some embodiments, the filter has an exhaust port at the top.

[0014] In some embodiments, the bottom of the filter is provided with several supports.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows: The pressure-holding virus removal filter provided by this utility model has elastic diaphragms in the inlet and outlet pipes. The opening and closing of the cross opening is controlled by the pressure difference between the inside and outside of the elastic diaphragm. When the pressure is interrupted, the cross opening of the elastic diaphragm closes, and the liquid cannot pass through. The filter maintains a certain pressure, thereby reducing the risk of virus penetration caused by pressure interruption. Attached Figure Description

[0016] Figure 1 This is a perspective view of the pressure-holding virus removal filter shown in this utility model;

[0017] Figure 2 This is a diagram showing the internal structure of the pressure-holding virus removal filter of this utility model;

[0018] Figure 3 for Figure 2 The diagram shows the internal structure of the elastic diaphragm mounting base.

[0019] Figure 4 for Figure 3 The diagram shows a perspective view of the elastic diaphragm mounting base. Detailed Implementation

[0020] The present invention will now be described in detail with reference to the embodiments shown in the accompanying drawings. However, it should be noted that these embodiments are not intended to limit the present invention. Equivalent transformations or substitutions in function, method, or structure made by those skilled in the art based on these embodiments are all within the protection scope of the present invention.

[0021] like Figure 1-4 The pressure-holding virus removal filter shown has several welded and stacked filter membranes 11 inside the filter 1 for filtering viruses in liquid. The liquid enters the filter 1 through the inlet pipe 2, passes through the filter membranes 11 to filter viruses, and is discharged through the outlet pipe 3.

[0022] The filter 1 is provided with an exhaust port 12 at the top. When liquid is introduced, the exhaust port 12 is opened. When liquid flows out of the exhaust port 12, the exhaust port 12 is closed. The filter 1 is provided with several supports 13 at the bottom.

[0023] Both the inlet pipe 2 and the outlet pipe 3 of the filter 1 are sealed with elastic diaphragm mounting seats 41, and the liquid needs to enter and exit the filter 1 through the elastic diaphragm mounting seats 41.

[0024] An elastic diaphragm 42 is mounted on the elastic diaphragm mounting base 41, and the elastic diaphragm 42 has a cross-shaped opening 424. Specifically, the elastic diaphragm mounting base 41 has a through hole 410, and the elastic diaphragm 42 is installed in the through hole 410.

[0025] The elastic diaphragm 42 includes a compression portion 421, a connecting portion 422, and a protrusion 423. The compression portion 421 and the protrusion 423 are connected by the connecting portion 422. Both the compression portion 421 and the connecting portion 422 are annular. The protrusion 423 is curved, and its cross-section is arc-shaped. The protrusion 423 protrudes towards the filter 1. The cross-shaped opening 424 is located at the apex of the protrusion 423.

[0026] The connecting part 422 is funnel-shaped. When the pressure is interrupted at the liquid inlet, the internal pressure of the filter 1 is high and the external pressure is low. The liquid inside the filter 1 exerts pressure on the elastic diaphragm 42, and the connecting part 422 provides auxiliary support for the protrusion 423. As the elastic diaphragm 42 continues to be squeezed by the liquid, the connecting part 422 slowly expands outward to fit the inner wall of the elastic diaphragm mounting base 41. At this time, the friction between the connecting part 422 and the inner wall of the elastic diaphragm mounting base 41 also provides auxiliary support for the protrusion 423, greatly improving the pressure resistance of the elastic diaphragm 42 when the pressure is interrupted and preventing the cross opening 424 from deforming and opening, thus preventing liquid flow.

[0027] The elastic diaphragm 42 has a diameter of 2-50 mm, a height of 3-50 mm, a thickness of 0.1-6 mm for the protrusion 423, and a thickness of 0.1-6 mm for the connecting portion 422. The elastic diaphragm 42 is made of elastic material such as TPE or TPU. Different materials and sizes of elastic diaphragms 42 can be selected depending on the internal and external pressure difference.

[0028] The elastic diaphragm mounting base 41 is provided with an annular groove 411. The squeezing part 421 is held in the annular groove 411 and squeezed and deformed, thereby ensuring a tight fit between the elastic diaphragm 42 and the elastic diaphragm mounting base 41, so that the liquid must pass through the cross opening 424 of the elastic diaphragm 42 to enter the filter 1 or be discharged from the filter 1.

[0029] The opening and closing of the cross opening 424 is controlled by the pressure difference between the inside and outside of the elastic diaphragm 42 to control the flow of liquid. The side of the elastic diaphragm 42 closest to the filter 1 is the inside, and the other side is the outside.

[0030] During normal liquid inlet operation, the pressure difference between the inside and outside of the elastic diaphragm 42 is large, causing the diaphragm 42 to deform and open the cross opening 424, allowing liquid to flow through. When a pressure interruption occurs at the inlet, the pressure difference between the inside and outside of the elastic diaphragm 42 becomes small, and the cross opening 424 returns to its original state and closes, preventing liquid from passing through. The filter 1 maintains a certain pressure, thereby reducing the risk of virus penetration due to pressure interruption.

[0031] The detailed descriptions listed above are merely specific descriptions of feasible implementations of this utility model, and are not intended to limit the scope of protection of this utility model. All equivalent implementations or modifications made without departing from the spirit of this utility model should be included within the scope of protection of this utility model.

[0032] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A pressure-holding virus removal filter, characterized in that, The filter has a sealed elastic diaphragm mounting base inside both the inlet and outlet pipes. An elastic diaphragm is mounted on the elastic diaphragm mounting base, and the elastic diaphragm has a cross opening. The opening and closing of the cross opening is controlled by the pressure difference between the inside and outside of the elastic diaphragm to control the flow of the liquid.

2. The pressure-holding virus removal filter according to claim 1, characterized in that, The elastic diaphragm includes a compression part, a connecting part, and a protrusion part. The elastic diaphragm mounting base is provided with an annular groove. The compression part is tightly held in the annular groove. The cross opening is opened on the protrusion part, which protrudes towards the filter. The connecting part is funnel-shaped.

3. The pressure-holding virus removal filter according to claim 2, characterized in that, The cross-section of the protrusion is arc-shaped.

4. The pressure-holding virus removal filter according to claim 3, characterized in that, The cross-shaped opening is located at the apex of the protrusion.

5. The pressure-holding virus removal filter according to claim 1, characterized in that, The elastic diaphragm mounting base has a through hole, and the elastic diaphragm is installed in the through hole.

6. The pressure-holding virus removal filter according to claim 1, characterized in that, The filter contains several welded and stacked filter membranes.

7. The pressure-holding virus removal filter according to claim 6, characterized in that, The filter has an exhaust port at the top.

8. The pressure-holding virus removal filter according to claim 7, characterized in that, The bottom of the filter is provided with several supports.

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