Fixed trickle bed reactor capable of stably trickling

Abstract

The utility model discloses a fixed trickle bed reactor capable of stabilizing trickle, which comprises a cylinder, an upper seal head arranged at the upper end of the cylinder and a lower seal head arranged at the lower end of the cylinder, a trickle distributor and a reaction tube are arranged in the cylinder from top to bottom, the trickle distributor is provided with a trickle tube, the trickle tube is in butt joint with the reaction tube, and the reaction tube is in butt joint with the trickle distributor. A liquid phase feeding pipe and a gas phase feeding pipe are arranged on the barrel or the upper sealing head, a closed cavity is formed by the upper sealing head, the barrel and the trickling distributor, and the fixed trickling bed reactor capable of stabilizing trickling further comprises a liquid level sensor used for detecting the liquid level of a liquid phase material in the closed cavity; the pressure sensor is used for detecting the air pressure in the closed cavity; one end of the pressure stabilizing pipe is communicated with the closed cavity, and the other end is connected with a pressure stabilizing gas source; and the regulating valve is mounted on the pressure stabilizing pipe. When the device is stopped or feeding is stopped, pressure stabilizing gas is conveyed to the closed cavity through the pressure stabilizing pipe, so that the air pressure in the closed cavity is kept, and stable dripping of residual materials in the stopping stage is achieved.

Description

Technical Field

[0001] This utility model relates to the field of trickle bed reactors, and more particularly to a fixed trickle bed reactor with stable trickle flow. Background Technology

[0002] Fixed-bed reactors are transforming from a supplement to traditional batch processes in active pharmaceutical ingredient (API) production to a core technology for continuous manufacturing, driven by advancements in catalysis technology, scale-up engineering, and regulatory support. Despite challenges such as catalyst management, process complexity, and compliance costs, fixed-bed reactors are poised to become a key platform for efficient and green API production, thanks to technological innovation and deepening industry collaboration. Companies, considering their own process characteristics and balancing technological maturity with economic benefits, are gradually advancing continuous manufacturing upgrades, potentially making it one of the mainstream choices for API production. The trickle distribution tank is the "heart" of the fixed-bed reactor, and its design directly determines the reactor's performance and economics.

[0003] In existing technologies, drip distributors are mostly open or semi-closed structures that rely on gravity or liquid level difference to control the flow rate of materials. When the machine stops or feeding stops, the liquid material remaining in the tank cannot be completely dripped away due to the drop in liquid level and unstable flow rate. This not only affects the continuity of production and material utilization, but also easily causes problems such as reduced conversion rate and increased by-products, which will deviate from the management requirements of compliance and quality consistency related to pharmaceutical production. Utility Model Content

[0004] To address the aforementioned problems, this invention proposes a fixed trickle bed reactor for stable trickle flow.

[0005] The technical solution adopted by this utility model is as follows:

[0006] A stable trickle-flow fixed trickle bed reactor includes a cylindrical body, an upper end cap disposed at the upper end of the cylindrical body, and a lower end cap disposed at the lower end of the cylindrical body. A trickle distributor and a reaction tube are arranged from top to bottom inside the cylindrical body. The trickle distributor has a trickle tube that is connected to the reaction tube. A liquid-phase feed pipe and a gas-phase feed pipe are disposed on the cylindrical body or the upper end cap. The upper end cap, the cylindrical body, and the trickle distributor form a closed cavity. The stable trickle-flow fixed trickle bed reactor further includes:

[0007] A liquid level sensor is used to detect the liquid level of a liquid material in a closed cavity.

[0008] Pressure sensor used to detect air pressure inside a closed cavity;

[0009] A pressure-stabilizing tube, one end of which is connected to the enclosed cavity, and the other end of which is used to connect to a pressure-stabilizing gas source;

[0010] A regulating valve, installed on the voltage regulator tube, is used to control the opening and closing of the voltage regulator tube.

[0011] This application enables the supply of pressure-stabilizing gas to the closed cavity through the pressure-stabilizing pipe when the machine stops or feeding stops, thereby maintaining the gas pressure in the closed cavity. The pressure of the pressure-stabilizing gas can compensate for the impact of the liquid level drop on the flow rate, thus achieving a stable dripping of residual material during the shutdown phase.

[0012] In one embodiment of the present invention, a controller is further included, the control valve is an electric regulating valve, and the level sensor, pressure sensor and regulating valve are electrically connected.

[0013] This application enables interlocking control, reduces manual intervention, and improves operational safety and stability. One form of control is as follows:

[0014] 1. During the normal feeding stage, the pump in the feed pipe is controlled by the feedback from the liquid level sensor to keep the liquid level basically within the set range and ensure a stable drip rate.

[0015] 2. During the shutdown phase, after feeding stops, the liquid level drops, the liquid level sensor triggers an interlock signal, and the regulating valve automatically increases the intake of stabilizing gas according to the pressure change to maintain a constant pressure in the closed chamber, allowing the residual material to drip at a normal flow rate until it is completely emptied.

[0016] In one embodiment of the present invention, one end of the voltage regulator tube is located at the upper end of the upper end cap.

[0017] In one embodiment of the present invention, the sealed cavity further includes a baffle located directly below the outlet of the pressure stabilizing tube.

[0018] Setting up a baffle can prevent the pressure-stabilizing gas from being blown directly onto the liquid phase material, reducing the impact of the replenished pressure-stabilizing gas on the liquid surface.

[0019] In one embodiment of the present invention, a conical groove is formed at the upper end of the stop block.

[0020] In one embodiment of this utility model, the pressure-stabilizing gas source is an inert gas.

[0021] In one embodiment of this utility model, the pressure-stabilizing gas source is nitrogen.

[0022] In one embodiment of this utility model, the pressure sensor is a pressure transmitter.

[0023] In one embodiment of the present invention, a balance tube is further included, both ends of which are connected to the cylinder body, and the two ends of the balance tube are arranged at intervals.

[0024] In one embodiment of this utility model, the cylinder or lower end cap is provided with a discharge pipe.

[0025] The beneficial effects of this utility model are: by setting a pressure stabilizing pipe and a pressure sensor, this application can realize the supply of pressure stabilizing gas to the closed cavity through the pressure stabilizing pipe when stopping or stopping feeding, thereby maintaining the gas pressure in the closed cavity. The pressure of the pressure stabilizing gas can compensate for the influence of the drop in liquid level on the flow rate, and realize the stable dripping of residual material during the stopping stage. Attached Figure Description

[0026] Figure 1 This is a schematic diagram of a fixed trickle bed reactor with stable trickle flow in Example 1;

[0027] Figure 2 This is a schematic diagram of a fixed trickle bed reactor for stable trickle flow in Example 2.

[0028] The labels for the attached figures are as follows:

[0029] 1. Shell; 2. Upper head; 3. Lower head; 31. Discharge pipe; 4. Drip distributor; 41. Drip pipe; 5. Reaction pipe; 6. Closed cavity; 71. Liquid feed pipe; 72. Gas feed pipe; 73. Liquid level sensor; 74. Pressure sensor; 75. Pressure stabilizing pipe; 76. Regulating valve; 77. Balance pipe; 8. Baffle. Detailed Implementation

[0030] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0031] In the description of this application, it should be noted that the terms "inner" and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product is in use. They are used only for the convenience of describing this application and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0032] In the description of this application, it should also be noted that, unless otherwise expressly specified and limited, the terms "setup" and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0033] The present invention will now be described in detail with reference to the accompanying drawings.

[0034] Example 1

[0035] like Figure 1 As shown, a fixed trickle bed reactor with stable trickle flow includes a cylindrical body 1, an upper head 2 disposed at the upper end of the cylindrical body 1, and a lower head 3 disposed at the lower end of the cylindrical body 1. Inside the cylindrical body 1, a trickle distributor 4 and a reaction tube 5 are arranged from top to bottom. The trickle distributor 4 has a trickle tube 41, which is connected to the reaction tube 5. A liquid feed pipe 71 and a gas feed pipe 72 are disposed on the cylindrical body 1 or the upper head 2. The upper head 2, the cylindrical body 1, and the trickle distributor 4 form a closed cavity 6. The fixed trickle bed reactor with stable trickle flow further includes:

[0036] Liquid level sensor 73 is used to detect the liquid level of the liquid phase material in the closed cavity 6;

[0037] Pressure sensor 74 is used to detect the air pressure inside the closed cavity 6;

[0038] The pressure stabilizing tube 75 has one end connected to the closed cavity 6 and the other end used to connect to the pressure stabilizing gas source;

[0039] The regulating valve 76 is installed on the pressure regulating tube 75 and is used to control the opening and closing of the pressure regulating tube 75.

[0040] This application enables the use of a pressure stabilizing pipe 75 and a pressure sensor 74 to deliver pressure-stabilizing gas to the closed chamber 6 through the pressure stabilizing pipe 75 when the machine stops or the feeding stops, thereby maintaining the gas pressure in the closed chamber 6. The pressure of the pressure-stabilizing gas can compensate for the impact of the liquid level drop on the flow rate, thus achieving stable dripping of residual material during the shutdown phase.

[0041] In this embodiment, a controller (not shown in the figure) is also included. The control valve is an electric regulating valve 76. The level sensor 73, the pressure sensor 74 and the regulating valve 76 are electrically connected.

[0042] This application enables interlocking control, reduces manual intervention, and improves operational safety and stability. One form of control is as follows:

[0043] 1. During the normal feeding stage, the pump in the feed pipe is controlled by the feedback from the liquid level sensor 73 to keep the liquid level basically within the set range and ensure a stable drip rate.

[0044] 2. During the shutdown phase, after feeding stops, the liquid level drops, and the liquid level sensor 73 triggers an interlock signal. The regulating valve 76 automatically increases the intake of the stabilizing gas according to the pressure change, maintaining a constant pressure in the closed chamber 6, so that the residual material drips at a normal flow rate until it is completely emptied.

[0045] like Figure 1 As shown, in this embodiment, one end of the voltage regulator tube 75 is located at the upper end of the upper end cap 2.

[0046] In this embodiment, the pressure-stabilizing gas source is an inert gas, such as nitrogen.

[0047] In practical applications, the sensor can be of various existing types, such as the pressure sensor 74, which is a pressure transmitter.

[0048] like Figure 1 As shown, in this embodiment, a balance pipe 77 is also included, with both ends connected to the cylinder 1, and the two ends of the balance pipe 77 are spaced apart vertically.

[0049] like Figure 1 As shown, in this embodiment, the cylinder 1 or the lower end cap 3 is provided with a discharge pipe 31.

[0050] Example 2

[0051] like Figure 2 As shown, the difference between this embodiment and the previous one is that the sealed cavity 6 also has a baffle 8 located directly below the outlet of the pressure stabilizing pipe 75. The baffle 8 prevents the pressure stabilizing gas from being directly blown onto the liquid phase material, reducing the impact of the replenished pressure stabilizing gas on the liquid surface.

[0052] In practical applications, preferably, the upper end of the stop block 8 forms a conical groove.

[0053] The above description is only a preferred embodiment of the present utility model and does not limit the scope of patent protection of the present utility model. Any equivalent structural transformations made based on the content of the present utility model specification and drawings, whether directly or indirectly applied to other related technical fields, are similarly included within the scope of protection of the present utility model.

Claims

1. A stationary trickle bed reactor for stable trickle flow, characterized in that, The reactor includes a cylindrical body, an upper end cap at the upper end of the cylindrical body, and a lower end cap at the lower end of the cylindrical body. A trickle distributor and a reaction tube are arranged from top to bottom inside the cylindrical body. The trickle distributor has a trickle tube that connects to the reaction tube. A liquid feed pipe and a gas feed pipe are provided on the cylindrical body or the upper end cap. The upper end cap, the cylindrical body, and the trickle distributor form a closed cavity. The fixed trickle bed reactor for stable trickle flow further includes: A liquid level sensor is used to detect the liquid level of a liquid material in a closed cavity. Pressure sensor used to detect air pressure inside a closed cavity; A pressure-stabilizing tube, one end of which is connected to the enclosed cavity, and the other end of which is used to connect to a pressure-stabilizing gas source; A regulating valve, installed on the voltage regulator tube, is used to control the opening and closing of the voltage regulator tube.

2. The stationary trickle bed reactor with stable trickle flow as described in claim 1, characterized in that, It also includes a controller, the regulating valve is an electric regulating valve, and the level sensor, pressure sensor and regulating valve are electrically connected.

3. The stationary trickle bed reactor with stable trickle flow as described in claim 1, characterized in that, One end of the voltage regulator tube is located at the upper end of the upper end cap.

4. The stationary trickle bed reactor with stable trickle flow as described in claim 3, characterized in that, The enclosed cavity also has a baffle located directly below the outlet of the pressure stabilizing pipe.

5. The stationary trickle bed reactor with stable trickle flow as described in claim 4, characterized in that, The upper end of the stop block forms a conical groove.

6. The stationary trickle bed reactor with stable trickle flow as described in claim 1, characterized in that, The pressure-stabilizing gas source is an inert gas.

7. The stationary trickle bed reactor with stable trickle flow as described in claim 6, characterized in that, The pressure-stabilizing gas source is nitrogen.

8. The stationary trickle bed reactor with stable trickle flow as described in claim 1, characterized in that, The pressure sensor is a pressure transmitter.

9. The stationary trickle bed reactor with stable trickle flow as described in claim 1, characterized in that, It also includes a balance pipe that is connected to the cylinder at both ends, with the two ends of the balance pipe spaced apart vertically.

10. The stationary trickle bed reactor with stable trickle flow as described in claim 1, characterized in that, The cylinder or lower end cap is equipped with a discharge pipe.

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