Medicine reaction kettle with anti-sinking structure

Abstract

The utility model discloses a medicine reaction kettle with an anti-sinking structure, which comprises a kettle body, a driving motor arranged at the top of the kettle body, a feed port and a discharge port, and further comprises a stirring shaft connected with the driving motor and provided with a spiral stirring paddle, and the spiral stirring paddle comprises an upper blade and a lower blade which face opposite directions; the scraping plate sleeves the lower end of the stirring shaft; and a high-pressure gas nozzle. The two-way vortex shearing effect is achieved through the design of the reverse double-inclined blades, the upper blade pressurizes downwards, liquid turbulence is enhanced, and layering is reduced; the lower blade lifts bottom materials upwards, and a stirring blind area is eliminated. And the high-pressure gas spray head and the scraper have a synergistic effect to form a dynamic stripping effect, so that the anti-sinking performance is improved. An anti-sticking coating on the surface of the spiral stirring paddle reduces the material adhesion rate, and the problem of cross contamination is avoided by matching with real-time scraping of the high-pressure gas spray head. And a solvent can be directly injected into the deposition area through the medicament supplementing channel, so that the shutdown and material supplementing times are reduced. And the layout design of the scraper and the nozzle reduces mechanical wear.

Description

Technical Field

[0001] This utility model relates to the pharmaceutical and chemical industry, and in particular to a drug reaction vessel with an anti-settling structure. Background Technology

[0002] In fields such as drug synthesis and biopharmaceuticals, reaction vessels are core equipment, and their mixing efficiency and anti-settling performance directly affect product quality and production efficiency. However, traditional reaction vessels still have the following prominent problems in terms of structural design and anti-settling: 1. Existing reaction vessels mostly use unidirectional stirring paddles, which can expand the stirring range, but their ability to lift materials from the bottom is limited, especially in high-viscosity systems where stratification is easily formed. 2. Traditional anti-settling solutions mostly rely on single methods, such as mechanical scrapers, which require frequent contact with the bottom of the vessel, leading to component wear. 3. Drug components easily adhere to the inner wall of the reaction vessel and stirring components. Existing technologies mainly reduce adhesion through surface polishing or ordinary coatings, but after long-term use, the coating is prone to peeling off, requiring frequent shutdowns for manual cleaning, increasing the risk of cross-contamination. 4. For reactions that require mid-process solvent addition, existing equipment mostly adds materials through side wall pipes, resulting in excessively high local concentrations and an inability to accurately target the sedimentation zone. 5. Traditional scrapers and stirring components are prone to deformation due to long-term mechanical friction, resulting in a 30%-40% reduction in equipment lifespan. Utility Model Content

[0003] In order to solve the above-mentioned technical problems, the purpose of this utility model is to provide a drug reaction vessel with an anti-settling structure, and a new type of reaction vessel integrating multi-stage anti-settling, cleaning and online feeding functions.

[0004] To achieve the above objectives, the present invention provides the following technical solution:

[0005] A pharmaceutical reaction vessel with an anti-settling structure includes a vessel body, a drive motor disposed on the top of the vessel body, a feed inlet, and a discharge outlet, and further includes:

[0006] A stirring shaft is connected to the drive motor. The shaft body is equipped with a spiral stirring blade, which includes an upper blade and a lower blade, and the upper blade and the lower blade face opposite directions.

[0007] A scraper is fitted onto the lower end of the stirring shaft;

[0008] The high-pressure gas nozzle is connected to an external gas source via a pipeline.

[0009] Preferably, the upper blade is tilted downwards at an angle between 40° and 50°.

[0010] Preferably, the lower blade is tilted upwards at an angle between 55° and 65°.

[0011] Preferably, the surface of the spiral agitator is coated with an anti-stick coating.

[0012] Preferably, the high-pressure gas nozzles are distributed in a ring at the bottom of the vessel.

[0013] Preferably, the angle between the high-pressure gas nozzle and the bottom plane of the vessel body is between 15° and 45°.

[0014] Preferably, the high-pressure gas nozzles are arranged along the edge of the scraper.

[0015] Preferably, the jet direction of the high-pressure gas nozzle is between 10° and 30° with the direction of movement of the scraper.

[0016] Preferably, the gas injection frequency of the high-pressure gas nozzle and the rotational speed of the stirring shaft are adjusted in conjunction with an external PID controller;

[0017] The injection modes of the high-pressure gas nozzle include:

[0018] Normal mode: Intermittent spraying every 5-10 seconds to maintain basic anti-deposition measures;

[0019] Enhanced mode: High-frequency spraying with a cycle of 1-3 seconds, which can be used to prevent deposition when replenishing agents.

[0020] Preferably, the stirring shaft has a hollow structure with an integrated reagent replenishment channel inside, and the outlet of the reagent replenishment channel is located at the bottom end of the stirring shaft.

[0021] This utility model has the following beneficial effects:

[0022] 1. The reverse double-tilted blade design creates a bidirectional vortex shearing effect: the upper blade presses downward to enhance liquid turbulence and reduce stratification; the lower blade lifts the bottom material upward to eliminate the stirring blind zone and improve the mixing uniformity by 30%-40%.

[0023] 2. The high-pressure gas nozzle and scraper work together to create a dynamic stripping effect, causing the sediment to detach from the bottom of the vessel and improving the anti-sinking performance.

[0024] 3. The anti-stick coating on the surface of the spiral agitator reduces the material adhesion rate. Combined with the real-time scraping of the high-pressure gas nozzle, the cleaning cycle is extended by 2-3 times, avoiding the cross-contamination problem caused by adhesion in traditional reactors.

[0025] 4. The stirring shaft integrates a reagent replenishment channel, which can directly inject solvent or dispersant into the sedimentation zone, reducing the number of times the machine needs to be stopped for replenishment.

[0026] 5. The scraper and nozzle layout design reduces mechanical wear; the combination of anti-stick coating and gas-assisted stripping technology extends the life of the mixing components. Attached Figure Description

[0027] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this utility model and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0028] Figure 1 This is a schematic diagram of a drug reaction vessel with an anti-sinking structure proposed in this utility model.

[0029] Figure 2 This is a schematic diagram of the stirring shaft structure of a drug reaction vessel with an anti-sinking structure proposed in this utility model.

[0030] Figure 3 This is a cross-sectional view of the stirring shaft of a drug reaction vessel with an anti-sinking structure proposed in this utility model. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model. Example

[0032] A pharmaceutical reaction vessel with an anti-settling structure includes a vessel body 1, a drive motor disposed on the top of the vessel body 1, a feed inlet, and a discharge outlet, and further includes:

[0033] The stirring shaft 2 is connected to the drive motor. The shaft body is equipped with a spiral stirring blade 3, which includes an upper blade 31 and a lower blade 32. The upper blade 31 and the lower blade 32 are oriented in opposite directions.

[0034] Scraper 4 is fitted onto the lower end of stirring shaft 2;

[0035] The high-pressure gas nozzle 5 is connected to an external gas source via a pipeline.

[0036] The upper blade 31 is tilted downwards at an angle between 40° and 50°.

[0037] The lower blade 32 is tilted upwards at an angle between 55° and 65°.

[0038] The reverse-oriented double-tilted spiral impeller 3 creates a bidirectional vortex shearing effect: the upper blade presses downward to enhance liquid turbulence and reduce stratification; the lower blade lifts the bottom material upward to eliminate the stirring blind zone and improve mixing uniformity.

[0039] The surface of the spiral agitator 3 is coated with an anti-stick coating.

[0040] High-pressure gas nozzles 5 are distributed in a ring at the bottom of the vessel body 1.

[0041] The angle between the high-pressure gas nozzle 5 and the bottom plane of the vessel body 1 is between 15° and 45°.

[0042] The gas injection frequency of the high-pressure gas nozzle 5 is adjusted in conjunction with the rotational speed of the stirring shaft 2 via an external PID controller.

[0043] The injection modes of the high-pressure gas nozzle 5 include:

[0044] Normal mode: Intermittent spraying every 5-10 seconds to maintain basic anti-deposition measures;

[0045] Enhanced mode: High-frequency spraying with a cycle of 1-3 seconds, which can be used to prevent deposition when replenishing agents.

[0046] The high-pressure gas nozzle 5, in conjunction with the scraper 4, dynamically peels off the sediment, causing the sediment to detach from the bottom of the vessel.

[0047] Preferably, a pressure sensor can be added to the bottom of the vessel 1 to detect the deposition and help the controller determine the automatic adjustment mode. Example

[0048] A pharmaceutical reaction vessel with an anti-settling structure includes a vessel body 1, a drive motor disposed on the top of the vessel body 1, a feed inlet, and a discharge outlet, and further includes:

[0049] The stirring shaft 2 is connected to the drive motor. The shaft body is equipped with a spiral stirring blade 3, which includes an upper blade 31 and a lower blade 32. The upper blade 31 and the lower blade 32 are oriented in opposite directions.

[0050] Scraper 4 is fitted onto the lower end of stirring shaft 2;

[0051] The high-pressure gas nozzle 5 is connected to an external gas source via a pipeline.

[0052] High-pressure gas nozzles 5 are arranged at the edge of scraper 4.

[0053] The jet direction of the high-pressure gas nozzle 5 is between 10° and 30° with the movement direction of the scraper 4. The gas ejected from the high-pressure gas nozzle 5 is used to assist the adhesion of the glass to the scraper 4, thereby improving drug utilization and reducing mechanical wear. Example

[0054] A pharmaceutical reaction vessel with an anti-settling structure includes a vessel body 1, a drive motor disposed on the top of the vessel body 1, a feed inlet, and a discharge outlet, and further includes:

[0055] The stirring shaft 2 is connected to the drive motor. The shaft body is equipped with a spiral stirring blade 3, which includes an upper blade 31 and a lower blade 32. The upper blade 31 and the lower blade 32 are oriented in opposite directions.

[0056] Scraper 4 is fitted onto the lower end of stirring shaft 2;

[0057] The high-pressure gas nozzle 5 is connected to an external gas source via a pipeline.

[0058] The stirring shaft 2 has a hollow structure and integrates a reagent replenishment channel 6 inside. The outlet of the reagent replenishment channel 6 is located at the bottom of the stirring shaft 2, which can directly inject solvent or dispersant into the deposition zone, reducing the number of downtime feedings. In the biopharmaceutical extraction process, the reaction interruption time is reduced by more than 60%.

[0059] The above are merely specific embodiments of this utility model, but the technical features of this utility model are not limited thereto. Any simple changes, equivalent substitutions, or modifications made based on this utility model to solve essentially the same technical problems and achieve essentially the same technical effects are all covered within the protection scope of this utility model.

Claims

1. A pharmaceutical reaction vessel with an anti-sinking structure, comprising a vessel body (1), a drive motor disposed on the top of the vessel body (1), a feed inlet, and a discharge outlet, characterized in that... Also includes: A stirring shaft (2) is connected to the drive motor. The shaft body is provided with a spiral stirring paddle (3). The spiral stirring paddle (3) includes an upper blade (31) and a lower blade (32). The upper blade (31) and the lower blade (32) are oriented in opposite directions. A scraper (4) is fitted onto the lower end of the stirring shaft (2); The high-pressure gas nozzle (5) is connected to an external gas source through a pipeline.

2. The pharmaceutical reaction vessel with an anti-settling structure according to claim 1, characterized in that: The upper blade (31) is tilted downward at an angle between 40° and 50°.

3. The pharmaceutical reaction vessel with an anti-settling structure according to claim 1, characterized in that: The lower blade (32) is tilted upward at an angle between 55° and 65°.

4. The drug reaction vessel with an anti-settling structure according to claim 1, characterized in that: The surface of the spiral agitator (3) is coated with an anti-stick coating.

5. The pharmaceutical reaction vessel with an anti-settling structure according to claim 1, characterized in that: The high-pressure gas nozzles (5) are distributed in a ring at the bottom of the vessel body (1).

6. The pharmaceutical reaction vessel with an anti-settling structure according to claim 5, characterized in that: The angle between the high-pressure gas nozzle (5) and the bottom plane of the vessel body (1) is between 15° and 45°.

7. The pharmaceutical reaction vessel with an anti-settling structure according to claim 1, characterized in that: The high-pressure gas nozzles (5) are arranged at the edge of the scraper (4).

8. The pharmaceutical reaction vessel with an anti-settling structure according to claim 7, characterized in that: The jet direction of the high-pressure gas nozzle (5) is between 10° and 30° with the direction of movement of the scraper (4).

9. The pharmaceutical reaction vessel with an anti-settling structure according to claim 1, characterized in that: The stirring shaft (2) is a hollow structure with an integrated agent replenishment channel (6) inside. The outlet of the agent replenishment channel (6) is located at the bottom end of the stirring shaft (2).

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