Immune cell sorting device

Abstract

The utility model relates to the field of biomedicine, and discloses an immune cell sorting device which comprises a box body, the bottom end of the box body is fixedly connected with a motor box, the top end of the motor box is rotatably connected with a rotating rod, the outer wall of the rotating rod is fixedly connected with a disc, and the inner wall of the left end of the disc is elastically connected with a sliding block through a movable spring. A positioning block is slidably connected to the inner wall of the sliding block, a movable disc penetrates through and is slidably connected to the outer wall of the positioning block, a positioning mechanism is arranged on the inner wall of the positioning block, and a box cover is fixedly connected to the inner wall of the box body. According to the test tube positioning device, the clamping blocks are extruded by the test tubes, the test tubes are preliminarily positioned by the clamping blocks, and the two groups of positioning blocks are close to each other, so that the reverse elastic force of the movable spring is increased, the test tubes are further positioned, the test tubes with different specifications can be quickly positioned, the tedious step of replacing the clamp is avoided, and the working efficiency is further improved.

Description

Technical Field

[0001] This utility model relates to the field of biomedicine, and in particular to an immune cell sorting device. Background Technology

[0002] Immune cells are cells that participate in or are related to the immune response. They are an important part of the immune system and play a key role in the body's defense against pathogen invasion, maintenance of internal homeostasis, and identification and elimination of abnormal cells. An immune cell sorting device is an instrument used to separate and enrich specific types of immune cells from biological samples. Its working principle is to use a series of technical means to accurately separate target immune cells from a mixed cell population to obtain high-purity specific immune cells for scientific research, clinical diagnosis and treatment.

[0003] A search revealed Chinese Patent Publication No. CN214244413U, which discloses a high-efficiency flow cytometry cell sorting device. The device includes a housing, a rotating mechanism fixedly connected to the bottom of the inner wall of the housing, a connecting column fixedly connected to the surface of the rotating mechanism, and placement blocks fixedly connected to both sides of the connecting column. Each placement block has a placement hole on its inner wall, and a test tube is placed inside the placement hole. A support plate is fixedly connected to the surface of the rotating mechanism. This invention, through the cooperation of the rotating mechanism, guide tube, and traction mechanism, allows the positions of the two placement blocks to be interchanged as needed. This enables the user to remove the test tube below the third through-hole from the housing and insert a new test tube into the placement hole while sorting cells, thus allowing the sorting device to continuously sort cells and improving its sorting efficiency.

[0004] The above-mentioned device has the following problems: the test tubes are positioned on the placement block, but the positioning range of the placement block is limited. For test tubes of different sizes, it is impossible to position them effectively, and different placement blocks need to be replaced. The replacement process is cumbersome, time-consuming and labor-intensive. Therefore, an immune cell sorting device is proposed to solve the above problems. Utility Model Content

[0005] To overcome the above shortcomings, this invention provides an immune cell sorting device, which aims to improve the problem that the existing technology cannot locate test tubes of different sizes.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: an immune cell sorting device, comprising a box, a motor box fixedly connected to the bottom end of the box, a rotating rod rotatably connected to the top end of the motor box, a disc fixedly connected to the outer wall of the rotating rod, a slider elastically connected to the inner wall of the left end of the disc via a movable spring, a positioning block slidably connected to the inner wall of the slider, a movable disk slidably connected to the outer wall of the positioning block, a positioning mechanism provided on the inner wall of the positioning block, a box cover fixedly connected to the inner wall of the box, an arc-shaped block fixedly connected to the inner wall of the box, and an opening and closing component provided on the inner wall of the box cover;

[0007] The positioning mechanism includes a clamping block, the inner sidewall of which is elastically connected to the positioning block via a movable spring, and the clamping block is slidably connected to the inner wall of the positioning block.

[0008] As a further description of the above technical solution:

[0009] The opening and closing assembly includes an opening and closing door. The right side wall of the opening and closing door is elastically connected to the box cover by a positioning spring. The side wall of the opening and closing door contacts a protrusion. The opening and closing door is slidably connected to the lower surface of the box cover.

[0010] As a further description of the above technical solution:

[0011] The inner sidewall of the clamping block is fixedly connected to one end of the movable spring, and the other end of the movable spring is fixedly connected to the inner front wall of the positioning block.

[0012] As a further description of the above technical solution:

[0013] The inner wall of the left end of the disk is fixedly connected to one end of the movable spring, and the other end of the movable spring is fixedly connected to the left side wall of the slider.

[0014] As a further description of the above technical solution:

[0015] The slider is slidably connected to the top of the disc, and the movable disc is fixedly connected to the top of the rotating rod.

[0016] As a further description of the above technical solution:

[0017] The rotating rod is rotatably connected to the inner wall of the housing, and the outer wall of the slider is in contact with the inner side of the arc-shaped block.

[0018] As a further description of the above technical solution:

[0019] The protrusion is fixedly connected to the top of the positioning block.

[0020] As a further description of the above technical solution:

[0021] The right side wall of the opening and closing door is fixedly connected to one end of the positioning spring, and the other end of the positioning spring is fixedly connected to the right inner wall of the box cover.

[0022] This utility model has the following beneficial effects:

[0023] 1. In this utility model, the test tube is squeezed by the clamping block to initially position the test tube. By bringing the two sets of positioning blocks closer together, the reverse elastic force of the moving spring is increased, further positioning the test tube. This allows for quick positioning of test tubes of different specifications, avoiding the tedious steps of changing clamps and further improving work efficiency.

[0024] 2. In this utility model, by setting up opening and closing doors, protruding blocks and positioning springs, the protruding blocks squeeze the opening and closing doors, allowing the two sets of opening and closing doors to close or open quickly, avoiding frequent manual opening and closing operations and further saving working time. Attached Figure Description

[0025] Figure 1 This is a schematic diagram showing the overall structure of the housing and lid of the immune cell sorting device proposed in this utility model;

[0026] Figure 2 This is a cross-sectional schematic diagram of the housing and lid of an immune cell sorting device proposed in this utility model;

[0027] Figure 3 This is a cross-sectional schematic diagram of the movable disc of an immune cell sorting device proposed in this utility model;

[0028] Figure 4 This is a schematic diagram showing the arc-shaped block of an immune cell sorting device proposed in this utility model;

[0029] Figure 5 This is a cross-sectional schematic diagram of the lid of an immune cell sorting device proposed in this utility model.

[0030] Legend:

[0031] 1. Box body; 2. Box cover; 3. Motor box; 4. Rotating rod; 5. Disc; 6. Movable disc; 7. Positioning block; 8. Slider; 9. Movable spring; 10. Clamping block; 11. Moving spring; 12. Arc block; 13. Opening and closing door; 14. Positioning spring; 15. Protruding block. Detailed Implementation

[0032] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0033] Reference Figures 1-3 This utility model provides an embodiment of an immune cell sorting device, comprising a housing 1, a motor housing 3 fixedly connected to the bottom of the housing 1, a rotating rod 4 rotatably connected to the top of the motor housing 3, a motor disposed in the motor housing 3, the output end of the motor being fixedly connected to the rotating rod 4, a disc 5 fixedly connected to the outer wall of the rotating rod 4, a slider 8 elastically connected to the inner wall of the left end of the disc 5 via a movable spring 9, a positioning block 7 slidably connected to the inner wall of the slider 8, a groove provided on the slider 8, which, when pressing the positioning block 7, causes the two sets of positioning blocks 7 to separate or move closer together, a movable disc 6 slidably connected through the outer wall of the positioning block 7, and a long... The rod and movable plate 6 have slots corresponding to the long rod, allowing the positioning block 7 to move back and forth. The inner wall of the positioning block 7 is provided with a positioning mechanism. The inner wall of the box 1 is fixedly connected to the box cover 2, which has an opening for easy access for test tubes. The inner wall of the box 1 is fixedly connected to the arc-shaped block 12, and the inner wall of the box cover 2 is provided with an opening and closing assembly. The positioning mechanism includes a clamping block 10. The inner side wall of the clamping block 10 is elastically connected to the positioning block 7 via a moving spring 11. The clamping block 10 passes through and slides on the inner wall of the positioning block 7. The positioning block 7 has slots corresponding to the clamping block 10, allowing the clamping block 10 to move back and forth.

[0034] Reference Figure 1 , Figure 2 and Figure 5 The opening and closing assembly includes an opening and closing door 13. The right side wall of the opening and closing door 13 is elastically connected to the lid 2 via a positioning spring 14. The side wall of the opening and closing door 13 contacts a protrusion 15. When the protrusion 15 presses the opening and closing door 13, it separates the two sets of opening and closing doors 13 from each other. The opening and closing door 13 is slidably connected to the lower surface of the lid 2. The lid 2 has a slot corresponding to the opening and closing door 13, allowing the opening and closing door 13 to move left and right. The right side wall of the opening and closing door 13 is fixedly connected to one end of the positioning spring 14. The other end of the positioning spring 14 is fixedly connected to the inner wall of the right end of the lid 2. When the opening and closing door 13 moves to the right, the positioning spring 14 is compressed. When resetting, the elastic force of the positioning spring 14 is used to reset the opening and closing door 13.

[0035] Reference Figures 2-4The inner sidewall of the clamping block 10 is fixedly connected to one end of the moving spring 11, and the other end of the moving spring 11 is fixedly connected to the inner wall of the front end of the positioning block 7. When the clamping block 10 moves forward, the moving spring 11 is compressed. When resetting, the elastic force of the moving spring 11 is used to move the clamping block 10 back to its original position. The inner wall of the left end of the disc 5 is fixedly connected to one end of the movable spring 9, and the other end of the movable spring 9 is fixedly connected to the left sidewall of the slider 8. When the slider 8 moves to the left, the movable spring 9 is compressed. When resetting, the elastic force of the movable spring 9 is used to move the positioning block 7 back to its original position. The elastic force causes the slider 8 to reset. The slider 8 is slidably connected to the top of the disc 5. The disc 5 has a slot corresponding to the slider 8, allowing the slider 8 to move left and right. The movable disc 6 is fixedly connected to the top of the rotating rod 4. The rotating rod 4 passes through and is rotatably connected to the inner wall of the box 1. The box 1 has a slot corresponding to the rotating rod 4, which facilitates the rotation of the rotating rod 4. The outer wall of the slider 8 contacts the inner side of the arc block 12. The arc block 12 will squeeze the slider 8, causing the slider 8 to move to the left. The protrusion 15 is fixedly connected to the top of the positioning block 7.

[0036] Working principle: When the test tube is placed between the two sets of clamping blocks 10, the test tube will squeeze the clamping blocks 10, causing the two sets of clamping blocks 10 to separate and compress the moving spring 11. Under the counter-elastic force of the moving spring 11, the two sets of clamping blocks 10 will initially position the test tube. Then, the motor in the motor box 3 is turned on, and the motor will drive the rotating rod 4, the movable disk 6, and the disc 5 to rotate. When the disc 5 rotates counterclockwise with the slider 8 and contacts the arc-shaped block 12, the arc-shaped block 12 will squeeze the slider 8, causing the slider 8 to move to the left and compress. The movable spring 9, at this time, the inclined groove on the slider 8 will squeeze the two sets of positioning blocks 7, causing the two sets of positioning blocks 7 to move closer together, further increasing the reverse elastic force of the moving spring 11, and further positioning the test tube. When the test tube rotates to the bottom of the sorter, the motor stops rotating to allow the cells to be sorted. When the sorting is completed, the motor will continue to rotate with the rotating rod 4, the disc 5 and the movable disc 6. When the arc-shaped block 12 is no longer in contact with the slider 8, the elastic force of the movable spring 9 will cause the two sets of positioning blocks 7 to separate from each other. At this time, the positioning blocks 7 move to the position shown in the image. Figure 2 At the position shown, the staff can remove the test tube by hand. When the test tube is no longer in contact with the clamping block 10, the elastic force of the moving spring 11 will cause the two sets of clamping blocks 10 to move closer to each other. When the staff puts in a new test tube, the clamping block 10 will repeat the above trajectory. If the test tube needs to be repositioned, simply repeat the above operation steps.

[0037] When the positioning block 7 rotates, the protrusion 15 on the positioning block 7 no longer contacts the opening and closing door 13. The elastic force of the positioning spring 14 causes the two sets of opening and closing doors 13 to move closer to each other and close. When the protrusion 15 contacts the opening and closing door 13 as the positioning block 7 rotates, the protrusion 15 will squeeze the two sets of opening and closing doors 13 to separate and open. The opening and closing door 13 will squeeze the positioning spring 14, and the positioning spring 14 will be in a compressed state. At this time, the opening and closing door 13 will not block the opening, and the staff can take and put in the test tube.

[0038] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. An immune cell sorting device, comprising a housing (1), characterized in that: The bottom of the box (1) is fixedly connected to a motor box (3), the top of the motor box (3) is rotatably connected to a rotating rod (4), the outer wall of the rotating rod (4) is fixedly connected to a disc (5), the inner wall of the left end of the disc (5) is elastically connected to a slider (8) via a movable spring (9), the inner wall of the slider (8) is slidably connected to a positioning block (7), the outer wall of the positioning block (7) is slidably connected to a movable disc (6), the inner wall of the positioning block (7) is provided with a positioning mechanism, the inner wall of the box (1) is fixedly connected to a box cover (2), the inner wall of the box (1) is fixedly connected to an arc-shaped block (12), and the inner wall of the box cover (2) is provided with an opening and closing component; The positioning mechanism includes a clamping block (10), the inner sidewall of which is elastically connected to the positioning block (7) via a moving spring (11), and the clamping block (10) is slidably connected to the inner wall of the positioning block (7).

2. The immune cell sorting device according to claim 1, characterized in that: The opening and closing assembly includes an opening and closing door (13). The right side wall of the opening and closing door (13) is elastically connected to the box cover (2) by a positioning spring (14). The side wall of the opening and closing door (13) is in contact with a protrusion (15). The opening and closing door (13) is slidably connected to the lower surface of the box cover (2).

3. The immune cell sorting device according to claim 1, characterized in that: The inner sidewall of the clamping block (10) is fixedly connected to one end of the moving spring (11), and the other end of the moving spring (11) is fixedly connected to the inner front wall of the positioning block (7).

4. The immune cell sorting device according to claim 1, characterized in that: The inner wall of the left end of the disc (5) is fixedly connected to one end of the movable spring (9), and the other end of the movable spring (9) is fixedly connected to the left side wall of the slider (8).

5. The immune cell sorting device according to claim 1, characterized in that: The slider (8) is slidably connected to the top of the disc (5), and the movable disc (6) is fixedly connected to the top of the rotating rod (4).

6. The immune cell sorting device according to claim 1, characterized in that: The rotating rod (4) is rotatably connected to the inner wall of the box (1), and the outer wall of the slider (8) is in contact with the inner side of the arc block (12).

7. An immune cell sorting device according to claim 2, characterized in that: The protrusion (15) is fixedly connected to the top of the positioning block (7).

8. An immune cell sorting device according to claim 2, characterized in that: The right side wall of the opening and closing door (13) is fixedly connected to one end of the positioning spring (14), and the other end of the positioning spring (14) is fixedly connected to the inner wall of the right end of the box cover (2).

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