Continuous efficient mixing device for medical intermediates

Abstract

The utility model relates to the technical field of pharmaceutical chemical equipment, in particular to a continuous efficient mixing device for medical intermediates, which comprises a supporting seat, two mixing tanks mounted at the top of the supporting seat, heating pipes mounted on the inner walls of the mixing tanks, a controller mounted on the supporting seat, and a discharge pipe connected to the lower end of the supporting seat. The top of the discharging pipe is branched and then communicated with the bottom of the mixing tank, a control valve is arranged at the upper end of the discharging pipe, a first motor is installed at the top of the mixing tank, a stirring rod is rotationally connected into the mixing tank, the top of the stirring rod is connected with an output shaft of the first motor, and two preheating assemblies used for heating production raw materials are arranged in the mixing tank. The tops of the mixing tanks are jointly connected with a material distributing assembly used for feeding in batches. Through cooperation of a guide plate driven by a second motor in the material distribution assembly and double mixing tanks, intelligent distribution of raw materials is achieved, the two mixing tanks alternately conduct feeding preheating and mixing discharging, and the problem of productivity bottleneck caused by intermittent production is solved.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical and chemical equipment technology, and in particular to a continuous high-efficiency mixing device for pharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates refer to key chemical raw materials or products used in drug synthesis processes. As an important component of the active pharmaceutical ingredient (API) synthesis step, they do not require drug manufacturing qualifications and can be produced in ordinary chemical plants that meet pharmaceutical-grade standards. With the increasing aging of my country's population and the upgrading of the pharmaceutical industry, the research and development of innovative drugs such as novel targeted drugs and biologics is accelerating, driving exponential growth in the market demand for pharmaceutical intermediates. Particularly in the fields of anticancer drugs, antibiotics, and cardiovascular drugs, the synthesis efficiency and quality control of intermediates directly determine the scale of API production.

[0003] In existing technologies, pharmaceutical intermediate synthesis equipment mostly adopts a batch reaction device structure. For example, a reaction synthesis device with heating and stirring functions (publication number CN214863507U) achieves temperature control through an electrically heated jacket at the bottom of the tank, and uses a top-mounted motor-driven anchor stirrer for material mixing. While this type of equipment improves reaction uniformity to some extent, it is essentially a batch processing device, revealing significant drawbacks in actual production: limited by the fixed-volume tank structure and the design of the bottom discharge valve, stirring must be stopped, the temperature lowered, and the valve opened to discharge the material after each synthesis batch, making continuous production impossible. This intermittent operation mode results in low equipment utilization. Utility Model Content

[0004] To overcome the drawbacks of intermittent production, this invention provides a continuous high-efficiency mixing device for pharmaceutical intermediates, aiming to solve the aforementioned shortcomings.

[0005] A continuous high-efficiency mixing device for pharmaceutical intermediates includes a support base, two mixing tanks mounted on the top of the support base, heating tubes installed on the inner walls of the mixing tanks, a controller mounted on the support base, a discharge pipe connected to the lower end of the support base, the top of the discharge pipe branching off and communicating with the bottom of the mixing tanks, and a control valve provided at the upper end of the discharge pipe, a first motor mounted on the top of the mixing tanks, a stirring rod rotatably connected inside the mixing tanks, the top of the stirring rod connected to the output shaft of the first motor, the controller being wired to all electrical equipment, a preheating component for heating the raw materials for production being provided inside the mixing tanks, and a batch feeding component being connected to the top of both mixing tanks.

[0006] Preferably, the material distribution assembly includes a feed pipe, the bottom of which is bifurcated and connected to the two mixing tanks respectively. A second motor is installed on the front side of the feed pipe, and the guide plate is connected to the output end of the second motor through a rotating shaft, so that it can rotate and swing inside the feed pipe driven by the second motor.

[0007] Preferably, the preheating assembly includes a partition plate connected to the mixing tank. A scraper is slidably connected to the top surface of the partition plate and fixedly connected to the stirring rod. A mounting plate is connected to the bottom of the partition plate, and a third motor is mounted on the bottom of the mounting plate. A sealing plate is rotatably connected to the bottom of the mounting plate. The partition plate has a discharge notch, and the sealing plate fits against the discharge notch of the partition plate, with the top surface of the sealing plate flush with the partition plate. A buffer pad is connected to the end of the sealing plate, and the buffer pad forms an interference fit with the inner wall of the mixing tank.

[0008] Preferably, a rubber pad is connected to the end of the guide plate, and the rubber pad is attached to the fork of the feed end.

[0009] Preferably, the top of the feed pipe is provided with a cover plate.

[0010] Preferably, the mixing tank has ventilation holes on the top, and a fan is installed at the ventilation holes.

[0011] Preferably, the mixing tank is provided with a transparent observation window on the front side.

[0012] Compared with the prior art, the beneficial effects of this utility model are:

[0013] 1. By cooperating with the guide plate driven by the second motor in the material distribution component and the double mixing tank, the raw materials are intelligently distributed. The two mixing tanks alternately perform feeding, preheating and mixing, forming a continuous production closed loop of "feeding-preheating-mixing-discharging", which solves the capacity bottleneck problem caused by intermittent production.

[0014] 2. The continuous scraping action of the scraper on the surface of the partition in the preheating component forms a three-dimensional heating network with the heating tube to complete the preheating. When the sealing plate is opened to discharge the material, the strong shear flow field generated by the spiral stirring rod improves the mixing uniformity, shortens the mixing time, and improves the mixing efficiency. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0016] Figure 2 This is a cross-sectional view showing the connection relationship between the first motor and the stirring rod of this utility model.

[0017] Figure 3 This is a cross-sectional view showing the connection relationship between the feed pipe and the guide plate of this utility model.

[0018] Figure 4 This is a cross-sectional view showing the connection relationship between the cover plate and the buffer pad of this utility model.

[0019] Explanation of reference numerals in the attached drawings: 1_Support base, 2_Mixing tank, 201_Heating tube, 202_Controller, 3_Discharge pipe, 4_Control valve, 5_First motor, 6_Stirring rod, 7_Infeed pipe, 8_Second motor, 9_Guide plate, 10_Baffle plate, 11_Scraper, 12_Mounting plate, 13_Third motor, 14_Sealing plate, 15_Buffer pad, 16_Rubber pad, 17_Cover plate, 18_Fan, 19_Observation window. Detailed Implementation

[0020] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0021] Example: A continuous high-efficiency mixing device for pharmaceutical intermediates, such as... Figure 1 and Figure 2 As shown, the assembly includes a support base 1, a mixing tank 2, a heating element 201, a controller 202, a discharge pipe 3, a control valve 4, a first motor 5, a stirring rod 6, a material distribution assembly, and a preheating assembly. Two mixing tanks 2 are mounted on the top of the support base 1, operating in a sequential alternating mode. Heating elements 201 are installed on the inner walls of the mixing tanks 2. The controller 202 is mounted on the support base 1. A discharge pipe 3 is connected to the lower end of the support base 1. The top of the discharge pipe 3 branches off and connects to the bottom of the mixing tanks 2. A control valve 4 is installed at the upper end of the discharge pipe 3. A first motor 5 is mounted on the top of the mixing tanks 2. The mixing tank 2 is equipped with a stirring rod 6 that is rotatably connected to the machine 5. The top of the stirring rod 6 is connected to the output shaft of the first motor 5. The first motor 5 drives the stirring rod 6 to rotate at a high speed of 1200r / min. The multi-layer spiral blades generate a strong turbulence effect. Combined with the constant temperature environment of 80℃ maintained by the heating tube 201, the materials are homogenized and mixed within 3-5 minutes. The controller 202 is wired to all electrical equipment. The mixing tank 2 is equipped with a preheating component for heating the raw materials. The tops of the two mixing tanks 2 are connected to a feeding component for batch feeding.

[0022] like Figure 2 and Figure 3 As shown, the material distribution assembly includes a feed pipe 7, a second motor 8, and a guide plate 9. The bottom of the feed pipe 7 is forked and connected to two mixing tanks 2 respectively. The second motor 8 is installed on the front side of the feed pipe 7. The guide plate 9 is connected to the output end of the second motor 8 via a rotating shaft and can rotate and swing inside the feed pipe 7 driven by the motor. After the operator puts the pre-treated raw material mixture into the feed pipe 7 through the top opening, the controller 202 starts the second motor 8 to drive the guide plate 9 to rotate. When the guide plate 9 is deflected by the motor to fit against the inner wall of one side of the feed pipe 7, the raw material flow channel is switched to the direction of the corresponding mixing tank 2.

[0023] like Figure 2 and Figure 4 As shown, the preheating assembly includes a partition 10, a scraper 11, a mounting plate 12, a third motor 13, a sealing plate 14, and a buffer pad 15. The partition 10 is connected to the mixing tank 2. The scraper 11 is slidably connected to the top surface of the partition 10 and is fixedly connected to the stirring rod 6. The mounting plate 12 is connected to the bottom of the partition 10, and the third motor 13 is mounted on the bottom of the mounting plate 12. The sealing plate 14 is rotatably connected to the bottom of the mounting plate 12. The partition 10 has a discharge notch, and the sealing plate 14 fits snugly against the discharge notch of the partition 10, with the top surface of the sealing plate 14 flush with the partition 10. The end of the sealing plate 14 is connected to the buffer pad 15, which forms an interference fit with the inner wall of the mixing tank 2. After the raw material enters the mixing tank 2, it is temporarily stored on the surface of the inclined partition 10. At this time, the sealing plate 14 is closed under the control of the third motor 13, tightly fitting against the discharge notch of the partition 10. The stirring rod 6 drives the scraper 11 to move in a circular motion along the surface of the partition 10. The edge of the scraper 11 maintains a 0.5mm gap with the partition 10. During the process of moving the raw material, the material temperature rises rapidly through frictional heat generation and in conjunction with the heating tube 201. When it is necessary to discharge the material, the third motor 13 drives the sealing plate 14 to rotate 45°, and the raw material falls into the stirring chamber through the notch. At the same time, the scraper 11 completely sweeps the residual material into the reaction zone.

[0024] like Figure 3 As shown, it also includes a rubber pad 16, which is connected to the end of the guide plate 9. The rubber pad 16 fits into the bifurcation of the feed end. The rubber pad 16 at the end of the guide plate 9 forms an elastic seal with the pipe wall, ensuring that the raw material is accurately introduced into the target tank.

[0025] like Figure 2 As shown, it also includes a cover plate 17, and the top of the feed pipe 7 is provided with a cover plate 17.

[0026] like Figure 2 As shown, it also includes a fan 18. A ventilation hole is opened at the top of the mixing tank 2, and a fan 18 is installed at the ventilation hole. During the mixing process, the top fan 18 operates at a speed of 0.5 m... 3 A continuous airflow of / min discharges volatile gases, which are then introduced into the exhaust gas treatment system through an external pipeline.

[0027] like Figure 2 As shown, it also includes an observation window 19, which is made of transparent material and is located on the front side of the mixing tank 2. The observation window 19 is made of high-temperature resistant tempered glass, allowing the operator to visually judge the transparency of the mixture and the degree of bubble dissipation, and adjust the stirring speed or heating power accordingly via the controller 202.

[0028] After mixing the raw materials, the workers pour them into the top of the feed pipe 7. The second motor 8 is started by the controller 202. The second motor 8 drives the guide plate 9 to rotate. After the top of the guide plate 9 is in contact with one side of the feed pipe 7, the second motor 8 is turned off. At this time, the poured raw materials flow along the guide plate 9 to the other side and enter the mixing tank 2. The rubber gasket 16 at the lower end of the guide plate 9 can optimize the sealing between the guide plate 9 and the feed pipe 7, thereby ensuring the diversion of the raw materials. The raw materials in the mixing tank 2 are blocked by the partition 10. The heating tube 201 remains open. After the first motor 5 is started, it drives the stirring rod 6 to rotate and stir the raw materials in the mixing tank 2. Together with the heating tube 201, the raw materials are efficiently mixed. The discharge pipe 3 discharges materials intermittently and continuously to the two mixing tanks 2.

[0029] The process of alternating discharge from two mixing tanks 2 involves discharging materials from tanks A and B respectively. When mixing tank B just begins to discharge, the control valve corresponding to mixing tank A remains closed, the third motor 13 inside mixing tank A is activated, and the control valve 4 on the branch pipe connecting the discharge pipe 3 to mixing tank A is closed. The third motor 13 drives the sealing plate 14 to rotate, disengaging it from the partition plate 10. Simultaneously, the scraper 11 rotates, scraping the raw materials off the partition plate 10 of mixing tank A. Previously, while the raw materials were on the partition plate 10, the stirring rod 6 drove the scraper 11 to rotate. The scraper 11 and the heating tube 201 perform preliminary mixing of the raw materials. After all the material has fallen, the third motor 13 drives the sealing plate 14 to rotate. When the sealing plate 14 re-fits the partition 10, the second motor 8 on the feed pipe 7 starts, driving the top of the guide plate 9 to fit against one side of the B mixing tank 2, thereby feeding the A mixing tank 2. The production raw materials are stored on the closed partition 10. The production raw materials falling from the partition 10 simultaneously come into contact with the stirring rod 6, achieving efficient mixing. As the discharge from the B mixing tank 2 is completed, the control valve 4 on the branch pipe connecting the discharge pipe 3 and the B mixing tank 2 is closed. The production raw materials in the A mixing tank 2 have been mixed. The control valve 4 below the A mixing tank 2 is then opened, thereby achieving continuous discharge.

[0030] The first motor 5 remains on, maintaining the high-speed rotation of the stirring rod 6. The fan 18 on top of the mixing tank 2 promptly discharges the gas generated during the mixing of raw materials, and this gas is collected and centrally processed. When the equipment is idle, the cover plate 17 closes the top opening of the feed pipe 7. The staff can observe the working conditions inside the mixing tank 2 through the observation window 19 and adjust the discharge rate. The opening and closing of the control valve 4 can control the discharge rate. The rotation speed of the first motor 5 can control the stirring rate. The controller 202 centrally controls all electrical equipment.

[0031] The above are merely embodiments of this utility model and do not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the content of this utility model specification, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A continuous high-efficiency mixing device for pharmaceutical intermediates, characterized in that, The system includes a support base (1), on which two mixing tanks (2) are mounted. Heating pipes (201) are installed on the inner walls of the mixing tanks (2). A controller (202) is mounted on the support base (1). A discharge pipe (3) is connected to the lower end of the support base (1). The top of the discharge pipe (3) branches off and connects to the bottom of the mixing tanks (2). A control valve (4) is installed at the upper end of the discharge pipe (3). A first motor (5) is mounted on the top of the mixing tanks (2). A stirring rod (6) is rotatably connected inside the mixing tanks (2). The top of the stirring rod (6) is connected to the output shaft of the first motor (5). The controller (202) is wired to all electrical equipment. A preheating component for heating the raw materials is installed inside the mixing tanks (2). The tops of the two mixing tanks (2) are connected together. The mixing tank (2) is connected to a feeding assembly for batch feeding; the preheating assembly includes a partition (10), which is connected to the mixing tank (2). A scraper (11) is slidably connected to the top surface of the partition (10). The scraper (11) is fixedly connected to the stirring rod (6). An installation plate (12) is connected to the bottom of the partition (10). A third motor (13) is installed at the bottom of the installation plate (12). A sealing plate (14) is rotatably connected to the bottom of the installation plate (12). The partition (10) has a feeding notch. The sealing plate (14) fits against the feeding notch of the partition (10). The top surface of the sealing plate (14) is flush with the partition (10). A buffer pad is connected to the end of the sealing plate (14). The buffer pad forms an interference fit with the inner wall of the mixing tank (2).

2. The continuous pharmaceutical intermediate high-efficiency mixing device according to claim 1, characterized in that, The feeding assembly includes a feed pipe (7), the bottom of which is bifurcated and connected to the two mixing tanks (2) respectively. A second motor (8) is installed on the front side of the feed pipe (7), and a guide plate (9) is connected to the output end of the second motor (8) through a rotating shaft. It can rotate and swing inside the feed pipe (7) as driven by the second motor (8).

3. The continuous pharmaceutical intermediate high-efficiency mixing device according to claim 2, characterized in that, The guide plate (9) is connected to a rubber pad (16) at its end, and the rubber pad (16) is attached to the feed end fork.

4. The continuous pharmaceutical intermediate high-efficiency mixing device according to claim 3, characterized in that, The feed pipe (7) is provided with a cover plate (17) at the top.

5. The continuous pharmaceutical intermediate high-efficiency mixing device according to claim 4, characterized in that, The mixing tank (2) has a ventilation hole on the top, and a fan (18) is installed at the ventilation hole.

6. The continuous pharmaceutical intermediate high-efficiency mixing device according to claim 5, characterized in that, The mixing tank (2) is provided with a transparent observation window (19) on the front side.

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