Protein purification fixing device

Abstract

The utility model relates to the technical field of adsorption separation, and provides a protein purification fixing device which comprises a base and a side plate, the base comprises a base body and a fixing assembly, the base body is of a square structure, and the fixing assembly is movably arranged on the base body and used for fixing the collecting frame; each side plate comprises a first plate body, a connecting plate and a second plate body; one end of the first plate body is rotatably arranged on one side of the seat body, two ends of the connecting plate are respectively connected with the other end of the first plate body and the second plate body, and the second plate body is arranged opposite to the surface of the seat body; the clamping assembly is movably arranged on the second plate body in the width direction of the base body, and the clamping assembly is used for clamping the gravity column; wherein the fixing assembly and the clamping assembly are correspondingly arranged. According to the protein purification fixing device provided by the utility model, the relative position of the gravity column and the collecting pipe can be flexibly adjusted, so that the gravity column and the collecting pipe can be accurately aligned, and accurate collection of samples in the gravity column by the collecting pipe is facilitated.

Description

Technical Field

[0001] This utility model relates to the field of adsorption separation technology, and in particular to a protein purification and immobilization device. Background Technology

[0002] Protein purification refers to the technique of separating and purifying target proteins from complex mixtures (such as cell lysates, culture media, etc.). Protein purification utilizes the similarities between various proteins to remove non-protein contaminants, and leverages the differences between proteins to purify the target protein from other proteins. It is broadly divided into two stages: a coarse separation stage and a fine purification stage.

[0003] Protein purification typically uses gravity columns for protein separation. Existing protein purification fixation devices are generally supports that can only fix the gravity column on the support. The support has a limited function, and it is not possible to accurately match the appropriate collection tube below the support to collect the sample, making it inconvenient to operate during protein purification experiments. Utility Model Content

[0004] This invention provides a protein purification and immobilization device to solve the problem that the existing purification scaffolds have limited functionality and cannot accurately match the collection tubes to collect samples, resulting in inconvenience in the experimental process.

[0005] This invention provides a protein purification and immobilization device, comprising:

[0006] The base includes a seat body and a fixing component. The seat body has a square structure, and the fixing component is movably disposed on the seat body. The fixing component is used to fix the collection rack.

[0007] The side plate includes a first plate, a connecting plate, and a second plate; one end of the first plate is rotatably disposed on one side of the base, and the two ends of the connecting plate are respectively connected to the other end of the first plate and the second plate, and the second plate is disposed opposite to the surface of the base;

[0008] A clamping assembly is movably disposed on the second plate along the width direction of the base body, and the clamping assembly is used to clamp the gravity column;

[0009] The fixing component is provided correspondingly to the clamping component.

[0010] According to the protein purification and immobilization device provided by this utility model, the clamping assembly includes:

[0011] A chuck is movably disposed on the second plate, and the chuck has an open end on the side opposite to the second plate.

[0012] An elastic element is provided on at least one side of the open end to clamp the gravity column at the open end.

[0013] According to the present invention, a protein purification and immobilization device is provided, wherein the immobilization component includes a clamping strip;

[0014] The clamping bar is provided in two places, and the two clamping bars are arranged side by side on the surface of the base. The clamping bar extends along the length direction of the base and can move along the width direction of the base. A clamping gap is formed between two adjacent clamping bars, and the clamping gap is used to clamp the collection rack.

[0015] According to the present invention, a protein purification and immobilization device is provided, wherein the second plate has a sliding groove, the sliding groove extends along the width direction of the base, and the clamping component is engaged with the sliding groove and can move along the sliding groove.

[0016] The protein purification and immobilization device provided by this utility model further includes a locking component;

[0017] The first plate is rotatably connected to the base via a hinge;

[0018] When the first plate rotates relative to the base to a preset angle, the locking assembly locks the angle of the first plate relative to the base.

[0019] According to the protein purification and immobilization device provided by this utility model, the locking assembly includes: a telescopic rod;

[0020] The first plate is provided with a plurality of support holes, which are spaced apart along the height direction of the first plate.

[0021] The first end of the telescopic rod is connected to the base, and the second end of the telescopic rod is inserted into one of the plurality of support holes.

[0022] According to the present invention, a protein purification and immobilization device is provided, wherein a plurality of clamping components are provided, and the plurality of clamping components are spaced apart along the width direction of the base;

[0023] Multiple fixing components are also provided, and the multiple fixing components are spaced apart along the width direction of the base body;

[0024] Each of the clamping components and the fixing components is configured in a one-to-one correspondence.

[0025] According to the present invention, a protein purification and fixation device is provided, wherein the seat has a hollow inner cavity, and the surface of the seat is provided with a leakage hole, the leakage hole is connected to the inner cavity, the leakage hole is opposite to the clamping assembly, and the leakage hole is used to collect the waste liquid of the gravity column.

[0026] According to the protein purification and immobilization device provided by this utility model, the base further includes: a drain pipe;

[0027] The side of the base is provided with a drain hole, and the drain pipe is inserted into the drain hole.

[0028] According to the present invention, a protein purification and immobilization device is provided, wherein the base and / or the side plate are made of stainless steel.

[0029] The protein purification and fixation device provided by this utility model includes a base and a side plate. The base includes a seat and a fixing component. The side plate includes a first plate, a connecting plate, and a second plate. The fixing component is used to fix the collection rack. The fixing component is movably disposed on the seat, thereby adjusting the position of the collection tube placed on the collection rack on the seat. Furthermore, by setting the first plate to be rotatable relative to the seat, and the clamping component being movably disposed on the second plate along the width direction, the height of the gravity column and the position of the gravity column along the length and width directions can be adjusted. This allows for adjustment of the horizontal position of the collection tube and the spatial position of the gravity column, flexibly adjusting the relative position of the gravity column and the collection tube, so that the gravity column and the collection tube can be precisely aligned, which is beneficial for the accurate collection of the sample in the gravity column by the collection tube. Attached Figure Description

[0030] To more clearly illustrate the technical solutions in this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0031] Figure 1 This is a three-dimensional structural diagram of the protein purification and immobilization device provided by this utility model.

[0032] Figure label:

[0033] 1. Protein purification and immobilization apparatus;

[0034] 11. Base; 12. Side plate; 13. Clamping assembly; 14. Hinge; 15. Telescopic rod; 111. Seat body; 112. Fixing assembly; 113. Drain pipe; 121. First plate; 122. Connecting plate; 123. Second plate; 1111. Leakage hole; 1112. Drainage hole; 1121. Clamping strip; 1211. Support hole; 1231. Sliding groove;

[0035] 2. Gravity column. Detailed Implementation

[0036] To make the objectives, technical solutions, and advantages of this utility model clearer, the technical solutions of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0037] In the description of the embodiments of this utility model, it should be noted that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings. They are only for the purpose of clarifying the embodiments of this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of this utility model. In addition, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0038] In the description of the embodiments of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in the embodiments of this utility model according to the specific circumstances.

[0039] In this embodiment of the utility model, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0040] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0041] The following is combined Figure 1 The protein purification and immobilization apparatus provided in this utility model will be described in detail through specific embodiments and application scenarios.

[0042] like Figure 1 As shown, this embodiment provides a protein purification and fixation device 1, including: a base 11 and a side plate 12; the base 11 includes a seat body 111 and a fixing component 112. The seat body 111 has a square structure, and the fixing component 112 is movably disposed on the seat body 111. The fixing component 112 is used to fix the collection rack.

[0043] The side plate 12 includes a first plate 121, a connecting plate 122, and a second plate 123. One end of the first plate 121 is rotatably disposed on one side of the base 111. The two ends of the connecting plate 122 are respectively connected to the other end of the first plate 121 and the second plate 123. The second plate 123 is disposed opposite to the surface of the base 111.

[0044] The clamping assembly 13 is movably disposed on the second plate 123 along the width direction of the base 111, and the clamping assembly 13 is used to clamp the gravity column 2.

[0045] The fixing component 112 is correspondingly set with the clamping component 13.

[0046] Understandably, protein purification experiments require filtering the reagent sample in gravity column 2 first, draining the waste liquid from gravity column 2, and then using a collection tube to collect the sample to be collected in gravity column 2. Due to the different specifications of the collection tubes, some collection tubes cannot be placed directly at the bottom and require a collection tube rack (usually centrifuge tubes and centrifuge tube racks) to hold the collection tubes. Furthermore, the specifications of gravity column 2 also vary; during the experiment, the collection tube and gravity column 2 need to be aligned, and gravity column 2 must be ensured to be vertical to facilitate the dripping of sample from gravity column 2 into the collection tube.

[0047] The fixing component 112 secures the collection rack, on which the collection tube is placed. The fixing component 112 ensures that the collection tube does not shake or tilt when receiving the sample from the gravity column 2, guaranteeing the reliability of the collection. In this embodiment, the fixing component 112 can move relative to the base 111 along the length and width directions of the base 111 to correspond to the dripping position of the gravity column 2. For gravity columns 2 of different positions and specifications, it ensures the alignment of the collection tube with the gravity column 2.

[0048] Specifically, the fixing component 112 can be a fixing frame that is movable on the base 111, and the fixing frame has a surrounding structure to fix the collection rack. The fixing component 112 can also be a structure with a clamping mechanism that clamps the collection rack and is movable relative to the base 111.

[0049] Since the first plate 121 can rotate relative to the seat 111, the height of the clamping assembly 13 on the second plate 123 and its position relative to the width of the seat 111 can be adjusted, thereby adjusting the position of the gravity column 2 in the height direction and the width direction of the seat 111.

[0050] Specifically, the first plate 121 and the base 111 can be realized by a rotating shaft structure or by the meshing transmission of a gear assembly.

[0051] The clamping assembly 13 can clamp the gravity column 2, providing stable support for it. For gravity columns 2 of different specifications, the clamping assembly 13 can also adjust the clamping space to accommodate different gravity columns 2. Furthermore, the clamping assembly 13 can move relative to the second plate 123 along the width direction of the base 111 to adjust the position of the gravity column 2 in the width direction. Simultaneously, the gravity column 2 can also rise and fall relative to the clamping assembly 13, thereby adjusting its height.

[0052] Optionally, the clamping assembly 13 may be equipped with two clamping blocks, and the gravity column 2 can be clamped by the relative movement of the two clamping blocks. The movement of the clamping assembly 13 and the second plate 123 can be achieved by a slide rail slider structure or by a lead screw mechanism.

[0053] The protein purification and fixation device 1 provided by this utility model includes a base 11 and a side plate 12. The base 11 includes a seat body 111 and a fixing component 112. The side plate 12 includes a first plate 121, a connecting plate 122 and a second plate 123. The fixing component 112 is used to fix the collection rack. The fixing component 112 is movably disposed on the seat body 111, thereby adjusting the position of the collection tube placed on the collection rack on the seat body 111. Furthermore, by setting the first plate 121 to be rotatable relative to the seat body 111, and the clamping component 13 being movably disposed on the second plate 123 along the width direction, the height of the gravity column 2 and the position of the gravity column 2 along the length and width directions can be adjusted. This allows for the adjustment of the horizontal position of the collection tube and the spatial position of the gravity column 2, flexibly adjusting the relative position of the gravity column 2 and the collection tube, so that the gravity column 2 and the collection tube can be precisely aligned, thereby facilitating the accurate collection of the sample from the gravity column 2 by the collection tube.

[0054] like Figure 1 As shown, the clamping assembly 13 in this embodiment includes a clamp and an elastic element.

[0055] The chuck is movably disposed on the second plate 123, and the side of the chuck opposite to the second plate 123 has an open end.

[0056] At least one side of the open end is provided with an elastic element to clamp the gravity column 2 at the open end.

[0057] Understandably, since the inner side of the chuck opening is equipped with an elastic element, when the gravity column 2 is installed into the opening, the elastic element is compressed, generating an elastic force. This elastic force tightly abuts and compresses the peripheral wall of the gravity column 2, forming a stable clamping force. Because the gravity columns 2 have different specifications, their height and outer diameter vary. The combination of the chuck and the elastic element in this embodiment allows for the installation of gravity columns 2 with different outer diameters, all of which can form a stable clamping force. Furthermore, the operator can apply force to the gravity column 2 to adjust its clamping position in the height direction, thus conveniently achieving both clamping and height adjustment of the gravity column 2.

[0058] Specifically, the elastic element can be a compression spring.

[0059] To enhance the clamping force on the gravity column 2, two compression springs are provided on the inner side of the opening end in this embodiment. The two compression springs clamp the gravity column 2 from both sides, providing a stable elastic clamping force for the gravity column 2.

[0060] like Figure 1 As shown, the fixing component 112 in this embodiment includes a clamping bar 1121.

[0061] Two clamping bars 1121 are provided, and the two clamping bars 1121 are arranged side by side on the surface of the base 111. The clamping bars 1121 extend along the length direction of the base 111 and can move along the width direction of the base 111. A clamping gap is formed between two adjacent clamping bars 1121, and the clamping gap is used to clamp the collection rack.

[0062] Understandably, since the collection rack is typically square, the two clamping bars 1121 can stably hold it in place. Because the clamping bars 1121 can move along the width of the base 111, they can be adjusted to fit collection racks of different sizes by varying the spacing between them, and their positions on the base 111 can be simultaneously adjusted to align the collection rack with the gravity column 2. The clamping bars 1121 have a simple structure and are easy to install.

[0063] In this embodiment, the clamping bar 1121 is detachably connected to the base 111, which facilitates replacement and maintenance.

[0064] Specifically, a protrusion can be provided at the bottom of the clamping bar 1121, and a groove can be provided on the surface of the base 111. The sliding of the clamping bar 1121 relative to the base 111 can be achieved by the sliding of the protrusion relative to the groove.

[0065] like Figure 1 As shown, the second plate 123 of this embodiment has a sliding groove 1231. The sliding groove 1231 extends along the width direction of the base 111. The clamping component 13 is engaged in the sliding groove 1231 and can move along the sliding groove 1231.

[0066] Understandably, in order to enable relative movement of the clamping component 13 along the second plate 123, the second plate 123 is provided with a sliding groove 1231. The connection end of the clamping component 13 and the second plate 123 is engaged in the sliding groove 1231. The position adjustment of the clamping component 13 along the width direction can be conveniently achieved by sliding the clamping component 13 relative to the sliding groove 1231.

[0067] Specifically, a sliding part is provided on the side of the clamp facing the second plate 123. The sliding part is engaged in the sliding groove 1231. By sliding the sliding part relative to the sliding groove 1231, the clamping assembly 13 can move along the sliding groove 1231, thereby adjusting the position of the gravity column 2 in the width direction.

[0068] like Figure 1 As shown, the protein purification and immobilization device 1 in this embodiment also includes a locking component.

[0069] The first plate 121 is rotatably connected to the base 111 via hinge 14.

[0070] When the first plate 121 rotates relative to the base 111 to a preset angle, the locking assembly locks the angle of the first plate 121 relative to the base 111.

[0071] Understandably, a hinge 14 is provided at the connection between the first plate 121 and the base 111 to allow the first plate 121 to rotate relative to the base 111. Since the first plate 121 needs to be locked in position when it rotates to a preset height, a locking assembly is used to lock the relative angle between the first plate 121 and the base 111, so that the first plate 121 is fixed relative to the base 111 at a preset angle, which facilitates the reliability of sample collection using the collection tube after the gravity column 2 is installed.

[0072] Specifically, the locking assembly can lock the rotation of the first plate 121 and the seat 111 by locking the nut.

[0073] like Figure 1 As shown, the locking assembly in this embodiment includes a telescopic rod 15.

[0074] The first plate 121 is provided with a plurality of support holes 1211, which are spaced apart along the height direction of the first plate 121.

[0075] The first end of the telescopic rod 15 is connected to the base 111, and the second end of the telescopic rod 15 is inserted into one of the multiple support holes 1211.

[0076] Understandably, the telescopic rod 15 includes a first rod body and a second rod body, with the first rod body sleeved on the second rod body and slidably connected relative to the second rod body. The first rod body is located at one end of the base 111 where the hinge 14 is mounted. The inner diameter of the plurality of support holes 1211 on the first plate 121 is adapted to the end of the second rod body opposite to the first rod body, allowing the second rod body to be inserted into the support holes 1211.

[0077] After adjusting the rotation angle of the first plate 121 relative to the base 111 to a preset angle, the second rod is extended or retracted relative to the first rod to adjust to a suitable length and the length of the extension rod 15 is locked. Then, the second rod is inserted into the corresponding support hole 1211. At this point, the rotation angle of the first plate 121 and the base 111 is locked. At the end of the experiment, the second rod can be pulled out of the support hole 1211 to unlock the relative angle between the first plate 121 and the base 111.

[0078] like Figure 1 As shown, this embodiment has multiple clamping components 13, which are spaced apart along the width direction of the base 111.

[0079] Multiple fixing components 112 are also provided, and the multiple fixing components 112 are spaced apart along the width direction of the base 111.

[0080] Multiple clamping components 13 are configured in a one-to-one correspondence with multiple fixing components 112.

[0081] Understandably, in order to collect samples from multiple gravity columns 2 simultaneously, this embodiment provides multiple fixing components 112 on the base 111 and multiple clamping components 13 on the second plate 123. Each clamping component 13 is correspondingly set with each fixing component 112 to achieve a one-to-one correspondence between the gravity column 2 and the collection tube.

[0082] Each clamping component 13 can be adjusted in width direction displacement, and each fixing component 112 can be adjusted in width direction displacement. The rotation of the first plate 121 relative to the seat 111 can synchronously adjust the displacement of the clamping component 13 in length direction and its height relative to the seat 111. Each clamping component 13 can adjust the height of each gravity column 2, realizing sample collection of multiple gravity columns 2 and multiple collection tubes, and broadening the application range of the protein purification and fixing device 1.

[0083] like Figure 1 As shown, the seat 111 of this embodiment has a hollow inner cavity. The surface of the seat 111 is provided with a leakage hole 1111. The leakage hole 1111 is connected to the inner cavity. The leakage hole 1111 is arranged opposite to the clamping assembly 13. The leakage hole 1111 is used to collect the waste liquid of the gravity column 2.

[0084] Understandably, the inner cavity of the base 111 can directly hold the waste liquid of the gravity column 2 without the need for an additional waste liquid tray. A drain hole 1111 is provided on the surface of the base 111, and the drain hole 1111 is located on the side of the base 111 near the second plate 123 so that the gravity column 2 can be aligned with the drain hole 1111.

[0085] Specifically, the number of leakage holes 1111 is the same as the number of clamping components 13, and each leakage hole 1111 is arranged opposite to the corresponding gravity column 2.

[0086] Optionally, the shape of the leakage hole 1111 can be circular, elliptical, or polygonal.

[0087] The waste liquid collected in the inner cavity of the seat 111 can be discharged through a pipe, or the waste liquid in the seat 111 can be periodically transferred to a waste liquid tank and discharged into the waste liquid tank.

[0088] like Figure 1 As shown, the base 11 in this embodiment also includes a drain pipe 113. The side of the base 111 is provided with a drain hole 1112, and the drain pipe 113 is inserted into the drain hole 1112.

[0089] Understandably, in order to flexibly discharge the waste liquid inside the seat 111, this embodiment provides a drain hole 1112 at the bottom of the side of the seat 111. A drain pipe 113 is inserted into the drain hole 1112, and the end of the drain pipe 113 is connected to the waste liquid tank. The waste liquid collected inside the seat 111 can be discharged into the waste liquid tank at any time, ensuring that the inside of the seat 111 will not overflow with waste liquid, and eliminating the need for operators to constantly monitor the level of waste liquid inside the seat 111, thus ensuring the reliability of waste liquid discharge.

[0090] like Figure 1 As shown, the base 11 and / or side plate 12 in this embodiment are made of stainless steel.

[0091] Understandably, stainless steel parts have relatively stable performance and will not age or come unglued, allowing the base 11 or side plate 12 to be used repeatedly for a long time, thus extending the service life of the base 11 or side plate 12.

[0092] Specifically, in this embodiment, both the base 11 and the side plate 12 are made of stainless steel.

[0093] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and not to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this utility model.

Claims

1. A protein purification and immobilization apparatus, characterized in that, include: The base includes a seat body and a fixing component. The seat body has a square structure, and the fixing component is movably disposed on the seat body. The fixing component is used to fix the collection rack. The side plate includes a first plate, a connecting plate, and a second plate; one end of the first plate is rotatably disposed on one side of the base, and the two ends of the connecting plate are respectively connected to the other end of the first plate and the second plate, and the second plate is disposed opposite to the surface of the base; A clamping assembly is movably disposed on the second plate along the width direction of the base body, and the clamping assembly is used to clamp the gravity column; The fixing component is provided correspondingly to the clamping component.

2. The protein purification and immobilization apparatus according to claim 1, characterized in that, The clamping assembly includes: A chuck is movably disposed on the second plate, and the chuck has an open end on the side opposite to the second plate. An elastic element is provided on at least one side of the open end to clamp the gravity column at the open end.

3. The protein purification and immobilization apparatus according to claim 1, characterized in that, The fixing component includes a clamping bar; The clamping bar is provided in two places, and the two clamping bars are arranged side by side on the surface of the base. The clamping bar extends along the length direction of the base and can move along the width direction of the base. A clamping gap is formed between two adjacent clamping bars, and the clamping gap is used to clamp the collection rack.

4. The protein purification and immobilization apparatus according to claim 1, characterized in that, The second plate has a sliding groove that extends along the width of the base. The clamping assembly is engaged with the sliding groove and can move along the sliding groove.

5. The protein purification and immobilization apparatus according to claim 1, characterized in that, It also includes locking components; The first plate is rotatably connected to the base via a hinge; When the first plate rotates relative to the base to a preset angle, the locking assembly locks the angle of the first plate relative to the base.

6. The protein purification and immobilization apparatus according to claim 5, characterized in that, The locking assembly includes: a telescopic rod; The first plate is provided with a plurality of support holes, which are spaced apart along the height direction of the first plate. The first end of the telescopic rod is connected to the base, and the second end of the telescopic rod is inserted into one of the plurality of support holes.

7. The protein purification and immobilization apparatus according to any one of claims 1 to 6, characterized in that, The clamping components are provided in multiple ways, and the multiple clamping components are spaced apart along the width direction of the base; Multiple fixing components are also provided, and the multiple fixing components are spaced apart along the width direction of the base body; Each of the clamping components and the fixing components is configured in a one-to-one correspondence.

8. The protein purification and immobilization apparatus according to claim 1, characterized in that, The seat has a hollow inner cavity, and the surface of the seat is provided with a leakage hole. The leakage hole is connected to the inner cavity and is disposed opposite to the clamping assembly. The leakage hole is used to collect the waste liquid of the gravity column.

9. The protein purification and immobilization apparatus according to claim 8, characterized in that, The base also includes: a drain pipe; The side of the base is provided with a drain hole, and the drain pipe is inserted into the drain hole.

10. The protein purification and immobilization apparatus according to claim 1, characterized in that, The base and / or the side plate are made of stainless steel.

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