Hematopoietic stem cell blood bag cryopreservation box

Abstract

The utility model relates to a hematopoietic stem cell blood bag cryopreservation box. The hematopoietic stem cell blood bag cryopreservation box comprises a first area and a second area, the first area is provided with a supporting plate for bearing the frost heaving blood bags, the frost heaving blood bags synchronously move along with the supporting plate, the supporting plate is provided with a connecting rod connected with the box body, the connecting rod moves in the second direction and moves in the first direction at the same time, and the connecting rod drives the supporting plate to move in the direction of the second area. According to the hematopoietic stem cell blood bag cryopreservation box, through the connecting rod moving in the first direction and the second direction at the same time, the supporting plate located in the first area of the box body can push the blood bag which is subjected to frost heaving in the second area, the blood bag is loosened, and therefore the blood bag can be moved out from the interior, and the blood bag can be conveniently taken out from the box body; the problem that the blood bag after frost heaving is clamped in the box, has no taking-out space and is inconvenient to take out is solved.

Description

Technical Field

[0001] This utility model relates to the field of blood bag cryopreservation technology, specifically a hematopoietic stem cell blood bag cryopreservation box. Background Technology

[0002] Hematopoietic stem cells are adult stem cells in the blood system. They are a heterogeneous population with the ability to self-renew for a long time and the potential to differentiate into various mature blood cells. They are often used to treat a variety of diseases. Hematopoietic stem cell samples in physical banks refer to a mixture of hematopoietic stem cells, white blood cells, and platelets after most of the plasma and red blood cells have been removed. After preparation, the hematopoietic stem cells are transferred from the collection bag to the cryopreservation bag, which is then placed in a square aluminum box and finally placed in liquid nitrogen for long-term cryopreservation.

[0003] When blood bags are cryopreserved in a liquid nitrogen environment for a long time, the cell suspension containing DMSO inside the blood bag will expand in volume. In order to prevent the blood bag from moving in the cryopreservation box during transportation, the traditional operation requires the blood bag to be placed tightly against the box wall. However, the expanded blood bag will completely abut against the inner wall of the cryopreservation box, forming an interference fit with the box wall and generating a large static friction. In addition, the expanded blood bag will fill the internal space of the box, leaving no space for removal. The expanded blood bag is inconvenient to remove from the cryopreservation box.

[0004] Therefore, a hematopoietic stem cell cryopreservation box is proposed to solve the problem of inconvenient removal of blood bags after freezing and swelling. Utility Model Content

[0005] To address the shortcomings of existing technologies, this invention provides a hematopoietic stem cell cryopreservation box, which solves the problem of inconvenient removal of blood bags after freezing and swelling.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a hematopoietic stem cell blood bag cryopreservation box, comprising a first zone and a second zone arranged sequentially in a first direction within the box; the first zone is provided with a support plate for supporting the frozen and swollen blood bag, and the frozen and swollen blood bag moves synchronously with the support plate; the support plate is provided with a connecting rod connected to the box body; the connecting rod moves in a second direction while simultaneously moving in the first direction, and the connecting rod drives the support plate to move towards the second zone.

[0007] Preferably, the side of the support plate is provided with a groove, and the side wall of the box body corresponding to the groove is provided with a sliding hole along the second direction, and the sliding hole is inclined towards the first direction. One end of the connecting rod is set in the groove, and the other end passes through the sliding hole.

[0008] A limiting part is formed on the outer side of the connecting rod and near one end of it located in the groove. A limiting groove is formed in the groove corresponding to the limiting part. The limiting part and the limiting groove are slidably connected.

[0009] The limiting part is adapted to the size of the limiting groove, and the distance between the two inner walls of the limiting groove along the first direction is greater than the distance between the two inner walls of the groove along the first direction.

[0010] Preferably, there are two connecting rods and two sliding holes, and the two sliding holes are symmetrically arranged on the box body in an alternating manner. The opposite ends of the two sliding holes are inclined ends; the inclined ends are provided with support holes along the second direction.

[0011] Preferably, a plurality of reinforcing ribs are formed on the side of the support plate near the second region, and the plurality of reinforcing ribs are distributed in a latitude and longitude pattern.

[0012] Preferably, a protruding block is provided on the inner wall of the box along the first direction, and a protruding surface is formed on the side of the protruding block near the second area, the protruding surface extending into the second area.

[0013] Preferably, a slot is provided on the inner wall of the box corresponding to the protrusion, and the protrusion is inserted into the slot.

[0014] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0015] This hematopoietic stem cell cryopreservation box uses a connecting rod that moves simultaneously in a first and a second direction. This allows a support plate located in the first zone of the box to push the frozen and swollen blood bag in the second zone, loosening the blood bag and allowing it to be moved out of the box. This solves the problem of frozen and swollen blood bags getting stuck inside the box and having no space to be removed, making them inconvenient to take out. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0017] Figure 2 This is a schematic diagram of another position of the support plate in this utility model;

[0018] Figure 3 This is a front view schematic diagram of the shell structure in this utility model;

[0019] Figure 4 This is a schematic diagram of the connection structure between the support plate and the connecting rod in this utility model;

[0020] Figure 5 This is a schematic diagram of the left-side structure of the support plate in this utility model;

[0021] Figure 6 This is a top view of the support plate in this utility model.

[0022] Figure 7 This is a schematic diagram of the distribution structure of the protrusions in this utility model;

[0023] Figure 8 This is a schematic diagram of the disassembled structure of the box body and the protruding block in this utility model.

[0024] In the diagram: 1. Box body; 11. First zone; 12. Second zone; 13. Sliding hole; 14. Support hole; 15. Slot; 2. Support plate; 21. Groove; 22. Restriction groove; 23. Reinforcing rib; 3. Connecting rod; 31. Restriction part; 4. Protrusion block; 41. Protrusion surface. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] Example 1:

[0027] Please see Figure 1-6 In this embodiment, a hematopoietic stem cell blood bag cryopreservation box includes a first zone 11 and a second zone 12 that are sequentially discharged in a first direction within a box body 1. The first zone 11 is provided with a support plate 2 for supporting the frozen and swollen blood bag, and the frozen and swollen blood bag moves synchronously with the support plate 2. The support plate 2 is provided with a connecting rod 3 connected to the box body 1. The connecting rod 3 moves in a second direction and moves in the first direction at the same time, and the connecting rod 3 drives the support plate 2 to move towards the second zone 12.

[0028] It should be noted that a lid is fastened to the box body 1; the second area 12 is used to place the liquid blood bag located on the support plate 2. When the liquid blood bag is frozen and swollen, the swollen blood bag will come into contact with the inner wall of the box body 1, and the swollen blood bag will also be adsorbed on the support plate 2; the first direction is from the bottom of the box to the opening of the box, and the second direction is perpendicular to the first direction.

[0029] In application, when it is necessary to remove the frozen blood bag from the box 1, push the connecting rod 3 to move in the second direction. After moving, the connecting rod 3 will also move in the first direction, thereby causing the support plate 2 to move from the first zone 11 to the second zone 12. After the support plate 2 moves, the frozen blood bag located in the second zone 12 moves out of the second zone 12 under the push of the support plate 2, causing the blood bag that is in contact with the inner wall of the box 1 to loosen. After moving the connecting rod 3 to remove part of the frozen blood bag from the box 1, it is easy to remove the frozen blood bag from the box 1, avoiding the frozen blood bag from getting stuck in the box 1. At the same time, after the blood bag part is removed from the box 1, the frozen blood bag can be removed from the box, which also solves the problem that the frozen blood bag fills the box 1 and there is no space to remove it, making it inconvenient to remove.

[0030] Furthermore, the side of the support plate 2 is provided with a groove 21, and the side wall of the box body 1 corresponding to the groove 21 is provided with a sliding hole 13 along the second direction, and the sliding hole 13 is inclined towards the first direction. One end of the connecting rod 3 is set in the groove 21, and the other end passes through the sliding hole 13.

[0031] It should be noted that when the connecting rod 3 moves in the sliding hole 13, it will move in the first direction while moving in the second direction, and move the support plate 2 from the first area 11 to the second area 12, thereby pushing the frozen blood bag to loosen it and allowing part of the frozen blood bag to be moved out of the box 1 so that the frozen blood bag can be taken out of the box 1.

[0032] Specifically, a limiting part 31 is formed on the outer side of the connecting rod 3 and near one end of it located in the groove 21. A limiting groove 22 is provided in the groove 21 corresponding to the limiting part 31. The limiting part 31 and the limiting groove 22 are slidably connected.

[0033] It should also be noted that when the connecting rod 3 moves within the sliding hole 13, it will move along the second direction within the groove 21. As the connecting rod 3 moves, the limiting part 31 will also move within the limiting groove 22.

[0034] More specifically, the size of the limiting part 31 is adapted to the limiting groove 22, and the distance between the two inner walls of the limiting groove 22 along the first direction is greater than the distance between the two inner walls of the groove 21 along the first direction.

[0035] It is known that the limiting part 31 provided on the connecting rod 3, and the size of the limiting part 31 matching the limiting groove 22, can limit the connecting rod 3 in the groove 21, prevent the connecting rod 3 from falling out of the groove 21, and constrain the connecting rod 3 to move only along the preset trajectory of the sliding hole 13, avoiding deflection. It can also allow the connecting rod 3 to stably drive the support plate 2 to move during the movement, so that the support plate 2 can effectively push the frozen blood bag to loosen it.

[0036] In a specific embodiment, as shown in the figure, the number of connecting rods 3 and sliding holes 13 in this embodiment is two. The two sliding holes 13 are symmetrically opened on the box body 1 in an alternating manner, and the opposite ends of the two sliding holes 13 are inclined ends; the inclined ends are provided with support holes 14 along the second direction.

[0037] It should be noted that when the connecting rod 3 moves to move the support plate 2, the connecting rod 3 is pushed to move within the sliding hole 13. While moving in the second direction, the connecting rod 3 also moves in the first direction, causing the support plate 2 to move from the first zone 11 to the second zone 12. At this time, the moved support plate 2 will push the frozen blood bag against the box 1 to loosen it. The loosened frozen blood bag will be partially exposed by the push of the support plate 2 for easy removal. Before removing the frozen blood bag, the connecting rod 3 can be moved into the support hole 14, which will support the connecting rod 3, thereby allowing the support plate 2 to support the frozen blood bag, ensuring that the frozen blood bag is partially exposed within the box 1. This makes it easier to remove the frozen blood bag from the box 1. When removing the frozen blood bag, it is not necessary to continuously apply force to the connecting rod 3 to prevent the loosened frozen blood bag from falling back into the box 1.

[0038] It is known that the corresponding sliding hole 13 is set on the box body 1, and the two support holes 14 are also staggered and symmetrically distributed. The two support holes 14, together with the two connecting rods 3, can support the connecting plate.

[0039] Example 2:

[0040] The basic content is the same as in Example 1, except that:

[0041] Please see Figure 6-8 In this embodiment, a plurality of reinforcing ribs 23 are formed on the side of the support plate 2 near the second region 12, and the plurality of reinforcing ribs 23 are distributed in a latitude and longitude pattern.

[0042] It should be noted that the liquid blood bag placed on the support plate 2 will come into contact with the reinforcing rib 23. The reinforcing rib 23 can reduce the contact area between the liquid blood bag and the support plate 2 after freezing and swelling, thereby reducing the adhesion between the blood bag and the support plate 2 after freezing and swelling, so as to facilitate the peeling of the frozen and swollen blood bag from the support plate 2.

[0043] Furthermore, a protruding block 4 is provided on the inner wall of the box body 1 along the first direction, and a protruding surface 41 is formed on the side of the protruding block 4 near the second region 12, and the protruding surface 41 extends into the second region 12.

[0044] Specifically, there are protruding blocks 4 on each of the four inner walls of the box 1, and the number of them is at least one.

[0045] It should be noted that the protruding surface 41 of the protruding block 4 extends into the second area 12, allowing the liquid blood bag to contact the protruding surface 41 after freezing and swelling, instead of contacting the inner wall of the box body 1. This reduces the contact area between the blood bag and the inner wall of the box body 1 after freezing and swelling, reduces the adhesion between the frozen and swollen blood bag and the inner wall of the box body 1, and allows the support plate 2 to loosen more quickly when pushing the frozen and swollen blood bag.

[0046] Furthermore, a slot 15 is provided on the inner wall of the box body 1 corresponding to the protrusion 4, and the protrusion 4 is inserted into the slot 15.

[0047] Understandably, before pushing the frozen blood bag through the support plate 2, the protrusion 4 can be pulled out of the slot 15, thereby releasing the contact between the protrusion 41 and the frozen blood bag, making it easier for the support plate 2 to push the frozen blood bag out.

[0048] Specifically, the side of the protrusion 4 away from the slot 15 extends through to the outside of the slot 15. The protrusion 4 is also inserted into the lid through the part extending outside the slot 15. When the protrusion 4 is pulled out, it can be easily pulled out through the part extending outside the slot 15.

[0049] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention.

Claims

1. A hematopoietic stem cell cryopreservation box, characterized in that: Includes a first zone (11) and a second zone (12) that are discharged sequentially in a first direction within the box body (1); the first zone (11) is provided with a support plate (2) for carrying frozen and swollen blood bags, and the frozen and swollen blood bags move synchronously with the support plate (2); the support plate (2) is provided with a connecting rod (3) connected to the box body (1); the connecting rod (3) moves in a second direction and moves in a first direction at the same time; and the connecting rod (3) drives the support plate (2) to move towards the second zone (12); The side of the support plate (2) is provided with a groove (21), and the side wall of the box body (1) corresponding to the groove (21) is provided with a sliding hole (13) along the second direction, and the sliding hole (13) is inclined towards the first direction. One end of the connecting rod (3) is set in the groove (21), and the other end passes through the sliding hole (13). A limiting part (31) is formed on the outside of the connecting rod (3) and near one end of it located in the groove (21). A limiting groove (22) is provided in the groove (21) corresponding to the limiting part (31). The limiting part (31) and the limiting groove (22) are slidably connected. The size of the limiting part (31) is adapted to the limiting groove (22), and the distance between the two inner walls of the limiting groove (22) along the first direction is greater than the distance between the two inner walls of the groove (21) along the first direction.

2. The hematopoietic stem cell cryopreservation box according to claim 1, characterized in that: The number of connecting rods (3) and sliding holes (13) is two each. The two sliding holes (13) are symmetrically opened on the box body (1) in an alternating manner. The opposite ends of the two sliding holes (13) are inclined ends. The inclined ends are provided with support holes (14) along the second direction.

3. The hematopoietic stem cell cryopreservation box according to claim 1, characterized in that: A number of reinforcing ribs (23) are formed on the side of the support plate (2) near the second zone (12), and the number of reinforcing ribs (23) are distributed in a latitude and longitude pattern.

4. The hematopoietic stem cell cryopreservation box according to claim 1, characterized in that: A protruding block (4) is provided on the inner wall of the box (1) along the first direction. A protruding surface (41) is formed on the side of the protruding block (4) near the second area (12). The protruding surface (41) extends into the second area (12).

5. A hematopoietic stem cell cryopreservation box according to claim 4, characterized in that: The inner wall of the box (1) has a slot (15) corresponding to the protrusion (4), and the protrusion (4) is inserted into the slot (15).

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