Stacked vessel for freeze drying

Abstract

The utility model provides a stacked vessel for freeze drying, which consists of a plurality of sub-vessels stacked in sequence, and solves the problem that the traditional vessel is difficult to stack stably during freeze drying. Furthermore, by adopting a stackable structural design for the sub-vessels, the size of the opening ends of the sub-vessels is larger than that of the bottom ends of the sub-vessels, and the bottom ends and the opening ends of the sub-vessels are of a stepped structure, so that the sub-vessels are accurately and stably embedded, and the problems that traditional vessels are difficult to stack neatly and stably during freeze drying, and the freeze drying efficiency is high are solved. The problems that containers are prone to shaking and not tight in connection after being stacked are solved, the problems that due to unstable stacking, the liquid level in a disc is inclined, the thickness of samples is uneven, and the freeze drying difficulty is increased are solved, the stability of the whole stacking structure is effectively enhanced, and the whole freeze drying process is facilitated.

Description

Technical Field

[0001] This utility model relates to the field of freeze-drying containers, and more particularly to a stackable container for freeze-drying. Background Technology

[0002] In existing technologies, commonly used freeze-drying vessels have a relatively regular and simple overall structure and a certain strength to support the sample, and are used to complete the freeze-drying process.

[0003] However, it has the following drawbacks:

[0004] (1) In the experimental analysis of samples, if a large number of samples need to be freeze-dried at one time, in order to ensure the consistency of the test environment, they generally need to be frozen in the same refrigerator at the same time, and then dried in the freeze dryer. However, ordinary utensils generally cannot be stacked and need to be laid flat. Since the refrigerator or freeze dryer has limited capacity, laying out a large number of utensils will cause problems such as taking up too much space or insufficient space.

[0005] (2) Ordinary containers are not stable enough during stacking, and liquid tilting is likely to occur. On the one hand, this will prolong the freezing time and cause inconsistent liquid form and freezing effect of the samples. On the other hand, the tilt will cause the frozen liquid to be thicker in some areas, making it difficult to achieve complete synchronous drying, thus affecting the effect and quality of freeze drying.

[0006] (3) Because the freeze dryer lacks graduation markings around its perimeter, it is difficult for operators to accurately control the height of the liquid level in the pan. In actual operation, there is a lack of accurate reference standards. When processing samples, operators can only make a rough judgment based on experience, which may result in the amount of sample added exceeding the optimal liquid level recommended by the machine.

[0007] (4) When the containers are stacked, the space inside the sample is relatively closed, and the exchange pathway with the outside of the container is limited, which restricts the efficiency of the water in the sample being removed after sublimation, which is not conducive to completing the freeze-drying process quickly and fully.

[0008] In view of the above background and problems, there is a need to provide a stackable container for freeze-drying. Utility Model Content

[0009] This invention aims to solve the comprehensive problems of unstable stacking of freeze-drying vessels, which leads to low processing accuracy in the freeze-drying process. It provides a stackable vessel for freeze-drying, which consists of several sub-vessels stacked sequentially.

[0010] Furthermore, the opening of the sub-vessel is larger than the bottom, and the bottom and opening are in a stepped structure.

[0011] Furthermore, both the open end and the bottom end are cylindrical or square cylinders.

[0012] Furthermore, the sidewall of the sub-vessel is provided with a hollow structure.

[0013] Furthermore, the side wall of the sub-vessel is provided with graduation lines.

[0014] Furthermore, the hollow structure is located between the top of the scale line and the top of the sub-vessel.

[0015] Furthermore, the sub-vessel can be a single-chamber vessel or a multi-chamber vessel.

[0016] Furthermore, the vessel is provided with a top lid.

[0017] Furthermore, the top cover is provided with a hollow structure.

[0018] Furthermore, the material of the sub-vessel is stainless steel, polytetrafluoroethylene, aluminosilicate glass, borosilicate glass, microcrystalline glass, or quartz glass.

[0019] The technical solution of this utility model has the following beneficial effects:

[0020] (1) Stacking vessels increases the vertical space for placing vessels and increases the number of vessels that can be placed in the same space, effectively solving the problem that a large number of vessels will occupy too much space or that there is not enough space when they are laid flat.

[0021] (2) By adopting a stacking structure for the containers, the problem of traditional containers being difficult to stack stably during pre-freeze-drying and prone to liquid tilting is solved, and the problem of extending the freezing time and affecting the effect and quality of freeze-drying is avoided. Furthermore, by setting the sub-containers to have a stepped structure at the bottom and the opening, the problem of containers easily shaking and not being tight after stacking is solved, and a stable fit between the sub-containers is achieved.

[0022] (3) By setting graduation lines on the side wall of the sub-vessel, the problem of operators having difficulty accurately controlling the height of the liquid level in the pan, resulting in low processing accuracy, is solved, and the problem of adding more samples than the optimal liquid level height recommended by the machine is avoided.

[0023] (4) By setting several through holes on the side wall of the sub-vessel, a smooth channel is provided for the sublimation and discharge of water, thus accelerating the freeze-drying process. Attached Figure Description

[0024] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0025] Figure 1 This is a schematic diagram of the stackable container of this utility model;

[0026] Figure 2 This is a schematic diagram of the sub-vessel of this utility model;

[0027] Figure 3 This is a schematic diagram of the sub-vessel of this utility model, which is a square prism.

[0028] Figure 4 This is a schematic diagram of a stacked vessel with a hollow structure and scale lines according to the present invention.

[0029] Figure 5 This is a schematic diagram of the multi-chambered sub-vessel of this utility model;

[0030] Figure 6 This is a schematic diagram of the stackable vessel with a top cover according to the present invention.

[0031] Explanation of icon numbers:

[0032] label name label name 10 Stackable containers 1030 hollow structure 10A Stacked containers of square cylinders 1040 scale lines 100 Sub-vessels 1050 Top cover 1010 Open end 1060 Hollowed-out top cover structure 1020 bottom / /

[0033] The realization of the purpose, functional features and advantages of this utility model will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0034] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0035] It should be noted that if the embodiments of this utility model involve directional indicators (such as up, down, left, right, front, back, etc.), the directional indicators are only used to explain the relative positional relationship and movement of the components in a specific posture. If the specific posture changes, the directional indicators will also change accordingly.

[0036] To better understand the above technical solution, the following detailed explanation is provided in conjunction with the accompanying drawings.

[0037] Please see Figure 1 and Figure 2 , Figure 1 This is a schematic diagram of the stackable container of this utility model; Figure 2 This is a schematic diagram of the sub-vessel of this utility model.

[0038] The stacked container 10 used in this embodiment for freeze-drying consists of a plurality of sub-containers 100 stacked sequentially.

[0039] Optionally, the size of the opening end 1010 of the sub-vessel 100 is larger than the size of the bottom end 1020, and the bottom end 1020 and the opening end 1010 form a stepped structure.

[0040] Optionally, the size of the open end 1010 is greater than that of the bottom end 1020, and equal to the thickness of the sub-vessel 100.

[0041] Specifically, when multiple sub-containers 100 are stacked, the bottom end 1020 of the previous sub-container 100 can be precisely embedded into the opening end 1010 of the next sub-container 100, forming a stable connection effect, making the stack more stable. The stacked containers 10 are then frozen and placed in a freeze dryer for drying. On the one hand, this can make full use of the internal space of the refrigerator and freeze dryer, which helps to improve the overall processing efficiency. On the other hand, it can also effectively avoid the problem that the sub-containers 100 are not stable enough when stacked, which can easily cause liquid tilting, affecting the freeze drying effect and the quality of the final product.

[0042] Please see Figure 3 , Figure 3 This is a schematic diagram of a stacked container with square prisms as the sub-container of this utility model.

[0043] Optionally, both the open end 1010 and the bottom end 1020 are cylindrical or square prisms; stacked cylindrical vessels are shown in [reference needed]. Figure 1 The stacked vessel 10 shown, a stacked vessel with a square column shape, can be seen in [reference needed]. Figure 3 The stacked container 10A is shown as a square column.

[0044] These two regular geometric cylindrical shapes facilitate freeze-drying operations and cleaning of the sub-vessel 100; further alternatively, the open end 1010 and the bottom end 1020 are both stacked polygonal cylindrical vessels 10A, which have a similar effect to the aforementioned cylindrical or square cylindrical shapes.

[0045] Please see Figure 4 , Figure 4 This is a schematic diagram of a stacked vessel with a hollow structure and scale lines according to the present invention.

[0046] Optionally, the side wall of the sub-vessel 100 is provided with a perforated structure 1030.

[0047] By setting a perforated structure 1030 on the side wall, water vapor can be discharged from the container 10 in time and drawn away by the freeze dryer, thereby improving the efficiency of freeze drying.

[0048] Optionally, the hollow structure 1030 is circular in shape, with a diameter of 1 mm to 3 mm, preferably 2 mm, which ensures the effect of water vapor exchange and prevents larger particulate impurities from entering the vessel and contaminating the sample.

[0049] Optionally, the hollow structure 1030 can be square, oval, rectangular, rhomboid, or other shapes. Using such regular geometric shapes can improve the uniformity of force distribution, and the edges of the hollow structure 1030 are less likely to break due to uneven force distribution during the stacking of vessels.

[0050] Optionally, the side wall of the sub-vessel 100 is provided with graduation lines 1040.

[0051] The amount of sample added can be clearly determined by using the 1040 scale, effectively avoiding the problems of low addition accuracy and sample volume exceeding the machine's recommended optimal liquid level.

[0052] Optionally, the sub-vessel 100 is marked with graduations 1040 from 0cm to 2cm from bottom to top.

[0053] Optionally, the transparent sub-vessel 100 may have scale lines 1040 on its outer wall, while the opaque sub-vessel 100 may have scale lines 1040 on its inner wall.

[0054] Furthermore, the openwork structure 1030 is located between the scale line 1040 and the top of the sub-vessel 100.

[0055] The hollow structure 1030 is set above the scale line 1040 to the top area, which can effectively prevent the sample from leaking out of the hollow structure 1030, and ensure that the sample can be stably stored in the container 10 and participate in the freeze-drying process.

[0056] Optionally, the distance between the scale line 1040 and the hollow structure 1030 is 3mm to 5mm.

[0057] Please see Figure 5 , Figure 5 This is a schematic diagram of the multi-chambered sub-vessel of this utility model.

[0058] Optionally, the sub-vessel 100 can be a single-chamber vessel or a multi-chamber vessel.

[0059] A single-chamber structure is relatively simple, making it more convenient and faster to load samples, clean them, and perform subsequent maintenance. In a multi-chamber vessel, the different chambers are independent of each other, allowing multiple samples to be placed in different chambers for simultaneous freeze-drying according to their characteristics or production needs. This not only improves overall work efficiency but also effectively prevents cross-contamination between different samples during the freeze-drying process.

[0060] Optionally, if the sample is a powdery inorganic material, due to its small particles and loose texture, it is easily dispersed by factors such as airflow during the freeze-drying process. In this case, it is preferable to use a single-chamber container, which is convenient for centralized processing and can more efficiently remove residual powder when cleaning the entire chamber later.

[0061] If the sample is a polymer material, after freeze-drying it will form a sponge-like material with a certain porous structure, which has good integrity, then it is preferable to use a multi-chamber vessel, which can give full play to the advantage that different chambers can independently set freeze-drying conditions, while avoiding the risk of cross-contamination between different samples.

[0062] Optionally, the inorganic material is hydroxyapatite or calcium phosphate.

[0063] Optionally, the polymer material is collagen, sodium hyaluronate, sodium alginate, modified collagen, modified gelatin, or chitosan.

[0064] Optionally, the multi-chamber vessel is a vessel containing ≥2 sub-chambers, preferably 2 or 4 sub-chambers that are evenly divided; the multi-chamber vessel with this evenly divided structure can achieve the effect of uniform sample volume in each sub-vessel, which is beneficial to ensuring the consistency of test conditions.

[0065] Please see Figure 6 , Figure 6 This is a schematic diagram of the stackable vessel with a top cover according to the present invention.

[0066] Optionally, the vessel 10 is provided with a top cover 1050 to effectively prevent external impurities from entering the interior of the sub-vessel 100 and reduce the risk of contamination of the freeze-dried sample.

[0067] Optionally, the top cover 1050 is provided with a top cover hollow structure 1060. On the one hand, the top cover hollow structure 1060 is not completely open and has a certain shielding effect, which can reduce the risk of contamination of the freeze-dried sample; on the other hand, the top cover hollow structure 1060 allows the water vapor formed by the sublimation of water in the frozen sample to be smoothly extracted.

[0068] Alternatively, the top cover hollow structure 1060 can also be in the shape of a circle, square, oval, rectangle, rhombus, etc., and its effect is similar to the hollow structure 1030 mentioned above.

[0069] Optionally, the material of the sub-vessel 100 may be stainless steel, polytetrafluoroethylene, aluminosilicate glass, borosilicate glass, microcrystalline glass, or quartz glass.

[0070] These materials have a low coefficient of thermal expansion, making them highly reliable in freeze-drying processes that require frequent temperature changes, thus providing a solid foundation for the freeze-drying process.

[0071] In application, the sample to be frozen is first placed in several sub-vessels 100, and the amount added is determined by the scale line 1040. Then, the bottom end 1020 and the opening end 1010 of each sub-vessel 100 are fitted together to form a stacked vessel 10. The top cover 1050 is then placed in a refrigerator to freeze. After freezing, the sample is taken out and placed in a freeze dryer for freeze drying. During the vacuuming process of the freeze dryer, the sublimated water vapor in the sample is discharged through the hollow structure 1030 and the hollow structure 1060 of the top cover, finally forming the desired sample.

[0072] The above description is only a preferred embodiment of the present utility model and does not limit the patent scope of the present utility model. All equivalent structural transformations made under the inventive concept of the present utility model and based on the description and drawings of the present utility model, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present utility model.

Claims

1. A stackable container for freeze-drying, characterized in that, The stacked vessel consists of several sub-vessels stacked sequentially; The opening of the sub-vessel is larger than the bottom, and the bottom and opening are in a stepped structure. The side wall of the sub-vessel is provided with a hollow structure; The side wall of the sub-vessel is provided with graduation lines; The hollow structure is located between the top of the scale line and the top of the sub-vessel.

2. The stackable container for freeze-drying as described in claim 1, characterized in that, Both the open end and the bottom end are cylindrical or square cylinders.

3. A stackable container for freeze-drying as described in claim 1, characterized in that, The sub-vessel can be a single-chamber vessel or a multi-chamber vessel.

4. A stackable container for freeze-drying as described in claim 1, characterized in that, The vessel is equipped with a top lid.

5. A stackable container for freeze-drying as described in claim 4, characterized in that, The top cover has a hollow structure.

6. A stackable container for freeze-drying as described in claim 1, characterized in that, The material of the sub-vessel is stainless steel, polytetrafluoroethylene, aluminosilicate glass, borosilicate glass, microcrystalline glass, or quartz glass.

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