Chromatographic filter

Abstract

The utility model provides a chromatographic filter which comprises a first shell, a second shell and a filter membrane clamped between the first shell and the second shell, and the filter membrane has a certain thickness and can adsorb a preservation solution; the LED lamp further comprises rubber coating, and the rubber coating covers the peripheries of the first shell and the second shell. The end face of one side, facing the filtering membrane, of the first shell and / or the second shell is provided with a pressing part, and the pressing part is used for extruding the end face of the filtering membrane and compressing the filtering membrane; the end face of the side, facing the second shell, of the first shell is provided with a closed annular first skirt portion, and the first skirt portion extends from the first shell to the second shell. The first skirt part is located on the radial outer side of the pressing part so that a liquid storage cavity can be formed between the first skirt part and the pressing part. The liquid storage cavity can contain the preservation liquid exuded from the filtering membrane due to extrusion, and the advantage that the preservation liquid is prevented from leaking is achieved.

Description

Technical Field

[0001] This utility model relates to the technical field of filtration devices, and in particular to a chromatography filter. Background Technology

[0002] Chromatographic filters typically include a chromatographic membrane, end caps, and an encapsulated portion. The chromatographic membrane is the main component responsible for separating the proteins in the mixture. It usually has a certain thickness, and a portion of the membrane is often impregnated with a preservation solution to prevent inactivation due to protein denaturation or collapse due to membrane drying. Two end caps are usually provided to hold the chromatographic membrane and reduce its thickness for easy encapsulation. The encapsulated portion is used to seal the periphery of the end caps, ensuring the overall airtightness of the chromatographic filter.

[0003] For example, the affinity matrix of the modified polysaccharide support disclosed in patent publication number US5059654A specifically discloses that: chamber 152 is formed by inlet shell member 112 and outlet shell member 114 (see...). Figure 4 (and 10). Chamber 152 contains stationary phase 116. ... The mating edges 186 of the inlet housing member 188 and the outlet housing member 190 engage to form an airtight and fluid seal. ... The stationary phase 116 is chromatographically functional and effective for chromatographic separation. The stationary phase 116 may include a multilayer sheet-like matrix 180, which is chromatographically functional and effective for chromatographic separation. One way the stationary phase 116 is attached is to create an alternating layer of sheet-like swellable matrix and a spacer layer, the periphery of which is compressed into a fluid-impermeable configuration 184.

[0004] In the above scheme, the chamber 152 is used to accommodate the stationary phase 116. The edges of the inlet shell member 188 and the inlet shell member 112 directly compress the stationary phase 116 and the fluid-impermeable configuration 184. When the stationary phase 116 (which can be understood as a chromatography membrane) adsorbs the preservation liquid, during the compression process, the preservation liquid is easy to leak out along the connection position of the inlet shell member 188 and the inlet shell member 112 to the outer surface of both, thereby affecting the airtight and fluid sealing effect of the mating edge 186 of the inlet shell member 188 and the outlet shell member 190. Summary of the Invention

[0005] The technical problem to be solved by this invention is to overcome the defects in the prior art and thus provide a chromatography filter.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A chromatography filter includes a first housing, a second housing, and a filter membrane sandwiched between the first housing and the second housing, the filter membrane having a thickness and being capable of adsorbing a preservation liquid;

[0008] It also includes an overmolding coating, which covers the outer periphery of the first housing and the second housing;

[0009] The first housing and / or the second housing have a pressing portion on one end face facing the filter membrane, which is used to press the end face of the filter membrane and compress the filter membrane;

[0010] The first housing has a closed annular first skirt on one end face facing the second housing, the first skirt extending from the first housing toward the second housing; and the first skirt is located radially outside the holding part to form a liquid storage cavity between the first skirt and the holding part; the liquid storage cavity can accommodate the preservation liquid that seeps out of the filter membrane under pressure.

[0011] Through the above scheme, a liquid storage cavity is formed between the holding part and the first skirt with a closed ring structure located radially outside the holding part. This allows the liquid storage cavity to be stored when the filter membrane with adsorbed preservation liquid is squeezed by the holding part. This prevents the preservation liquid from leaking onto the outer surfaces of the first and second shells and affecting the coating effect. In other words, it prevents the preservation liquid from leaking onto the outer surfaces of the first and second shells and affecting the bonding effect between the coating adhesive and the first and second shells, thus ensuring the airtightness of the entire chromatography filter.

[0012] Preferably, the second housing has a closed-loop second skirt on one end face facing the first housing, and the second skirt is located radially outside the first skirt;

[0013] At least a portion of the outer wall surface of the first skirt forms a first abutting surface; the inner wall surface of the second skirt includes a second abutting surface; when the first housing and the second housing compress the filter membrane, the first abutting surface and the second abutting surface can form an abutting seal.

[0014] With the above solution, when the first and second housings move towards each other, the first and second contact surfaces come into contact and form a seal. This allows the filter membrane to be compressed, and the first and second contact surfaces to form a seal, further preventing the storage liquid in the reservoir from leaking onto the outer surfaces of the first and second housings and affecting the bonding effect of the adhesive to the first and second housings. Furthermore, as the degree of compression of the filter membrane gradually increases, the contact area between the first and second contact surfaces also gradually increases, or the contact force between the first and second contact surfaces gradually increases, resulting in a better seal.

[0015] Preferably, the second skirt further includes a first guide surface, which is closer to the first housing than the second abutment surface; the maximum inner diameter of the first guide surface is greater than the outer diameter of the end of the first abutment surface away from the first housing.

[0016] Through the above scheme, the first guide surface can guide the first housing and the second housing to move towards each other, so that a good abutment seal can be formed between the first abutment surface and the second abutment surface.

[0017] It is worth noting that when the outer wall of the first skirt and the inner wall of the second skirt completely abut to form a seal, higher machining precision is required for both the first and second skirts to meet the sealing requirements. If the machining precision of the outer wall of the first skirt and the inner wall of the second skirt is insufficient, poor contact between the two skirts can easily affect the seal. In the above solution, the maximum inner diameter of the first guide surface is greater than the outer diameter of the first abutting surface furthest from the first housing end. On the one hand, this guides the first and second housings to move towards each other, enabling the first and second abutting surfaces to achieve a seal. On the other hand, it reduces machining difficulty, ensuring a good seal between the first and second abutting surfaces. This avoids machining difficulties caused by an excessively large contact area between the outer wall of the first skirt and the inner wall of the second skirt, as well as the potential for insufficient machining precision affecting the seal, thus preventing leakage of the storage liquid from the reservoir.

[0018] Preferably, the end face of the first skirt facing the second housing forms an abutment seal with the end face of the second housing.

[0019] With the above solution, the first skirt and the second housing end faces are sealed by abutment, which eliminates the need for further processing compared to welding or gluing, making assembly more convenient. Furthermore, since the abutment position between the first skirt and the second housing end faces is located at the port (i.e., the opening) of the liquid storage cavity, the abutment seal method can prevent leakage of the storage liquid from the cavity and also prevent contamination of the storage liquid by adhesive or solder.

[0020] Preferably, a portion of the outer wall of the first skirt forms a first limiting surface, and the first limiting surface is located on the side of the first abutment surface near the first housing.

[0021] The inner wall surface of the second skirt includes a second limiting surface near the first housing side;

[0022] The maximum gap between the first limiting surface and the second limiting surface is less than or equal to 0.05 mm.

[0023] The above solution ensures a reasonable gap between the first and second limiting surfaces, preventing the second limiting surface from moving too far away from the first limiting surface and causing the adhesive to penetrate between the first and second skirts. This also prevents the fluid force of the adhesive from pushing the second skirt radially away from the first skirt, thus affecting the sealing effect between the first and second contact surfaces.

[0024] It should be understood that, compared to the preservation fluid, the adhesive used to form the coating has greater viscosity. The maximum gap between the first and second limiting surfaces is less than 0.05 mm. This reduces assembly difficulty and restricts the passage of the adhesive used to form the coating between the first and second limiting surfaces, preventing the adhesive from entering between the first and second skirts and affecting the sealing effect between the first and second abutting surfaces.

[0025] Preferably, the pressing part includes a first pressing part disposed on the first housing and a second pressing part disposed on the second housing; the height of the first pressing part is smaller than that of the second pressing part.

[0026] Through the above scheme, the first and second pressing parts press the filter membrane from both ends of the filter membrane, thereby increasing the pressing effect and increasing the installable thickness of the filter membrane to a certain extent. Furthermore, it is easy to understand that a liquid storage cavity is formed between the first pressing part, the second pressing part, and the first skirt, which increases the liquid storage capacity and further prevents leakage of the protective liquid.

[0027] Preferably, the outer surfaces of the first and second pressing portions are conical, and the cross-sectional width of the first and second pressing portions gradually decreases along the direction that gradually approaches the filter membrane.

[0028] The above solution achieves two advantages. First, it reduces the contact area between the filter membrane and the first and second holding portions, thereby increasing the squeezing force exerted by the first and second holding portions on the filter membrane, resulting in better squeezing effect. Second, because the cross-sectional width of the first and second holding portions gradually decreases along the direction closer to the filter membrane, an inclined conical surface can be formed. This not only increases the area of ​​the liquid storage chamber to a certain extent but also guides the storage liquid flowing to the end faces of the first and second shells (especially the end faces of the first skirt and the second shell) towards the filter membrane, thus preventing leakage of the storage liquid.

[0029] Preferably, the pressing part includes a second pressing part disposed on the second housing; the first housing is provided with a pressing step; the filter membrane is pressed between the pressing step and the second pressing part.

[0030] Preferably, the outer wall surface of the second skirt has a flange extending radially outward;

[0031] The first housing has a base on the radially outer side of the first skirt, and one end of the base has a connecting portion extending axially, and the connecting portion has a buckle extending radially inward.

[0032] The latch can abut against the flange in the axial direction to prevent the second housing from detaching from the first housing.

[0033] The above solution allows for pre-installation of the first and second housings during assembly, preventing them from moving away from each other due to the elasticity of the filter membrane after the force applied to them is removed, thus ensuring the formation of the overmolded coating. Simultaneously, it ensures an effective seal between the first and second contact surfaces, preventing leakage of the squeezed-out protective fluid.

[0034] Preferably, the base has a plurality of through holes; the axial projection of the through holes covers the buckle.

[0035] The above solution, through the through-hole design, allows the adhesive on the outer periphery of the first skirt to permeate through the through-hole to the end face of the second housing away from the second skirt during the overmolding process. This prevents excessive adhesive buildup on the outer periphery of the first and second skirts, which could lead to adhesive seeping between the first and second skirts. Furthermore, the through-hole's location on the side of the connecting part with the snap-fit ​​mechanism facilitates demolding during the processing of the first housing.

[0036] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0037] 1. By forming a liquid storage cavity between the holding part and the first skirt with a closed annular structure located radially outside the holding part, the liquid storage cavity is stored in the liquid storage cavity when the filter membrane with adsorbed preservation liquid is squeezed by the holding part. This prevents the preservation liquid from leaking onto the outer surfaces of the first and second shells and affecting the coating effect. In other words, it prevents the preservation liquid from leaking onto the outer surfaces of the first and second shells and affecting the bonding effect between the coating adhesive and the first and second shells, thus ensuring the airtightness of the entire chromatography filter.

[0038] 2. A sealing seal can be formed between the first and second contact surfaces. When the first and second housings move towards each other, the contact surfaces come into contact and form a seal. This ensures that the filter membrane, under pressure, maintains a seal between the first and second contact surfaces, further preventing the storage liquid in the reservoir from leaking onto the outer surfaces of the first and second housings and affecting the bonding effect of the adhesive. Furthermore, as the degree of pressure on the filter membrane gradually increases, the contact area between the first and second contact surfaces also gradually increases, resulting in a better sealing effect.

[0039] 3. By ensuring a reasonable gap between the first limiting surface and the second limiting surface, it is possible to prevent the second limiting surface from moving too far away from the first limiting surface, which would cause the adhesive forming the coating to penetrate between the first skirt and the second skirt. This would prevent the fluid force of the adhesive from pushing the second skirt radially away from the first skirt and affecting the sealing effect between the first abutting surface and the second abutting surface. Attached Figure Description

[0040] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0041] Figure 1 This is a structural schematic diagram of Embodiment 1 of the present invention.

[0042] Figure 2 for Figure 1 An enlarged diagram of position D1.

[0043] Figure 3 for Figure 1 A schematic diagram of the structure of the first shell.

[0044] Figure 4 for Figure 1 A schematic diagram of the structure of the second shell.

[0045] Figure 5 This is a schematic diagram of the structure of Embodiment 2 provided by this utility model.

[0046] Figure 6 for Figure 5 An enlarged view of position D2 in the middle.

[0047] Explanation of reference numerals in the attached figures:

[0048] 1. First housing; 101. First pipeline; 102. First pipe connector; 2. Second housing; 201. Second pipeline; 202. Second pipe connector; 3. Filter membrane; 4. Coated; 5. Holding part; 51. First holding part; 52. Second holding part; 53. Holding step; 6. First skirt; 61. First abutting surface; 62. First limiting surface; 7. Second skirt; 71. Second abutting surface; 72. First guide surface; 73. Second limiting surface; 8. Flange; 9. Base; 11. Connecting part; 12. Buckle; 13. Through hole; 100. Liquid storage chamber. Detailed Implementation

[0049] The technical solution of this utility model will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0050] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0051] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0052] Example 1

[0053] See Figures 1 to 4This invention provides a chromatography filter, comprising a first housing 1, a second housing 2, a filter membrane 3, and an adhesive coating 4. The filter membrane 3 is sandwiched between the first housing 1 and the second housing 2, and has a thickness capable of adsorbing the preservation liquid. The adhesive coating 4 covers the outer periphery of the first housing 1 and the second housing 2, achieving a seal for the entire chromatography filter. It should be noted that the filter membrane 3 in this invention is composed of multiple porous polymer membranes, and its thickness refers to a thickness exceeding 0.3 mm. During the adhesive coating process, the preservation liquid is adsorbed between the multiple porous polymer membranes or exists within the pores of a single polymer membrane.

[0054] Specifically, the upper end of the first housing 1 is provided with a first pipe 101, which is connected to an external pipe (such as an outlet pipe) through a first pipe connector 102. Correspondingly, the second housing 2 is also provided with a second pipe 201, which is connected to an external pipe (such as an inlet pipe) through a second pipe connector 202.

[0055] The following explanation uses an example where the first pipe 101 on the first housing 1 is connected to the outlet pipe via the first pipe connector 102, and the second pipe 201 on the second housing 2 is connected to the inlet pipe via the second pipe connector 202. In this case, the fluid to be filtered enters the chromatography filter through the second pipe 201 and passes through the filter membrane 3 to achieve filtration, forming a filtrate. The filtrate then flows out from the first pipe 101, and its flow direction is as follows: Figure 1 The direction L is shown.

[0056] Furthermore, threaded connections can be used between the first pipe 101 and the first pipe joint 102, and between the second pipe 201 and the second pipe joint 202.

[0057] Furthermore, the coating 4 is formed by curing adhesive liquid on the outer surfaces of the first housing 1 and the second housing 2, that is, the coating 4 is bonded to the first housing 1 and the second housing 2.

[0058] To ensure filtration efficiency, the filter membrane 3 is usually stacked in multiple layers. After compression, the thickness of the filter membrane 3 is compressed and it is pressed (i.e. fixed) between the first housing 1 and the second housing 2. This prevents the filter membrane 3 from being washed away by the liquid to be filtered (the feed liquid) when it passes through the filter membrane 3, which would cause the filter membrane 3 to shift and affect the filtration efficiency.

[0059] See Figures 1 to 4 In order to ensure the clamping effect of the filter membrane 3, the first housing 1 and the second housing 2 both have a pressing part 5 on the side end face facing the filter membrane 3. The pressing part 5 is used to squeeze the end face of the filter membrane 3 and compress the filter membrane 3.

[0060] Furthermore, since some filter membranes 3 (such as the chromatography membrane in the A membrane chromatography filter, where "A" refers to Protein A) are usually impregnated with a preservation solution to prevent the chromatography membrane from becoming moldy, losing its activity, or being damaged, when the filter membrane 3 is compressed, the preservation solution inside will seep out due to the squeezing force. If the preservation solution leaks onto the outer wall surface of the first housing 1 and the second housing 2, it will affect the bonding effect between the adhesive forming the coating 4 and the first housing 1 and the second housing 2, thereby affecting the sealing performance of the chromatography filter.

[0061] See Figures 1 to 4 To prevent the preservation liquid from leaking out when the filter membrane 3 is compressed, a closed annular first skirt 6 is provided on the end face of the first housing 1 facing the second housing 2. The first skirt 6 and the first housing 1 are integrally connected by molding. The first skirt 6 extends from the first housing 1 toward the second housing 2. The first skirt 6 is located radially outside the holding part 5 to form a liquid storage cavity 100 between the first skirt 6 and the holding part 5. The liquid storage cavity 100 can accommodate the preservation liquid that seeps out when the filter membrane 3 is squeezed, preventing the preservation liquid from leaking onto the outer surfaces of the first housing 1 and the second housing 2 and affecting the coating effect of the coating 4. That is, preventing the preservation liquid from leaking onto the outer surfaces of the first housing 1 and the second housing 2 and affecting the bonding effect between the adhesive forming the coating 4 and the first housing 1 and the second housing 2, so as to ensure the sealing of the entire chromatography filter.

[0062] Furthermore, the second housing 2 has a closed-loop second skirt 7 on one end face facing the first housing 1. The second skirt 7 is integrally connected to the second housing 2 by molding. The second skirt 7 is located radially outside the first skirt 6. A portion of the outer wall surface of the first skirt 6 forms a first abutting surface 61. The inner wall surface of the second skirt 7 includes a second abutting surface 71. When the first housing 1 and the second housing 2 compress the filter membrane 3, the first abutting surface 61 and the second abutting surface 71 can form an abutting seal.

[0063] It is easy to understand that when the first housing 1 and the second housing 2 move towards each other, the first contact surface 61 and the second contact surface 71 come into contact and form a sealing seal. This allows the filter membrane 3 to be compressed, and the first contact surface 61 and the second contact surface 71 can form a sealing seal between them. This further prevents the storage liquid in the storage chamber 100 from leaking to the outer surfaces of the first housing 1 and the second housing 2, thus affecting the bonding effect between the adhesive forming the coating 4 and the first housing 1 and the second housing 2. Furthermore, as the degree of compression of the filter membrane 3 gradually increases, the contact area of ​​the first contact surface 61 and the second contact surface 71 also gradually increases, or the contact force between the first contact surface 61 and the second contact surface 71 gradually increases, resulting in a better sealing effect.

[0064] Furthermore, the second skirt 7 also includes a first guide surface 72, which is closer to the first housing 1 than the second abutment surface 71. The maximum inner diameter of the first guide surface 72 is greater than the outer diameter of the end of the first abutment surface 61 furthest from the first housing 1. It is understood that by providing the first guide surface 72, when the first housing 1 and the second housing 2 move towards each other, the end of the first abutment surface 61 furthest from the first housing 1 can first contact the first guide surface 72. Under the guidance of the first guide surface 72, the first housing 1 and the second housing 2 can move stably together, further enabling a good abutment seal to be formed between the first abutment surface 61 and the second abutment surface 71.

[0065] It is worth noting that when the outer wall surface of the first skirt 6 and the inner wall surface of the second skirt 7 completely abut to form a seal, the machining precision of the first skirt 6 and the second skirt 7 must be higher to meet the sealing requirements. When the machining precision of the outer wall surface of the first skirt 6 and the inner wall surface of the second skirt 7 is insufficient, the seal between the two can easily be affected due to poor contact between the first skirt 6 and the second skirt 7, and may even lead to the loss of the seal. In this embodiment, the maximum inner diameter of the first guide surface 72 is greater than the outer diameter of the first abutting surface 61 at the end away from the first housing 1. On the one hand, it can guide the first housing 1 and the second housing 2 to move towards each other so that the first abutting surface 61 and the second abutting surface 71 can achieve abutting seal; on the other hand, it can reduce the machining difficulty and ensure the abutting seal effect between the first abutting surface 61 and the second abutting surface 71. This avoids the machining difficulties caused by the excessively large contact area between the outer wall surface of the first skirt 6 and the inner wall surface of the second skirt 7, as well as the hidden danger of insufficient machining precision affecting the sealing performance, and prevents the leakage of the storage liquid in the liquid storage cavity 100. Specifically, in this embodiment, when the first guide surface 72 guides the first abutting surface 61 to move toward the second housing 2, the second skirt 7 elastically deforms radially outward, and the first abutting surface 61 and the second abutting surface 71 form a seal through elastic contact.

[0066] Of course, in other embodiments, the entire outer wall surface of the first skirt 6 can be made to form the first abutting surface 61, which can ensure that a stable abutting seal can be formed between the first skirt 6 and the second skirt 7 (that is, between the first abutting surface 61 and the second abutting surface 71).

[0067] It is also worth noting that in other embodiments, only the first skirt 6 may be provided, without the second skirt 7. In this case, during actual use, the first housing 1 can be positioned below the second housing 2, that is, the opening end of the first skirt 6 can be positioned near the upper end of the second housing 2, that is, along the direction of gravity, the opening end of the liquid storage cavity 100 can be positioned above the closed end of the liquid storage cavity 100.

[0068] See Figures 2 to 4The first skirt 6 forms an abutment seal with the end face of the second housing 2 on the side facing the second housing 2. Compared with welding or gluing, this method requires no further processing, making assembly more convenient. Furthermore, with the formation of the adhesive 4, the abutment seal between the first skirt 6 and the end face of the second housing 2 is even better.

[0069] Furthermore, since the first skirt 6 and the second housing 2 abut against each other at the port (i.e. the opening) of the liquid storage cavity 100, the abutment sealing method can not only prevent the storage liquid in the liquid storage cavity 100 from leaking out, but also prevent the adhesive or solder from contaminating the storage liquid compared to welding or gluing.

[0070] See Figures 2 to 4 A portion of the outer wall of the first skirt 6 forms a first limiting surface 62, which is located on the side of the first abutment surface 61 near the first housing 1. The inner wall of the second skirt 7 includes a second limiting surface 73 near the first housing 1. The maximum gap between the first limiting surface 62 and the second limiting surface 73 is set to 0.05mm, 0.04mm, or 0.02mm. It is easy to understand that when there is a reasonable gap between the first limiting surface 62 and the second limiting surface 73, it can prevent the second limiting surface 73 from moving too far away from the first limiting surface 62, thus preventing the adhesive forming the overlay 4 from penetrating between the first skirt 6 and the second skirt 7. This also prevents the fluid force of the adhesive from pushing the second skirt 7 radially away from the first skirt 6, thereby affecting the sealing effect between the first abutment surface 61 and the second abutment surface 71.

[0071] It is worth noting that, since the adhesive used to form the coating 4 has a certain viscosity, the maximum gap between the first limiting surface 62 and the second limiting surface 73 should not exceed 0.05mm, so as to limit the adhesive used to form the coating 4 from entering between the first skirt 6 and the second skirt 7.

[0072] Furthermore, it is worth noting that in this embodiment, multiple levels of seals are sequentially arranged along the direction in which the preservation liquid may leak. Specifically, the end face of the first skirt 6 facing the second housing 2 forms an abutment seal with the end face of the second housing 2 (first-level seal); an abutment seal is formed between the first abutment surface 61 and the second abutment surface 71 (second-level seal); and a seal is formed between the first limiting surface 62 and the second limiting surface 73 to the adhesive liquid of the coating 4 (third-level seal). This effectively increases the sealing effect and prevents the preservation liquid from leaking out. Among them, the first-level and second-level seals can prevent the preservation liquid from leaking out, and the third-level seal can prevent the adhesive liquid from entering between the first skirt 6 and the second skirt 7, ensuring the sealing effect of the second-level seal.

[0073] There are various ways to set the holding part 5, as long as it can achieve stable holding of the filter membrane 3.

[0074] See Figures 1 to 4In this embodiment, the pressing part 5 includes a first pressing part 51 disposed on the first housing 1 and a second pressing part 52 disposed on the second housing 2.

[0075] It is understandable that the first pressing part 51 and the second pressing part 52 press the filter membrane 3 from both ends of the filter membrane 3, thereby increasing the pressing effect on the filter membrane 3 and increasing the installable thickness of the filter membrane 3 to a certain extent. It is also easy to understand that at this time, a liquid storage cavity 100 is formed between the first pressing part 51, the second pressing part 52, and the first skirt 6, thereby increasing the liquid storage capacity to a certain extent and further preventing leakage of the protective liquid.

[0076] Specifically, the height of the first pressing portion 51 is less than that of the second pressing portion 52. Here, "height" refers to the axial extension length, that is: the height of the first pressing portion 51 is H1 (see...). Figure 2 The height of the second pressing part 52 is H2 (see...). Figure 2 ).

[0077] Specifically, the end face of the first pressing part 51 away from the first housing 1 and the end face of the second pressing part 52 away from the second housing 2 are arranged opposite to each other (that is, there is an overlapping area in the projection along the axial direction, which can be partially overlapping or completely overlapping), so that the first pressing part 51 and the second pressing part 52 can cooperate with each other to squeeze the filter membrane 3, so that the squeezing effect of the filter membrane 3 is better.

[0078] Furthermore, the outer surfaces of the first holding portion 51 and the second holding portion 52 are conical, and the cross-sectional width of the first holding portion 51 and the second holding portion 52 gradually decreases along the direction gradually approaching the filter membrane 3. On the one hand, this reduces the contact area between the filter membrane 3 and the first holding portion 51, and between the filter membrane 3 and the second holding portion 52, thereby increasing the squeezing force of the first holding portion 51 on the filter membrane 3 and the second holding portion 52 on the filter membrane 3, resulting in a better squeezing effect of the first holding portion 51 and the second holding portion 52 on the filter membrane 3. On the other hand, since the cross-sectional width of the first holding portion 51 and the second holding portion 52 gradually decreases along the direction gradually approaching the filter membrane 3, an inclined conical surface can be formed. This can increase the area of ​​the liquid storage cavity 100 to a certain extent, and can also guide the storage liquid flowing to the end faces of the first shell 1 and the second shell 2 (especially the end faces of the first skirt 6 and the second shell 2) to the filter membrane 3, thereby preventing leakage of the storage liquid.

[0079] See Figures 1 to 4The outer wall of the second skirt 7 has a flange 8 extending radially outward; the first housing 1 has a base 9 on the radially outer side of the first skirt 6, one end of the base 9 has a connecting portion 11 extending axially, and the connecting portion 11 has a buckle 12 extending radially inward; the buckle 12 can abut against the flange 8 in the axial direction to restrict the second housing 2 from detaching from the first housing 1.

[0080] Specifically, the connecting part 11 is an injection molded part with a certain deformation capability; meanwhile, a guide slope is provided on one side of the buckle 12 and the flange 8.

[0081] When the first housing 1 and the second housing 2 move toward each other, the guide slope on the flange 8 abuts against the guide slope on the buckle 12 and pushes the buckle 12, thereby causing the connecting part 11 to deform radially outward until the guide slope on the flange 8 and the guide slope on the buckle 12 disengage from each other. At this time, the connecting part 11 drives the buckle 12 to spring back and reset, thereby limiting the flange 8 and restricting the second housing 2 from disengaging from the first housing 1 in the axial direction. This achieves the pre-installation of the first housing 1 and the second housing 2, preventing the first housing 1 and the second housing 2 from moving away from each other and disengaging under the elastic action of the filter membrane 3 after the force applied to the first housing 1 and the second housing 2 is removed. This is conducive to the formation of the coating 4 and can also ensure the effective sealing between the first contact surface 61 and the second contact surface 71, preventing the leakage of the squeezed protective liquid.

[0082] Furthermore, the first housing 1, base 9, connecting part 11, and buckle 12 are injection molded together. To facilitate demolding of the first housing 1 during processing, several through holes 13 are provided through the base 9; the axial projection of the through holes 13 covers the buckle 12. In addition, the through holes 13 allow the adhesive around the first skirt 6 to permeate through the through holes 13 to the end face of the second housing 2 away from the second skirt 7 during the overmolding process, preventing excessive adhesive buildup around the first skirt 6 and the second skirt 7 from seeping between the first skirt 6 and the second skirt 7.

[0083] Example 2

[0084] See Figure 5 and Figure 6 Based on the above embodiment 1, the difference in this embodiment is that: the pressing part 5 includes a second pressing part 52 disposed on the second housing 2; the first housing 1 is provided with a pressing step 53; the filter membrane 3 is pressed between the pressing step 53 and the second pressing part 52.

[0085] The above embodiments are merely preferred embodiments of this utility model and should not be construed as limiting the scope of protection of this utility model. Any non-substantial changes and substitutions made by those skilled in the art based on this utility model shall fall within the scope of protection claimed by this utility model.

Claims

1. A chromatography filter, comprising a first housing, a second housing, and a filter membrane sandwiched between the first housing and the second housing, the filter membrane having a thickness and being capable of adsorbing and storing a liquid; Its features are, It also includes an overmolding coating, which covers the outer periphery of the first housing and the second housing; The first housing and / or the second housing have a pressing portion on one end face facing the filter membrane, which is used to press the end face of the filter membrane and compress the filter membrane; The first housing has a closed annular first skirt on one end face facing the second housing, the first skirt extending from the first housing toward the second housing; and the first skirt is located radially outside the holding part to form a liquid storage cavity between the first skirt and the holding part; the liquid storage cavity can accommodate the preservation liquid that seeps out of the filter membrane under pressure.

2. A chromatography filter according to claim 1, characterized in that, The second housing has a closed-loop second skirt on one end face facing the first housing, and the second skirt is located radially outside the first skirt; At least a portion of the outer wall surface of the first skirt forms a first abutting surface; the inner wall surface of the second skirt includes a second abutting surface; when the first housing and the second housing compress the filter membrane, the first abutting surface and the second abutting surface can form an abutting seal.

3. A chromatography filter according to claim 2, characterized in that, The second skirt also includes a first guide surface, which is closer to the first housing than the second abutment surface; the maximum inner diameter of the first guide surface is greater than the outer diameter of the end of the first abutment surface away from the first housing.

4. A chromatography filter according to claim 1, characterized in that, The end face of the first skirt facing the second housing forms an abutment seal with the end face of the second housing.

5. A chromatography filter according to claim 2, characterized in that, A portion of the outer wall of the first skirt forms a first limiting surface, which is located on the side of the first abutting surface near the first housing. The inner wall surface of the second skirt includes a second limiting surface near the first housing side; The maximum gap between the first limiting surface and the second limiting surface is less than or equal to 0.05 mm.

6. A chromatography filter according to claim 1, characterized in that, The pressing part includes a first pressing part disposed on the first housing and a second pressing part disposed on the second housing; the height of the first pressing part is smaller than that of the second pressing part.

7. A chromatography filter according to claim 6, characterized in that, The outer surfaces of the first and second pressing portions are conical, and the cross-sectional width of the first and second pressing portions gradually decreases along the direction that gradually approaches the filter membrane.

8. A chromatography filter according to claim 1, characterized in that, The pressing part includes a second pressing part disposed on the second housing; the first housing is provided with a pressing step; the filter membrane is pressed between the pressing step and the second pressing part.

9. A chromatography filter according to claim 2, characterized in that, The outer wall surface of the second skirt has a flange extending radially outward; The first housing has a base on the radially outer side of the first skirt, and one end of the base has a connecting portion extending axially, and the connecting portion has a buckle extending radially inward. The latch can abut against the flange in the axial direction to prevent the second housing from detaching from the first housing.

10. A chromatography filter according to claim 9, characterized in that, The base has several through holes; the axial projection of the through holes covers the buckle.

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