Microfluidic emulsifying unit for iodophol and chemotherapeutic drugs

Abstract

The utility model relates to the field of medicine emulsifying devices, in particular to a micro-fluidic emulsifying unit for iodophol and chemotherapeutics, which comprises a micro-channel reaction module and an electronic tag, a micro-channel for emulsifying chemotherapeutics and iodophol is arranged in the micro-channel reaction module, and the electronic tag is arranged in the micro-channel reaction module. Three Luer tapers connected with the micro-channel are arranged outside the micro-channel reaction module, and the electronic tag is installed on the surface of the micro-channel reaction module and used for storing emulsion configuration information. According to the embodiment of the utility model, a doctor can select the micro-channel reaction module with a proper model according to the diameter of a tumor blood supply artery and confirm the model of the micro-channel reaction module by scanning the electronic tag, so that the emulsion with the droplet size meeting the requirement is formed.

Description

Technical Field

[0001] This utility model relates to the field of drug emulsification devices, specifically to a microfluidic emulsification unit for iodized oil and chemotherapy drugs. Background Technology

[0002] Currently, the preparation of iodized oil and chemotherapy drug emulsions in clinical practice usually adopts the pump delivery method. The standard method is to use one syringe filled with iodized oil and another syringe filled with chemotherapy drugs, and pump the two syringes back and forth 60 times through a three-way valve within 60 seconds to prepare the emulsion. A simplified method is to use one syringe to repeatedly draw and draw into an open cup containing iodized oil and chemotherapy drugs to form an emulsion.

[0003] The above methods face the following problems in clinical practice:

[0004] First, the homogenization effect depends on the personal experience of the surgical operator, making it difficult to obtain a homogeneous water-in-oil emulsion.

[0005] Second, the size of the generated droplets cannot be adjusted according to the diameter of the tumor's blood supply artery.

[0006] Third, the risk of infection arises from the repeated aspiration and emulsification of chemotherapy drugs and iodized oil in open cups, as well as the difficulty in achieving sterility in the air of interventional operating rooms. Utility Model Content

[0007] The purpose of this invention is to provide a microfluidic emulsification unit for iodized oil and chemotherapy drugs, in order to solve the problems of unstable homogenization, inability to control droplet size, and susceptibility to infection associated with pump delivery methods.

[0008] To solve the above-mentioned technical problems, this utility model specifically provides the following technical solution:

[0009] A microfluidic emulsification unit for iodized oil and chemotherapy drugs includes a microchannel reaction module and an electronic tag. The microchannel reaction module has internal microchannels for emulsifying chemotherapy drugs and iodized oil. The external part of the microchannel reaction module has three Luer connectors connecting two inlets and one outlet of the microchannels. The electronic tag is mounted on the surface of the microchannel reaction module and is used to store information on the configuration of the emulsion.

[0010] Furthermore, it also includes an anti-reverse valve, which is connected to the outlet of the microchannel reaction module via a Luer connector, and the anti-reverse valve is used to connect an interventional catheter or puncture needle.

[0011] Furthermore, the anti-reverse valve has a spindle-shaped channel that is small at both ends and large in the middle. A floating ball is installed inside the spindle-shaped channel. The diameter of the ball is larger than the diameter of both ends of the spindle-shaped channel. One end of the spindle-shaped channel is a round hole, and the other end is a star-shaped hole. Both the round hole and the star-shaped hole can prevent the ball from passing through. When the ball contacts the round hole, it prevents the liquid from passing through. When the ball contacts the star-shaped hole, it does not prevent the liquid from passing through.

[0012] Furthermore, the outlet of the anti-reverse valve is pre-fitted with a waste liquid collection bag.

[0013] Furthermore, it also includes a three-way valve, one end of which is detachably connected to the outlet of the anti-reverse valve, and one remaining end of which is used to connect an injection needle and the other remaining end is used to connect an additional syringe.

[0014] Compared with the prior art, this application has the following advantages:

[0015] A microfluidic emulsification unit for iodized oil and chemotherapy drugs is provided. Doctors can select the appropriate model of microchannel reaction module according to the diameter of the tumor's blood supply artery, and confirm the model of the microchannel reaction module by scanning an electronic tag, thereby forming an emulsion with droplet size that meets the requirements. Attached Figure Description

[0016] To more clearly illustrate the embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are merely exemplary, and those skilled in the art can derive other embodiments based on the provided drawings without creative effort.

[0017] Figure 1 This is a perspective view of one working condition according to an embodiment of the present utility model;

[0018] Figure 2 This is a partially sectional perspective view of an embodiment of the present invention;

[0019] Figure 3 This is a front view of another working condition according to an embodiment of the present utility model;

[0020] The labels in the diagram represent the following:

[0021] 1-Injector; 2-Microchannel reaction module; 21-Microchannel; 3-Luer connector; 4-Electronic tag; 5-Anti-reverse valve; 51-Spindle-shaped channel; 52-Ball; 53-Round hole; 54-Star-shaped hole; 6-Three-way valve. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] To address the problems associated with the pumping method commonly used in the clinical preparation of iodized oil and chemotherapy drug emulsions, this invention provides a microfluidic emulsification unit for iodized oil and chemotherapy drugs, hereinafter referred to as the emulsification unit. It uses a microchannel reactor to perform emulsification of iodized oil and chemotherapy drugs, enabling control over homogenization and droplet size, and the closed environment reduces the risk of infection.

[0024] refer to Figure 1 The emulsification unit includes:

[0025] The microchannel reaction module 2 is connected to the outlets of two syringes 1 via two Luer connectors 3, and contains microchannels 21 (e.g., T-shaped or Y-shaped structures) for emulsifying chemotherapy drugs and iodized oil.

[0026] Electronic tag 4 is used to store information about the configuration of the emulsion, including: chemotherapy drug type, iodized oil type, production batch number, expiration date, and preset flow rate ratio, droplet size, injection volume, etc.

[0027] Anti-backflow valve 5, connected to the outlet of microchannel reaction module 2 via a Luer connector 3, is used to connect to the patient's interventional catheter or puncture needle. Anti-backflow valve 5 is normally closed to prevent blood backflow from causing blockage of microchannel 21.

[0028] Waste collection bag (not shown) is pre-installed at the outlet of anti-reverse valve 5 to collect the mixture of iodized oil and chemotherapy drugs discharged when medical personnel first push syringe 1 to expel air from inside microchannel 21.

[0029] The advantages of emulsification units are that doctors can use one syringe 1 to fill with a specified volume and concentration of chemotherapy drugs, and another syringe 1 to fill with a specified volume of iodized oil. By selecting the appropriate model of emulsification unit according to the diameter of the tumor's blood supply artery, an emulsion with a droplet size range that meets the requirements can be formed, eliminating the variables in clinical mixing.

[0030] Furthermore, the anti-backflow valve 5 in this embodiment adopts a special design, which not only prevents backflow but also breaks down large particles in the emulsion into smaller particles.

[0031] refer to Figure 2The anti-reverse valve 5 has a spindle-shaped channel 51 that is small at both ends and large in the middle. The spindle-shaped channel 51 is equipped with a floating ball 52. The diameter of the ball 52 is larger than the diameter of both ends of the spindle-shaped channel 51. One end of the spindle-shaped channel 51 is a round hole 53 and the other end is a star-shaped hole 54. Both the round hole 53 and the star-shaped hole 54 can prevent the ball 52 from passing through. When the ball 52 contacts the round hole 53, it prevents the liquid from passing through. When the ball 52 contacts the star-shaped hole 54, it can not prevent the liquid from passing through.

[0032] The anti-backflow valve 5 has a circular hole 53 at one end connected to the microchannel reaction module 2, and the other end connected to the patient's interventional catheter or puncture needle. This design allows the ball 52 to close the circular hole 53 when blood flows back, thus preventing backflow. When the emulsion is delivered in the correct direction, the ball 52 rests against the center of the star-shaped hole 54, and the emulsion flows through the edge of the star-shaped hole 54. When large particles in the emulsion reach the position of the star-shaped hole 54, they are crushed by the ball 52 and cut by the star-shaped hole 54 to form small particles.

[0033] Furthermore, doctors sometimes need to prepare several vials of diluted iodized oil and chemotherapy drug emulsion for later use. To solve this problem, the emulsification unit also includes a three-way valve 6. One end of the three-way valve 6 can be detachably connected to the outlet of the anti-reverse valve 5. One remaining end of the three-way valve 6 can be connected to an injection needle, and the other remaining end can be connected to an additional syringe 1. The doctor operates the internal passage of the three-way valve 6 through the handle on the three-way valve 6, so that the iodized oil and chemotherapy drug emulsion can be directly injected into the patient's body through the injection needle, or injected into the additional syringe 1 for later use.

[0034] The working principle of the emulsification unit includes the following steps:

[0035] Step 1, Preparation: Medical staff load the predetermined volume and concentration of chemotherapy drugs and iodized oil into two syringes 1 respectively. Electronic tags 4 pre-store configuration information for specific treatment needs, such as the flow rate ratio of the two liquids and the droplet size of the target emulsion, providing a basis for precise operation.

[0036] Step 2, Emulsification: When both syringes 1 are pressed simultaneously, the chemotherapy drug and iodized oil are precisely pumped into the microchannel 21 reaction module 2. Inside this module, the two liquids meet in the T-shaped or Y-shaped microchannels 21. The narrow space and special structure of the microchannels 21 generate strong shear forces, forcing the two immiscible liquids to mix rapidly and thoroughly, forming a fine emulsion with uniform and controllable droplet size. This process is completed in a closed environment, greatly reducing the risk of contamination and infection.

[0037] Step 3, Safe Infusion and Anti-clogging: After the generated emulsion flows out of the microchannel 21, it passes through a specially designed anti-backflow valve 5. The anti-backflow valve 5 has the function of preventing backflow and secondary fragmentation. When blood backflow pressure occurs, the ball 52 in the anti-backflow valve 5 will close the inlet to prevent blood from entering and clogging the precision microchannel 21. During normal infusion, the emulsion will bypass the ball 52 and flow out from a star-shaped hole 54. This structure can crush and cut larger particles that may be accidentally mixed in the emulsion, further ensuring the homogeneity and safety of the output emulsion.

[0038] Step 4, Other Operations: By adding a three-way valve, the prepared emulsion can be injected directly into the patient or dispensed into other syringes 1 for later use, meeting different clinical application scenarios.

[0039] The above embodiments are merely exemplary embodiments of this utility model and are not intended to limit this utility model. The scope of protection of this utility model is defined by the claims. Those skilled in the art can make various modifications or equivalent substitutions to this utility model within its substance and scope of protection, and such modifications or equivalent substitutions should also be considered as falling within the scope of protection of this utility model.

Claims

1. A microfluidic emulsification unit for iodized oil and chemotherapy drugs, characterized in that, The device includes a microchannel reaction module (2) and an electronic tag (4). The microchannel reaction module (2) has a microchannel (21) inside for emulsifying chemotherapy drugs and iodized oil. The microchannel reaction module (2) has three Luer connectors (3) on the outside for connecting two inlets and one outlet of the microchannel (21). The electronic tag (4) is installed on the surface of the microchannel reaction module (2) and is used to store information on the configuration of the emulsion.

2. The microfluidic emulsification unit for iodized oil and chemotherapy drugs according to claim 1, characterized in that, It also includes an anti-reverse valve (5), which is connected to the outlet of the microchannel reaction module (2) via a Luer connector (3), and the anti-reverse valve (5) is used to connect an interventional catheter or puncture needle.

3. The microfluidic emulsification unit for iodized oil and chemotherapy drugs according to claim 2, characterized in that, The anti-reverse valve (5) has a spindle-shaped channel (51) with small ends and a large middle. The spindle-shaped channel (51) is equipped with a floating ball (52). The diameter of the ball (52) is larger than the diameter of the two ends of the spindle-shaped channel (51). One end of the spindle-shaped channel (51) is a round hole (53) and the other end is a star-shaped hole (54). Both the round hole (53) and the star-shaped hole (54) can prevent the ball (52) from passing through. When the ball (52) contacts the round hole (53), it prevents the liquid from passing through. When the ball (52) contacts the star-shaped hole (54), it cannot prevent the liquid from passing through.

4. The microfluidic emulsification unit for iodized oil and chemotherapy drugs according to claim 2, characterized in that, The outlet of the anti-reverse valve (5) is pre-fitted with a waste liquid collection bag.

5. The microfluidic emulsification unit for iodized oil and chemotherapy drugs according to claim 2, characterized in that, It also includes a three-way valve (6), one end of which is detachably connected to the outlet of the anti-reverse valve (5), and one remaining end of the three-way valve (6) is used to connect an injection needle and the other remaining end is used to connect an additional syringe (1).

Images