Supermacroporous organic polymer microsphere chromatographic column

Abstract

The super-macroporous organic polymer microsphere chromatographic column comprises a column body and a fixing mechanism, an inlet sieve plate is arranged at the top end of the inner wall of the column body, a feeding port is formed in the top end of the column body, and an inlet sealing plug is arranged at the top end of the feeding port. According to the super-macroporous organic polymer microsphere chromatographic column, through the arrangement of the fixing mechanism, when the chromatographic column and an instrument are fixedly installed, the column body is sleeved with a flexible fixing ring in the fixing mechanism, and the flexible fixing ring has certain elasticity and can be conveniently installed and taken down; the flexible fixing ring and the column body are fixed through the fixing rod, the column body can be protected through the protection sleeve in the flexible fixing ring during fixing, the column body can be prevented from falling off from the flexible fixing ring, the anti-skid effect is achieved, the sliding sleeve is installed on an instrument support, the height of the chromatographic column can be adjusted through the sliding sleeve, and the sliding sleeve is convenient to use. And locking is carried out through a locking rod, and the adjustability is high.

Description

Technical Field

[0001] This utility model relates to the technical field of chromatography columns, specifically to ultra-large pore organic polymer microsphere chromatography columns. Background Technology

[0002] Chromatographic columns, as a key tool in the field of chemical analysis, are fundamentally designed to achieve the effective separation and detection of mixtures using specific materials. They form clear bands based on the different behaviors of compounds within the column material, enabling precise identification. Operationally, the mixture to be analyzed is injected into the column, propelled through by a specific solvent, and captured by a detector to achieve efficient analysis. In the medical field, chromatographic columns aid in drug development and quality control, accurately analyzing drug components and metabolites. In food and environmental testing, they are indispensable for identifying additives and monitoring water pollution. In short, chromatographic columns, with their superior separation efficiency and detection accuracy, play a vital role in multiple fields such as chemistry, biology, and medicine, providing solid support for scientific research and quality control. Therefore, there is an urgent need for ultra-large pore organic polymer microsphere chromatographic columns.

[0003] Currently used ultra-large pore organic polymer microsphere chromatographic columns have the disadvantages of being inconvenient to fix and adjust to the instrument, and also inconvenient to replace and discharge the internal packing material. Utility Model Content

[0004] The purpose of this invention is to provide an ultra-large pore organic polymer microsphere chromatographic column to solve the problems mentioned in the background art, such as the inconvenience of fixing and adjusting the chromatographic column to the instrument and the inconvenience of replacing and discharging the internal packing material during use.

[0005] To achieve the above objectives, this utility model provides the following technical solution: an ultra-large pore organic polymer microsphere chromatographic column, comprising a column body and a fixing mechanism. An inlet sieve plate is provided at the top of the inner wall of the column body, and a feed inlet is provided at the top of the column body. An inlet sealing plug is provided at the top of the feed inlet. The inner wall of the column body is filled with porous microsphere packing material, and an outlet sieve plate is provided at the bottom of the inner wall of the column body. An outlet is provided at the bottom of the inner wall of the column body, and an outlet sealing plug is installed at the bottom of the outlet. The fixing mechanism is installed on the outer wall of the column body. The fixing mechanism includes a flexible fixing ring, a protective sleeve, a fixing rod, a mounting frame, a sliding sleeve, a mounting hole, and a locking rod. The flexible fixing ring is sleeved on the outer wall of the column body. A protective sleeve is provided on the inner wall of the flexible fixing ring, and a fixing rod is installed at one end of the outer wall of the flexible fixing ring. A mounting frame is welded to the other end of the outer wall of the flexible fixing ring, and a sliding sleeve is welded to the outer wall of the mounting frame. A mounting hole is provided on the inner wall of the sliding sleeve, and a locking rod is installed on the outer wall of the sliding sleeve.

[0006] Preferably, the inlet sealing plug and the feed port are connected by a thread, and the outer wall of the inlet sealing plug and the inner wall of the feed port are both threaded.

[0007] Preferably, the inlet screen plate and the outlet screen plate are configured in a one-to-one correspondence, and each screen plate has the same specifications.

[0008] Preferably, the porous microsphere packing material is silicone microspheres.

[0009] Preferably, the flexible fixing ring and the fixing rod are connected by a thread, and both the outer wall of the fixing rod and the inner wall of the flexible fixing ring are threaded.

[0010] Compared with the prior art, the beneficial effects of this utility model are:

[0011] 1. This ultra-large pore organic polymer microsphere chromatographic column features a fixed mechanism that facilitates the installation of the column and instrument. A flexible fixing ring is fitted over the column body, and the ring's elasticity allows for easy installation and removal. A fixing rod secures the ring to the column. An internal protective sleeve within the ring protects the column during installation and prevents it from detaching, providing an anti-slip function. A sliding sleeve is mounted on the instrument support, allowing for column height adjustment and locking via a locking rod, offering high adjustability.

[0012] 2. This ultra-large pore organic polymer microsphere chromatographic column is equipped with an inlet and outlet sealing plug, which facilitates the replacement or discharge of the packing material. The outlet sealing plug can be removed by unscrewing it, thereby discharging the internal packing material. The outer wall of the sealing plug has a threaded design, which facilitates the disassembly and assembly of the sealing plug. At the same time, it is also convenient to inject materials into the column during use. Attached Figure Description

[0013] Figure 1 This is a diagram illustrating the installation effect of the chromatographic column of this utility model.

[0014] Figure 2 This is a drawing of the fixing mechanism parts of this utility model;

[0015] Figure 3 This is a cross-sectional view of the porous microsphere packing of this utility model.

[0016] In the diagram: 1. Column; 2. Inlet screen plate; 3. Feed inlet; 4. Inlet sealing plug; 5. Porous microsphere packing; 6. Outlet screen plate; 7. Discharge port; 8. Outlet sealing plug; 9. Fixing mechanism; 901. Flexible fixing ring; 902. Protective sleeve; 903. Fixing rod; 904. Mounting bracket; 905. Sliding sleeve; 906. Mounting hole; 907. Locking rod. Detailed Implementation

[0017] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0018] Please see Figure 1-3 This utility model provides a technical solution: an ultra-large pore organic polymer microsphere chromatographic column, including a column body 1 and a fixing mechanism 9. An inlet sieve plate 2 is provided at the top of the inner wall of the column body 1, and a feed inlet 3 is opened at the top of the column body 1. An inlet sealing plug 4 is provided at the top of the feed inlet 3, and the inlet sealing plug 4 and the feed inlet 3 are threaded together. Both the outer wall of the inlet sealing plug 4 and the inner wall of the feed inlet 3 are threaded. The inner wall of the column body 1 is filled with porous microsphere packing material 5, which is made of organosilicone microspheres. A [further details about the column body 1 are needed for accurate translation]. The outlet screen plate 6 and the inlet screen plate 2 are set one-to-one with the outlet screen plate 6, and each screen plate has the same specifications. The bottom of the inner wall of the column 1 is provided with a discharge port 7, and the bottom of the discharge port 7 is equipped with an outlet sealing plug 8. With the inlet sealing plug 4, the porous microsphere packing 5 and the outlet sealing plug 8, it is convenient to replace or discharge the packing. The sealing plug can be removed by twisting the outlet sealing plug 8, thereby discharging the internal packing. The outer wall of the sealing plug has a threaded design, which makes it easy to disassemble and install the sealing plug. At the same time, it is also convenient to inject materials into the inside of the column 1 during use.

[0019] The fixing mechanism 9 is installed on the outer wall of the column 1. The fixing mechanism 9 includes a flexible fixing ring 901, a protective sleeve 902, a fixing rod 903, a mounting bracket 904, a sliding sleeve 905, a mounting hole 906, and a locking rod 907. The flexible fixing ring 901 is sleeved on the outer wall of the column 1. The inner wall of the flexible fixing ring 901 is provided with a protective sleeve 902. A fixing rod 903 is installed at one end of the outer wall of the flexible fixing ring 901, and a mounting bracket 904 is welded to the other end of the outer wall of the flexible fixing ring 901. A sliding sleeve 905 is welded to the outer wall of the mounting bracket 904. A mounting hole 906 is opened on the inner wall of the sliding sleeve 905, and a locking rod 907 is installed on the outer wall of the sliding sleeve 905. The flexible fixing ring 901 and the fixing rod 903 are connected by a thread, and the fixing rod 903... Both the outer wall and the inner wall of the flexible retaining ring 901 are threaded. The retaining mechanism 9 allows the flexible retaining ring 901 to be fitted over the column 1 during installation. The flexible retaining ring 901 has a certain degree of elasticity, facilitating easy installation and removal. The retaining rod 903 then secures the flexible retaining ring 901 to the column 1. The protective sleeve 902 inside the flexible retaining ring 901 protects the column 1 during installation and prevents it from detaching, providing an anti-slip function. A sliding sleeve 905 is mounted on the instrument support, allowing adjustment of the column height, which is then locked by a locking rod 907, providing high adjustability.

[0020] Working principle: When installing and using the chromatographic column, firstly, the flexible fixing ring 901 in the fixing mechanism 9 is sleeved on the outside of the column body 1. The flexible fixing ring 901 has a certain degree of elasticity, which can be easily installed and removed. Then, the flexible fixing ring 901 is fixed to the column body 1 by the fixing rod 903. The protective sleeve 902 inside the flexible fixing ring 901 can protect the column body 1 during fixing and prevent the column body 1 from falling off the flexible fixing ring 901, thus playing an anti-slip role. Then, the sliding sleeve 905 is installed on the instrument support. The height of the chromatographic column can be adjusted by the sliding sleeve 905. Locked by locking rod 907, highly adjustable, then the inlet sealing plug 4 is rotated off. The porous microsphere packing 5 is injected into the column 1 through the feed port 3. Then the material solvent to be tested is injected into the column 1 and discharged through the discharge port 7. The inlet sealing plug 4 and the outlet sealing plug 8 facilitate the replacement or discharge of the packing. The outlet sealing plug 8 is screwed off to remove the sealing plug and discharge the internal packing. The outer wall of the sealing plug has a threaded design, which facilitates the disassembly and assembly of the sealing plug. At the same time, it is also convenient to inject materials into the column 1 during use.

[0021] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A hyperpore organic polymeric microsphere chromatography column, characterized in that, The system includes a column (1) and a fixing mechanism (9). The top of the inner wall of the column (1) is provided with an inlet screen plate (2), and the top of the column (1) is provided with a feed inlet (3). The top of the feed inlet (3) is provided with an inlet sealing plug (4). The inner wall of the column (1) is filled with porous microsphere packing (5), and the bottom of the inner wall of the column (1) is provided with an outlet screen plate (6). The bottom of the inner wall of the column (1) is provided with a discharge outlet (7), and the bottom of the discharge outlet (7) is provided with an outlet sealing plug (8). The fixing mechanism (9) is installed on the outer wall of the column (1). The fixing mechanism (9) includes a flexible fixing ring (901), a protective sleeve (902), and a fixed... The components include a fixed rod (903), a mounting bracket (904), a sliding sleeve (905), a mounting hole (906), and a locking rod (907). The flexible fixing ring (901) is sleeved on the outer wall of the column (1). The inner wall of the flexible fixing ring (901) is provided with a protective sleeve (902). A fixing rod (903) is installed at one end of the outer wall of the flexible fixing ring (901). A mounting bracket (904) is welded to the other end of the outer wall of the flexible fixing ring (901). A sliding sleeve (905) is welded to the outer wall of the mounting bracket (904). A mounting hole (906) is opened on the inner wall of the sliding sleeve (905). A locking rod (907) is installed on the outer wall of the sliding sleeve (905).

2. The hypercrosslinked polymer microsphere column of claim 1, wherein: The inlet sealing plug (4) and the feed port (3) are connected by threads, and the outer wall of the inlet sealing plug (4) and the inner wall of the feed port (3) are both threaded.

3. The hypercrosslinked polymer microsphere column of claim 1, wherein: The inlet screen plate (2) and the outlet screen plate (6) are set in a one-to-one correspondence, and each screen plate has the same specifications.

4. The hypercrosslinked polymer microsphere column of claim 1, wherein: The porous microsphere packing (5) is made of silicone microspheres.

5. The hypercrosslinked polymer microsphere column of claim 1, wherein: The flexible fixing ring (901) and the fixing rod (903) are connected by threads, and the outer wall of the fixing rod (903) and the inner wall of the flexible fixing ring (901) are both threaded.

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