Processing equipment for efficiently extracting heparin sodium in pig intestine mucosa

Abstract

The utility model discloses processing equipment for efficiently extracting heparin sodium in pig intestine mucosa, which comprises an extraction tank, a feed inlet, a stirring piece and a feed channel, the feed inlet is arranged at the top end of one side of the extraction tank, two groups of stirring rollers are arranged in the center of the interior of the feed inlet, a rolling shaft is transversely arranged in the feed channel, and the stirring piece is arranged in the rolling shaft. A rolling shaft is arranged in the extraction tank, spiral blades are uniformly distributed on the rolling shaft, a third driving motor is fixed at one end of the feeding channel, a rotating shaft is arranged in the center of the interior of the extraction tank, stirring pieces are uniformly arranged at the bottom end of the rotating shaft, a movable frame is arranged above the extraction tank, and a first driving motor is fixed at the top of the movable frame. According to the utility model, the extraction tank, the feeding hole, the crushing roller, the crushing teeth, the feeding channel, the rolling shaft, the third driving motor and the spiral blade are arranged, and through an integrated crushing and conveying structure, continuous feeding can be realized, and the equipment utilization rate and the extraction efficiency are improved.

Description

Technical Field

[0001] This utility model relates to the field of heparin sodium extraction technology from porcine intestinal mucosa, specifically to a processing device for efficiently extracting heparin sodium from porcine intestinal mucosa. Background Technology

[0002] Sodium heparin is an acidic mucopolysaccharide naturally found in tissues such as the intestinal mucosa of pigs. It is a commonly used anticoagulant in clinical practice and is widely used in the prevention of thrombotic diseases, extracorporeal circulation (such as dialysis), and is also a raw material for the preparation of low molecular weight heparin.

[0003] When extracting heparin sodium from porcine intestinal mucosa, the intestinal mucosa needs to be placed in an extraction tank, a certain concentration of sodium chloride (table salt) solution is added, and the pH is adjusted to alkaline. The mixture is then stirred and extracted at a certain temperature for several hours, allowing heparin sodium to dissolve from the intestinal mucosal cells into the solution. However, conventional extraction equipment has a simple feed inlet structure and lacks the function of pre-breaking the porcine intestinal mucosa. The insufficient surface area of ​​the porcine intestinal mucosa prevents the sodium chloride solution from fully contacting the cell contents, resulting in a reduced heparin sodium dissolution rate and a lower yield per extraction. This necessitates increasing the number of extraction cycles or extending the reaction time, leading to low extraction efficiency of heparin sodium. Therefore, a high-efficiency processing device for extracting heparin sodium from porcine intestinal mucosa is needed. Utility Model Content

[0004] The purpose of this invention is to provide a processing device for efficiently extracting heparin sodium from porcine intestinal mucosa, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a processing device for efficiently extracting heparin sodium from porcine intestinal mucosa, comprising an extraction tank, a feed inlet, a stirring element, and a feeding channel. The top of one side of the extraction tank is provided with a feed inlet, and two sets of agitating rollers are arranged at the center of the feed inlet. The bottom of the feed inlet is connected to the extraction tank via the feeding channel, and a roller is arranged laterally inside the feeding channel. Spiral blades are evenly distributed on the roller. A third drive motor is fixed to one end of the feeding channel, and the output end of the third drive motor is connected to the roller. A rotating shaft is arranged at the center of the extraction tank, and a stirring element is evenly arranged at the bottom of the rotating shaft. A movable frame is arranged above the extraction tank, and a first drive motor is fixed to the top of the movable frame. The output end of the first drive motor is connected to the rotating shaft.

[0006] Preferably, a heating jacket is provided on the outside of the extraction tank, and a resistance ring is provided at the center of the heating jacket. A temperature sensor is provided on one side of the inside of the extraction tank. The temperature inside the tank can be precisely controlled by heating the resistance ring and monitoring the temperature in real time using the temperature sensor.

[0007] Preferably, both ends of the heating jacket are provided with heat-conducting rings, and the heat-conducting rings are uniformly connected to the resistance rings through heat-conducting rods. The heat-conducting rings and heat-conducting rods are made of copper alloy, which can quickly and evenly conduct the heat of the resistance rings to the extraction tank by means of the good thermal conductivity of copper alloy, thereby improving heating efficiency and temperature uniformity.

[0008] Preferably, a lead screw is provided on one side of the extraction tank via a frame, and a drive block is sleeved on the lead screw. One end of the drive block is connected to the movable frame to realize flexible adjustment of the height of the stirring component.

[0009] Preferably, a second drive motor is fixed at the bottom of the frame, and the output end of the second drive motor is connected to a lead screw. The motor can drive the lead screw to rotate, providing power for the lifting and lowering of the movable frame and the stirring components, thereby achieving automated adjustment.

[0010] Preferably, a guide block is provided on one side of the drive block, and a guide groove matching the guide block is opened on the side of the frame near the guide block, which can play a guiding and positioning role when the drive block is raised and lowered, ensuring that the movable frame moves smoothly and enhancing the structural stability.

[0011] Preferably, the outer side of the crushing roller is evenly distributed with crushing teeth, and the crushing teeth are fixedly connected to each other by connecting plates. The two sides inside the feed inlet are evenly distributed with auxiliary teeth. The crushing teeth and auxiliary teeth form a shearing structure, which can efficiently crush the pig intestinal mucosa, increase the surface area of ​​the material, and improve the extraction efficiency of heparin sodium.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: This high-efficiency processing equipment for extracting heparin sodium from porcine intestinal mucosa is equipped with an extraction tank, a feed inlet, a mixing roller, crushing teeth, a feed channel, a roller, a third drive motor, and spiral blades. The porcine intestinal mucosa is introduced through the feed inlet, and the external drive device drives the mixing roller to rotate relative to it. The crushing teeth break the porcine intestinal mucosa into fine particles, greatly increasing the tissue surface area, making it easier for heparin sodium to dissolve from the cells, shortening the dissolution time, and improving the single extraction efficiency. At the same time, the third drive motor drives the roller and spiral blades to rotate, conveying the broken porcine intestinal mucosa to the extraction tank through the feed channel. While pushing the material, it can continuously shear and squeeze the porcine intestinal mucosa to ensure uniform crushing and avoid large tissue residues. Through the integrated crushing and conveying structure, continuous feeding can be achieved, improving equipment utilization and increasing the processing capacity per unit time. Attached Figure Description

[0013] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this utility model and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0014] Figure 1 This is a frontal cross-sectional view of the present invention.

[0015] Figure 2 This is a schematic diagram of the cross-sectional structure of the feed inlet of this utility model;

[0016] Figure 3 For the present utility model Figure 2 Enlarged structural diagram at point B;

[0017] Figure 4 This is a schematic diagram of the cross-sectional structure of the heating jacket of this utility model;

[0018] Figure 5 For the present utility model Figure 1 Enlarged structural diagram at point A in the middle.

[0019] In the diagram: 1. Extraction tank; 2. Feed inlet; 3. Rotating shaft; 4. First drive motor; 5. Movable frame; 6. Temperature sensor; 7. Heating jacket; 8. Stirring component; 9. Lead screw; 10. Frame; 11. Second drive motor; 12. Crushing roller; 13. Feed channel; 14. Third drive motor; 15. Roller; 16. Spiral blade; 17. Crushing teeth; 18. Auxiliary teeth; 19. Connecting plate; 20. Resistance ring; 21. Heat-conducting ring; 22. Heat-conducting rod; 23. Drive block; 24. Guide block. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the scope of protection of the present utility model.

[0021] Please see Figure 1-5 An embodiment of this utility model is provided: a processing device for efficiently extracting heparin sodium from pig intestinal mucosa, including an extraction tank 1, a feed inlet 2, a stirring component 8 and a feeding channel 13. The feed inlet 2 is provided at the top of one side of the extraction tank 1, and two sets of agitating rollers 12 are provided at the center of the feed inlet 2.

[0022] The outer side of the crushing roller 12 is evenly distributed with crushing teeth 17, and the crushing teeth 17 are all fixedly connected by connecting plates 19. The two sides inside the feed inlet 2 are evenly distributed with auxiliary teeth 18.

[0023] Pig intestinal mucosa is introduced into the equipment through the feed inlet 2. The two sets of crushing rollers 12 inside the feed inlet 2 rotate relative to each other under external drive. The crushing teeth 17 on the outside of the crushing rollers 12 and the auxiliary teeth 18 on the inner wall of the feed inlet 2 form a shearing pair to crush the pig intestinal mucosa into fine particles. The crushing teeth 17 are fixed by the connecting plate 19 to enhance the structural stability, while the auxiliary teeth 18 prevent the raw material from slipping and enhance the crushing effect.

[0024] The bottom of the feed inlet 2 is connected to the extraction tank 1 through the feed channel 13, and a roller 15 is arranged horizontally inside the feed channel 13. Spiral blades 16 are evenly distributed on the roller 15. A third drive motor 14 is fixed at one end of the feed channel 13, and the output end of the third drive motor 14 is connected to the roller 15.

[0025] The crushed material falls into the feeding channel 13. The third drive motor 14 drives the roller 15 to rotate, which drives the spiral blades 16 to transport the material to the extraction tank 1. During the process of pushing, the spiral blades 16 continuously shear and squeeze the material to ensure uniform crushing and avoid large pieces of tissue remaining.

[0026] The material enters the extraction tank 1 through the feed channel 13, and sodium chloride solution is added at the same time. The pH value is adjusted to alkaline by adding sodium hydroxide solution.

[0027] A rotating shaft 3 is provided in the center of the extraction tank 1, and stirring components 8 are evenly arranged at the bottom of the rotating shaft 3. A movable frame 5 is provided above the extraction tank 1, and a first drive motor 4 is fixed on the top of the movable frame 5. The output end of the first drive motor 4 is connected to the rotating shaft 3.

[0028] The first drive motor 4 drives the rotating shaft 3 on the movable frame 5 to rotate, so that the stirring component 8 can uniformly stir the pig intestinal mucosal particles and sodium chloride solution, thereby increasing the contact area between heparin sodium and sodium chloride solution.

[0029] A heating jacket 7 is provided on the outside of the extraction tank 1, and a resistance ring 20 is provided in the center of the heating jacket 7. A temperature sensor 6 is provided on one side of the inside of the extraction tank 1.

[0030] Both ends of the heating jacket 7 are provided with heat-conducting rings 21, and the heat-conducting rings 21 are evenly connected to the resistance rings 20 through heat-conducting rods 22.

[0031] The resistance ring 20 inside the heating jacket 7 is energized and heats up. The heat is evenly conducted to the outer wall of the extraction tank 1 through the heat-conducting rod 22 and the heat-conducting ring 21. The temperature sensor 6 monitors the temperature inside the tank in real time and transmits the temperature signal to the control system. The control system controls the power of the resistance ring 20 to control the heating temperature, so that the extraction temperature is maintained at 50-60℃.

[0032] Both the heat-conducting ring 21 and the heat-conducting rod 22 are made of copper alloy, which helps to improve heat conduction efficiency and reduce energy consumption;

[0033] A lead screw 9 is provided on one side of the extraction tank 1 via the frame 10, and a drive block 23 is sleeved on the lead screw 9. One end of the drive block 23 is connected to the movable frame 5.

[0034] The bottom end of the frame 10 is fixed with a second drive motor 11, and the output end of the second drive motor 11 is connected to the lead screw 9;

[0035] During the stirring process, the second drive motor 11 drives the lead screw 9 to rotate, which in turn drives the drive block 23 to move up and down along the frame 10, thereby adjusting the height of the movable frame 5 and causing the stirring piece 8 to move up and down, increasing the mixing range and ensuring that the materials in the extraction tank 1 can be effectively stirred.

[0036] A guide block 24 is provided on one side of the drive block 23. A guide groove matching the guide block 24 is opened on the side of the frame 10 near the guide block 24. The guide block 24 slides straight along the guide groove to avoid radial offset or shaking when the screw 9 rotates, and to ensure that the stirring component 8 is raised and lowered smoothly.

[0037] After stirring at a controlled temperature for a period of time, sodium heparin dissolves from the porcine intestinal mucosal cells into the solution, yielding a sodium heparin extract, which can then be exported for subsequent steps.

[0038] The specific models and specifications of the first drive motor 4, the second drive motor 11, the third drive motor 14, and the temperature sensor 6 need to be determined based on the specifications and parameters of the device. The selection and calculation method is existing technology, so it will not be described in detail here.

[0039] Working Principle: In this embodiment, pig intestinal mucosa is introduced into the equipment through the feed inlet 2. Two sets of crushing rollers 12 inside the feed inlet 2 rotate relative to each other under external drive. The crushing teeth 17 on the outer side of the crushing rollers 12 and the auxiliary teeth 18 on the inner wall of the feed inlet 2 form a shearing pair, crushing the pig intestinal mucosa into fine particles. The crushing teeth 17 are fixed by the connecting plate 19 to enhance structural stability, while the auxiliary teeth 18 prevent the raw material from slipping and enhance the crushing effect. The crushed material falls into the feed channel 13. The third drive motor 14 drives the roller 15 to rotate, driving the spiral blades 16 to convey the material to the extraction tank 1. During the propulsion process, the spiral blades 16 continuously shear and compress the material to ensure uniform crushing and avoid large pieces of tissue residue. The material enters the extraction tank 1 through the feed channel 13. Simultaneously, sodium chloride solution is added, and the pH value is adjusted to alkalinity by adding sodium hydroxide solution. Then, the first drive motor 4 drives... The rotating shaft 3 on the movable frame 5 rotates, causing the stirring element 8 to uniformly stir the porcine intestinal mucosal particles and sodium chloride solution, increasing the contact area between heparin sodium and sodium chloride solution. The resistance ring 20 inside the heating jacket 7 is energized and heats up, and the heat is evenly conducted to the outer wall of the extraction tank 1 through the heat-conducting rod 22 and heat-conducting ring 21. The temperature sensor 6 monitors the temperature inside the tank in real time to ensure that the extraction temperature is maintained at 50-60℃. Both the heat-conducting ring 21 and the heat-conducting rod 22 are made of copper alloy to improve heat conduction efficiency and reduce energy consumption. During the stirring process, the second drive motor 11 drives the lead screw 9 to rotate, which drives the drive block 23 to move up and down along the frame 10, thereby adjusting the height of the movable frame 5 and causing the stirring element 8 to move up and down, increasing the mixing range and ensuring that the materials in the extraction tank 1 are effectively stirred. After stirring for a period of time, the heparin sodium dissolves from the porcine intestinal mucosal cells into the solution to obtain the heparin sodium extract, which can then be exported for subsequent steps.

[0040] Obviously, the embodiments described above are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort should fall within the protection scope of this utility model.

[0041] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to this application. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0042] It should be noted that the terms "first," "second," etc., used in the specification, claims, and accompanying drawings of this application are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of this application described herein can be implemented in sequences other than those illustrated or described herein.

[0043] The above are merely preferred embodiments of this utility model and are not intended to limit the scope of this utility model. Various modifications and variations can be made to this utility model by those skilled in the art. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A processing device for efficiently extracting heparin sodium from porcine intestinal mucosa, characterized in that, The extraction tank (1) includes an extraction tank (1), a feed inlet (2), a stirring component (8), and a feeding channel (13). The top of one side of the extraction tank (1) has a feed inlet (2), and two sets of agitating rollers (12) are located in the center of the feed inlet (2). The bottom of the feed inlet (2) is connected to the extraction tank (1) via the feeding channel (13), and a roller (15) is horizontally arranged inside the feeding channel (13). Spiral blades (16) are evenly distributed on the roller (15). A third drive motor (14) is fixed at one end of the material channel (13), and the output end of the third drive motor (14) is connected to the roller (15). A rotating shaft (3) is provided at the center of the extraction tank (1), and a stirring component (8) is evenly provided at the bottom end of the rotating shaft (3). A movable frame (5) is provided above the extraction tank (1), and a first drive motor (4) is fixed at the top of the movable frame (5). The output end of the first drive motor (4) is connected to the rotating shaft (3).

2. The processing equipment for efficiently extracting heparin sodium from porcine intestinal mucosa according to claim 1, characterized in that: A heating jacket (7) is provided on the outside of the extraction tank (1), and a resistance ring (20) is provided at the center of the heating jacket (7). A temperature sensor (6) is provided on one side of the inside of the extraction tank (1).

3. The processing equipment for efficiently extracting heparin sodium from porcine intestinal mucosa according to claim 2, characterized in that: The heating sleeve (7) has heat-conducting rings (21) at both ends inside, and the heat-conducting rings (21) are evenly connected to the resistance rings (20) through heat-conducting rods (22). The heat-conducting rings (21) and the heat-conducting rods (22) are both made of copper alloy.

4. The processing equipment for efficiently extracting heparin sodium from porcine intestinal mucosa according to claim 1, characterized in that: A lead screw (9) is provided on one side of the extraction tank (1) via a frame (10), and a drive block (23) is sleeved on the lead screw (9). One end of the drive block (23) is connected to the movable frame (5).

5. The processing equipment for efficiently extracting heparin sodium from porcine intestinal mucosa according to claim 4, characterized in that: The bottom end of the frame (10) is fixed with a second drive motor (11), and the output end of the second drive motor (11) is connected to the lead screw (9).

6. The processing equipment for efficiently extracting heparin sodium from porcine intestinal mucosa according to claim 4, characterized in that: A guide block (24) is provided on one side of the drive block (23), and a guide groove matching the guide block (24) is opened on the side of the frame (10) near the guide block (24).

7. The processing equipment for efficiently extracting heparin sodium from porcine intestinal mucosa according to claim 1, characterized in that: The outer side of the pulverizing roller (12) is evenly distributed with pulverizing teeth (17), and the pulverizing teeth (17) are all fixedly connected by connecting plates (19). The two sides inside the feed inlet (2) are evenly distributed with auxiliary teeth (18).

Images