Raw material mixing device for preparing biological medicine polypeptide

Abstract

The utility model relates to the technical field of biomedical polypeptide preparation, in particular to a raw material mixing device for biomedical polypeptide preparation, which comprises a mixing barrel and an electromagnetic valve, the electromagnetic valve is arranged at the output end of the tail end of the mixing barrel, and an auxiliary material pipe joint and an air inlet pipeline are fixedly mounted on the top surface of the mixing barrel. And the gas inlet pipeline is located in the center of the mixing barrel, combined joints are installed on the curved surfaces above the two ends of the bottom of the gas inlet pipeline, and positioning middle holes are formed in the centers of the combined joints in a penetrating mode. According to the electromagnetic valves arranged at the two ends of the mixing barrel, automatic feeding and discharging work can be carried out, the auxiliary material connecting pipe head arranged on the mixing barrel can be conveniently combined with an external conveying pipe in a sealed mode, so that different auxiliary materials are added in a sealed mode, overall mixing is in a sealed state, gas conveying work is carried out according to the gas inlet pipeline, and the working efficiency is improved. And pneumatic mixing is achieved.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceutical polypeptide preparation technology, and in particular to a raw material mixing device for biopharmaceutical polypeptide preparation. Background Technology

[0002] Biopharmaceutical peptide preparation involves processing peptides, including processing peptide raw materials. In the processing steps, peptide raw materials are prepared by mixing, and this method is suitable for low-viscosity solutions / suspensions of peptide raw materials.

[0003] Existing raw material mixing devices for biopharmaceutical peptide preparation use pneumatic mixing at the bottom when gas mixing is required. However, the mixing efficiency at the top of the liquid is not high. When the exhaust component is located in the middle of the liquid, liquid can easily enter the exhaust component, affecting subsequent mixing operations and making it inconvenient to continuously perform sealed mixing processes.

[0004] Therefore, to address the above issues, an innovative design was developed based on the existing raw material mixing device for biopharmaceutical peptide preparation. Utility Model Content

[0005] To overcome the problem that in common biopharmaceutical peptide preparation raw material mixing devices, when the exhaust component is located in the middle of the liquid, the liquid can easily enter the exhaust component, affecting subsequent mixing operations.

[0006] The technical solution of this utility model is as follows: a raw material mixing device for preparing biopharmaceutical peptides, comprising a mixing cylinder and a solenoid valve. The solenoid valve is provided at the output end of the mixing cylinder, and an auxiliary material connector and an air inlet pipe are fixedly installed on the top surface of the mixing cylinder. The air inlet pipe is located at the center of the mixing cylinder. A combination joint is installed on the curved surface above both ends of the bottom of the air inlet pipe. A positioning hole is opened through the center of the combination joint, and an exhaust groove is opened on the inner wall of the combination joint and the air inlet pipe. A first magnetic ring is installed on the top of the combination joint, and a positioning shaft is installed inside the positioning hole, extending out of the top surface of the combination joint through the positioning hole.

[0007] Preferably, the combination joint and the intake pipe are integrated into a single structure, and the combination joints are evenly distributed on the intake pipe.

[0008] Preferably, the internal space of the positioning hole is interconnected with the internal space of the air intake pipe and the internal space of the exhaust groove, and the exhaust grooves are distributed at equal angles on the combined joint.

[0009] Preferably, the top space of the exhaust groove is an outwardly inclined structure, and the maximum diameter of the exhaust groove is smaller than the inner diameter of the first magnetic ring.

[0010] Preferably, a sealing cover is provided at the top of the positioning shaft, and a second magnetic ring is installed at the bottom of the sealing cover. A limit rod is installed above the sealing cover, and the limit rod is fixedly installed on the air intake pipe and is symmetrically distributed on the air intake pipe.

[0011] Preferably, the sealing cover and the positioning shaft are integrated into one structure, the positioning shaft is connected to the positioning hole by a rotary sliding connection, and the sealing cover and the limiting rod are connected by an abutment connection.

[0012] Preferably, the second magnetic ring is connected to the first magnetic ring by magnetic force, and the second magnetic ring and the first magnetic ring are respectively connected to the sealing cover and the combination joint by embedding and fixing. The bottom surface of the second magnetic ring is flush with the bottom surface of the sealing cover, and the top surface of the first magnetic ring is flush with the top surface of the combination joint.

[0013] The beneficial effects of this utility model are:

[0014] 1. The solenoid valves at both ends of the mixing cylinder enable automatic feeding and discharging. The auxiliary material connector on the mixing cylinder facilitates sealing with external conveying pipes, allowing for the addition of different auxiliary materials in a sealed manner. The overall mixing process is also sealed, and air is supplied through the air inlet pipe to achieve pneumatic mixing.

[0015] 2. The intake pipe is combined with an external pneumatic conveying device to transport gas inside the intake pipe. The gas can pressurize the positioning shaft and sealing cover plate through the positioning hole and exhaust groove. When the pressure is greater than the magnetic attraction of the second and first magnetic rings, the sealing cover plate and positioning shaft rise, opening the exhaust groove and releasing the gas for mixing. The subsequent gas supply is reduced. When the gas pressure is less than the magnetic attraction of the second and first magnetic rings, the second and first magnetic rings quickly adhere, causing the sealing cover plate and positioning shaft to seal, reducing the phenomenon of liquid entering the intake pipe and facilitating the next mixing process.

[0016] 3. After the sealing cover and positioning shaft are moved by air pressure, they can be limited by the limiting rod on the air intake pipe to avoid separation and facilitate subsequent magnetic repositioning. Attached Figure Description

[0017] Figure 1 The diagram shown is a three-dimensional structural illustration of the present invention.

[0018] Figure 2 The diagram shown is a three-dimensional structural illustration of the internal structure of the hybrid cylinder of this utility model.

[0019] Figure 3 This utility model is shown. Figure 2 Enlarged structural diagram of point A in the middle;

[0020] Figure 4 The diagram shown is a three-dimensional structural illustration of the combined sealing cover and the joint of this utility model.

[0021] Figure 5 The diagram shown is a three-dimensional cross-sectional view of the sealing cover and the combined joint of this utility model.

[0022] Explanation of reference numerals in the attached drawings: 1. Mixing cylinder; 2. Solenoid valve; 3. Auxiliary material connector; 4. Air inlet pipe; 5. Combination joint; 6. Positioning center hole; 7. Exhaust groove; 8. First magnetic ring; 9. Positioning shaft; 10. Sealing cover plate; 11. Second magnetic ring; 12. Limiting rod. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Please see Figures 1-5 This utility model provides a technical solution: a raw material mixing device for preparing biopeptides, including a mixing cylinder 1 and a solenoid valve 2. The solenoid valve 2 is provided at the output end of the mixing cylinder 1, and an auxiliary material connector 3 and an air inlet pipe 4 are fixedly installed on the top surface of the mixing cylinder 1. The air inlet pipe 4 is located at the center of the mixing cylinder 1. A combination joint 5 is installed on the curved surface above both ends of the bottom of the air inlet pipe 4. A positioning hole 6 is opened through the center of the combination joint 5, and an exhaust groove 7 is opened on the inner wall of the combination joint 5 and the air inlet pipe 4. A first magnetic ring 8 is installed on the top of the combination joint 5. A positioning shaft 9 is installed inside the positioning hole 6, and the positioning shaft 9 extends out of the top surface of the combination joint 5 through the positioning hole 6.

[0025] The combination joint 5 and the air inlet pipe 4 are integrated into one structure, and the combination joint 5 is evenly distributed on the air inlet pipe 4, which facilitates the subsequent gas supply to the area inside the mixing cylinder 1 to achieve uniform pneumatic mixing.

[0026] The internal space of the positioning hole 6 is interconnected with the internal space of the air intake pipe 4 and the internal space of the exhaust groove 7. The exhaust groove 7 is distributed at equal angles on the combination joint 5, which facilitates the discharge of gas inside the air intake pipe 4 through the positioning hole 6 and the exhaust groove 7. The distribution of the exhaust groove 7 increases the uniformity of subsequent exhaust.

[0027] The top space of the exhaust groove 7 is an outward inclined structure, and the maximum diameter of the exhaust groove 7 is smaller than the inner diameter of the first magnetic ring 8. The top structure of the exhaust groove 7 facilitates the outward transportation of gas during the exhaust process, improves the mixing efficiency, and avoids direct upward collision with the bottom surface of the sealing cover plate 10.

[0028] A sealing cover plate 10 is provided at the top of the positioning shaft 9, and a second magnetic ring 11 is installed at the bottom of the sealing cover plate 10. A limit rod 12 is installed above the sealing cover plate 10 and is fixedly installed on the air intake pipe 4. The limit rods 12 are symmetrically distributed on the air intake pipe 4. The sealing cover plate 10 and the positioning shaft 9 are integrated into one structure. The positioning shaft 9 is connected to the positioning hole 6 by a rotary sliding connection. The sealing cover plate 10 is connected to the limit rod 12 by an abutment connection. The sealing cover plate 10 can be raised and lowered smoothly through the positioning shaft 9. At the same time, the sealing cover plate 10 is restricted by the limit rod 12 during the rising process to prevent separation.

[0029] The second magnetic ring 11 is connected to the first magnetic ring 8 by magnetic force, and the second magnetic ring 11 and the first magnetic ring 8 are respectively connected to the sealing cover plate 10 and the combination joint 5 by embedding and fixing. The bottom surface of the second magnetic ring 11 is flush with the bottom surface of the sealing cover plate 10, and the top surface of the first magnetic ring 8 is flush with the top surface of the combination joint 5. According to the magnetic attraction between the second magnetic ring 11 and the first magnetic ring 8, when the gas pressure is greater than the magnetic attraction between the second magnetic ring 11 and the first magnetic ring 8, the sealing cover plate 10 opens to exhaust gas and perform pneumatic mixing. When the gas pressure is less than the magnetic attraction between the second magnetic ring 11 and the positioning shaft 9, the gas prevents the liquid from entering the air intake pipe 4 through the exhaust groove 7. At the same time, the second magnetic ring 11 and the first magnetic ring 8 are quickly magnetically attracted, so that the sealing cover plate 10 and the combination joint 5 are combined to seal, thereby improving the protection function and facilitating subsequent mixing work.

[0030] Working principle: According to Figure 1 First, the two ends of the mixing cylinder 1 can be sealed and connected to the external conveying pipe, the auxiliary material pipe head 3 can be sealed and connected to the external auxiliary material conveying pipe, and the air inlet pipe 4 can be sealed and connected to the external pneumatic conveying device. Thus, the amount of polypeptide liquid raw material inside the mixing cylinder 1 can be controlled by the solenoid valve 2. When mixing is required, the solenoid valve 2 is closed to seal.

[0031] according to Figures 2-3 and Figure 5The pneumatic conveying device delivers gas into the inlet pipe 4. The gas can push the positioning shaft 9 and the sealing cover plate 10 with air pressure through the positioning hole 6 and the exhaust groove 7. When the air pressure is greater than the magnetic attraction between the second magnetic ring 11 and the first magnetic ring 8, the sealing cover plate 10 rises smoothly through the sliding of the positioning shaft 9 in the positioning hole 6. At the same time, the sealing cover plate 10 rises to abut against the limit rod 12 and is positioned to prevent separation and falling off. After the sealing cover plate 10 is opened, the gas can be quickly discharged through the exhaust groove 7 to perform pneumatic mixing of the liquid inside the mixing cylinder 1. The inclined structure of the exhaust groove 7 faces outward to improve the exhaust efficiency.

[0032] according to Figures 3-5 When the mixing process is complete, the gas supply is reduced, thereby lowering the air pressure on the sealing cover 10 and the positioning shaft 9, causing the sealing cover 10 to gradually descend while maintaining the gas supply to prevent liquid from entering the air intake pipe 4. When the air pressure is less than the magnetic attraction between the second magnetic ring 11 and the first magnetic ring 8, the sealing cover 10 can be quickly merged with the combination joint 5 through the magnetic attraction of the second magnetic ring 11 and the first magnetic ring 8, which can seal the exhaust groove 7, thereby facilitating subsequent mixing processes and reducing the phenomenon of liquid entering the air intake pipe 4.

[0033] The above is the entire working process of the device, and all contents not described in detail in this specification are existing technologies known to those skilled in the art.

[0034] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A raw material mixing device for preparing biopharmaceutical peptides, comprising a mixing cylinder (1) and a solenoid valve (2), characterized in that: The mixing cylinder (1) is equipped with a solenoid valve (2) at its end output end. The top surface of the mixing cylinder (1) is fixedly equipped with an auxiliary material connector (3) and an air inlet pipe (4). The air inlet pipe (4) is located at the center of the mixing cylinder (1). The bottom ends of the air inlet pipe (4) are equipped with a combination joint (5) on the upper curved surface. The center of the combination joint (5) is provided with a positioning hole (6). The inner walls of the combination joint (5) and the air inlet pipe (4) are provided with exhaust grooves (7). The top of the combination joint (5) is equipped with a first magnetic ring (8). The positioning hole (6) is equipped with a positioning shaft (9). The positioning shaft (9) extends out of the top surface of the combination joint (5) through the positioning hole (6).

2. The raw material mixing device for preparing biopharmaceutical polypeptides according to claim 1, characterized in that: The combined connector (5) and the air intake pipe (4) are integrated into one structure, and the combined connector (5) is evenly distributed on the air intake pipe (4).

3. The raw material mixing device for preparing biopharmaceutical polypeptides according to claim 1, characterized in that: The internal space of the positioning hole (6) is connected to the internal space of the air intake pipe (4) and the internal space of the exhaust groove (7), and the exhaust groove (7) is distributed at equal angles on the combination joint (5).

4. The raw material mixing device for preparing biopharmaceutical polypeptides according to claim 1, characterized in that: The top space of the exhaust groove (7) is an outward inclined structure, and the maximum diameter of the exhaust groove (7) is smaller than the inner diameter of the first magnetic ring (8).

5. The raw material mixing device for preparing biopharmaceutical polypeptides according to claim 1, characterized in that: The top of the positioning shaft (9) is provided with a sealing cover plate (10), and a second magnetic ring (11) is installed at the bottom of the sealing cover plate (10). A limit rod (12) is installed above the sealing cover plate (10), and the limit rod (12) is fixedly installed on the air intake pipe (4). The limit rod (12) is symmetrically distributed on the air intake pipe (4).

6. The raw material mixing device for preparing biopharmaceutical polypeptides according to claim 5, characterized in that: The sealing cover (10) and the positioning shaft (9) are integrated into one structure, and the positioning shaft (9) and the positioning hole (6) are connected by a rotary sliding connection, and the sealing cover (10) and the limiting rod (12) are connected by an abutment connection.

7. The raw material mixing device for preparing biopharmaceutical polypeptides according to claim 5, characterized in that: The second magnetic ring (11) is connected to the first magnetic ring (8) by magnetic force, and the second magnetic ring (11) and the first magnetic ring (8) are respectively connected to the sealing cover plate (10) and the combination joint (5) by embedding and fixing. The bottom surface of the second magnetic ring (11) is flush with the bottom surface of the sealing cover plate (10), and the top surface of the first magnetic ring (8) is flush with the top surface of the combination joint (5).

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