Transcranial magnetic stimulation mouse fixation device

Abstract

The utility model provides a kind of transcranial magnetic stimulation mouse fixing device, it is related to mouse fixing technical field.The device includes: fixed base and mouse fixing assembly, wherein, fixed base and mouse fixing assembly are movably connected;Mouse fixing assembly includes: piston component, barrel and mouse head fixing component, piston component is arranged in the one end of barrel close to fixed base, and with the inner wall of barrel sliding connection, mouse head fixing component is arranged in the one end of barrel away from fixed base, and with the lower edge of barrel rotatably connected;And, mouse head fixing component is also provided with transcranial magnetic stimulation skylight.This application solves the problem of unreasonable structure and inconvenience of use of mouse fixing device in the prior art, uses non-violence, gentle means to fix mouse, and the fixing effect is better, more accurate stimulation mouse head can be carried out when experiment is operated, and the stress of mouse can also be avoided.

Description

Technical Field

[0001] This utility model relates to the field of mouse fixation technology, specifically to a transcranial magnetic stimulation mouse fixation device. Background Technology

[0002] Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and safe physical therapy widely used to treat neuropsychiatric disorders such as depression, anxiety, and stroke. Currently, research into the mechanisms of TMS primarily focuses on mice. During treatment, the mouse's head needs to be fixed at the center of the TMS probe, and the mouse's head must be relatively stationary. However, unlike patients in clinical applications (who are relatively still, allowing for accurate brain stimulation via neuronavigation technology), mouse movement is uncontrollable, making it impossible to stimulate mice without intervention.

[0003] Existing technologies include methods such as anesthetizing mice, binding the mouse body with coils, or directly grasping the mouse to achieve the purpose of immobilizing the mouse.

[0004] However, the injection of anesthetic drugs may affect the experimental results, while restraint and manual grasping can cause significant stress in mice, also impacting the results. Therefore, there is an urgent need to provide a non-violent and gentle fixation device for transcranial magnetic stimulation of mice, ensuring effective fixation and accurate stimulation of the mouse's head while avoiding stress. Utility Model Content

[0005] (a) Technical problems to be solved

[0006] To address the shortcomings of existing technologies, this invention provides a transcranial magnetic stimulation mouse fixation device, which at least solves the problems of unreasonable structure and inconvenient use of existing mouse fixation devices.

[0007] (II) Technical Solution

[0008] To achieve the above objectives, this utility model provides the following technical solution:

[0009] A transcranial magnetic stimulation mouse immobilization device, comprising:

[0010] A fixed base and a mouse fixation assembly, wherein the fixed base and the mouse fixation assembly are movably connected;

[0011] The mouse fixation assembly includes: a piston component, a cylinder, and a mouse head fixation component. The piston component is located at one end of the cylinder near the fixation base and is slidably connected to the inner wall of the cylinder. The mouse head fixation component is located at one end of the cylinder away from the fixation base and is rotatably connected to the lower edge of the cylinder.

[0012] The rat head fixation component is provided with a transcranial magnetic stimulation window.

[0013] Furthermore, the cylinder is a semi-circular tube open at both ends.

[0014] Preferably, the inner side of the cylinder is provided with an anti-slip layer.

[0015] More preferably, the anti-slip layer has several circular protrusions.

[0016] In one embodiment, the cylindrical body includes a first arc-shaped outer cover and a first bottom plate, the first arc-shaped outer cover including a fixed cover and a movable cover; wherein, the fixed cover is fixedly connected to one long side of the first bottom plate, and the movable cover is movably connected to the other long side of the first bottom plate;

[0017] The rat head fixing component is rotatably connected to the short side of the first base plate via a hinge structure.

[0018] Furthermore, the movable cover is rotatably connected to the other long side of the first base plate via a hinge structure; or

[0019] The movable cover is slidably connected to the other long side of the first base plate via a groove.

[0020] Furthermore, the first base plate is provided with several support rods arranged at intervals.

[0021] Furthermore, the first arc-shaped outer cover also includes fasteners, which are disposed on the fixed cover and the movable cover.

[0022] Preferably, the method includes snaps or Velcro.

[0023] In one embodiment, the piston component includes a piston handle, a piston shaft, and a piston head. The piston head is located inside the cylinder and is slidably connected to the inner wall of the cylinder. One end of the piston shaft is connected to the piston head, and the other end extends out of the cylinder and is connected to the piston handle.

[0024] Preferably, the piston head is a semi-circular plate.

[0025] In one embodiment, the rat head fixing component includes a second arc-shaped outer cover and a second base plate, with a transcranial magnetic stimulation window and a ventilation hole provided above the second arc-shaped outer cover.

[0026] In one embodiment, the fixing base includes a base, a bracket fixed on the base, and an adjusting screw, wherein the mouse fixing assembly is movably connected to the bracket via the adjusting screw.

[0027] Furthermore, the fixing base also includes a hollow sleeve, the adjusting screw is movably connected to the sleeve, and the cylindrical body of the mouse fixing assembly near the piston handle is detachably inserted into the sleeve.

[0028] Preferably, there are two of each of the aforementioned brackets and adjusting screws.

[0029] More preferably, the support is a telescopic support.

[0030] Furthermore, the stent includes an outer tube and an inner tube, and the inner tube and the outer tube are connected by a damped sliding connection.

[0031] In any of the above embodiments, the cylindrical body is made of a transparent material.

[0032] Preferably, the transparent material includes transparent glass or transparent plastic.

[0033] (III) Beneficial Effects

[0034] This invention provides a transcranial magnetic stimulation mouse fixation device. Compared with the prior art, it has the following advantages:

[0035] The transcranial magnetic stimulation (TMS) mouse restraint device proposed in this application includes a restraint base for securing the entire device and a mouse restraint assembly for securing the mouse. The restraint base and the mouse restraint assembly are movably connected. The mouse restraint assembly includes a piston component, a cylinder, and a mouse head restraint component. The piston component is located at the end of the cylinder near the restraint base and is slidably connected to the inner wall of the cylinder. The mouse head restraint component is located at the end of the cylinder away from the restraint base and is rotatably connected to the lower edge of the cylinder. Furthermore, the mouse head restraint component has a TMS window for exposing the top of the mouse's head during experiments. The mouse restraint device of this application has a reasonable structure, and the method of mouse restraint is non-violent and gentler. It can not only effectively restrain the mouse but also accurately stimulate the top of the mouse's head while avoiding stress on the mouse. Attached Figure Description

[0036] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0037] Figure 1This is a schematic diagram of the transcranial magnetic stimulation mouse fixation device in an embodiment of the present invention when the first arc-shaped outer cover is opened;

[0038] Figure 2 This is a schematic diagram of the transcranial magnetic stimulation mouse fixation device in an embodiment of the present invention when the first arc-shaped outer cover is closed.

[0039] In the picture:

[0040] 1-Fixed base; 11-Base platform; 12-Bracket; 13-Adjusting screw; 14-Sleeve;

[0041] 2-Mouse restraint assembly; 21-Piston assembly; 22-Cylinder body; 23-Mouse head restraint assembly;

[0042] 211-Piston handle; 212-Piston shaft; 213-Piston head;

[0043] 221-First arc-shaped outer cover; 222-First base plate; 223-Support rod; 2211-Fixed cover; 2212-Modible cover; 2213-Fastener;

[0044] 231-Second arc-shaped outer cover; 232-Second base plate; 233-Transcranial magnetic stimulation window; 234-Ventilation hole. Detailed Implementation

[0045] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions in the embodiments of this utility model are described clearly and completely. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0046] Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and safe physical therapy that is currently widely used to treat neuropsychiatric disorders such as depression, anxiety, and stroke, but the underlying mechanisms are unclear.

[0047] In clinical applications, since patients are relatively still, accurate brain stimulation can currently be achieved using neuronavigation technology. Current research on the mechanisms of TMS primarily focuses on mice. During treatment, the mouse's head needs to be fixed in the center of the TMS probe, requiring relative head stabilization. However, due to the uncontrollable nature of mouse movement, stimulation cannot be achieved without intervention. Previous studies have shown that some groups have used anesthesia to achieve fixation, but the influence of anesthesia itself cannot be ruled out. Furthermore, some rTMS modalities require multiple treatments per day, making anesthesia unsuitable. Most groups primarily use grasping to achieve fixation, but this causes significant stress to the mice and may affect experimental results. Additionally, there are methods using coil binding to fix the mouse's body. However, this method requires forcibly inserting the mouse into the coil, causing violent struggles and severe stress, affecting experimental results. Therefore, there is an urgent need for a non-violent, gentle fixation device for transcranial magnetic stimulation of mice that can effectively fix the mouse, accurately stimulate the top of the head, and avoid stress.

[0048] The technical solution in this application is to solve the above-mentioned technical problems, and the general idea is as follows:

[0049] The transcranial magnetic stimulation (TMS) mouse fixation device proposed in this application first includes a fixation base that secures the entire device and a mouse fixation assembly for fixing the mouse. The fixation base and the mouse fixation assembly are movably connected to facilitate adjustment of the mouse's height and position during subsequent experiments. The mouse fixation assembly includes a piston component, a cylinder, and a mouse head fixation component. The piston component is located at the end of the cylinder near the fixation base and is slidably connected to the inner wall of the cylinder, allowing for adjustment and limitation of the mouse's position within the cylinder. The mouse head fixation component is located at the end of the cylinder away from the fixation base and is rotatably connected to the lower edge of the cylinder, facilitating the insertion and removal of the mouse and its fixation. Furthermore, the mouse head fixation component also includes a TMS window and a ventilation hole to expose the top of the mouse's head and allow for respiration during experiments, thereby reducing stress on the mouse. In addition, considering the possibility of mice sliding inside the cylinder, anti-slip pads and support rods are provided to facilitate the mice's gripping with their limbs and prevent them from slipping inside the cylinder, thus causing displacement and stress. The fixed base includes a base platform, a bracket fixed on the base platform, and adjusting screws, which allow the mouse fixation components to be movably connected to the bracket via the adjusting screws. At the same time, the base platform is designed to be telescopic, which allows for flexible adjustment of the height of the mouse's head according to the needs of the experiment, facilitating experimental operation, and so on.

[0050] This application provides a transcranial magnetic stimulation mouse fixation device, which solves the problems of unreasonable structure and inconvenient use of existing mouse fixation devices, and achieves the purpose of fixing mice in a non-violent and gentle manner.

[0051] To better understand the above technical solutions, the following will provide a detailed explanation of the technical solutions in conjunction with the accompanying drawings and specific implementation methods.

[0052] like Figure 1-2 As shown, an embodiment of this application provides a transcranial magnetic stimulation mouse fixation device, which includes:

[0053] The apparatus consists of a base 1 and a mouse restraint component 2. The base 1 secures the entire restraint device, preventing it from wobbling or becoming unstable during experiments, which could hinder researchers' operation. The mouse restraint component 2 is used for non-violent and gentle restraint of the mouse. The base 1 and the mouse restraint component 2 are movably connected, allowing the component to be detachably mounted on the base 1 and to rotate slightly, enabling adjustment of the mouse's head position and height for easier operation by researchers. Specifically:

[0054] The mouse restraint assembly 2 includes a piston component 21, a cylinder 22, and a mouse head restraint component 23. The piston component 21 is located at the end of the cylinder 22 near the fixing base 1 and is slidably connected to the inner wall of the cylinder 22, allowing the piston component 21 to move within the cylinder 22. The mouse head restraint component 23 is located at the end of the cylinder 22 away from the fixing base 1 and is rotatably connected to the lower edge of the cylinder 22, allowing the mouse head restraint component 23 to open or close along the rotation axis.

[0055] In one embodiment, the cylinder 22 is a semi-circular tube open at both ends. The semi-circular tube 22 includes a first arc-shaped outer cover 221 and a first base plate 222. The first arc-shaped outer cover 221 includes a fixed cover 2211 and a movable cover 2212. The fixed cover 2211 is fixedly connected to one long side of the first base plate 222 (the side along the piston movement direction is the long side), and the movable cover 2212 is movably connected to the other long side of the first base plate 222. The movable cover 2212 can open or close the first arc-shaped outer cover 221 by rotation or movement.

[0056] Furthermore, the movable cover 2212 is movably connected to the other long side of the first base plate 222 via a hinge structure, allowing the movable cover 2212 to rotate around the hinge structure, thereby achieving the closing and opening of the first arc-shaped outer cover 221. Of course, the movable cover 2212 can also be connected to the other long side of the first base plate 222 via other movable connection methods, as long as the purpose of opening or closing the first arc-shaped outer cover 221 can be achieved. For example, in another embodiment, the movable cover 2212 can also be slidably connected to the other long side of the first base plate 222 via a groove. In this case, the first arc-shaped outer cover 221 can be opened or closed by sliding the movable cover 2212 left or right along the long side of the first base plate 222. See details... Figure 1-2 ,in, Figure 1 This is a schematic diagram of the transcranial magnetic stimulation mouse fixation device in the embodiment when the first arc-shaped outer cover is opened. Figure 2 This is a schematic diagram of the transcranial magnetic stimulation mouse fixation device in the embodiment when the first arc-shaped outer cover is closed.

[0057] In a more preferred embodiment, fasteners 2213 are provided on the fixed cover 2211 and the movable cover 2212 for cooperation. Preferably, the fasteners 2213 include buckles, Velcro, and other fasteners. After the mouse is placed into the cylinder 22 and its position is adjusted, the movable cover 2212 is rotated or moved to close the first arc-shaped outer cover 221, and finally the buckles or Velcro are engaged. This operation is simple and quick, and the position of the mouse can be quickly adjusted and fixed.

[0058] To facilitate observation of the mouse's condition at any time, in a preferred embodiment, the cylinder 22 is made of a transparent material. Preferably, the transparent material is transparent glass, transparent plastic, or other transparent materials.

[0059] In one embodiment, to reduce the stress response of mice, a plurality of spaced-apart support rods 223 are provided on the first base plate 222. After the support rods 223 are set, the mouse's limbs can grasp the support rods 223 to further maintain the mouse's position, while reducing the mouse's stress response and avoiding interference with the transcranial magnetic stimulation experiment.

[0060] Furthermore, to facilitate the gripping of the mouse's limbs, several spaced support rods 223 are arranged perpendicular to the long side of the first base plate 222.

[0061] Furthermore, to prevent the mouse from sliding inside the cylinder 22, a preferred method is to provide an anti-slip layer on the inner side of the cylinder 22. This anti-slip layer can increase the friction between the mouse and the inner side of the cylinder 22, reducing the mouse's sliding inside the cylinder 22. More preferably, the anti-slip layer has several circular protrusions to further increase the coefficient of friction of the inner wall of the cylinder 22 and improve the anti-slip resistance.

[0062] In one embodiment, the piston component 21 includes a piston handle 211, a piston shaft 212, and a piston head 213 connected in sequence. The piston head 213 is located inside the cylinder 22 and is slidably connected to the inner wall of the cylinder 22. The piston head 213 is a semi-circular plate that matches the semi-circular tubular cylinder 22, and its diameter is the same as the inner wall diameter of the cylinder 22. The piston shaft 212 is a slender round rod, one end of which is connected to the piston head 213, and the other end extends out of the cylinder 22 and is connected to the piston handle 211. In the experiment, by pushing the piston component 21 and adjusting the position of the piston head 213, the position of the mouse can be limited, preventing the mouse from shifting during the experiment.

[0063] Preferably, the thickness of the piston head 213 plate is slightly smaller than the gap between the two adjacent support rods 223. After the position of the mouse is determined, the piston head 213 can be pressed down to make it fit in the gap between the two support rods 223, thereby preventing the piston head from moving due to the mouse's movement or its own weight, which would cause the mouse's head to deviate from its position.

[0064] In one embodiment, the mouse head fixing component 23 is rotatably connected to the short side of the first base plate 222 of the cylinder 22 (i.e., the lower edge of the cylinder 22 away from the fixed base 1) by a hinge structure, so that when the mouse head fixing component 23 rotates downward about the hinge structure as the axis, a certain space can be opened at the end of the cylinder 22 away from the piston head, which is convenient for inserting the mouse and thus reducing the stress response of the mouse.

[0065] The mouse head fixation component 23 is generally shaped like a hollow semi-circular frustum, including a second arc-shaped outer cover 231 and a second base plate 232. The second arc-shaped outer cover 231 has a transcranial magnetic stimulation window 233 and a vent 234 above it. The vent 234 is used to expose the mouse's nose when the mouse's head is fixed, ensuring unobstructed breathing. The transcranial magnetic stimulation window 233 is used to place the top of the experimental mouse's head, and its opening size matches the probe of the therapeutic instrument. For ease of operation, preferably, the opening of the transcranial magnetic stimulation window 233 is slightly larger than the probe of the therapeutic instrument. Furthermore, similar to the first base plate 222, the second base plate 232 also has several spaced-apart support rods 223.

[0066] In one embodiment, the fixed base 1 includes a base 11, a bracket 12 fixed on the base 11, and an adjusting screw 13. The mouse fixation component 2 is movably connected to the bracket 12 via the adjusting screw 13. By rotating the adjusting screw 13, the mouse fixation component 2 can be rotated at a certain angle, which facilitates raising or lowering the position of the mouse's head according to the needs of different experimental scenarios during the experiment.

[0067] Preferably, there are two brackets 12 and two adjusting screws 13. The two brackets 12 are fixed on the base 11, the mouse fixing component 2 is located between the two brackets 12, and the two adjusting screws 13 pass through the through holes at the upper end of the brackets 12 and are movably connected to the two threaded holes with internal threads on both sides of the cylinder 22 near the piston handle 211.

[0068] In a preferred embodiment, the support 11 is a telescopic support to facilitate further adjustment of the mouse to a suitable position during experimental procedures. Preferably, the support 11 has an outer tube and an inner tube, which are connected by a damped sliding connection, thereby allowing for free adjustment of the height of the support 11.

[0069] In another, more preferred embodiment, the fixing base 1 further includes a hollow sleeve 14, with a threaded hole on each side of the sleeve 14, which engages with the two adjusting screws 13. The inner diameter of the sleeve 14 is the same as the outer diameter of the cylinder 22, so that the end of the mouse fixing component 2 near the piston handle 211 can be inserted into the sleeve 14. At this time, by turning the adjusting screws 13 and rotating the sleeve 14, the position of the mouse's head can be indirectly raised or lowered.

[0070] The working principle of the transcranial magnetic stimulation mouse fixation device in this application:

[0071] In actual use, the piston component 21 is retracted to its end, then the fastener 2213, movable cover 2212, and mouse head fixing component 23 are opened, and the mouse is placed into the cylinder 22. Once the mouse is fully inside the cylinder 22, the piston component 21 is pushed to adjust the position of the piston head 213, thereby adjusting the mouse's position. When the top of the mouse's head is just exposed at the transcranial magnetic stimulation window 233, and the mouse's nose is located at the vent 234, the mouse's position is considered appropriate. The piston head 213 is then pressed down, causing it to engage in the gap between the two support rods 223, thus limiting the mouse's position. Finally, the movable cover 2212, mouse head fixing component 23, and fastener 2213 are closed. Inside the cylinder 22, the mouse's limbs can grasp the support rods 223, further maintaining the mouse's position and reducing stress response, thus avoiding interference with the transcranial magnetic stimulation experiment.

[0072] In summary, compared with existing technologies, it has the following beneficial effects:

[0073] 1. This transcranial magnetic stimulation (TMS) mouse restraint device includes a restraint base for securing the entire device and a mouse restraint assembly for securing the mouse. The restraint base and the mouse restraint assembly are movably connected. The mouse restraint assembly includes a piston component, a cylinder, and a mouse head restraint component. The piston component is located at the end of the cylinder near the restraint base and is slidably connected to the inner wall of the cylinder. The mouse head restraint component is located at the end of the cylinder away from the restraint base and is rotatably connected to the lower edge of the cylinder. Furthermore, the mouse head restraint component has a TMS window for exposing the top of the experimental mouse's head during the experiment. The mouse restraint device of this application has a reasonable structure, and the method of mouse restraint is non-violent and gentler. It can not only effectively restrain the mouse but also accurately stimulate the top of the mouse's head while avoiding stress on the mouse.

[0074] 2. The inner side of the transcranial magnetic stimulation (TMS) mouse fixation device is equipped with an anti-slip layer, which has several circular protrusions to increase the anti-slip coefficient of the inner wall of the cylinder. Simultaneously, the first base plate has several spaced support rods to facilitate the mouse's gripping with its limbs, preventing the mouse from slipping inside the cylinder and thus causing displacement and stress. Furthermore, the mouse head fixation component also has a TMS window and ventilation holes to expose the top of the mouse's head and allow for respiration during experiments, thereby reducing stress on the mouse.

[0075] 3. The transcranial magnetic stimulation mouse fixation device comprises a first arc-shaped outer cover and a first base plate. The first arc-shaped outer cover further comprises a fixed cover and a movable cover. The fixed cover is fixedly connected to one long side of the first base plate, and the movable cover is movably connected to the other long side of the first base plate. Simultaneously, the mouse head fixation component is rotatably connected to the short side of the first base plate via a hinge structure. Furthermore, fasteners are provided on the fixed cover and the movable cover. Through these steps, the cylinder and mouse head fixation component can be opened or closed as needed during the experiment, facilitating the removal and placement of the mouse. This not only makes the mouse fixation device more secure but also simplifies and facilitates operation.

[0076] 4. The fixation base of the transcranial magnetic stimulation mouse fixation device includes a base, a bracket fixed on the base, and an adjusting screw, which allows the mouse fixation component to be movably connected to the bracket via the adjusting screw. At the same time, the base is designed to be telescopic, which makes it easy to flexibly adjust the height of the mouse's head according to the needs of the experiment, thus facilitating the experimental operation.

[0077] 5. The body of the transcranial magnetic stimulation mouse fixation device is made of transparent material, which facilitates observation of the mice during the experiment and timely adjustments.

[0078] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0079] The above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this utility model.

Claims

1. A transcranial magnetic stimulation mouse immobilization device, characterized in that, The device includes: A fixed base (1) and a mouse fixation component (2) are movably connected; The mouse fixation assembly (2) includes: a piston component (21), a cylinder (22), and a mouse head fixation component (23). The piston component (21) is located at one end of the cylinder (22) near the fixing base (1) and is slidably connected to the inner wall of the cylinder (22). The mouse head fixation component (23) is located at one end of the cylinder (22) away from the fixing base (1) and is rotatably connected to the lower edge of the cylinder (22). The rat head fixing component (23) is provided with a transcranial magnetic stimulation window (233).

2. The apparatus as claimed in claim 1, characterized in that, The cylindrical body (22) includes a first arc-shaped outer cover (221) and a first bottom plate (222). The first arc-shaped outer cover (221) includes a fixed cover (2211) and a movable cover (2212). The fixed cover (2211) is fixedly connected to one long side of the first bottom plate (222), and the movable cover (2212) is movably connected to the other long side of the first bottom plate (222). The rat head fixing component (23) is rotatably connected to the short side of the first base plate (222) via a hinge structure.

3. The apparatus as described in claim 2, characterized in that, The movable cover (2212) is rotatably connected to the other long side of the first base plate (222) via a hinge structure; or The movable cover (2212) is slidably connected to the other long side of the first base plate (222) via a groove.

4. The apparatus as claimed in claim 2, characterized in that, The first arc-shaped outer cover (221) further includes a fastener (2213), which is disposed on the fixed cover (2211) and the movable cover (2212).

5. The apparatus as claimed in claim 1, characterized in that, The piston component (21) includes a piston handle (211), a piston shaft (212), and a piston head (213). The piston head (213) is located inside the cylinder (22) and is slidably connected to the inner wall of the cylinder (22). One end of the piston shaft (212) is connected to the piston head (213), and the other end extends out of the cylinder (22) and is connected to the piston handle (211).

6. The apparatus as claimed in claim 1, characterized in that, The rat head fixing component (23) includes a second arc-shaped outer cover (231) and a second base plate (232). A transcranial magnetic stimulation window (233) and a ventilation hole (234) are provided above the second arc-shaped outer cover (231).

7. The apparatus as claimed in claim 3, characterized in that, The first base plate (222) is provided with a number of spaced support rods (223).

8. The apparatus as claimed in claim 1, characterized in that, The fixed base (1) includes a base (11), a bracket (12) fixed on the base (11), and an adjusting screw (13). The mouse fixing component (2) is movably connected to the bracket (12) through the adjusting screw (13).

9. The apparatus as claimed in claim 8, characterized in that, The fixed base (1) also includes a hollow sleeve (14), the adjusting screw (13) is movably connected to the sleeve (14), and the cylindrical body (22) of the mouse fixing assembly (2) near the piston handle (211) is detachably inserted into the sleeve (14).

10. The apparatus according to any one of claims 1-9, characterized in that, The cylindrical body (22) is made of transparent material.

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