A component for rapid separation of a vilanterol intermediate

Abstract

The application discloses a component for rapidly separating a vilanterol intermediate, which comprises an extractor, the inside of the extractor is provided with a shell, the top of the inside of the shell is provided with an extraction assembly for rotating extraction, a filter plate is arranged at the inlet of the extraction assembly at the bottom of the shell through a connecting rod, the bottom of the shell is provided with a cleaning assembly for cleaning the filter plate, the cleaning assembly comprises: a connecting seat arranged at the bottom of the inside of the shell; a cleaning brush arranged at the top of the connecting seat and in contact with the bottom of the filter plate; and a stirring piece arranged at the bottom of the shell and rotating the connecting seat to stir and mix two-phase liquid, the stirring piece is arranged at the bottom of the shell and rotates the connecting seat to stir and mix two-phase liquid, the precipitated particles are filtered through the filter plate, the cleaning brush is driven to rotate on the filter plate through the rotation of the stirring rod, thereby cleaning the stains attached to the filter plate, preventing the precipitates from accumulating at the rotating drum and affecting the extraction efficiency, and the rotation of the stirring rod enables the two-phase liquid entering the bottom of the shell to be rapidly mixed together.

Description

Technical Field

[0001] This application relates to the field of extraction and separation, and more particularly to a component for rapidly separating vilanterol intermediates. Background Technology

[0002] Vilanterol is a long-acting adrenergic receptor agonist used to treat chronic obstructive pulmonary disease and asthma. Its synthesis involves several key intermediates, which act as bridges in the drug synthesis process and determine the purity, yield, and cost of the final product. During the synthesis of vilanteol intermediates, it is necessary to quickly separate the liquid-liquid phases, which requires the use of a centrifugal extractor.

[0003] However, during the implementation of the relevant technical solutions, at least the following technical problems were found: In the separation process of vilanterol intermediates, precipitation will occur after the intermediates are placed due to hydrolysis, complexation reaction or changes in solubility. The precipitation will accumulate in the drum or pipeline of the centrifugal extractor, reduce the throughput of the centrifugal extractor, interfere with the two-phase interface, reduce the separation efficiency, and also cause internal wear of the extractor, affecting its service life. Utility Model Content

[0004] This application provides a component for rapidly separating vilanterol intermediates, which solves the problem of precipitate accumulation in centrifugal extractors in the prior art, and achieves the effect of filtering and cleaning at the drum using a filter plate.

[0005] This application provides a component for rapidly separating vilanterol intermediates, including an extractor. The extractor has an internal shell. An extraction assembly for rotary extraction is located at the top of the shell. A filter plate is connected to the inlet of the extraction assembly at the bottom of the shell via a connecting rod. A cleaning assembly for cleaning the filter plate is located at the bottom of the shell. The cleaning assembly includes: a connecting seat located at the bottom of the shell; a cleaning brush located at the top of the connecting seat, and the cleaning brush is in contact with the bottom of the filter plate; and a stirring element located at the bottom of the shell, which drives the connecting seat to rotate and mix the two liquid phases.

[0006] Furthermore, the extraction assembly includes: a rotating drum, rotatably connected to the top inside the housing; a drive motor, mounted on the top of the extractor, with the output shaft of the drive motor fixedly connected to the rotating drum; and a baffle, disposed in the middle of the rotating drum.

[0007] Furthermore, the bottom of the extractor is provided with two liquid inlets, which are connected to the bottom of the outer shell.

[0008] Furthermore, the top of the extractor is provided with two liquid outlets, one of which is connected to the heavy phase chamber at the top of the extractor, and the other of which is connected to the light phase chamber in the middle of the extractor.

[0009] Furthermore, a turbine disk is provided at the bottom of the drum, and the turbine disk is located on top of the filter plate.

[0010] Furthermore, the stirring components include: a motor installed at the bottom of the extractor; a rotating shaft rotatably connected to the bottom of the housing, with the output shaft of the motor fixedly connected to the rotating shaft, the top of the rotating shaft fixedly connected to the connecting seat, and the rotation of the rotating shaft being opposite to the rotation direction of the drum; and a stirring rod disposed on the outside of the rotating shaft.

[0011] Furthermore, a cleaning tube is provided on one side of the bottom of the extractor, and the cleaning tube is connected to the bottom of the outer shell.

[0012] The technical solution provided in this application has at least the following technical effects or advantages:

[0013] The precipitated particles are filtered through a filter plate, and then the rotating agitator drives a cleaning brush to rotate on the filter plate, thereby cleaning the dirt attached to the filter plate and preventing the precipitate from accumulating at the drum and affecting the extraction efficiency. The motor drives the rotating shaft and agitator to rotate, so that the agitator quickly mixes the two-phase liquid entering the bottom of the shell together, improving the extraction efficiency. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of the separation device in the embodiments of this application;

[0015] Figure 2 This is a cross-sectional structural diagram of the extractor in an embodiment of this application;

[0016] Figure 3 This is a schematic diagram of the structure of the drum in the embodiments of this application;

[0017] In the diagram: 10, extractor; 20, outer shell; 30, extraction assembly; 40, liquid inlet; 50, liquid outlet; 60, cleaning assembly; 70, filter plate; 31, drum; 32, drive motor; 33, baffle; 34, turbine disk; 61, motor; 62, shaft; 63, stirring rod; 64, connecting seat; 65, cleaning brush; 66, cleaning tube. Detailed Implementation

[0018] This application discloses a component for rapidly separating vilanterol intermediates. The rotation of the stirring rod 63 drives the liquid entering through the two inlets 40 to mix, and then enters the rotating drum 31 for extraction, thereby improving the extraction efficiency. The rotation of the cleaning brush 65 at the bottom of the filter plate 70 cleans the precipitates attached to the filter plate 70, preventing the filter plate 70 from becoming clogged and affecting the extraction efficiency.

[0019] To better understand the above technical solutions, the following will provide a detailed explanation of the technical solutions in conjunction with the accompanying drawings and specific implementation methods.

[0020] Please refer to Figure 1 and Figure 2 This embodiment provides a component for rapidly separating vilanterol intermediates, including an extractor 10. The extractor 10 has an internal housing 20. An extraction assembly 30 for rotary extraction is located at the top of the housing 20. A filter plate 70 is connected to the inlet of the extraction assembly 30 at the bottom of the housing 20 via a connecting rod. The extraction assembly 30 includes a rotating drum 31, a drive motor 32, a baffle 33, and a turbine disk 34. The rotating drum 31 is rotatably connected to the top of the housing 20. The drive motor 32 is mounted on the top of the extractor 10, and its output shaft is fixedly connected to the rotating drum 31. The bottom of the extractor 10 has two liquid inlets 40, which communicate with the bottom of the housing 20. The top of the extractor 10 has two liquid outlets 50, one of which is connected to... The heavy phase chamber at the top of the extractor 10 is connected to the light phase chamber in the middle of the extractor 10. A light phase weir is provided in the middle of the outer shell 20, and a heavy phase weir is provided at the top of the outer shell 20. The two phase liquids are input into the bottom of the outer shell 20 through two inlets 40. After being filtered by the filter plate 70, they are input into the drum 31 for extraction. The drum 31 is rotated by the drive motor 32. The extracted heavy phase liquid flows from the heavy phase weir into the heavy phase chamber and then flows out from one outlet 50. The light phase liquid flows from the light phase weir into the light phase chamber and then flows out from the other outlet 50, completing the extraction. The precipitate in the two phase liquids is filtered by the filter plate 70 at the bottom of the drum 31 to prevent the precipitate from entering the drum 31 and affecting the extraction and separation efficiency.

[0021] Please refer to Figure 1 , Figure 2 and Figure 3The bottom of the outer casing 20 is provided with a cleaning assembly 60 for cleaning the filter plate 70. The cleaning assembly 60 includes a stirring element, a connecting seat 64, a cleaning brush 65, and a cleaning tube 66. The stirring element is located at the bottom of the outer casing 20 and drives the connecting seat 64 to rotate and mix the two phase liquids. The stirring element includes a motor 61, a rotating shaft 62, and a stirring rod 63. The motor 61 is installed at the bottom of the extractor 10, the rotating shaft 62 is rotatably connected to the bottom of the outer casing 20, and the output shaft of the motor 61 is fixedly connected to the rotating shaft 62. The stirring rod 63 is located outside the rotating shaft 62. The rotating shaft 62 and the stirring rod 63 are connected together. The rotation direction is opposite to that of the drum 31. The baffle 33 is located in the middle of the drum 31 and blocks the mixed liquid at the bottom of the outer shell 20. The turbine disk 34 is located at the bottom of the drum 31 and at the top of the filter plate 70. The rotation of the drum 31 drives the turbine disk 34 to rotate, which stirs the mixed liquid at the bottom of the outer shell 20. The rotation of the rotating shaft 62 and the stirring rod 63 is driven by the motor 61, which drives the mixed liquid at the bottom of the outer shell 20 to rotate in the opposite direction, thereby improving the stirring efficiency and allowing the two phase liquids to mix more quickly and be fed into the drum 31 for extraction.

[0022] Please refer to Figure 1 , Figure 2 and Figure 3 The connecting seat 64 is located at the bottom inside the housing 20. The top of the rotating shaft 62 is fixedly connected to the connecting seat 64. The cleaning brush 65 is located at the top of the connecting seat 64 and is in contact with the bottom of the filter plate 70. The cleaning tube 66 is located on one side of the bottom of the extractor 10 and is connected to the bottom of the housing 20. The rotation of the rotating shaft 62 drives the connecting seat 64 and the cleaning brush 65 to rotate, so that the cleaning brush 65 can clean the bottom of the filter plate 70. This prevents the precipitates in the two phase liquids from clogging the filter plate 70, maintains the flow rate of the centrifugal extractor, and prevents the accumulation of precipitates from reducing the extraction and separation efficiency. After long-term use, water can be introduced into the housing 20 through the cleaning tube 66 to clean the housing 20 and the filter plate 70 in conjunction with the rotation of the stirring rod 63 and the cleaning brush 65, and discharge the precipitates, thus cleaning the precipitates at the bottom of the housing 20.

[0023] The functional principle of this application can be explained through the following methods:

[0024] In use, the two-phase liquid is introduced into the bottom of the outer casing 20 through the two inlets 40 at the bottom of the extractor 10. The motor 61 is started, causing its output shaft to drive the rotating shaft 62 to rotate. The stirring rod 63 on the outside of the rotating shaft 62 mixes the liquid at the bottom of the outer casing 20. The drive motor 32 is then started, causing the rotating drum 31 to rotate. The rotation of the turbine disk 34 at the bottom of the drum 31, combined with the counter-rotation of the stirring rod 63, improves the mixing efficiency. After mixing, the liquid passes through the filter plate 70 and enters the drum 31. Sediments in the liquid are blocked by the filter plate 70, and the rotation of the drum 31 further enhances the extraction efficiency. The heavy phase liquid flows into the heavy phase chamber from the heavy phase weir plate and then flows out from one outlet 50, allowing the light phase liquid to enter the light phase chamber from the light phase weir plate and then flow out from another outlet 50, completing the extraction process. The rotation of the rotating shaft 62 drives the connecting seat 64 and the cleaning brush 65 to rotate, so that the cleaning brush 65 cleans the precipitate attached to the bottom of the filter plate 70, preventing the accumulation of precipitate from affecting the flow rate of the liquid entering the drum 31. After long-term use, the liquid is fed into the bottom of the outer shell 20 from the cleaning pipe 66. The rotation of the stirring rod 63 and the cleaning brush 65 cleans the precipitate and discharges it, preventing the precipitate from clogging the container.

[0025] Obviously, those skilled in the art can make various modifications and variations to this application without departing from the spirit and scope of this application. Therefore, if such modifications and variations fall within the scope of the claims of this application and their equivalents, this application also intends to include such modifications and variations.

[0026] The above description is merely a preferred embodiment of the present application, but the scope of protection of the present application is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present application, based on the technical solution and concept of the present application, should be covered within the scope of protection of the present application.

Claims

1. A component for rapidly separating vilanterol intermediates, comprising an extractor (10), characterized in that, The extractor (10) has an inner shell (20). An extraction assembly (30) for rotary extraction is located at the top of the inner shell (20). A filter plate (70) is connected to the inlet of the extraction assembly (30) at the bottom of the outer shell (20) via a connecting rod. A cleaning assembly (60) for cleaning the filter plate (70) is located at the bottom of the outer shell (20). The cleaning assembly (60) includes: A connecting seat (64) is disposed at the bottom inside the housing (20); A cleaning brush (65) is disposed on the top of the connecting seat (64), and the cleaning brush (65) is in contact with the bottom of the filter plate (70); A stirring element is disposed at the bottom of the outer shell (20), and the stirring element drives the connecting seat (64) to rotate and stir and mix the two phase liquids.

2. The component for rapidly separating vilanterol intermediates as described in claim 1, characterized in that, The extraction component (30) includes: The drum (31) is rotatably connected to the top inside the housing (20); A drive motor (32) is mounted on the top of the extractor (10), and the output shaft of the drive motor (32) is fixedly connected to the drum (31); A baffle (33) is disposed in the middle of the drum (31).

3. The component for rapidly separating vilanterol intermediates as described in claim 1, characterized in that, The bottom of the extractor (10) is provided with two liquid inlets (40), and the two liquid inlets (40) are connected to the bottom of the outer shell (20).

4. The component for rapidly separating vilanterol intermediates as described in claim 1, characterized in that, The top of the extractor (10) is provided with two liquid outlets (50), one of which is connected to the heavy phase chamber at the top of the extractor (10), and the other is connected to the light phase chamber in the middle of the extractor (10).

5. The component for rapidly separating vilanterol intermediates as described in claim 2, characterized in that, A turbine disk (34) is provided at the bottom of the drum (31), and the turbine disk (34) is located at the top of the filter plate (70).

6. The component for rapidly separating vilanterol intermediates as described in claim 2, characterized in that, The stirring component: A motor (61) is installed at the bottom of the extractor (10); A rotating shaft (62) is rotatably connected to the bottom of the housing (20), and the output shaft of the motor (61) is fixedly connected to the rotating shaft (62). The top of the rotating shaft (62) is fixedly connected to the connecting seat (64). The rotation of the rotating shaft (62) is opposite to the rotation direction of the drum (31). A stirring rod (63) is located on the outside of the rotating shaft (62).

7. The component for rapidly separating vilanterol intermediates as described in claim 1, characterized in that, A cleaning tube (66) is provided on one side of the bottom of the extractor (10), and the cleaning tube (66) is connected to the bottom of the outer shell (20).

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