Constant temperature water bath device and sample pretreatment system

Abstract

The utility model discloses a constant temperature water bath device and sample pre -treatment system, constant temperature water bath device includes water bath box and temperature control subassembly, and water bath box includes the box body of being equipped with inner chamber and the opening of a plurality of sleeves of setting upwards, and the inner chamber is used for injecting heat transfer agent, and the sleeve is worn in the inner chamber and is sealedly connected with the end face of box body, and the sleeve is used for setting sample tube and will heat transfer agent's temperature transfer to sample tube on, temperature control subassembly is connected on the box body and is used for through adjusting the temperature of inner chamber to make the liquid in sample tube keep constant temperature. The device can directly with manipulator system matching use carries out sample tube's taking and placing, improves the efficiency and degree of automation of sample storage and access, and can to sample tube high -efficient temperature control's while, make sample tube pass through the sleeve and the inner chamber isolation of box, avoid sample tube to cause the pollution of heat transfer agent, prevent sample tube cross -contamination and sample tube take out when the outer wall hang water. The device can integrate with other pre -treatment equipment, forms the complete sample pre -treatment system, and the scope of application is wide.

Description

Technical Field

[0001] This utility model relates to the field of sample processing technology, and in particular, to a constant temperature water bath device. Furthermore, it also relates to a sample pretreatment system including the constant temperature water bath device. Background Technology

[0002] Before conducting sample analysis, sample pretreatment is usually required to bring the samples to a state suitable for the final analysis or detection. This process is commonly referred to as sample pretreatment. Sample pretreatment typically includes various steps such as liquid addition, nitrogen blowing, centrifugation, ultrasonic extraction, filtration, solid-phase extraction, and vortex mixing. Researchers need to perform the appropriate sample pretreatment according to the requirements of the corresponding standard methods for sample testing. In some sample pretreatment processes, a constant, stable, and oscillating environment is required, necessitating the use of a constant-temperature water bath shaker. A constant-temperature water bath shaker is a device combining a temperature-controlled constant-temperature water bath and a shaker. It can precisely set and maintain a specific temperature and generate uniform shaking motion through the shaker, thereby simulating the conditions required for various biological or chemical reactions.

[0003] Chinese patent CN212982930U discloses a water bath shaker body, including a shell. A cover is hinged to the top of the shell, and a plasma generator is screwed to the top of the cover. The output end of the plasma generator is connected to the cover. A second sleeve is sleeved on one end of a second rod, and the bottom of the second sleeve is bolted to the bottom of the shell. A second spring is sleeved on the outer side of the second rod and the second sleeve. This water bath shaker body can directly kill various bacteria, viruses, parasites, and other pathogens, solving the problem of contamination of the water bath shaker's interior when using it for extended periods in a constant temperature environment to cultivate different types of bacteria. However, on the one hand, the water bath shaker uses a flip-top design, requiring manual opening and closing of the lid to retrieve and place the culture tubes inside the water tank. This operation is cumbersome, time-consuming, and labor-intensive, resulting in low sampling efficiency. Furthermore, the flipping of the lid requires a sufficiently large operating space, making it difficult to integrate with high-precision robotic arm systems and affecting the level of automation. On the other hand, placing the culture tubes directly into the machine chamber and exposing them to the coolant can cause water to cling to the outer wall when the tubes are removed, affecting their usability. Utility Model Content

[0004] This invention provides a constant temperature water bath device to solve the technical problems of low sample tube retrieval efficiency and easy cross-contamination between sample tubes in the existing constant temperature water bath device.

[0005] This utility model also provides a sample pretreatment system that uses the above-mentioned constant temperature water bath device.

[0006] According to one aspect of the present invention, a constant temperature water bath device is provided, comprising:

[0007] A water bath includes a box body with an inner cavity and several sleeves with the opening facing upward. The inner cavity is used to inject a heat-conducting agent, and the sleeves are inserted into the inner cavity and sealed to the end face of the box body. The sleeves are used to hold sample tubes and transfer the temperature of the heat-conducting agent to the sample tubes.

[0008] The temperature control component is connected to the chamber and is used to maintain a constant temperature of the liquid in the sample tube by adjusting the temperature of the inner cavity.

[0009] Furthermore, the enclosure includes a bottom plate, side plates that are arranged in an enclosing manner and fixed to the bottom plate, and a cover plate that is placed on the side plates. The bottom plate, side plates, and cover plate are fixedly connected and enclose to form an inner cavity.

[0010] The cover plate has several mounting holes for inserting and sealing the sleeve. The mounting holes are arranged in an array on the cover plate.

[0011] Furthermore, the temperature control assembly includes a cooling pipe disposed in the inner cavity of the housing and used to contact the heat transfer fluid, and a cooling supply component for introducing coolant into the cooling pipe to adjust the temperature of the heat transfer fluid, the cooling pipe being arranged around the outer periphery of the sleeve;

[0012] The side panel of the housing has a coolant inlet connected to the first end of the cooling pipe and a coolant outlet connected to the second end of the cooling pipe, so that the cooling components can be connected to the coolant inlet.

[0013] Furthermore, the temperature control assembly also includes a temperature sensor for monitoring the temperature of the heat transfer agent, which is mounted on the cover plate (1013) and communicates with the inner cavity of the housing.

[0014] Furthermore, the temperature control assembly also includes an insulation layer to prevent heat loss from the heat transfer fluid. The insulation layer is located inside the cavity of the enclosure and is installed on the upper end of the bottom plate and / or the inner wall of the side plate.

[0015] Furthermore, the enclosure also includes a heat transfer port for introducing and discharging heat transfer fluid into and out of the inner cavity, the heat transfer port being located on the side plate and / or cover plate.

[0016] Furthermore, a sealing ring is provided at the inlet end of the sleeve. The sealing ring is arranged around the inner wall of the sleeve and is used to seal and position itself by contacting the outer wall of the sample tube (400).

[0017] Furthermore, the lower end of the box is provided with an oscillation mechanism for oscillating the sample tube. The oscillation mechanism includes a rotary platform, an eccentric shaft assembly and a base arranged sequentially from top to bottom, as well as a power assembly installed in the base. The rotary platform is connected to the box.

[0018] The eccentric shaft assembly includes several eccentric shafts eccentrically positioned at the lower end of the rotary platform. The power assembly is connected to the eccentric shafts via a transmission wheel set. The power assembly is used to drive the eccentric shafts to reciprocate and swing, thereby causing the housing to sway through the rotary platform and stopping the swaying at a set position.

[0019] Furthermore, the enclosure also includes a fixing plate for connecting the rotating platform, which is located at the bottom of the enclosure and installed on the outer wall of the side panel.

[0020] According to another aspect of the present invention, a sample pretreatment system is also provided, including the above-mentioned constant temperature water bath device.

[0021] This utility model has the following beneficial effects:

[0022] This invention relates to a constant-temperature water bath device. The water bath chamber, by connecting a temperature control component to the chamber body, can precisely regulate and stabilize the temperature within the chamber's internal cavity, maintaining a constant temperature for the sample tube placed inside the sleeve to meet the precise temperature requirements of various experiments. The sample tube is placed inside the sleeve and in close contact with its inner wall. The sleeve passes through the chamber's internal cavity and is sealed to the chamber's end face. This not only allows for rapid temperature transfer from the chamber's internal cavity to the sample tube within the sleeve for precise temperature control, but also isolates the sample tube from the chamber's internal cavity, preventing liquid leakage during chamber vibration. It also prevents contamination of the heat-conducting agent within the internal cavity from contact between the sample tube and the liquid, and prevents cross-contamination between sample tubes. Furthermore, it avoids water residue on the outer wall after sample removal, effectively improving the device's reliability and experimental safety. This device can be directly matched with a high-precision robotic arm system for picking up and placing sample tubes without the need for flipping the cap, which greatly improves experimental efficiency and automation. It can also be adapted to a variety of sample tubes of different specifications and is easy to integrate with other pretreatment equipment to form a complete sample pretreatment system. It is suitable for applications in laboratories, medical fields, environmental protection and other fields.

[0023] In addition to the objectives, features, and advantages described above, this utility model has other objectives, features, and advantages. The present utility model will now be described in further detail with reference to the figures. Attached Figure Description

[0024] The accompanying drawings, which form part of this application, are used to provide a further understanding of the present invention. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an undue limitation of the present invention. In the drawings:

[0025] Figure 1 This is a cross-sectional view of the constant temperature water bath device of the preferred embodiment of the present invention mounted on the oscillation mechanism;

[0026] Figure 2This is a schematic diagram of the structure of the constant temperature water bath device installed on the oscillation mechanism according to a preferred embodiment of the present invention;

[0027] Figure 3 This is a side view of the constant temperature water bath device installed on the oscillation mechanism according to a preferred embodiment of the present invention.

[0028] Legend:

[0029] 100. Water bath; 101. Chamber body; 1011. Base plate; 1012. Side plate; 1013. Cover plate; 1014. Fixing plate; 102. Sleeve; 103. Thermal conductive agent; 200. Temperature control component; 201. Cooling pipe; 202. Temperature sensor; 203. Insulation layer; 300. Oscillating mechanism; 301. Rotary platform; 302. Eccentric shaft; 303. Base; 304. Power component; 3041. Motor; 3042. Transmission wheel set; 400. Sample tube; 500. Coolant inlet; 600. Coolant outlet. Detailed Implementation

[0030] The embodiments of the present invention will be described in detail below with reference to the accompanying drawings. However, the present invention can be implemented in many different ways as defined and covered below.

[0031] like Figure 1 , Figure 2 and Figure 3As shown, the constant temperature water bath device of this embodiment includes a water bath 100 and a temperature control component 200. The water bath 100 includes a box body 101 with an inner cavity and a plurality of sleeves 102 with their openings facing upwards. The inner cavity of the box body 101 is used to inject a heat-conducting agent 103. The sleeves 102 pass through the inner cavity and are sealed to the end face of the box body 101. The sleeves 102 are used to contain the sample tube 400 and transfer the temperature of the heat-conducting agent 103 to the sample tube 400. The temperature control component 200 is connected to the box body 101 and is used to maintain the liquid in the sample tube 400 at a constant temperature by adjusting the temperature of the inner cavity. In this embodiment, the box body 101 has a cuboid or cube structure; optionally, the box body 101 can also be a cylindrical structure. The water bath 100, by connecting the temperature control component 200 to the chamber 101, can precisely regulate and stabilize the temperature of the heat-conducting agent 103 inside the chamber 101. A sleeve 102 is inserted into the inner cavity of the chamber 101 and contacts the heat-conducting agent 103. A sample tube 400 is fitted inside the sleeve 102, allowing the temperature of the heat-conducting agent 103 to be transferred to the sample tube 400, maintaining a constant temperature within the sleeve 102 to meet the precise temperature requirements of different experiments. The chamber 101 features a lidless design, enabling direct compatibility with high-precision robotic arms for loading and unloading the sample tube 400 without manual lid-opening operations, saving time and effort and significantly improving experimental efficiency and automation. Preferably, in this embodiment, the heat-conducting agent 103 is hot water.

[0032] Preferably, the sleeve 102 is made of aluminum. Aluminum has good corrosion resistance and high thermal conductivity, and has little impact on the temperature balance of the sample tube 400. The sample tube 400 is placed inside the sleeve 102 and in close contact with the inner wall of the sleeve 102. The sleeve 102 passes through the inner cavity of the box 101, contacts the thermal conductive agent 103, and is sealed to the end face of the box 101. This not only keeps the inner cavity of the box 101 sealed, ensuring stable temperature, and rapidly and stably transfers the temperature of the thermal conductive agent 103 in the inner cavity of the box 101 to the sample tube 400 inside the sleeve 102, thus achieving precise temperature control of the sample in the sample tube 400, but also isolates the sample tube 400 from the inner cavity of the box 101, preventing leakage of the thermal conductive agent 103 in the inner cavity of the box 101 during oscillation, preventing contamination of the thermal conductive agent 103 by contact between the sample tube 400 and the thermal conductive agent 103 in the inner cavity of the box 101, and reducing cross-contamination between sample tubes 400, but also prevents water from adhering to the outer wall of the sample tube 400 after it is removed, thus effectively improving the reliability and experimental safety of the device. Preferably, the sleeve 102 can be designed according to the specifications of the sample tube 400, and can be adapted to a variety of sample tubes 400 of different specifications, thereby improving the versatility of the device.

[0033] like Figure 1 and Figure 2As shown, the enclosure 101 includes a base plate 1011, side plates 1012 enclosing and fixed to the base plate 1011, and a cover plate 1013 covering the side plates 1012. Specifically, the base plate 1011 is a square metal plate, preferably made of stainless steel, which has good thermal conductivity and corrosion resistance. The side plates 1012 are located around the base plate 1011 and can be fixed to the base plate 1011 by welding or bolting to ensure airtightness. The cover plate 1013 covers the upper end of the side plates 1012 and can be fixed to the cover plate 1013 by bolts or clips for easy disassembly and maintenance. Thus, the base plate 1011, side plates 1012, and cover plate 1013 are fixedly connected and enclose to form an inner cavity, ensuring the airtightness of the inner cavity and ensuring the temperature stability of the inner cavity.

[0034] The cover plate 1013 has several mounting holes. The sleeve 102 passes through the inner cavity of the box 101 and is sealed to the mounting hole end face of the cover plate 1013 to prevent liquid leakage or contamination of the inner cavity of the box 101. The shape and size of the sleeve 102 are adapted to the sample tube 400 so that the sample tube 400 can be placed inside the sleeve 102 and in contact with the inner wall of the sleeve 102. This not only isolates the sample tube 400 from the inner cavity of the box 101, preventing the sample tube 400 from contacting the liquid in the inner cavity of the box 101 and causing contamination of the liquid in the inner cavity, eliminating the need for frequent replacement of the liquid in the inner cavity of the box 101, but also reduces cross-contamination between sample tubes 400. It also prevents water from dripping onto the outer wall when the sample tube 400 is removed. Furthermore, the sleeve 102 facilitates the conduction of the temperature of the inner cavity of the box 101 to the sample tube 400, thereby achieving precise and rapid temperature control of the sample tube 400, keeping the temperature inside the sample tube 400 constant, and improving the accuracy of the experiment. Preferably, a number of mounting holes are arranged in an array on the cover plate 1013 to facilitate the placement and removal of sample tubes 400 with a high-precision robotic arm system, thereby improving experimental efficiency.

[0035] like Figure 1As shown, the temperature control assembly 200 includes a cooling pipe 201 and a cooling supply component. The cooling supply component serves as a cold source, providing coolant to the cooling pipe 201. Specifically, the thermally conductive agent 103 fills the inner cavity of the housing 101 and contacts the outer wall of the sleeve 102 to uniformly transfer heat to the sleeve 102. The cooling pipe 201 is disposed in the inner cavity of the housing 101 and contacts the thermally conductive agent 103 to regulate the temperature of the thermally conductive agent 103. Preferably, the cooling pipe 201 is arranged around the outer periphery of the sleeve 102 to ensure that the temperature of the thermally conductive agent 103 on the outer periphery of the sleeve 102 is uniformly transferred into the sleeve 102. Preferably, the cooling pipe 201 is made of copper or stainless steel to improve heat exchange efficiency. The side plate 1012 of the housing 101 has a coolant inlet 500 and a coolant outlet 600. The coolant inlet 500 is connected to the first end of the cooling pipe 201, and the coolant outlet 600 is connected to the second end of the cooling pipe 201. A cooling supply component is connected to the coolant inlet 500 to introduce coolant into the cooling pipe 201 and provide a certain amount of circulation power. Preferably, the temperature of the coolant is controlled at around 1-3℃. Preferably, in this embodiment, the coolant is cooling water; preferably, the cooling supply component is a circulating water pump.

[0036] In use, the circulating water pump is turned on, and the coolant enters through the coolant inlet 500, exits through the coolant outlet 600 via the cooling pipe 201, and returns to the circulating water pump for cooling. The cooling pipe 201 is coiled inside the chamber 101 to increase the contact area with the heat-conducting agent 103 inside the chamber, thereby carrying away the heat of the heat-conducting agent 103 and reducing the temperature of the heat-conducting agent 103 inside the chamber 101. This achieves temperature regulation of the chamber 101 and provides constant temperature control for the sample tube 400. Preferably, in this embodiment, the coolant inlet 500 and the coolant outlet 600 are located on the same side plate 1012, and there are at least two coolant inlets 500 and two coolant outlets 600 to improve the cooling circulation efficiency of the chamber 101. By controlling the temperature of the heat-conducting agent 103 through the cooling pipe 201, the temperature of the sample tube 400 is indirectly controlled, resulting in better temperature stability and constant temperature control of the sample tube 400. Meanwhile, the airtightness requirements for the water bath 100 are lower, simplifying the structural design.

[0037] like Figure 2 and Figure 3As shown, the temperature control assembly 200 also includes a temperature sensor 202, which is mounted on the cover plate 1013 and communicates with the inner cavity of the housing 101 to monitor the temperature of the heat transfer fluid 103. Preferably, the temperature sensor 202 and the cooling element are electrically connected to the control system. The control system can receive the real-time measurement value of the temperature sensor 202 and adjust the flow rate of the cooling element accordingly to ensure temperature stability. Preferably, the temperature sensor 202 controls the heat transfer fluid 103 in the inner cavity of the housing 101 at 4±1℃. The internal temperature of the sleeve 102 immersed in the heat transfer fluid 103 changes with the temperature of the heat transfer fluid 103. After the sample tube 400 is placed in the sleeve 102 and stabilized for a period of time, the temperature of the sample tube 400 can be stabilized at 4±1℃.

[0038] like Figure 1 As shown, the temperature control component 200 also includes a heat insulation layer 203 disposed in the inner cavity of the housing 101. The heat insulation layer 203 is installed on the upper end of the bottom plate 1011 and / or the inner wall of the side plate 1012 to prevent the heat transfer agent 103 from losing heat, reduce heat loss, and improve energy efficiency. Preferably, the bottom of the sleeve 102 is in contact with the heat insulation layer 203 on the bottom plate 1011, which can stably position the sleeve 102 in the inner cavity of the housing 101 and prevent heat loss from the bottom of the sleeve 102, thereby further improving the temperature control effect of the sleeve 102.

[0039] Preferably, a sealing ring is provided at the inlet end of the sleeve 102. The sealing ring is arranged around the inner wall of the sleeve 102 to make close contact with the outer wall of the sample tube 400, thereby sealing and positioning the sample tube 400. This ensures the sealing and stability of the sample tube 400 within the sleeve 102, preventing displacement or shaking of the sample tube 400 during oscillation, ensuring the oscillation effect of the liquid inside the sample tube 400, and preventing temperature loss within the sleeve 102. This ensures temperature stability within the sleeve 102, guarantees effective heat conduction from the sleeve 102 to the sample tube 400, and improves the temperature control effect of the sample tube 400. Preferably, the sealing ring is an O-ring rubber ring or an O-ring silicone ring.

[0040] Preferably, the housing 101 further includes a heat transfer fluid inlet, which is located on the side plate 1012 and / or the cover plate 1013 to allow heat transfer fluid 103 to enter and exit the inner cavity, facilitating replacement or maintenance. Since the sample tube 400 is separated from the inner cavity of the housing 101 by the sleeve 102, the sample tube 400 will not come into contact with the heat transfer fluid 103 inside the housing 101, thus preventing contamination of the heat transfer fluid 103 and effectively reducing the frequency of heat transfer fluid 103 replacement. The heat transfer fluid inlet serves as a spare port, facilitating replacement when the temperature of the heat transfer fluid 103 is insufficient. It can also be used to heat the heat transfer fluid 103 inside the housing 101, stabilizing it within a certain temperature range and further improving the temperature control of the sample tube 400.

[0041] like Figure 1 and Figure 3 As shown, an oscillation mechanism 300 is installed at the lower end of the housing 101. The oscillation mechanism 300 controls the shaking of the housing 101 through mechanical transmission, thereby oscillating the sample tube 400 and making the liquid in the sample tube 400 evenly mixed. Specifically, the oscillation mechanism 300 includes a rotary platform 301, an eccentric shaft assembly, and a base 303 arranged sequentially from top to bottom, as well as a power assembly 304 installed in the base 303. The rotary platform 301 is located below the housing 101 and fixed to the housing 101. The eccentric shaft assembly includes several eccentric shafts 302 eccentrically located at the lower end of the rotary platform 301. The power assembly 304 is connected to the eccentric shafts 302 through a transmission wheel set 3042. The power assembly 304 is used to drive the eccentric shafts 302 to reciprocate so as to shake the housing 101 through the rotary platform 301 and stop the shaking of the rotary platform 301 at a set position. Specifically, in this embodiment, three eccentric shafts 302 are provided at the lower end of the rotary platform 301. Preferably, the eccentricity of the eccentric shafts 302 is adjustable to adapt to different oscillation amplitude requirements. Preferably, the eccentric shafts 302 are mounted at the lower end of the rotary platform 301 via bearings to ensure the smooth oscillation of the rotary platform 301. The power assembly 304 includes a motor 3041 and a transmission wheel set 3042. Preferably, the motor 3041 is a stepper motor 3041 or a servo motor 3041, and the transmission wheel set 3042 is a pulley. The motor 3041 drives the eccentric shafts 302 to rotate through the transmission wheel set 3042, causing the rotary platform 301 to produce a swaying motion. Preferably, a position sensor and a position switch are installed on the transmission wheel set 3042. The position switch determines the position of the rotary platform 301 by sensing the position sensor, so that the rotary platform 301 stops at the same position after each rotation. Preferably, the motor 3041 is programmable and can achieve adjustable speed and timed stop functions. Through the synergistic action of the water bath 100 and the oscillation mechanism 300, the sample tube 400 can be uniformly oscillated under constant temperature conditions, significantly improving the efficiency and consistency of sample pretreatment. The oscillation mechanism 300 is integrated into the lower end of the chamber 101, simplifying the operation process. Simply placing the sample tube 400 inside the chamber 101 is sufficient to simultaneously complete the temperature control and oscillation treatments, reducing manual intervention and improving the automation level of the experiment.

[0042] like Figure 1 and Figure 2 As shown, the housing 101 also includes a fixing plate 1014, which is located at the lower part of the housing 101 and installed on the outer wall of the side plate 1012 to connect to the rotary platform 301. The fixing plate 1014 is fixed to the outer wall of the side plate 1012 by bolts and connected to the rotary platform 301 by bolts to ensure that the housing 101 and the rotary platform 301 move synchronously during oscillation.

[0043] In use, a high-precision robotic arm system inserts the sample tube 400 into the sleeve 102. The cooling system is activated and the coolant temperature is adjusted. The temperature of the heat-conducting agent 103 inside the chamber 101 is monitored and fed back in real time by the temperature sensor 202, and the flow rate of the coolant output from the cooling system is automatically adjusted to ensure that the sample tube 400 reaches a preset constant temperature state after stabilizing in the sleeve 102 for a certain period of time. The motor 3041 of the oscillation mechanism 300 is started, causing the eccentric shaft 302 to drive the rotary platform 301 to shake, so as to uniformly mix the liquid in the sample tube 400. After the oscillation is completed, the motor 3041 automatically stops, and the high-precision robotic arm system removes the sample tube 400 from the sleeve 102 for subsequent analysis.

[0044] According to another aspect of this utility model, a sample pretreatment system is also provided, including the aforementioned constant temperature water bath device. The constant temperature water bath device is placed in the mixing zone of the sample pretreatment system and cooperates with the oscillation mechanism 300 to uniformly oscillate the sample tube 400, which can effectively improve the accuracy of sample processing. Moreover, the constant temperature water bath device can be directly cooperated with a high-precision robotic arm system to pick up and drop the sample tube 400 without flipping the cap, which greatly improves the experimental efficiency and the intelligence of the device. The constant temperature water bath device can be integrated with other pretreatment equipment to form a complete sample pretreatment system, which can be applied to multiple fields such as laboratories, medical care, and environmental protection, and has a wide range of applications.

[0045] The above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Various modifications and variations can be made to this utility model by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A constant temperature water bath device, characterized in that, include: A water bath (100) includes a box body (101) with an inner cavity and a plurality of sleeves (102) with the opening facing upward. The inner cavity is used to inject a heat-conducting agent (103). The sleeves (102) pass through the inner cavity and are sealed to the end face of the box body (101). The sleeves (102) are used to cover the sample tube (400) and transfer the temperature of the heat-conducting agent (103) to the sample tube (400). A temperature control assembly (200) is connected to the housing (101) and is used to maintain the liquid in the sample tube (400) at a constant temperature by adjusting the temperature of the inner cavity.

2. The constant temperature water bath device according to claim 1, characterized in that, The housing (101) includes a bottom plate (1011), a side plate (1012) arranged in a surrounding manner and fixed to the bottom plate (1011), and a cover plate (1013) covering the side plate (1012). The bottom plate (1011), the side plate (1012) and the cover plate (1013) are fixedly connected and enclosed to form the inner cavity. The cover plate (1013) has a plurality of mounting holes for the sleeve (102) to pass through and for sealing the sleeve (102) to be installed. The plurality of mounting holes are arranged in an array on the cover plate (1013).

3. The constant temperature water bath device according to claim 2, characterized in that, The temperature control assembly (200) includes a cooling pipe (201) disposed in the inner cavity of the housing (101) and used to contact the heat-conducting agent (103), and a cooling supply component for introducing coolant into the cooling pipe (201) to adjust the temperature of the heat-conducting agent (103). The cooling pipe (201) is arranged around the outer periphery of the sleeve (102). The side plate (1012) of the housing (101) is provided with a coolant inlet (500) communicating with the first end of the cooling pipe (201) and a coolant outlet (600) communicating with the second end of the cooling pipe (201), and the cooling component is connected to the coolant inlet (500).

4. The constant temperature water bath device according to claim 3, characterized in that, The temperature control assembly (200) also includes a temperature sensor (202) for monitoring the temperature of the heat transfer agent (103), the temperature sensor (202) being mounted on the cover plate (1013) and communicating with the inner cavity of the housing (101).

5. The constant temperature water bath device according to claim 3, characterized in that, The temperature control component (200) also includes a heat insulation layer (203) for preventing the heat transfer agent (103) from losing temperature. The heat insulation layer (203) is disposed in the inner cavity of the housing (101) and installed on the upper end of the bottom plate (1011) and / or the inner wall of the side plate (1012).

6. The constant temperature water bath device according to claim 2, characterized in that, The housing (101) also includes a heat transfer port for introducing and discharging the heat transfer agent (103) into and out of the inner cavity, the heat transfer port being opened on the side plate (1012) and / or the cover plate (1013).

7. The constant temperature water bath device according to claim 1, characterized in that, The inlet end of the sleeve (102) is provided with a sealing ring, which is arranged around the inner wall of the sleeve (102) and is used to contact the outer wall of the sample tube (400) for sealing and positioning.

8. The constant temperature water bath device according to claim 2, characterized in that, The lower end of the housing (101) is provided with an oscillation mechanism (300) for oscillating the sample tube (400). The oscillation mechanism (300) includes a rotary platform (301), an eccentric shaft assembly and a base (303) arranged sequentially from top to bottom, and a power assembly (304) installed in the base (303). The rotary platform (301) is connected to the housing (101). The eccentric shaft assembly includes a plurality of eccentric shafts (302) eccentrically disposed at the lower end of the rotary platform (301). The power assembly (304) is connected to the eccentric shafts (302) via a transmission wheel set (3042). The power assembly (304) is used to drive the eccentric shafts (302) to reciprocate so as to drive the housing (101) to shake through the rotary platform (301) and stop the rotary platform (301) from shaking at a set position.

9. The constant temperature water bath device according to claim 8, characterized in that, The housing (101) also includes a fixing plate (1014) for connecting the rotary platform (301), the fixing plate (1014) being located at the lower part of the housing (101) and mounted on the outer wall of the side plate (1012).

10. A sample pretreatment system, characterized in that, The thermostatic water bath device includes any one of claims 1 to 9.

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