Rotary disc reactor for drug substance intermediates

Abstract

The utility model relates to the field of reaction kettle, concretely to the rotary disc type reaction kettle for raw material medicine intermediate, including the casing, is set up with processing cavity in the casing, the casing upper surface plug -in installation has the cover, still include: the mounting shaft, the mounting shaft rotatory installation is in the processing cavity, the mounting shaft side wall fixed mounting has a plurality of rotary disc, the mounting shaft side wall is fixed mounting below each rotary disc has a plurality of groups of vane. This rotary disc type reaction kettle for raw material medicine intermediate is provided with the mounting shaft, and the radius of the rotary disc forms the conical flow passage in increasing downwards, and the axial secondary flow of induced fluid is generated, the dead zone problem of traditional flat disc structure is avoided, to increase the reaction efficiency in the processing cavity, the upper surface of rotary disc is provided with a plurality of radial dispersion grooves, and the radial dispersion groove produces radial pressure gradient when rotating, drives fluid directional flow along the dispersion groove, and the lateral vortex of dispersion groove edge is generated, to increase the mixing uniformity of raw material medicine intermediate, makes the processing cavity fully react.

Description

Technical Field

[0001] This utility model relates to the field of reaction vessels, and in particular to a rotary disc reaction vessel for pharmaceutical intermediates. Background Technology

[0002] Active pharmaceutical ingredients (APIs) intermediates are key transitional compounds in the synthesis of APIs, playing a crucial role throughout the entire drug production chain and directly affecting the quality, cost, and safety of the final drug. Rotary disc reactors are core reaction equipment widely used in chemical, pharmaceutical, food, and materials industries. Their core function is to provide a controllable reaction environment for the chemical or physical processes in the production of API intermediates by controlling conditions such as temperature, pressure, and stirring.

[0003] In the processing of active pharmaceutical ingredients (APIs) intermediates, existing rotary disc reactors are generally equipped with ordinary stirrers to agitate the APIs intermediates. However, most ordinary stirrers directly use a motor to drive the stirring shaft to achieve agitation. This agitation method cannot effectively and quickly disperse the APIs intermediates, which can lead to incomplete reactions within the reactor. Therefore, a rotary disc reactor for APIs intermediates is provided. Summary of the Invention

[0004] The main purpose of this invention is to provide a rotary disc reactor for pharmaceutical intermediates, in order to solve the problem that existing rotary disc reactors generally use ordinary stirrers to stir the pharmaceutical intermediates. However, most ordinary stirrers directly use a motor to drive the stirring shaft to rotate, which cannot effectively disperse and stir the pharmaceutical intermediates quickly and thoroughly, thus leading to incomplete reaction in the reactor.

[0005] To achieve the above objectives, according to one aspect of the present invention, a rotary disc reactor for pharmaceutical intermediates is provided, comprising a shell, a processing chamber inside the shell, a cover inserted and installed on the upper surface of the shell, and further comprising: a mounting shaft, the mounting shaft being rotatably mounted in the processing chamber, a plurality of rotating discs being fixedly mounted on the side wall of the mounting shaft, a plurality of sets of blades being fixedly mounted on the side wall of the mounting shaft below each rotating disc, and a collecting plate being fixedly mounted on the side wall of the mounting shaft near the lower end, wherein the rotating discs and blades stir, disperse, and react the pharmaceutical intermediates, which are then collected by the collecting plate.

[0006] Furthermore, the radius of the rotating disk increases sequentially from top to bottom.

[0007] Furthermore, the upper surface of the rotating disk is provided with several radially distributed grooves.

[0008] Furthermore, the blades have an arc-shaped structure, and the number of blades in each group increases sequentially from top to bottom.

[0009] Furthermore, a mounting groove is provided at the center of the lower surface of the processing cavity, one end of the mounting shaft is rotatably mounted in the mounting groove, a motor is fixedly mounted on the lower surface of the mounting shaft, and the motor output shaft is fixedly connected to the mounting shaft.

[0010] Furthermore, a baffle is fixedly installed at the edge of the collecting plate. The baffle has an arc-shaped structure, and an oblique angle that slopes downward toward the center of the collecting plate is opened at the inner edge of the upper surface of the baffle. A vortex-shaped groove is opened on the upper surface of the collecting plate.

[0011] Furthermore, a feeding groove is fixedly installed at the center of the upper surface of the cover, and a feeding port is opened through the center of the feeding groove. A mounting bracket is fixedly installed inside the feeding port, and one end of the mounting shaft is inserted into the mounting bracket. A sealing ring is fixedly installed on the lower surface of the cover.

[0012] Furthermore, a sealing groove is provided on the upper surface of the housing, and a sealing ring is inserted and installed in the sealing groove.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] This rotary disc reactor for pharmaceutical intermediates is equipped with a mounting shaft. Several rotary discs are fixedly mounted on the sidewall of the mounting shaft. Below each rotary disc, several sets of blades are fixedly mounted on the sidewall of the mounting shaft. The radius of the rotary discs increases from top to bottom, and the blades have an arc-shaped structure with the number of blades increasing sequentially from top to bottom. The upper, smaller radius rotary discs generate high shear rates for initial and rapid dispersion of the pharmaceutical intermediates, while the lower, larger radius rotary discs provide high linear velocity, enhancing macroscopic circulation within the processing chamber, thereby increasing dispersion and mixing effects and making the reaction more complete. The blades drive the fluid axially, avoiding laminar dead zones, and the rotary discs break up bubbles and droplets. The blades provide stronger pumping force and prevent the accumulation of high-viscosity pharmaceutical intermediates to increase mixing efficiency. The upper surface of the rotating disk has several radial dispersion grooves. When the radial dispersion grooves rotate, they generate a radial pressure gradient, driving the fluid to flow directionally along the dispersion grooves. At the same time, transverse vortices are generated at the edge of the grooves, which is suitable for rapid precipitation reactions to increase the mixing effect. A collecting plate is fixedly installed at the lower end of the mounting shaft, and a baffle is fixedly installed at the edge of the collecting plate. The collecting plate and the baffle collect the pharmaceutical intermediates after the reaction. The upper surface of the collecting plate has vortex-shaped grooves. The vortex-shaped grooves apply periodic shearing to the high-viscosity fluid, thereby increasing the mixing effect. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the outer structure of the reactor in a preferred embodiment of the present invention;

[0016] Figure 2This is a schematic cross-sectional view of the reaction vessel in a preferred embodiment of the present invention;

[0017] Figure 3 This is a schematic cross-sectional view of the processing cavity in a preferred embodiment of the present invention;

[0018] Figure 4 This is a schematic cross-sectional view of the cover body in a preferred embodiment of the present invention;

[0019] Figure 5 This is a schematic diagram of the mounting shaft structure in a preferred embodiment of the present invention;

[0020] Figure 6 This is a cross-sectional view of the baffle structure in a preferred embodiment of the present invention.

[0021] Figure label:

[0022] 1. Housing; 11. Machining cavity; 12. Sealing groove; 13. Mounting groove; 131. Motor;

[0023] 2. Cover; 21. Feed chute; 22. Mounting bracket; 23. Sealing ring; 211. Feed inlet;

[0024] 3. Mounting shaft; 31. Collecting plate; 32. Blade; 33. Rotary disk; 311. Baffle; 312. Groove; 331. Dispersion trough. Detailed Implementation

[0025] To further illustrate the technical means and effects adopted by this utility model in order to achieve the intended utility model purpose, the following detailed description of the specific implementation methods, structure, features and effects of this utility model is provided in conjunction with the accompanying drawings and preferred embodiments.

[0026] This embodiment provides a rotary disc reactor for pharmaceutical intermediates, including a shell 1, a processing chamber 11 inside the shell 1, a cover 2 inserted and installed on the upper surface of the shell 1, and a mounting shaft 3, which is rotatably installed in the processing chamber 11. Several rotating discs 33 are fixedly installed on the side wall of the mounting shaft 3, and several sets of blades 32 are fixedly installed on the side wall of the mounting shaft 3 below each rotating disc 33. A collection plate 31 is fixedly installed on the side wall of the mounting shaft 3 near the lower end. The rotating discs 33 and blades 32 stir, disperse, and react the pharmaceutical intermediates, which are then collected by the collection plate 31.

[0027] like Figure 2 , Figure 3 , Figure 5 , Figure 6As shown, the radius of the rotating disk 33 increases from top to bottom. The small-radius rotating disk 33 at the top generates a high shear rate to initially and rapidly disperse the active pharmaceutical ingredient intermediate, while the large-radius rotating disk 33 at the bottom provides a high linear velocity to enhance the macroscopic circulation within the processing chamber 11, thereby increasing the dispersion and mixing effect and making the reaction more complete.

[0028] like Figure 2 , Figure 3 , Figure 5 , Figure 6 As shown, the upper surface of the rotating disk 33 is provided with several radial dispersion grooves 331. When the radial dispersion grooves 331 rotate, they generate a radial pressure gradient, which drives the fluid to flow in a direction along the dispersion grooves 331. At the same time, transverse vortices are generated at the edge of the grooves, which is suitable for rapid precipitation reactions to increase the mixing effect.

[0029] like Figure 5 , Figure 6 As shown, the blades 32 have an arc-shaped structure. The number of blades 32 in each group increases from top to bottom. The blades 32 drive the fluid to flow axially, avoiding laminar dead zones. The upper blades 32 initially disperse the high-viscosity raw material intermediates to prevent agglomeration. The number of lower blades 32 increases to thoroughly break up residual agglomerates with high shear force, while extending the residence time to ensure complete reaction.

[0030] like Figure 2 , Figure 3 As shown, a mounting groove 13 is provided at the center of the lower surface of the processing cavity 11. One end of the mounting shaft 3 is rotatably mounted in the mounting groove 13. A motor 131 is fixedly mounted on the lower surface of the mounting shaft 3. The motor 131 is fixedly mounted in the mounting groove 13. The output shaft of the motor 131 is fixedly connected to the mounting shaft 3. The motor 131 provides power to the mounting shaft 3 to drive the mounting shaft 3 to rotate.

[0031] like Figure 6 As shown, a baffle 311 is fixedly installed at the edge of the collecting plate 31. The baffle 311 has an arc-shaped structure. An angled slope that slopes downward toward the center of the collecting plate 31 is opened at the inner edge of the upper surface of the baffle 311. A vortex-shaped groove 312 is opened on the upper surface of the collecting plate 31. The angled slope at the edge of the upper surface of the baffle 311 facilitates the entry of the raw material intermediate into the baffle 311. The vortex-shaped groove 312 applies periodic shearing to the high-viscosity fluid, thereby increasing the mixing effect.

[0032] like Figure 1 , Figure 2 , Figure 4As shown, a feeding groove 21 is fixedly installed at the center of the upper surface of the cover 2. A feeding port 211 is opened through the center of the feeding groove 21. A mounting bracket 22 is fixedly installed inside the feeding port 211. One end of the mounting shaft 3 is inserted into the mounting bracket 22. A sealing ring 23 is fixedly installed on the lower surface of the cover 2. The raw material intermediate is added into the processing cavity 11 from the feeding port 211. The mounting shaft 3 is inserted into the mounting bracket 22 to facilitate the removal of the cover 2.

[0033] like Figure 3 As shown, a sealing groove 12 is provided on the upper surface of the shell 1, and a sealing ring 23 is inserted into the sealing groove 12. The sealing performance of the processing cavity 11 is increased by the cooperation of the sealing ring 23 and the sealing groove 12. The raw material intermediate is removed by removing the cover 2.

[0034] In practical use, the active pharmaceutical ingredient (API) intermediate is added into the processing chamber 11 through the inlet 211. After being dispersed by the rotating disk 33, the API intermediate is stirred by the blades 32. The radius of the rotating disk 33 increases from top to bottom. The upper, smaller radius rotating disk 33 generates a high shear rate for initial rapid dispersion of the API intermediate, while the lower, larger radius rotating disk 33 provides a high linear velocity, enhancing macroscopic circulation within the processing chamber 11, thereby increasing dispersion and mixing effects and making the reaction more complete. The blades 32 promote axial flow of the fluid, avoiding laminar dead zones. The rotating disk 33 breaks up air bubbles and droplets, and the blades 32 provide stronger pumping force to prevent high-viscosity APIs from being stirred. The pharmaceutical intermediates are stacked to increase mixing efficiency. The upper surface of the rotating disk 33 has several radial dispersion grooves 331. When the radial dispersion grooves 331 rotate, they generate a radial pressure gradient, driving the fluid to flow directionally along the dispersion grooves 331. At the same time, transverse vortices are generated at the edge of the grooves, which is suitable for rapid precipitation reactions to increase the mixing effect. A collecting plate 31 is fixedly installed at the lower end of the mounting shaft 3. A baffle 311 is fixedly installed at the edge of the collecting plate 31. The collecting plate 31 and the baffle 311 collect the raw material pharmaceutical intermediates after the reaction. The upper surface of the collecting plate 31 has vortex-shaped grooves 312. The vortex-shaped grooves 312 apply periodic shearing to the high viscosity fluid, thereby increasing the mixing effect.

[0035] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Although the present utility model has been disclosed above with reference to a preferred embodiment, it is not intended to limit the present utility model. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present utility model. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present utility model without departing from the scope of the present utility model shall still fall within the scope of the present utility model.

Claims

1. A rotary disc reactor for producing intermediates of active pharmaceutical ingredients, comprising a shell (1), wherein a processing chamber (11) is provided inside the shell (1), and a cover (2) is inserted and installed on the upper surface of the shell (1), characterized in that, Also includes: Mounting shaft (3) is rotatably mounted in machining cavity (11). Several rotating disks (33) are fixedly mounted on the side wall of mounting shaft (3). Several sets of blades (32) are fixedly mounted on the side wall of mounting shaft (3) below each rotating disk (33). A collecting plate (31) is fixedly mounted on the side wall of mounting shaft (3) near the lower end.

2. The rotary disc reactor for pharmaceutical intermediates according to claim 1, characterized in that, The radius of the rotating disk (33) increases sequentially from top to bottom.

3. The rotary disc reactor for pharmaceutical intermediates according to claim 1, characterized in that, The upper surface of the rotating disk (33) is provided with several radially distributed grooves (331).

4. The rotary disc reactor for pharmaceutical intermediates according to claim 1, characterized in that, The blades (32) are arc-shaped structures, and the number of blades (32) in each group increases sequentially from top to bottom.

5. The rotary disc reactor for pharmaceutical intermediates according to claim 1, characterized in that, An installation groove (13) is provided at the center of the lower surface of the processing cavity (11). One end of the installation shaft (3) is rotatably installed in the installation groove (13). A motor (131) is fixedly installed on the lower surface of the installation shaft (3). The output shaft of the motor (131) is fixedly connected to the installation shaft (3).

6. The rotary disc reactor for pharmaceutical intermediates according to claim 1, characterized in that, A baffle (311) is fixedly installed at the edge of the collecting plate (31). The baffle (311) has an arc-shaped structure. An oblique angle inclined downward toward the center of the collecting plate (31) is opened at the inner edge of the upper surface of the baffle (311). A vortex-shaped groove (312) is opened on the upper surface of the collecting plate (31).

7. The rotary disc reactor for pharmaceutical intermediates according to claim 1, characterized in that, A feed trough (21) is fixedly installed at the center of the upper surface of the cover (2). A feed inlet (211) is opened through the center of the feed trough (211). A mounting bracket (22) is fixedly installed inside the feed inlet (211). One end of the mounting shaft (3) is inserted into the mounting bracket (22). A sealing ring (23) is fixedly installed on the lower surface of the cover (2).

8. The rotary disc reactor for pharmaceutical intermediates according to claim 1, characterized in that, A sealing groove (12) is provided on the upper surface of the housing (1), and a sealing ring (23) is inserted into the sealing groove (12).

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