An organoid chemical preparation device

By designing an organoid chemical preparation device with a digestion chamber and cutting components, the problem of low efficiency in manual operation in existing technologies has been solved, and the standardization and mechanization of organoid digestion have been realized, improving sample quality and utilization rate and meeting high-throughput requirements.

CN224313492UActive Publication Date: 2026-06-02ZHONGSHAN HOSPITAL FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
ZHONGSHAN HOSPITAL FUDAN UNIV
Filing Date
2025-03-19
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing organoid chemical preparation methods rely on manual operation, which is inefficient, has poor reproducibility, and is subject to human error, resulting in unstable cell digestion, low utilization of tissue samples, and difficulty in meeting the requirements of high throughput and standardization.

Method used

Design an organoid chemical preparation device including a digestion chamber and a cutting component. The cutting component cuts the tissue into a preset shape and size and stirs it in the digestion chamber. Combined with a filtration section and a termination chamber, it realizes automated digestion and screening, ensures full contact between the tissue and the digestive fluid, prevents accumulation, and standardizes the digestion process.

Benefits of technology

The standardization and mechanization of organoid digestion steps have been achieved, which has improved the consistency of sample quality, reduced manpower consumption, prevented over-digestion or under-digestion, and improved the utilization rate of tissue samples and the efficiency of organoid modeling.

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Abstract

The utility model provides a kind of organoids chemical preparation device, including digestion chamber and cutting part, the opposite entrance and export are provided on the digestion chamber, the entrance of the digestion chamber is provided with the cutting part, the cutting part is opened with discharge port to the side of the export of the digestion chamber, the cutting part is set to be adapted to cut and form preset shape size tissue and discharge through the discharge port, the discharge port side of the cutting part and the export side of the digestion chamber and the inner wall of the digestion chamber form digestion area, the digestion area is set to be adapted to pump into digestive juice. The organoids chemical preparation device, the digestion step of organoids is standardized, mechanized, reduces the human consumption in digestion process, improves the consistency of sample quality, improves the utilization rate of tissue sample, prevents excessive digestion and underdigestion.
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