Milk exosome particle size screening filtration equipment system

Abstract

The utility model discloses a kind of milk exosome particle size screening filtration equipment systems, including ultrafiltration module and controller, the front end of ultrafiltration module is provided with heating module, the rear end of ultrafiltration module is provided with cooling module, and ultrafiltration module includes ultrafiltration membrane, feed pipe, reflux pipe and buffer bucket and discharge pipe, feed pipe is installed at the front end of ultrafiltration membrane, buffer bucket is installed on feed pipe, and ultrafiltration membrane is connected with buffer bucket through reflux pipe, discharge pipe is installed at the rear end of ultrafiltration membrane, heating module is installed on feed pipe, and heating module is located between buffer bucket and ultrafiltration membrane, cooling module is installed at the end of discharge pipe.The utility model has the advantages of uniform heating, temperature control precision, high filtration efficiency and rapid cooling, solves the problem of low temperature raw material high viscosity, low ultrafiltration efficiency, easy to block ultrafiltration membrane.

Description

Technical Field

[0001] This utility model relates to the field of ultrafiltration equipment technology, specifically to a milk exosome particle size screening and filtration equipment system. Background Technology

[0002] Exosomes are nanoscale membrane vesicles secreted by cells, widely distributed in various biological fluids such as blood, emulsions, and urine, and play important roles in signal transduction and biological regulation. In recent years, with the deepening of research on exosomes, their application potential in biomedicine, tissue engineering, and cosmetics has been gradually discovered. Especially in the cosmetics industry, milk exosomes are considered a highly promising active ingredient due to their abundant source, convenient extraction, and high biocompatibility, possessing various skincare benefits such as promoting skin repair, anti-inflammation, anti-oxidation, and enhancing barrier function.

[0003] Currently, in the preparation of cosmetic raw materials, the acquisition of milk exosomes mainly relies on physical separation methods such as centrifugation, ultrafiltration, and precipitation. Among these, ultrafiltration technology has become one of the mainstream methods due to its ease of operation, lack of chemical reagents, and ability to better preserve the biological activity of exosomes. However, traditional ultrafiltration equipment has many problems when processing milk raw materials stored at low temperatures. Milk is usually stored under refrigeration conditions, and low temperatures significantly increase its viscosity and reduce its fluidity, thereby leading to decreased filtration efficiency, increased risk of membrane fouling and clogging, and impact on production efficiency and product quality. Therefore, a milk exosome particle size screening and filtration equipment system is needed to solve the above problems. Utility Model Content

[0004] The purpose of this invention is to provide a milk exosome particle size screening and filtration equipment system, which has the advantages of uniform heating, precise temperature control, high filtration efficiency and rapid cooling, and solves the problems of low ultrafiltration efficiency and easy clogging of ultrafiltration membrane caused by high viscosity of raw materials at low temperature.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a milk exosome particle size screening and filtration equipment system, including an ultrafiltration module and a controller, wherein a heating module is provided at the front end of the ultrafiltration module and a cooling module is provided at the rear end of the ultrafiltration module;

[0006] The ultrafiltration module includes an ultrafiltration membrane, a feed pipe, a reflux pipe, a buffer tank, and a discharge pipe. The feed pipe is installed at the front end of the ultrafiltration membrane, the buffer tank is installed on the feed pipe, the ultrafiltration membrane is connected to the buffer tank through the reflux pipe, the discharge pipe is installed at the rear end of the ultrafiltration membrane, the heating module is installed on the feed pipe and located between the buffer tank and the ultrafiltration membrane, and the cooling module is installed at the end of the discharge pipe.

[0007] In a preferred embodiment of the milk exosome particle size screening and filtration equipment system of this utility model, the heating module is provided with a raw material inlet and a raw material outlet on its left and right sides, a heating chamber is provided on the side wall of the heating module, a temperature sensor and a heating wire are provided in the heating chamber, and the heating chamber is filled with heat-conducting oil.

[0008] In a preferred embodiment of the milk exosome particle size screening and filtration equipment system of this utility model, the heating module has a heat insulation cavity on its side wall, and the heat insulation cavity is located outside the heating chamber.

[0009] In a preferred embodiment of the milk exosome particle size screening and filtration equipment system of this utility model, a first conical isolation cylinder is provided near the raw material inlet of the heating module, and a second conical isolation cylinder is provided near the raw material outlet of the heating module.

[0010] In a preferred embodiment of the milk exosome particle size screening and filtration equipment system of this utility model, the inner end face of the heating module is uniformly provided with a circumferential array of heat exchange plates.

[0011] In a preferred embodiment of the milk exosome particle size screening and filtration equipment system of this utility model, a coarse filter screen is provided at the end of the first conical isolation cylinder.

[0012] In a preferred embodiment of the milk exosome particle size screening and filtration equipment system of this utility model, the cooling module is provided with a finished product inlet and a finished product outlet on its left and right sides, a spiral tube is provided between the finished product inlet and the finished product outlet, a cooling chamber is provided inside the cooling module, a refrigerant inlet is provided at the bottom of the cooling chamber, and a refrigerant outlet is provided at the top of the cooling chamber.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0014] 1. This utility model solves the problems of high viscosity and poor flowability caused by low-temperature storage of raw materials by adding a heating module at the front end of the ultrafiltration module and using heat-conducting oil for uniform heating combined with temperature sensor for precise temperature control. It significantly reduces the load on the ultrafiltration membrane. The unique conical isolation cylinder design and spiral flow channel extend the residence time of the raw material in the heating zone. Combined with the uniform heat conduction structure of the heat exchange plate, it ensures that the material is heated evenly and the temperature is stable within the activity protection threshold. The cooling module at the rear end quickly cools down through the spiral tube and refrigerant circulation system. After filtration, the temperature of the finished product is immediately reduced to a suitable storage range, avoiding the loss of exosome activity caused by high temperature environment and extending the product shelf life.

[0015] 2. This utility model reduces heat loss by setting a heat insulation cavity on the outside of the heating module, which reduces energy consumption and shortens the heating time. Combined with the pre-interception function of the coarse filter, it effectively blocks solid impurities and oxide films in the raw materials. This design forms a dual protection mechanism: the coarse filter acts as a physical barrier to prevent the ultrafiltration membrane from clogging, while the precise temperature control avoids high-temperature denaturation of the raw materials caused by local overheating. The cooling module adopts a dynamic refrigerant circulation system to replace the traditional static cooling, and maintains stable heat exchange efficiency through continuous refrigerant replenishment. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0017] Figure 2 This is a front view of the present invention;

[0018] Figure 3 This is a schematic diagram of the heating module structure of this utility model;

[0019] Figure 4 This is a schematic diagram of the cooling module structure of this utility model.

[0020] In the diagram: 1. Ultrafiltration module; 101. Ultrafiltration membrane; 102. Feed pipe; 103. Return pipe; 104. Buffer tank; 105. Discharge pipe; 2. Heating module; 201. Raw material inlet; 202. Raw material outlet; 203. First conical isolation cylinder; 204. Second conical isolation cylinder; 205. Heating chamber; 206. Insulation chamber; 207. Heating wire; 208. Temperature sensor; 209. Heat exchange plate; 210. Coarse filter screen; 3. Cooling module; 301. Finished product inlet; 302. Finished product outlet; 303. Spiral tube; 304. Cooling chamber; 305. Refrigerant inlet; 306. Refrigerant outlet; 4. Controller. Detailed Implementation

[0021] Please see Figures 1-4 A milk exosome particle size screening and filtration equipment system includes an ultrafiltration module 1 and a controller 4. The front end of the ultrafiltration module 1 is provided with a heating module 2, and the rear end of the ultrafiltration module 1 is provided with a cooling module 3.

[0022] The ultrafiltration module 1 includes an ultrafiltration membrane 101, a feed pipe 102, a reflux pipe 103, a buffer tank 104, and a discharge pipe 105. The feed pipe 102 is installed at the front end of the ultrafiltration membrane 101, the buffer tank 104 is installed on the feed pipe 102, the ultrafiltration membrane 101 is connected to the buffer tank 104 through the reflux pipe 103, the discharge pipe 105 is installed at the rear end of the ultrafiltration membrane 101, the heating module 2 is installed on the feed pipe 102, the heating module 2 is located between the buffer tank 104 and the ultrafiltration membrane 101, and the cooling module 3 is installed at the end of the discharge pipe 105.

[0023] Furthermore, the heating module 2 has a raw material inlet 201 and a raw material outlet 202 on its left and right sides, and a heating chamber 205 is provided on the side wall of the heating module 2. A temperature sensor 208 and a heating wire 207 are provided in the heating chamber 205, and the heating chamber 205 is filled with heat-conducting oil.

[0024] Since raw materials are usually stored at low temperatures, their viscosity increases and their flowability decreases under low-temperature conditions, increasing the burden on ultrafiltration. The raw materials enter the heating module 2 through the raw material inlet 201. The heating wire 207 heats the heat transfer oil, thereby heating the raw materials passing through the heating module 2, raising their temperature and improving their flowability. The temperature of the heat transfer oil is monitored by the temperature sensor 208 to prevent the temperature from getting too high. The heat transfer oil evenly conducts heat to all positions of the heating module 2 to avoid uneven heating or local overheating, which could lead to deactivation and denaturation of the raw materials.

[0025] Furthermore, the side wall of the heating module 2 is provided with a heat insulation cavity 206, which is located outside the heating chamber 205.

[0026] The insulation cavity 206 improves the heat preservation performance of the heating module 2, reduces the energy consumption of the heating wire 207, and improves the heating efficiency, enabling it to quickly reach the preset temperature and heat the raw materials.

[0027] Furthermore, a first conical isolation cylinder 203 is provided near the raw material inlet 201 of the heating module 2, and a second conical isolation cylinder 204 is provided near the raw material outlet 202 of the heating module 2.

[0028] By using the first conical isolation cylinder 203 and the second conical isolation cylinder 204, the raw material is forced to flow from the first conical isolation cylinder 203 to the inside of the second conical isolation cylinder 204, then around the edge of the second conical isolation cylinder 204, and out from the outside of the second conical isolation cylinder 204. This increases the residence time of the raw material in the heating module 2 and the heating time, thereby enabling the raw material to be fully heated.

[0029] Furthermore, the inner end face of the heating module 2 is uniformly provided with a circumferential array of heat exchange plates 209.

[0030] By increasing the heat exchange area between the raw material and the heating module 2 through the heat exchange plate 209, the heating rate of the raw material and the uniformity of heating are further improved.

[0031] Furthermore, a coarse filter screen 210 is provided at the end of the first conical isolation cylinder 203.

[0032] The pre-filter 210 intercepts impurities in the raw material or the oxide film formed on the surface of the raw material, preventing impurities from entering the ultrafiltration membrane 101 and causing blockage of the ultrafiltration membrane 101.

[0033] Furthermore, the cooling module 3 is provided with a finished material inlet 301 and a finished material outlet 302 on the left and right sides, a spiral tube 303 is provided between the finished material inlet 301 and the finished material outlet 302, a cooling chamber 304 is provided inside the cooling module 3, a refrigerant inlet 305 is provided at the bottom of the cooling chamber 304, and a refrigerant outlet 306 is provided at the top of the cooling chamber 304.

[0034] By introducing refrigerant into the cooling inlet and allowing it to flow back through the refrigerant outlet 306, the finished material flowing through the cooling module 3 is rapidly cooled, extending the product's shelf life. The spiral tube 303 greatly increases the heat exchange area and time between the product and the refrigerant, thus enabling the raw material to cool down rapidly.

[0035] In operation, the device first introduces a low-temperature stored, high-viscosity, and poorly flowing raw material into the raw material inlet 201 of the heating module 2. After the raw material enters, the heating wire 207 in the heating chamber 205 heats the filled heat-conducting oil. The heat-conducting oil evenly transfers heat to all parts of the heating module 2. Simultaneously, the temperature sensor 208 monitors the temperature of the heat-conducting oil in real time, controlling it between 30 and 50 degrees Celsius to prevent excessive temperature from causing deactivation or denaturation of the raw material. During the flow process, the raw material is forced to change its flow direction by the action of the first conical isolation cylinder 203 and the second conical isolation cylinder 204, extending its residence time within the heating module 2. Combined with the heat exchange plates 209 arranged in a circumferential array on the inner end face, this achieves sufficient heating and improves fluidity. The coarse filter 210 at the end of the first conical isolation cylinder 203 can also intercept impurities and oxide films in the raw material, preventing damage to the ultrafiltration membrane 101. The heated raw material enters the ultrafiltration module 1 through the raw material outlet 202. The ultrafiltration membrane 101 filters the raw material by particle size screening. The raw material that does not pass through the ultrafiltration membrane 101 returns to the buffer tank 104 through the return pipe 103 for filtration again. The finished material that passes through the ultrafiltration membrane 101 enters the cooling module 3 through the discharge pipe 105. The finished material enters the cooling module 3 through the finished material inlet 301 and flows in the spiral tube 303. At this time, refrigerant is introduced into the refrigerant inlet 305 at the bottom of the cooling chamber 304. The refrigerant flows in the cooling chamber 304 and exchanges heat with the finished material in the spiral tube 303. The refrigerant returns from the refrigerant outlet 306 at the top. The spiral tube 303 greatly increases the heat exchange area and time between the finished material and the refrigerant, thereby rapidly cooling the finished material. Finally, it is discharged from the finished material outlet 302, resulting in a product that meets the requirements and has an extended shelf life.

[0036] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A milk exosome particle size screening and filtration equipment system, comprising an ultrafiltration module (1) and a controller (4), characterized in that: The ultrafiltration module (1) is provided with a heating module (2) at its front end and a cooling module (3) at its rear end. The ultrafiltration module (1) includes an ultrafiltration membrane (101), a feed pipe (102), a reflux pipe (103), a buffer tank (104), and a discharge pipe (105). The feed pipe (102) is installed at the front end of the ultrafiltration membrane (101), the buffer tank (104) is installed on the feed pipe (102), the ultrafiltration membrane (101) is connected to the buffer tank (104) through the reflux pipe (103), the discharge pipe (105) is installed at the rear end of the ultrafiltration membrane (101), the heating module (2) is installed on the feed pipe (102), the heating module (2) is located between the buffer tank (104) and the ultrafiltration membrane (101), and the cooling module (3) is installed at the end of the discharge pipe (105).

2. The milk exosome particle size screening and filtration equipment system as described in claim 1, characterized in that: The heating module (2) has a raw material inlet (201) and a raw material outlet (202) on its left and right sides. The heating module (2) has a heating chamber (205) on its side wall. The heating chamber (205) is equipped with a temperature sensor (208) and a heating wire (207). The heating chamber (205) is filled with heat-conducting oil.

3. The milk exosome particle size screening and filtration equipment system as described in claim 1, characterized in that: The heating module (2) has a heat insulation cavity (206) on its side wall, and the heat insulation cavity (206) is located outside the heating chamber (205).

4. The milk exosome particle size screening and filtration equipment system as described in claim 1, characterized in that: The heating module (2) is provided with a first conical isolation cylinder (203) near the raw material inlet (201) and a second conical isolation cylinder (204) near the raw material outlet (202).

5. The milk exosome particle size screening and filtration equipment system as described in claim 1, characterized in that: The inner end face of the heating module (2) is uniformly provided with a circumferential array of heat exchange plates (209).

6. The milk exosome particle size screening and filtration equipment system as described in claim 4, characterized in that: A coarse filter screen (210) is provided at the end of the first conical isolation cylinder (203).

7. The milk exosome particle size screening and filtration equipment system as described in claim 1, characterized in that: The cooling module (3) has a finished material inlet (301) and a finished material outlet (302) on its left and right sides. A spiral tube (303) is provided between the finished material inlet (301) and the finished material outlet (302). A cooling chamber (304) is provided inside the cooling module (3). A refrigerant inlet (305) is provided at the bottom of the cooling chamber (304), and a refrigerant outlet (306) is provided at the top of the cooling chamber (304).

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