A lid opening and closing device and a nucleic acid analysis apparatus
By designing an automated clamping and vertical movement mechanism for opening and closing the cap, the problems of low efficiency and high risk of contamination in manual operation during nucleic acid testing were solved. This automated opening and closing of the nucleic acid extraction tube ensures no splashing or leakage, and improves the accuracy and safety of the operation.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SHANGHAI BIOGERM MEDICAL TECH CO LTD
- Filing Date
- 2025-07-10
- Publication Date
- 2026-06-09
AI Technical Summary
In the current nucleic acid testing process, the extraction tube of the nucleic acid analyzer requires manual operation to open and close the cap, which is inefficient and poses a risk of contamination, making it difficult to achieve full automation and eliminate splashing and leakage.
Design a cover opening and closing device that includes a clamping mechanism and a vertical moving mechanism. The clamping mechanism holds the cover and works in conjunction with the vertical moving mechanism to achieve automated opening and closing of the cover, ensuring no liquid splashing and sealing during the opening and closing process, reducing labor costs and the risk of contamination.
The automated cap-opening and closing mechanism of the nucleic acid extraction process has been implemented, which improves operational efficiency, reduces error rate and contamination risk, and ensures reliable connection and sealing between the cap and the tube body.
Smart Images
Figure CN224337198U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of medical device technology, and in particular to a cover opening and closing device and a nucleic acid analysis device. Background Technology
[0002] Currently, with the increasingly widespread application of molecular diagnostic technology, extraction tubes are typically required for nucleic acid extraction and amplification detection of samples. In existing nucleic acid detection processes, the extraction tubes used in nucleic acid analyzers are usually opened and closed manually. This manual operation is not only inefficient but also increases the probability of errors during the opening and closing process, while also increasing labor costs and the risk of contamination. Nucleic acid extraction involves processes such as pipetting, lysis, washing, and elution, and all related reagents and consumables need to be stored in the extraction tubes. Improper operation can easily cause liquid splashing or liquid to stick to the tube cap, contaminating the equipment and experimental environment. Furthermore, only by sealing the consumables and reagents used in nucleic acid extraction after the experiment can the entire operation be guaranteed to be free from contamination of the equipment and environment. Existing nucleic acid extraction equipment struggles to achieve fully automated cap opening during nucleic acid extraction without liquid splashing or sticking to the cap, and it is also difficult to prevent leakage of reagents and consumables after the experiment. Utility Model Content
[0003] The purpose of this invention is to provide a cap-opening and closing device and a nucleic acid analysis equipment that can automatically open and close the cap without splashing or leaking liquid, thereby solving the problems of low efficiency and high contamination caused by manual operation of opening or closing the cap in the prior art.
[0004] To achieve the above objectives, the present invention adopts the following technical solution:
[0005] On one hand, this utility model provides a cover-opening device for opening or closing a reaction consumable, wherein the reaction consumable includes a tube body and a cover detachably connected to the tube body, and the cover-opening device includes:
[0006] A clamping mechanism includes a support bracket, a first driving assembly, a pressing assembly, a first clamp, and a second clamp. The first driving assembly and the pressing assembly are both disposed on the support bracket. The pressing assembly is located between the first clamp and the second clamp and is used to elastically press the tube cap. The driving end of the first driving assembly is connected to the first clamp and the second clamp and is used to drive the first clamp and the second clamp to move closer to each other or further away from each other in the X direction. When they move closer to each other, the tube cap is clamped; when they move further away from each other, the tube cap is released.
[0007] A vertical moving mechanism, the driving end of which is connected to the bearing bracket, is used to drive the bearing bracket to move along the Z direction; the bearing bracket can drive the first clamp and the second clamp to move closer to or away from the tube body, and the bearing bracket can drive the pressing assembly to press against the tube cap and move closer to the tube body.
[0008] As an optional solution for the above-mentioned switch cover device, the support bracket includes a first carrier plate, a second carrier plate, and a connecting guide rod. The first carrier plate is connected to the drive end of the vertical moving mechanism. The two ends of the connecting guide rod are respectively connected to the first carrier plate and the second carrier plate. The first driving component is disposed on the second carrier plate. The second carrier plate is connected to the pressing component so that the pressing component is fixed in a direction perpendicular to the Z direction and movable along the Z direction. One end of the pressing component elastically abuts against the first carrier plate.
[0009] As an optional embodiment of the above-mentioned switch cover device, the crimping assembly includes a crimping guide rod, a first elastic element, and a pressure plate. The crimping guide rod is movably disposed on the second carrier plate along the Z direction. The first elastic element is disposed between the crimping guide rod and the first carrier plate. The pressure plate is disposed at the end of the crimping guide rod away from the first elastic element and is used to crimp the tube cover. The pressure plate is located between the first clamp and the second clamp. When the first clamp and the second clamp hold the tube cover, the pressure plate elastically crimps the tube cover.
[0010] As an alternative to the aforementioned switch cover device, the pressure plate is provided with a positioning element. When the pressure plate is pressed against the tube cover, the positioning element can be inserted into the positioning hole of the tube cover.
[0011] As an alternative to the above-mentioned switch cover device, the second carrier plate is movably connected to the first carrier plate along the Z direction via the connecting guide rod. The bearing bracket also includes a second elastic member, which is sleeved outside the connecting guide rod, and the two ends of the second elastic member abut against the first carrier plate and the second carrier plate respectively.
[0012] As an alternative to the above-mentioned switch cover device, the first clamp is provided with a first limiting groove, and the second clamp is provided with a second limiting groove, with the first limiting groove and the second limiting groove being arranged opposite to each other.
[0013] As an alternative to the aforementioned cover opening and closing device, the clamping mechanism further includes a position sensor, which is mounted on the support bracket and used to sense the position of the cover.
[0014] As an optional embodiment of the above-mentioned cover opening and closing device, the cover opening and closing device further includes a loading mechanism, which includes a loading frame, a second driving component, a third clamp, and a fourth clamp. The second driving component is disposed on the loading frame, and the tube body can be placed on the loading frame. The driving end of the second driving component is connected to the third clamp and the fourth clamp, and is used to drive the third clamp and the fourth clamp to move closer to each other or further away from each other in the direction perpendicular to the Z direction. When they move closer to each other, they clamp the tube body, and when they move further away from each other, they release the tube body.
[0015] As an alternative to the above-mentioned cover opening and closing device, the cover opening and closing device further includes a horizontal moving mechanism, the driving end of which is connected to the vertical moving mechanism and is used to drive the vertical moving mechanism to move in a direction perpendicular to the Z direction.
[0016] On the other hand, this utility model provides a nucleic acid analysis device, including the switch cover device as described above.
[0017] The beneficial effects of this utility model are as follows:
[0018] The cover opening and closing device includes a clamping mechanism and a vertical moving mechanism. The clamping mechanism includes a support bracket, a first driving assembly, a pressing assembly, a first clamp, and a second clamp. The first driving assembly and the pressing assembly are both located on the support bracket. The pressing assembly is located between the first clamp and the second clamp and is used to elastically press the cover. The driving end of the first driving assembly is connected to the first clamp and the second clamp and is used to drive the first clamp and the second clamp to move closer to each other or further away from each other in the X direction. When they move closer, the cover is clamped; when they move further away, the cover is released, thereby realizing the gripping or releasing of the reaction consumable cover. The driving end of the vertical moving mechanism is connected to the support bracket and is used to drive the support bracket to move in the Z direction. The support bracket can drive the first clamp and the second clamp to move closer to or further away from the tube body. Thus, after the first clamp and the second clamp clamp the cover, the vertical moving mechanism drives the support bracket to rise, which allows the cover to detach from the tube body; the vertical moving mechanism drives the support bracket to fall, which allows the cover to contact the tube body. The support bracket can drive the crimping assembly to press against the tube cap and bring it close to the tube body. That is, during the process of the vertical moving mechanism driving the support bracket to approach the reaction consumables, the support bracket can drive the crimping assembly to press down and contact the tube cap. Through the pressing contact of the crimping assembly with the tube cap, combined with the clamping of the first and second clamps, the tube cap can be kept horizontal during the opening or closing process on the tube body. This prevents the tube cap from tilting or shaking when it is placed on the tube body, which would affect the normal closing of the tube cap on the tube body. When opening the cap, the crimping assembly elastically abuts against the tube cap to prevent the tube cap from popping out and splashing liquid. Before and after the tube cap is separated from the tube body, it is always in a controlled state in all directions and will not stick or drip liquid. In addition, the crimping assembly can also ensure that the tube cap is tightly closed to the tube body, improve the reliability of the connection between the tube cap and the tube body, enhance the sealing performance, and eliminate experimental contamination. This opening and closing device can automate the opening and closing of reaction consumables. It is not only highly efficient, but also reduces the chance of errors by using the first clamp, the second clamp and the pressing assembly together. It improves the accuracy and reliability of the tube cap being placed on the tube body, while also reducing labor costs and the risk of contamination. Attached Figure Description
[0019] Figure 1 This is a schematic diagram of the structure of the switch cover device provided in an embodiment of the present utility model;
[0020] Figure 2 This is a first structural schematic diagram of the clamping mechanism provided in an embodiment of the present utility model;
[0021] Figure 3 This is a schematic diagram of the second structure of the clamping mechanism provided in an embodiment of the present utility model;
[0022] Figure 4 This is a schematic diagram of the loading mechanism provided in an embodiment of the present utility model;
[0023] Figure 5This is a schematic diagram of the structure of the reaction consumables provided in an embodiment of the present invention.
[0024] In the picture:
[0025] 1. Clamping mechanism; 11. Support bracket; 111. First carrier plate; 112. Second carrier plate; 113. Connecting guide rod; 114. Second elastic element; 12. First drive assembly; 13. Crimping assembly; 131. Crimping guide rod; 132. First elastic element; 133. Pressure plate; 1331. Positioning element; 14. First clamping member; 141. First limiting groove; 15. Second clamping member; 151. Second limiting groove; 16. Position sensor; 2. Vertical moving mechanism; 3. Loading mechanism; 31. Loading frame; 32. Second drive assembly; 33. Third clamping member; 34. Fourth clamping member; 4. Reaction consumables; 41. Tube body; 42. Tube cap. Detailed Implementation
[0026] The technical solution of this utility model will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.
[0027] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this utility model and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance. The terms "first position" and "second position" refer to two different positions. Moreover, "above," "on top of," and "over" the first feature in relation to the second feature includes the first feature directly above and diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "under," and "below" the first feature in relation to the second feature includes the first feature directly below and diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.
[0028] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.
[0029] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.
[0030] like Figures 1-5 As shown, this embodiment provides a cover opening and closing device for opening or closing the cover of the reaction consumable 4. The reaction consumable 4 includes a tube body 41 and a cover 42 detachably connected to the tube body 41.
[0031] The cover opening and closing device includes a clamping mechanism 1 and a vertical moving mechanism 2. The clamping mechanism 1 includes a support bracket 11, a first driving assembly 12, a pressing assembly 13, a first clamp 14, and a second clamp 15. The first driving assembly 12 and the pressing assembly 13 are both located on the support bracket 11. The pressing assembly 13 is positioned between the first clamp 14 and the second clamp 15 and is used to elastically press the cover 42. The driving end of the first driving assembly 12 is connected to the first clamp 14 and the second clamp 15, and is used to drive the first clamp 14 and the second clamp 15 to move closer to or further away from each other in the X direction. When they move closer, the cover 42 is clamped; when they move further away, they are released. The tube cap 42 is used to grasp or release the tube cap 42 of the reaction consumable 4. The driving end of the vertical moving mechanism 2 is connected to the support bracket 11 and is used to drive the support bracket 11 to move along the Z direction. The support bracket 11 can drive the first clamp 14 and the second clamp 15 to move closer to or away from the tube body 41. After the first clamp 14 and the second clamp 15 clamp the tube cap 42, the vertical moving mechanism 2 drives the support bracket 11 to rise so that the tube cap 42 can be separated from the tube body 41. The vertical moving mechanism 2 drives the support bracket 11 to fall so that the tube cap 42 can contact the tube body 41.
[0032] The support bracket 11 can drive the crimping assembly 13 to press against the tube cap 42 and bring it close to the tube body. Specifically, during the process of the vertical moving mechanism 2 driving the support bracket 11 to approach the reaction consumable 4, the support bracket 11 can drive the crimping assembly 13 to press down and contact the tube cap 42. Through the downward pressure of the crimping assembly 13 on the tube cap 42, combined with the clamping of the first clamp 14 and the second clamp 15, the horizontal position of the tube cap 42 during opening or closing on the tube body 41 is ensured, preventing the tube cap 42 from tilting or swaying when placed on the tube body 41, thus avoiding any impact. When the cap 42 is closed normally on the tube body 41, the crimping assembly 13 elastically abuts against the cap 42 when the cap is opened, preventing the cap 42 from popping out and splashing liquid. Before and after the cap 42 is separated from the tube body 41, it is always in a controlled state of up, down, left and right, and will not stick or drip liquid. Furthermore, the crimping assembly 13 ensures that the cap 42 will not pop out or shift when the cap is opened, causing liquid splashing. When the cap is closed, the crimping assembly 13 presses down vertically, and the cap 42 is tightly closed to the tube body 41, improving the reliability of the connection between the cap 42 and the tube body 41, providing strong sealing and preventing laboratory contamination.
[0033] This cap-opening and closing device automates the opening and closing of the reaction consumable 4, achieving high efficiency. Furthermore, through the coordinated use of the first clamp 14, the second clamp 15, and the crimping assembly 13, it reduces the probability of errors, improves the accuracy and reliability of the cap 42 being placed on the tube body 41, and also reduces labor costs and the risk of contamination. Optionally, the reaction consumable 4 is an extraction tube. Of course, the reaction consumable 4 can also be other types of consumables; this embodiment does not impose specific limitations.
[0034] Specifically, the first drive assembly 12 includes a first drive motor, a first transmission belt, and a first bidirectional lead screw. Both the first drive motor and the first bidirectional lead screw are mounted on the support bracket 11. The drive end of the first drive motor is connected to the first bidirectional lead screw via the first transmission belt. The first clamp 14 and the second clamp 15 are respectively connected to the two drive ends of the first bidirectional lead screw. Thus, the drive of the first drive motor enables control over the movement of the first clamp 14 and the second clamp 15 towards or away from each other. Optionally, both the first clamp 14 and the second clamp 15 are movably mounted on the support bracket 11 along the X-direction to improve their stability during movement. The vertical moving mechanism 2 includes a support plate, a vertical drive motor, a transmission belt, and a linear lead screw. Both the vertical drive motor and the linear lead screw are mounted on the support plate. The drive end of the vertical drive motor is connected to the linear lead screw via the transmission belt. The support bracket 11 is connected to the drive end of the linear lead screw. Thus, the drive of the vertical drive motor enables adjustment control of the height of the clamping mechanism 1.
[0035] like Figures 1-3As shown, the support bracket 11 includes a first carrier plate 111, a second carrier plate 112, and a connecting guide rod 113. The first carrier plate 111 is connected to the drive end of the vertical moving mechanism 2. The two ends of the connecting guide rod 113 are respectively connected to the first carrier plate 111 and the second carrier plate 112. The first driving assembly 12 is disposed on the second carrier plate 112. The second carrier plate 112 is connected to the pressing assembly 13 so that the pressing assembly 13 is fixed in a direction perpendicular to the Z direction and can move along the Z direction. One end of the pressing assembly 13 elastically abuts against the first carrier plate 111. Thus, during the process of pressing the pressing assembly 13 against the tube cap 42, the pressing assembly 13 can move upward and generate elastic buffer with the first carrier plate 111, thereby avoiding the pressing assembly 13 from damaging the reaction consumable 4 and increasing the cost.
[0036] Specifically, the crimping assembly 13 includes a crimping guide rod 131, a first elastic element 132, and a pressure plate 133. The crimping guide rod 131 is movably disposed along the Z-direction on the second carrier plate 112. The first elastic element 132 is disposed between the crimping guide rod 131 and the first carrier plate 111. The pressure plate 133 is disposed at the end of the crimping guide rod 131 away from the first elastic element 132 and is used to crimp the pipe cap 42. Thus, the pressure plate 133 can achieve planar contact with the pipe cap 42, thereby improving the pressure on the pipe cap 42. The horizontal control of 2, and the use of the first elastic member 132, realizes the buffer contact between the pressure plate 133 and the pipe cover 42. The pressure plate 133 is located between the first clamp 14 and the second clamp 15. When the first clamp 14 and the second clamp 15 clamp the pipe cover 42, the pressure plate 133 elastically presses against the pipe cover 42, which can limit the distance between the first clamp 14 and the second clamp 15, thereby avoiding the first clamp 14 and the second clamp 15 from damaging the pipe cover 42. Meanwhile, the pressure plate 133 is provided with a positioning element 1331. When the pressure plate 133 is pressed against the pipe cover 42, the positioning element 1331 can be inserted into the positioning hole of the pipe cover 42. The positioning element 1331 is used to realize the positioning between the pressure plate 133 and the pipe cover 42, which improves the accuracy of the position of the pipe cover 42 on the opening and closing device, facilitates the clamping of the pipe cover 42 by the first clamp 14 and the second clamp 15, and reduces the difficulty of aligning the pipe cover 42 with the pipe body 41 during the subsequent closing process.
[0037] Furthermore, the second carrier 112 is movably connected to the first carrier 111 along the Z-direction via the connecting guide rod 113. The bearing bracket 11 also includes a second elastic element 114, which is sleeved on the connecting guide rod 113, and its two ends abut against the first carrier 111 and the second carrier 112 respectively. This allows the second carrier 112 to move relative to the first carrier 111 along the Z-direction, preventing the first clamp 14 and the second clamp 15 from pressing down during the clamping process of the tube cap 42. The faulty pipe cap 42, that is, the second elastic member 114 enables the first clamp 14 and the second clamp 15 to have elastic buffering with the pipe cap 42 in the Z direction. At the same time, if the first clamp 14 and the second clamp 15 clamp the pipe cap 42 but the crimping assembly 13 does not contact the pipe cap 42 or the pressure of the crimping assembly 13 pressing down on the pipe cap 42 is too small, the second carrier 112 can move relative to the first carrier 111 in the Z direction to achieve contact between the crimping assembly 13 and the pipe cap 42 and press the pipe cap 42 tightly against the pipe body 41.
[0038] Furthermore, the first clamping member 14 has a first limiting groove 141, and the second clamping member 15 has a second limiting groove 151. The first limiting groove 141 and the second limiting groove 151 are arranged opposite to each other, so that the first limiting groove 141 and the second limiting groove 151 can limit the pipe cover 42 from both sides, thereby improving the accuracy of the position of the pipe cover 42 on the opening and closing device. Optionally, there are multiple first limiting grooves 141 and multiple second limiting grooves 151, and the multiple first limiting grooves 141 and multiple second limiting grooves 151 are arranged one-to-one to realize the synchronous limiting and clamping of multiple pipe covers 42.
[0039] Furthermore, the clamping mechanism 1 also includes a position sensor 16, which is mounted on the support bracket 11 and is used to sense the position of the tube cap 42 to ensure that the first clamp 14 and the second clamp 15 accurately clamp the tube cap 42, so as to avoid gaping or misalignment that would affect the subsequent closing of the cap.
[0040] like Figure 4 As shown, the opening and closing device also includes a loading mechanism 3. The loading mechanism 3 includes a loading frame 31, a second driving component 32, a third clamp 33, and a fourth clamp 34. The second driving component 32 is disposed on the loading frame 31, and the tube body 41 can be placed on the loading frame 31. The driving end of the second driving component 32 is connected to the third clamp 33 and the fourth clamp 34, and is used to drive the third clamp 33 and the fourth clamp 34 to move closer to each other or further away from each other in a direction perpendicular to the Z direction. When they move closer to each other, they clamp the tube body 41, and when they move further away from each other, they release the tube body 41, thereby realizing the gripping or release of the tube body 41 of the reaction consumable 4. This process is simple to operate, the installation or removal of the reaction consumable 4 is relatively easy, and it can effectively improve efficiency.
[0041] Specifically, the second drive assembly 32 includes a second drive motor, a second transmission belt, and a second bidirectional lead screw. Both the second drive motor and the second bidirectional lead screw are mounted on the loading frame 31. The drive end of the second drive motor is connected to the second bidirectional lead screw via the second transmission belt. The third clamp 33 and the fourth clamp 34 are respectively connected to the two drive ends of the second bidirectional lead screw. Thus, the third clamp 33 and the fourth clamp 34 are controlled to move closer to or further away from each other by the drive of the second drive motor.
[0042] Furthermore, the cover opening and closing device also includes a horizontal moving mechanism. The driving end of the horizontal moving mechanism is connected to the vertical moving mechanism 2 and is used to drive the vertical moving mechanism 2 to move in a direction perpendicular to the Z direction, thereby adjusting the position of the clamping mechanism 1 in the direction perpendicular to the Z direction, so as to facilitate the alignment of the clamping mechanism 1 with the cover 42.
[0043] The switch cover device in this embodiment includes four working states: before opening reaction consumable 4, when opening reaction consumable 4, when closing reaction consumable 4, and after closing reaction consumable 4.
[0044] Before opening the reaction consumable 4, the reaction consumable 4 is installed by the loading mechanism 3. The clamping mechanism 1 is aligned with the tube cap 42 of the reaction consumable 4 by the horizontal moving mechanism and the vertical moving mechanism 2, and the first clamp 14 and the second clamp 15 are opened by the first driving assembly 12.
[0045] When the reaction consumable 4 is opened, the loading mechanism 3 remains in the state of clamping the tube body 41 of the reaction consumable 4. The first drive assembly 12 brings the first clamp 14 and the second clamp 15 closer together to clamp the tube cap 42 of the reaction consumable 4, and ensures that the crimping assembly 13 is crimped onto the tube cap 42. Then, the vertical moving mechanism 2 drives the support bracket 11 to rise, so that the tube cap 42 is disengaged from the tube body 41, and the tube cap 42 is moved to the intermediate position.
[0046] When the reaction consumable 4 is closed, the loading mechanism 3 remains in the state of clamping the tube body 41 of the reaction consumable 4. The vertical moving mechanism 2 drives the support bracket 11 to descend so that the tube cap 42 contacts the tube body 41, and the pressing assembly 13 presses the tube cap 42 onto the tube body 41.
[0047] After the reaction consumable 4 is closed, the loading mechanism 3 remains in the state of clamping the tube body 41 of the reaction consumable 4. The vertical moving mechanism 2 moves upward, so that the second elastic member 114 between the second carrier 112 and the first carrier 111 is in a lightly pressed state. Then, the first driving assembly 12 moves the first clamp 14 and the second clamp 15 away from each other to release the tube cap 42. The first driving assembly 12 drives the first clamp 14 and the second clamp 15 back to the origin. The vertical moving mechanism 2 rises back to the origin, and the loading mechanism 3 releases the reaction consumable 4.
[0048] This embodiment also provides a nucleic acid analysis device, including the opening and closing cap device as described above. By using the opening and closing cap device as described above, the nucleic acid analysis device can automate the opening and closing of the reaction consumable 4. This not only improves efficiency, but also reduces the probability of errors through the coordinated use of the first clamp 14, the second clamp 15 and the crimping assembly 13. This improves the accuracy and reliability of the cap 42 being placed on the tube body 41, while also reducing labor costs and the risk of contamination.
[0049] Obviously, the above embodiments of this utility model are merely examples for clearly illustrating the present utility model, and are not intended to limit the implementation of the present utility model. Those skilled in the art can make other variations or modifications based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this utility model should be included within the protection scope of the claims of this utility model.
Claims
1. A cover opening and closing device for opening or closing a reaction consumable (4), the reaction consumable (4) comprising a tube body (41) and a cover (42) detachably connected to the tube body (41), characterized in that, The cover opening / closing device includes: The clamping mechanism (1) includes a support bracket (11), a first drive assembly (12), a pressing assembly (13), a first clamp (14), and a second clamp (15). The first drive assembly (12) and the pressing assembly (13) are both disposed on the support bracket (11). The pressing assembly (13) is located between the first clamp (14) and the second clamp (15) and is used to elastically press the tube cap (42). The driving end of the first drive assembly (12) is connected to the first clamp (14) and the second clamp (15) and is used to drive the first clamp (14) and the second clamp (15) to move closer to each other or further away from each other in the X direction. When they move closer to each other, the tube cap (42) is clamped. When they move further away from each other, the tube cap (42) is released. A vertical moving mechanism (2) is connected to the bearing bracket (11) at its driving end, and is used to drive the bearing bracket (11) to move along the Z direction. The bearing bracket (11) can drive the first clamp (14) and the second clamp (15) to move closer to or away from the tube body (41). The bearing bracket (11) can drive the pressing assembly (13) to press against the tube cap (42) and move closer to the tube body (41).
2. The opening and closing cover device according to claim 1, characterized in that, The support bracket (11) includes a first carrier plate (111), a second carrier plate (112), and a connecting guide rod (113). The first carrier plate (111) is connected to the driving end of the vertical moving mechanism (2). The two ends of the connecting guide rod (113) are respectively connected to the first carrier plate (111) and the second carrier plate (112). The first driving assembly (12) is disposed on the second carrier plate (112). The second carrier plate (112) is connected to the pressing assembly (13) so that the pressing assembly (13) is fixed in a direction perpendicular to the Z direction and movable along the Z direction. One end of the pressing assembly (13) elastically abuts against the first carrier plate (111).
3. The opening and closing cover device according to claim 2, characterized in that, The crimping assembly (13) includes a crimping guide rod (131), a first elastic element (132), and a pressure plate (133). The crimping guide rod (131) is movably disposed on the second carrier plate (112) along the Z direction. The first elastic element (132) is disposed between the crimping guide rod (131) and the first carrier plate (111). The pressure plate (133) is disposed at the end of the crimping guide rod (131) away from the first elastic element (132) and is used to crimp the tube cap (42). The pressure plate (133) is located between the first clamp (14) and the second clamp (15). When the first clamp (14) and the second clamp (15) clamp the tube cap (42), the pressure plate (133) elastically crimps the tube cap (42).
4. The opening and closing cover device according to claim 3, characterized in that, The pressure plate (133) is provided with a positioning element (1331). When the pressure plate (133) is pressed against the pipe cover (42), the positioning element (1331) can be inserted into the positioning hole of the pipe cover (42).
5. The opening and closing cover device according to claim 2, characterized in that, The second carrier plate (112) is movably connected to the first carrier plate (111) along the Z direction via the connecting guide rod (113). The bearing bracket (11) also includes a second elastic element (114), which is sleeved on the connecting guide rod (113), and the two ends of the second elastic element (114) abut against the first carrier plate (111) and the second carrier plate (112) respectively.
6. The opening and closing cover device according to claim 1, characterized in that, The first clamp (14) has a first limiting groove (141), and the second clamp (15) has a second limiting groove (151). The first limiting groove (141) and the second limiting groove (151) are arranged opposite to each other.
7. The opening and closing cover device according to claim 1, characterized in that, The clamping mechanism (1) further includes a position sensor (16), which is mounted on the support bracket (11) and is used to sense the position of the tube cap (42).
8. The opening and closing cover device according to claim 1, characterized in that, The opening and closing device further includes a loading mechanism (3), which includes a loading frame (31), a second drive assembly (32), a third clamp (33), and a fourth clamp (34). The second drive assembly (32) is disposed on the loading frame (31), and the tube body (41) can be placed on the loading frame (31). The drive end of the second drive assembly (32) is connected to the third clamp (33) and the fourth clamp (34) to drive the third clamp (33) and the fourth clamp (34) to move closer to each other or further away from each other in a direction perpendicular to the Z direction. When they move closer to each other, they clamp the tube body (41), and when they move further away from each other, they release the tube body (41).
9. The opening and closing cover device according to any one of claims 1 to 8, characterized in that, The cover opening and closing device further includes a horizontal moving mechanism, the driving end of which is connected to the vertical moving mechanism (2) and is used to drive the vertical moving mechanism (2) to move in a direction perpendicular to the Z direction.
10. A nucleic acid analysis device, characterized in that, Includes the cover opening and closing device as described in any one of claims 1 to 9.