Pipeline system convenient to disassemble, irradiation sterilization

Abstract

The utility model discloses a kind of pipeline system of convenient dismounting, irradiation sterilization, comprising: inflow pipe, hollow fiber column, first pump head, return pipe and second pump head;Inflow pipe and return pipe are silica gel hose;Hollow fiber column has inlet, outlet, first dip outlet and second dip outlet;First pump head is connected with the one end of inflow pipe by pagoda joint;The inlet of hollow fiber column is connected with the other end of inflow pipe by TC hoop, and the outlet of hollow fiber column is connected with the one end of return pipe by TC hoop;Second pump head is connected with the other end of return pipe by pagoda joint.The utility model can realize single-point connection time-consuming less, irradiation sterilization uniformity is good and pipeline system is not polluted after sterilization is completed, effectively avoid once because pipeline sterilization is not thorough to lead to culture pollution to cause human, material, time cost loss.

Description

Technical Field

[0001] This utility model relates to the fields of biopharmaceutical and cell culture technology, and in particular to a pipeline system that is easy to disassemble and sterilize by irradiation. Background Technology

[0002] In laboratory perfusion culture systems, the tubing system is the critical interface between cells / cultures and the external environment, and a key component of the sterility barrier. Effective irradiation sterilization of the tubing system during the initial preparation stage can minimize the risk of culture failure, invalid data, and loss of valuable cells or samples due to tubing contamination, ensuring the smooth progress of the experiment and the reliability of the results.

[0003] In existing technologies, traditional pipelines use metal joints (such as stainless steel Luer joints), which generate a shielding effect during irradiation, resulting in sterilization dead zones; the connection uses multi-layer sealing rings, which are cumbersome to assemble, time-consuming to disassemble and assemble, and repeated disassembly and assembly can easily lead to seal failure. Summary of the Invention

[0004] According to an embodiment of the present invention, a pipeline system that is easy to disassemble and assemble and can be sterilized by irradiation is provided, comprising: an inlet pipe, a hollow fiber column, a first pump head, a return pipe, and a second pump head;

[0005] Both the inlet and return tubes are made of silicone tubing;

[0006] The hollow fiber column has an inlet, an outlet, a first immersion outlet, and a second immersion outlet;

[0007] The first pump head is connected to one end of the inlet pipe via a pagoda connector;

[0008] The inlet of the hollow fiber column is connected to the other end of the inlet pipe via a TC clamp, and the outlet of the hollow fiber column is connected to one end of the return pipe via a TC clamp.

[0009] The second pump head is connected to the other end of the return pipe via a pagoda connector.

[0010] Furthermore, a first pressure gauge is installed on the inlet pipe, and the first pressure gauge is installed on the inlet pipe through a pagoda connector.

[0011] Furthermore, a second pressure gauge is installed on the reflux pipe, and the second pressure gauge is installed on the reflux pipe via a pagoda connector.

[0012] Furthermore, it also includes: an outlet tube and a flow meter;

[0013] The removal tube is a silicone flexible tube, which is connected to the first immersion outlet of the hollow fiber column.

[0014] The flow meter is installed on the outlet pipe, and its two ends are connected to the outlet pipe by TC clamps.

[0015] Furthermore, a third pressure gauge is installed on the removal tube via a pagoda connector.

[0016] Furthermore, it also includes: an exhaust pipe, an air pipe, and an air filter;

[0017] The drain pipe is connected to the second immersion outlet;

[0018] The trachea is connected to the removal tube;

[0019] The air filter is installed on the air duct;

[0020] Both the vent tube and the air tube are made of silicone tubing.

[0021] Furthermore, the air filter is connected to the air pipe via a pagoda connector.

[0022] The pipeline system according to the present invention, which is easy to disassemble and assemble and can be sterilized by irradiation, can achieve single-point connection with less time consumption, excellent uniformity of irradiation sterilization, and no pollution of the pipeline system after sterilization. It effectively avoids the loss of manpower, materials and time costs caused by culture contamination due to incomplete pipeline sterilization.

[0023] It should be understood that both the foregoing general description and the following detailed description are exemplary and intended to provide further illustration of the claimed technology. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of a pipeline system that is easy to disassemble and irradiate for sterilization according to an embodiment of the present invention;

[0025] Figure 2 This is a schematic diagram of the first pump head of a pipeline system for easy disassembly and irradiation sterilization according to an embodiment of the present invention;

[0026] Figure 3 This is a schematic diagram of the first pressure gauge of a pipeline system that is easy to disassemble and irradiate for sterilization according to an embodiment of the present invention.

[0027] Figure reference numerals: 1. Inlet pipe; 2. Hollow fiber column; 3. First pump head; 4. Return pipe; 5. Second pump head; 6. First pressure gauge; 7. Second pressure gauge; 8. Pagoda connector; 9. TC clamp; 10. Outlet pipe; 11. Flow meter; 12. Third pressure gauge; 13. Exhaust pipe; 14. Air pipe; 15. Air filter. Detailed Implementation

[0028] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings, further illustrating the present invention.

[0029] First, combine Figures 1-3The present invention describes a pipeline system that is easy to disassemble and sterilize by irradiation according to an embodiment of the present invention. It provides a pipeline system that is tool-free to disassemble and assemble, has zero metal components, and is optimized for irradiation compatibility, and has a wide range of applications.

[0030] like Figures 1-3 As shown, the pipeline system of this utility model, which is easy to disassemble and irradiate for sterilization, includes: an inlet pipe 1, a hollow fiber column 2, a first pump head 3, a return pipe 4, and a second pump head 5.

[0031] Specifically, such as Figures 1-3 As shown, in this embodiment, both the inlet pipe 1 and the return pipe 4 are silicone flexible tubes. The silicone flexible tubes support irradiation sterilization, avoiding the shielding effect caused by the use of metal, which would lead to sterilization dead zones. The hollow fiber column 2 has an inlet, an outlet, a first immersion outlet, and a second immersion outlet. The first pump head 3 is connected to one end of the inlet pipe 1 through a pagoda connector 8. The inlet of the hollow fiber column 2 is connected to the other end of the inlet pipe 1 through a TC clamp 9, and the outlet of the hollow fiber column 2 is connected to one end of the return pipe 4 through a TC clamp 9. The TC clamp 9 can realize the quick connection and disassembly of the hollow fiber column 2 with the inlet pipe 1 and the return pipe 4. At the same time, the TC clamp 9 is made of PP material and supports irradiation sterilization. The second pump head 5 is connected to the other end of the return pipe 4 through a pagoda connector 8. Both the first pump head 3 and the second pump head 5 are centrifugal pump heads, which can be quickly connected to the flexible silicone tube through the pagoda connector 8.

[0032] Furthermore, such as Figures 1-3 As shown, in this embodiment, a first pressure gauge 6 is installed on the inlet pipe 1, and the first pressure gauge 6 is installed on the inlet pipe 1 through a pagoda connector 8; a second pressure gauge 7 is installed on the return pipe 4, and the second pressure gauge 7 is installed on the return pipe 4 through a pagoda connector 8. The pagoda connector 8 can be quickly connected to a flexible silicone tube. The first pressure gauge 6 and the second pressure gauge 7 measure the pressure values ​​at both ends of the hollow fiber column 2, respectively.

[0033] Furthermore, such as Figures 1-3 As shown, in this embodiment, it also includes: a removal tube 10 and a flow meter 11; the removal tube 10 is a silicone flexible tube, which supports irradiation sterilization and avoids the shielding effect caused by the use of metal, resulting in sterilization dead zones; the removal tube 10 is connected to the first immersion outlet of the hollow fiber column 2, and the removal tube 10 is used to output the filtered material in the hollow fiber column 2; the flow meter 11 is installed on the removal tube 10, and the two ends of the flow meter 11 are connected to the removal tube 10 through TC clamps 9. The flow meter 11 is used to control the output flow rate, and the TC clamps 9 can realize the quick connection and disassembly of the flow meter 11 and the removal tube 10. At the same time, the TC clamps 9 are made of PP material and support irradiation sterilization.

[0034] Furthermore, such as Figures 1-3As shown, in this embodiment, a third pressure gauge 12 is provided on the removal tube 10. The third pressure gauge 12 is installed on the removal tube 10 through a pagoda connector 8. The pagoda connector 8 can be quickly connected to a flexible silicone tube. The third pressure gauge 12 detects the pressure value of the removal tube 10.

[0035] Furthermore, such as Figures 1-3 As shown, in this embodiment, it also includes: an exhaust pipe 13, an air pipe 14, and an air filter 15; the exhaust pipe 13 is connected to the second immersion outlet; the air pipe 14 is connected to the removal pipe 10.

[0036] Air filter 15 is installed on air tube 14; both exhaust tube 13 and air tube 14 are made of silicone tubing. The silicone tubing supports irradiation sterilization and avoids the shielding effect caused by the use of metal, which would lead to sterilization dead zones. Air filter 15 is connected to air tube 14 through pagoda connector 8. Pagoda connector 8 can be quickly connected to flexible silicone tubing. Air filter 15 filters air impurities in air tube 14 and introduces gas through air tube 14 to expel substances remaining in hollow fiber column 2, which are then discharged through exhaust tube 13.

[0037] Working principle: After unpacking each component in a clean environment, according to... Figure 1 Assemble the piping system according to the schematic diagram shown; conduct a tightness test on the system using the positive pressure method to ensure that there are no leaks in the piping system; flow pure water into the piping system to ensure stable flow and normal function; after the functional test, perform deep cleaning and drying; lay the entire piping system flat on the PP grid in the incubator for irradiation sterilization, and the sterilization dosage and irradiation value can be performed in accordance with the ISO11137 standard; after sterilization, it can be used as a whole system in the perfusion culture process.

[0038] Above, refer to Figures 1-3 The present invention describes a pipeline system that is easy to disassemble and assemble and is sterilized by irradiation according to an embodiment of the present invention. It can achieve single-point connection with less time consumption, good uniformity of irradiation sterilization, and no pollution of the pipeline system after sterilization. It effectively avoids the loss of manpower, materials and time costs caused by culture contamination due to incomplete pipeline sterilization.

[0039] It should be noted that, in this specification, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising..." does not exclude the presence of additional identical elements in the process, method, article, or apparatus that includes that element.

[0040] Although the present invention has been described in detail through the above preferred embodiments, it should be understood that the above description should not be considered as a limitation of the present invention. Various modifications and substitutions to the present invention will be apparent to those skilled in the art after reading the above content. Therefore, the scope of protection of the present invention should be defined by the appended claims.

Claims

1. A piping system that is easy to disassemble and assemble, and can be sterilized by irradiation, characterized in that, Includes: inlet tube, hollow fiber column, first pump head, return tube and second pump head; Both the inlet tube and the return tube are silicone flexible tubes; The hollow fiber column has an inlet, an outlet, a first immersion outlet, and a second immersion outlet; The first pump head is connected to one end of the inlet pipe via a pagoda connector; The inlet of the hollow fiber column is connected to the other end of the inlet pipe via a TC clamp, and the outlet of the hollow fiber column is connected to one end of the return pipe via a TC clamp. The second pump head is connected to the other end of the return pipe via a pagoda connector.

2. The piping system as described in claim 1, which is easy to disassemble and sterilize via irradiation, is characterized in that... A first pressure gauge is installed on the inlet pipe, and the first pressure gauge is installed on the inlet pipe through a pagoda connector.

3. The piping system as described in claim 1, characterized in that, A second pressure gauge is installed on the reflux pipe, and the second pressure gauge is installed on the reflux pipe through a pagoda connector.

4. The piping system as described in claim 1, characterized in that, It also includes: the outlet tube and the flow meter; The removal tube is a silicone flexible tube, and the removal tube is connected to the first immersion outlet of the hollow fiber column; The flow meter is mounted on the outlet pipe, and both ends of the flow meter are connected to the outlet pipe via TC clamps.

5. The piping system as described in claim 4, characterized in that, A third pressure gauge is provided on the removal tube, and the third pressure gauge is installed on the removal tube through a pagoda connector.

6. The piping system as described in claim 4, which is easy to disassemble and sterilize by irradiation, is characterized in that... It also includes: an exhaust pipe, an air tube, and an air filter; The drain pipe is connected to the second immersion outlet; The trachea is connected to the removal tube; The air filter is installed on the air pipe; Both the vent pipe and the air pipe are silicone flexible tubes.

7. The piping system as described in claim 6, which is easy to disassemble and sterilize via irradiation, is characterized in that... The air filter is connected to the air pipe via a pagoda connector.

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