A device for collecting blood-derived mesenchymal stem cells

Abstract

The utility model relates to a mesenchymal stem cell medical instrument technical field, especially through blood source mesenchymal stem cell collection device aspect. The device of collecting blood source mesenchymal stem cell has the function such as preventing vaginal flora pollution and is composed of the following structures: fixed ring (1), fixed ring attachment point (2), closed part (3), collection part (4), drainage part (6), the outer protective film (5) surrounding collection part and drainage part, the pulling handle (7) outside outer protective film and closed device (8) composition. In the process of collecting blood source mesenchymal stem cell, the pollution caused to the collection sample is avoided.

Description

Technical Field

[0001] This utility model patent relates to the field of mesenchymal stem cell medical device technology, and particularly to a blood-derived mesenchymal stem cell collection device. Background Technology

[0002] Menstrual blood has traditionally been treated as physiological waste. Menstrual blood-derived mesenchymal stem cells (MenSCs), a novel type of stem cell with mesenchymal stem cell (MenSC) characteristics, are found in menstrual blood and are derived from the endometrial stroma of the uterus, expelled along with menstrual blood. MenSCs can proliferate rapidly, have low immunogenicity, and do not cause rejection during allogeneic transplantation. Menstrual blood-derived mesenchymal stem cells can be passaged. Studies have found that menstrual blood stem cells have significant efficacy in treating intrauterine adhesions, premature ovarian failure, and anti-aging, demonstrating considerable clinical value. Obtaining stem cells from human menstrual blood, unlike other invasive methods, allows for the non-invasive acquisition of autologous stem cells, providing a pathway for autologous stem cell therapy. Furthermore, direct treatment with stem cell components completely avoids the ethical controversies surrounding allogeneic or autologous transplantation and the risks of live cell therapy, showing broad application prospects.

[0003] Currently, there is no dedicated collection device for menstrual blood-derived mesenchymal stem cells; menstrual cups are typically used. A menstrual cup is placed in the vagina to collect menstrual blood, replacing traditional sanitary napkins and tampons. When a menstrual cup is removed from the vagina during collection, the bacteria in the vaginal folds can easily enter the collected sample, significantly impacting subsequent passage culture of the menstrual blood-derived mesenchymal stem cells. Summary of the Invention

[0004] The technical problem to be solved by this utility model is to provide a special device for collecting menstrual blood-derived mesenchymal stem cells, which solves the problem of existing menstrual blood sample collection devices bringing the flora in the vaginal folds into the menstrual blood sample and causing contamination.

[0005] To achieve this objective, the present invention adopts the following technical solution: A device for collecting mesenchymal stem cells from blood, which has functions such as preventing vaginal flora contamination, is composed of the following structure: a fixing ring, a fixing ring attachment point, a sealing part, a collection part, a drainage part, an outer protective membrane surrounding the collection part and the drainage part, a traction handle outside the outer protective membrane, and a sealing device.

[0006] The preferred method involves a lower fixing ring connected to the upper opening of the collection section via two attachment points. When the fixing ring is in the collection state, it can be fastened to the cervix for menstrual blood collection. After collection, it is pulled out, forming two semi-circular external pull rings. Inside the collection section, a sealing section composed of six triangular elastic pieces is installed. The inner fixing ring is located within the collection of menstrual blood-derived mesenchymal stem cells. This sealing section is attached to the inner side of the collection section and is openable. The lower part of the cup body connects to the drainage section, which is interconnected with the collection section. The lower outlet of the drainage section contains a switch, forming a second opening, surrounded by an outer protective membrane. A pull handle is installed outside the outer protective membrane. The entire collection device is placed in the vagina to collect menstrual blood. After collection, the cup body is pulled out of the vagina using ovum forceps and the pull handle. During the pull-out process, the fixing ring contracts, and the sealing section is closed, automatically forming a protective cover. After the cup body is pulled out of the vagina, the fixing ring is pried open, forming a "pull ring". Pull the ring to hold the collection device upright, then peel off the protective film. Pinch the switch to collect the menstrual blood, which will then flow through the drainage section into the culture dish.

[0007] With this structure, the sealing part greatly reduces vaginal microbial infection; the fixing ring and protective membrane prevent the bacteria in the vaginal folds from contaminating the outer wall of the collection device, thus improving the passage quality of blood-derived mesenchymal stem cells. Attached Figure Description

[0008] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0009] Figure 1 This is a top view of the closed portion of the first embodiment of the blood-derived mesenchymal stem cell collection device of this utility model.

[0010] Figure 2 This is a side view of the first embodiment of the blood-derived mesenchymal stem cell collection device of this utility model.

[0011] Figure 3 This is a cross-sectional view of the closed section of the first embodiment of the blood-derived mesenchymal stem cell collection device of this utility model.

[0012] Figure 4 This is a top view of the first embodiment of the blood-derived mesenchymal stem cell collection device of this utility model in the open state of the closed part.

[0013] Figure 5 This is a bottom view of the first embodiment of the blood-derived mesenchymal stem cell collection device of this utility model.

[0014] Figure 6 This is a cross-sectional view of the second embodiment of the blood-derived mesenchymal stem cell collection device of this utility model. Detailed Implementation

[0015] The following is a detailed description with reference to the accompanying drawings. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and not intended to limit it. Furthermore, it should be noted that, for ease of description, the accompanying drawings show only the parts relevant to the invention and not all structures. In the description of the invention, unless otherwise expressly specified and limited, the terms "connected," "linked," and "fixed" should be interpreted broadly.

[0016] Example 1... (The preceding text remains unchanged) For example... Figures 1-6 As shown, this embodiment provides a blood-derived mesenchymal stem cell collection device for collecting menstrual blood from women for mesenchymal stem cell passage culture. The device includes: a fixing ring (1), a sealing part (3) composed of six triangular elastic sheets, a collection part (4), a drainage part (6), an outer protective membrane (5), a pull handle (7), and a pinch switch (8). The fixing ring (1) is connected to the upper opening of the collection part (4) through two attachment points (2). When the fixing ring is in the collection state, it can be fastened to the cervix to collect menstrual blood; when the collection is finished and pulled up, it forms two semi-circular outer pull rings. During collection, the collection device is inserted into the vagina to collect menstrual blood, with the retaining ring securing the cervix. The closure is in an open state when the elastic ring is opened, adhering to the inside of the collection cup. An outer protective film covers the pinch switch; a pull handle is located outside the outer protective film. After collecting menstrual blood, the pull handle is clamped with ovum forceps, the retaining ring is removed from the cervix, and the elastic triangular piece of the closure covers the opening of the collection cup. The device is then pulled out and handed to laboratory personnel. Laboratory personnel remove the outer protective film in a sterile environment, wear sterile gloves, and press the pinch switch to collect menstrual blood, avoiding contamination of the collected sample.

[0017] Example 2 Figure 6 As shown, this embodiment provides a menstrual blood-derived mesenchymal stem cell collection device for collecting menstrual blood from women for mesenchymal stem cell passage culture. The device includes: a fixing ring (1), a sealing part (3) composed of six triangular elastic plates, a collection part (4), a drainage part (6), an outer protective membrane (5), a traction handle (7), and a rubber stopper (8). During collection, the collection device is placed in the vagina to collect menstrual blood, with the fixing ring fastened to the cervix; the sealing part is in an open state when the elastic ring is opened, adhering to the inside of the collection cup; the outer protective membrane covers the rubber stopper; a traction handle is located outside the outer protective membrane; after collecting menstrual blood, the traction handle is clamped with ovum forceps, the fixing ring is removed from the cervix, and the elastic triangular plates of the sealing part cover the opening of the collection cup; after pulling out the device, it is handed over to laboratory personnel. Laboratory personnel tear off the outer protective membrane in a sterile environment, wear sterile gloves, and remove the rubber stopper of the drainage part to collect menstrual blood mesenchymal stem cells, avoiding contamination of the collected sample.

Claims

1. A device for collecting hematogenous mesenchymal stem cells, characterized in that, include: The components include a fixing ring (1), a sealing part (3), a collection part (4), a drainage part (6), an outer protective membrane (5), and a pulling handle (7). The fixing ring (1) is connected to the upper opening of the collection part (4). The sealing part (3) is connected to the inner side of the collection part (4). One end of the drainage part (6) is connected to the lower part of the collection part (4), and the other end is equipped with a sealing device (8). The outer protective membrane (5) surrounds the outer surface of the collection part (4) and the drainage part (6). The pulling handle (7) is installed outside the outer protective membrane (5).

2. The hematogenous mesenchymal stem cell collection device according to claim 1, characterized in that: The fixing ring (1) is connected to the upper opening of the collection part (4) through two symmetrical attachment points (2). When the fixing ring (1) is in the collection state, the fixing ring (1) unfolds into a circular structure through the attachment points (2); when the fixing ring is in the removal state, the fixing ring (1) folds into a semi-circular pull ring through the attachment points (2).

3. The hematogenous mesenchymal stem cell collection device according to claim 2, characterized in that: The closure part (3) is composed of six triangular elastic pieces and is connected to the inside of the collection part (4). When the closure part (3) is in the collection state, the closure part (3) is attached to the inside of the collection part (4); when the closure part is in the removal state, the closure part (3) shrinks into a closed plane.

4. The hematogenous mesenchymal stem cell collection device according to claim 3, characterized in that: The sealing device (8) is a pinch switch.

5. The hematogenous mesenchymal stem cell collection device according to claim 3, characterized in that: The sealing device (8) is a rubber stopper.

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