Integrated drug processing device

Abstract

The application relates to the technical field of pharmaceutical equipment, in particular to an integrated drug processing device, which comprises a crystallization tank, the crystallization tank is provided with an adding opening, a releasing opening and a reflux opening, a first circulating pipe is connected with the releasing opening, a second circulating pipe is connected with the reflux opening, a filter is connected with the first circulating pipe and the second circulating pipe, and a product collecting system is connected with the first circulating pipe. The integrated drug processing device combines a material circulating conveying system with a crystallization tank, a filter and other devices to form a multifunctional process system, can realize integrated design of multiple functions such as crystallization, concentration, filtration, washing and drying in a highly integrated and closed system, and avoids material transfer exposure risk.

Description

Technical Field

[0001] This application relates to the field of pharmaceutical equipment technology, and in particular to an integrated drug processing device. Background Technology

[0002] Currently, in the field of drug harvesting and post-processing, the process chain from drug separation and purification to harvest is very long, potentially involving multiple systems used in series, and the materials need to undergo multiple transfers and exposure operations. This process may include multiple stages such as crystallization, filtration, centrifugation, washing, and drying. In traditional processes, crystallization and separation often require separate equipment, and subsequent processes may also require multiple machines. Some products can be processed centrally using a three-in-one filtration, washing, and drying system, but this system suffers from a lack of process flexibility, incomplete discharge, filter cake clogging, limited processing capabilities, and high costs. Other filtration or centrifugation processes require separate operation and material transfer under exposure conditions; moreover, the machines are complex and difficult to clean and sterilize. Utility Model Content

[0003] The purpose of this application is to provide an integrated drug processing device to solve, to some extent, the technical problem that the drug harvesting and post-processing process in the prior art requires multiple transfers and exposure operations of materials.

[0004] This application provides an integrated drug processing device, including: a crystallization tank, wherein the crystallization tank is provided with an addition port, a release port and a reflux port;

[0005] A first circulation tube is connected to the release port;

[0006] The second circulation pipe is connected to the return port;

[0007] A filter, which is connected to both the first circulation pipe and the second circulation pipe;

[0008] A product collection system is connected to the first circulation pipe.

[0009] In the above technical solution, the integrated drug processing device further includes a stirrer, which is disposed inside the crystallization tank.

[0010] In any of the above technical solutions, the addition port further includes a first solvent inlet, a material inlet, and a first gas inlet arranged at intervals.

[0011] In any of the above technical solutions, the integrated drug processing device further includes a delivery pump, which is disposed in the first circulation pipe.

[0012] In any of the above technical solutions, the first circulation pipe is further provided with a second gas inlet and a second solvent inlet.

[0013] In any of the above technical solutions, the filter further includes a first connection port, a second connection port, a first solvent recovery interface and a backwash interface arranged at intervals, the first connection port being connected to the first circulation pipe and the second connection port being connected to the second circulation pipe.

[0014] In any of the above technical solutions, the product collection system further includes:

[0015] A collection tube, one end of which is connected to the first circulation tube;

[0016] The product collector is at least one, and each product collector is provided with a product inlet and a product outlet. The other end of the collection pipe is connected to the product inlet of each product collector.

[0017] A recovery tube is provided, which is connected to the product outlet of each of the product collectors, and the recovery tube is provided with a second solvent recovery interface.

[0018] In any of the above technical solutions, the recovery tube is further provided with an venting port and a vacuuming port.

[0019] In any of the above technical solutions, at least one of the first gas inlet and the second gas inlet is used to convey drying gas.

[0020] In any of the above technical solutions, the integrated drug processing device further includes a sprayer, which is connected to the first solvent inlet inside the crystallization tank.

[0021] Compared with the prior art, the beneficial effects of this application are as follows:

[0022] The integrated drug processing device provided in this application includes: a crystallization tank, which is provided with an addition port, a release port and a reflux port; a first circulation pipe, which is connected to the release port; a second circulation pipe, which is connected to the reflux port; a filter, which is connected to both the first and second circulation pipes; and a product collection system, which is connected to the first circulation pipe.

[0023] The integrated drug processing device provided in this application combines a material circulation and conveying system with crystallizers, filters and other devices to form a multifunctional process system. It can realize multiple functions such as crystallization, concentration, filtration, washing and drying in a highly integrated and closed system, avoiding the risk of material transfer and exposure. Attached Figure Description

[0024] To more clearly illustrate the technical solutions in the specific embodiments of this application or the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0025] Figure 1 This is a schematic diagram of the integrated drug processing device provided in the embodiments of this application.

[0026] Figure label:

[0027] 1-Crystallization tank, 101-First solvent inlet, 102-Material inlet, 103-First gas inlet, 104-Release port, 105-Reflux port, 2-Agitator, 3-Sprayer, 4-First circulation pipe, 401-Second gas inlet, 402-Second solvent inlet, 5-Transfer pump, 6-Filter, 601-First connection port, 602-Second connection port, 603-First solvent recovery interface, 604-Backwash interface, 7-Second circulation pipe, 8-Pressure sensor, 9-Collection pipe, 10-Product collector, 11-Recovery pipe, 12-Drain interface, 13-Vacuum interface, 14-Second solvent recovery interface, 15-First valve, 16-Second valve, 17-Third valve, 18-Fourth valve, 19-Fifth valve, 20-Sixth valve, 21-Seventh valve, 22-Eighth valve, 23-Ninth valve, 24-Tenth valve, 25-Eleventh valve. Detailed Implementation

[0028] The technical solutions of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are some embodiments of this application, but not all embodiments.

[0029] The components of the embodiments of this application described and shown in the accompanying drawings can be arranged and designed in a variety of different configurations. Therefore, the following detailed description of the embodiments of this application provided in the drawings is not intended to limit the scope of the claimed application, but merely to illustrate selected embodiments of the application.

[0030] Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0031] In the description of this application, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0032] In the description of this application, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0033] The following reference Figure 1 The integrated drug processing apparatus described in the embodiments of this application is illustrated.

[0034] See Figure 1 As shown, an embodiment of this application provides an integrated drug processing device, which includes: a crystallization tank 1, a first circulation pipe 4, a second circulation pipe 7, a filter 6, and a product collection system. The crystallization tank 1 is provided with an addition port, a release port 104, and a reflux port 105. The addition port is used to add raw materials, solvents, etc., to be processed into the crystallization tank 1. The release port 104 is used to release the material from the crystallization tank 1. One end of the first circulation pipe 4 is connected to the release port 104, and the other end is connected to the filter 6. One end of the second circulation pipe 7 is connected to the filter 6, and the other end is connected to the reflux port 105. The material filtered by the filter 6 can flow back into the crystallization tank 1 through the reflux port 105. The product collection system is connected to the first circulation pipe 4, allowing the processed material to flow through the release port 104 and the first circulation pipe 4 to the product collection system for further processing and collection. Preferably, the crystallization tank 1 is provided with a pressure sensor 8.

[0035] Specifically, the addition port includes a first solvent inlet 101, a material inlet 102, and a first gas inlet 103. The first solvent inlet 101, material inlet 102, and first gas inlet 103 are each independently provided. Preferably, the three are located near the top of the crystallization tank 1. The raw material to be processed is added into the crystallization tank 1 through the material inlet 102. The first solvent inlet 101 is used to add solvent into the crystallization tank 1. The solvent and the material mix in the crystallization tank 1, which can wash the material. The first gas inlet 103 is used to introduce clean air into the crystallization tank 1 to purge the crystallization tank 1 and various pipelines. In addition, the first gas inlet 103 can also be used to introduce heated crystallizing and drying air into the crystallization tank 1 or various pipelines to dry the material, the crystallization tank 1, or the pipelines.

[0036] Preferably, a sprayer 3 is provided in the crystallization tank 1, and the sprayer 3 is connected to the first solvent inlet 101 so that the solvent is added in the form of spraying.

[0037] Furthermore, this integrated drug processing device also includes a stirrer 2, which is installed inside the crystallization tank 1. The materials and solvents added in a certain proportion are fully stirred in the crystallization tank 1 to complete crystallization and achieve the ideal crystal form.

[0038] Furthermore, a release port 104 is provided at the bottom of the crystallization tank 1. One end of the first circulation pipe 4 is connected to the release port 104, and the other end of the first circulation pipe 4 is connected to the filter 6. The material released through the release port 104 can flow to the filter 6 for filtration.

[0039] Preferably, a first valve 15 is provided at one end of the first circulation pipe 4 near the release port 104, and the first valve 15 can control the opening and closing of the release port 104.

[0040] Furthermore, a delivery pump 5 is installed on the first circulation pipe 4 to enable the integrated drug processing device to form a forced circulation flow path.

[0041] Furthermore, filter 6 is preferably a cross-flow filter 6, which includes a first connection port 601, a second connection port 602, and a first solvent recovery port 603. The first connection port 601 is connected to the first circulation pipe 4, one end of the second circulation pipe 7 is connected to the second connection port 602, and the other end of the second circulation pipe 7 is connected to the return port 105. Under the action of the delivery pump 5, the material released through the release port 104 can enter the filter 6 through the first connection port 601. After filtration, the components containing the material flow back to the crystallization tank 1 through the second connection port 602, the second circulation pipe 7, and the return port 105. The solvent generated by the filter 6 during the filtration operation flows out through the first solvent recovery port 603 and is recovered. Filter 6 is also provided with a backwash port 604, which is used to introduce solvent into the filter 6 to backwash the filter 6, reducing the risk of clogging. This continuous cross-flow filtration process reaches the process settings and required state. At this point, the crystals formed by the material crystallization are trapped in the circulation pipe and crystallization tank 1, and the material reaches a state of high solid content, completing one round of concentration and filtration.

[0042] Preferably, a second valve 16 is provided on the first circulation pipe 4 near the first connection port 601, and the second valve 16 is used to control the opening and closing of the first circulation pipe 4 and the filter 6; a third valve 17 is provided on the end of the second circulation pipe 7 near the return port 105, and the third valve 17 is used to control the opening and closing of the second connection port 602 and the return port 105; a pressure sensor 8 is also provided on the second circulation pipe 7. In addition, a fourth valve 18 is provided on the first solvent recovery port 603, and a fifth valve 19 is provided on the backwash port 604.

[0043] Furthermore, a second gas inlet 401 and a second solvent inlet 402 are provided near the first valve 15 in the first circulation pipe 4. The second solvent inlet 402 is used to supply solvent, which can enter the first circulation pipe 4 from the bottom of the crystallizer 1 and flow to the filter 6 and the second circulation pipe 7 to realize the material ejection function. The second gas inlet 401 is used to supply clean air, which is used to purge the material so that the material at each circulation node can be purged into the tank.

[0044] Preferably, the second gas inlet 401 is provided with a sixth valve 20, and the second solvent inlet 402 is provided with a seventh valve 21.

[0045] According to process requirements, solvent is added back into the tube at this point, and stirrer 2 is turned on to wash the material returning to the tank, ensuring complete dispersion. This process is repeated until the concentration, filtration, and washing of the material are complete.

[0046] After the material is fully concentrated, filtered and washed, a slurry is obtained. The ratio of slurry to solvent is adjusted according to the requirements, and an appropriate amount of solvent is added again to make the solvent and slurry mix evenly.

[0047] Furthermore, the product collection system includes a collection pipe 9 and a product collector 10. One end of the collection pipe 9 is connected to the first circulation pipe 4, and the other end of the collection pipe 9 is connected to the product collector 10. The number of product collectors 10 is at least one. In this embodiment, the number of product collectors 10 is two. The end of the collection pipe 9 away from the first circulation pipe 4 is connected to the two product collectors 10 respectively. Preferably, an eighth valve 22 is provided at the end of the collection pipe 9 near the first circulation pipe 4. Another pressure sensor 8 is also provided on the collection pipe 9. When the second valve 16 is closed, the slurry flowing out of the release port 104 flows into the product collector 10 under the action of the transfer pump 5. The product collector 10 includes multiple drying chambers, each of which can be used to dry or collect slurry. After the slurry flows into the product collector 10, gas is introduced into the crystallization tank 1 through the first gas inlet 103 to pressurize it, and solvent is injected into the crystallization tank 1 through the first solvent inlet 101 to purge and clean the crystallization tank 1 with compressed air. Clean gas and solvent are introduced into the first circulation pipe 4 and the collection pipe 9 through the second gas inlet 401 and the second solvent inlet 402, respectively, to flush and clean the first circulation pipe 4 and the collection pipe 9, so that the material is transferred to the product collector 10 to the greatest extent.

[0048] Furthermore, the product collection system also includes a recovery pipe 11. The product collector 10 includes a product inlet and a product outlet. The aforementioned collection pipe 9 is connected to the product inlet, and the recovery pipe 11 is connected to the product outlet. The recovery pipe 11 is provided with an venting port 12 and a vacuum port 13. The venting port 12 is used to release residual materials and, when pressure relief is needed, to release clean air introduced into this integrated drug processing device. Air is continuously supplied to the product collector 10 and pressurized through the first gas inlet 103 and / or the second gas inlet 401, or air is drawn from the product collector 10 to the outside through the vacuum port 13 to control the liquid residue in the crystals within the drying chamber. This removes most of the moisture from the slurry. Preferably, the venting port 12 is provided with a ninth valve 23, and the vacuum port 13 is provided with a tenth valve 24. Further still, the end of the recovery pipe 11 furthest from the product collector 10 is a second solvent recovery port 14. Preferably, the second solvent recovery port 14 is provided with an eleventh valve 25. It should be noted that the product collector 10 is a collector commonly used in pharmaceutical equipment and systems, which is fully understood by those skilled in the art, and its specific structure will not be described in detail.

[0049] According to process requirements, solvent can be added again to crystallizer 1 or first circulation pipe 4, and the solvent will wash the material in product collector 10. The solvent flowing out of the washing flows to second solvent recovery port 14 through recovery pipe 11.

[0050] Repeatedly pressurize or vacuum the product collector 10 to remove moisture from the material.

[0051] Then, heated clean air can be introduced through the first gas inlet 103 and / or the second gas inlet 401 as drying gas to dry the material in the drying chamber of the product collector 10. After the material is dried, it can be unloaded from the drying collector and stored. This completes a series of operations for crystallization, concentration, filtration, washing and drying of the material.

[0052] As can be seen, the integrated drug processing device provided in this application combines the material circulation and conveying system with crystallizer 1, filter 6 and other devices to form a multi-functional process system. It can realize the integrated design of multiple functions such as crystallization, concentration, filtration, washing and drying in a highly integrated and closed system, avoiding the risk of material transfer and exposure.

[0053] Furthermore, this integrated drug processing unit can flexibly change the combination of equipment and design the process flow according to changes in process requirements, thus achieving diverse production processes.

[0054] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. An integrated drug processing device, characterized in that, include: A crystallization tank, wherein the crystallization tank is provided with an addition port, a release port and a reflux port; A first circulation tube is connected to the release port; The second circulation pipe is connected to the return port; A filter, which is connected to both the first circulation pipe and the second circulation pipe; The product collection system is connected to the first circulation pipe.

2. The integrated drug processing device according to claim 1, characterized in that, The integrated drug processing device also includes a stirrer, which is disposed inside the crystallization tank.

3. The integrated drug processing device according to claim 1, characterized in that, The addition port includes a first solvent inlet, a material inlet, and a first gas inlet arranged at intervals.

4. The integrated drug processing device according to claim 1, characterized in that, The integrated drug processing device also includes a delivery pump, which is located in the first circulation pipe.

5. The integrated drug processing device according to claim 3, characterized in that, The first circulation pipe is provided with a second gas inlet and a second solvent inlet.

6. The integrated drug processing device according to claim 1, characterized in that, The filter includes a first connection port, a second connection port, a first solvent recovery port, and a backwash port arranged at intervals. The first connection port is connected to the first circulation pipe, and the second connection port is connected to the second circulation pipe.

7. The integrated drug processing device according to any one of claims 1 to 6, characterized in that, The product collection system includes: A collection tube, one end of which is connected to the first circulation tube; The product collector is at least one in number, and each product collector is provided with a product inlet and a product outlet. The other end of the collection pipe is connected to the product inlet of each product collector. The product collector is provided with a drying chamber. A recovery tube is provided, which is connected to the product outlet of each of the product collectors, and the recovery tube is provided with a second solvent recovery interface.

8. The integrated drug processing device according to claim 7, characterized in that, The recovery tube is equipped with an air vent and a vacuum evacuation port.

9. The integrated drug processing device according to claim 5, characterized in that, At least one of the first gas inlet and the second gas inlet is used to deliver drying gas.

10. The integrated drug processing device according to claim 3, characterized in that, The integrated drug processing device also includes a sprayer, which is connected to the first solvent inlet inside the crystallization tank.

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