Production equipment for non-recombinant class human collagen

Abstract

The utility model discloses belong to collagen production technical field, concretely be a kind of production equipment of non-recombinant human-derived collagen, including first chip main body and third chip main body, it is equipped with a plurality of second chip main body between the first chip main body and the third chip main body, it is equipped with the first flow component for mixing supercritical fluid, polypeptide and enzyme preparation in the first chip main body, it is equipped with the second flow component for mixing supercritical fluid, polypeptide and enzyme preparation in the second chip main body.The utility model greatly increases reaction area and reaction site by the synergic operation of countless microchannels and spray tower component, so that purification process can be completed in short time;Compared with traditional production mode, efficiency has qualitative leap, like from trickling stream change into surging torrent, greatly improve the capacity.

Description

Technical Field

[0001] This utility model relates to the field of collagen production technology, specifically to a production equipment for non-recombinant human collagen. Background Technology

[0002] Traditional recombinant collagen production primarily relies on genetic engineering for recombinant synthesis. This process is akin to navigating a complex molecular maze, incurring high costs and immense technical difficulty. Each step requires highly specialized technicians and expensive experimental equipment. From gene screening and introduction to cell culture and regulation, even minor deviations at any stage can lead to the failure of the entire production process. Furthermore, genetic engineering involves the artificial intervention of biological genetic material, sparking a series of ethical controversies—a Damocles' sword hanging over our heads, constantly threatening the widespread application of the technology. Therefore, the invention of a production equipment for non-recombinant human-derived collagen is crucial. Utility Model Content

[0003] To solve the above-mentioned technical problems, according to one aspect of the present invention, the present invention provides the following technical solution:

[0004] A production equipment for non-recombinant human collagen includes a first chip body and a third chip body, with a plurality of second chip bodies disposed between the first chip body and the third chip body. The first chip body is provided with a first flow component for mixing supercritical fluid, peptides and enzyme preparations. The second chip bodies are provided with a second flow component for mixing supercritical fluid, peptides and enzyme preparations. The third chip body is provided with a third flow component for mixing supercritical fluid, peptides and enzyme preparations.

[0005] In a preferred embodiment of the production equipment for non-recombinant human collagen described in this utility model, the first chip body and the second chip body, the two sets of the second chip bodies, and the second chip body and the third chip body are all fixedly connected together by screws.

[0006] In a preferred embodiment of the production equipment for non-recombinant human collagen described in this utility model, the first flow component comprises:

[0007] The first microchannel, a plurality of parallel first microchannels are formed in the first chip body;

[0008] The first connection channel is located in the first chip body between the two sets of first microchannels, and a plurality of first connection channels are provided therein.

[0009] The first flow groove is provided on the left side of the first chip body and is connected to the first microchannel;

[0010] The first conduit has three sets of first conduits connected to the first flow channel at the left end of the first chip body;

[0011] The first vertical channel is located in the first chip body on the right side of the first microchannel and is connected to the first microchannel.

[0012] As a preferred embodiment of the production equipment for non-recombinant human collagen according to the present invention, wherein: a plurality of first spray tower components are equidistantly arranged on the first microchannel;

[0013] The first spray tower assembly includes:

[0014] The first cavity is a plurality of first cavities that are connected to the first microchannel in the first chip body located on the first microchannel.

[0015] A first circular plate is fixedly installed in a first cavity;

[0016] The first spray hole is provided in the first circular plate.

[0017] In a preferred embodiment of the production equipment for non-recombinant human collagen described in this utility model, the second flow component includes:

[0018] The second microchannel, a plurality of parallel second microchannels are formed in the second chip body;

[0019] The second connection channel is provided in the second chip body located between the two sets of second microchannels;

[0020] The second vertical channel is provided in the second chip body located on one side of the second microchannel and is connected to the second microchannel. The uppermost second vertical channel is connected to the first vertical channel.

[0021] The third vertical channel is located on the other side of the second microchannel. The second chip body has a third vertical channel that is connected to the second microchannel, and the third vertical channel is connected to the second vertical channel.

[0022] As a preferred embodiment of the production equipment for non-recombinant human collagen according to the present invention, wherein: a plurality of second spray tower components are equidistantly arranged on the second microchannel;

[0023] The second spray tower assembly includes:

[0024] The second cavity is provided in the second chip body located on the second microchannel, and several second cavities are connected to the second microchannel.

[0025] The second circular plate is fixedly installed in the second cavity;

[0026] The second spray hole is provided in the second circular plate.

[0027] In a preferred embodiment of the production equipment for non-recombinant human collagen described in this utility model, the third flow component includes:

[0028] The third microchannel, wherein a plurality of parallel third microchannels are formed in the main body of the third chip;

[0029] The third connection channel is located in the third chip body between the two sets of third microchannels, and several third connection channels are provided therein.

[0030] The second flow groove is provided on the left side of the third chip body and is connected to the third microchannel;

[0031] The second conduit is provided at the left end of the third chip body, which is connected to the second flow groove;

[0032] The fourth vertical channel is located in the third chip body to the right of the third microchannel and is connected to the third microchannel. The fourth vertical channel is also connected to the bottommost third vertical channel.

[0033] As a preferred embodiment of the production equipment for non-recombinant human collagen according to the present invention, wherein: a plurality of third spray tower components are equidistantly arranged on the third microchannel;

[0034] The third spray tower assembly includes:

[0035] The third cavity is located in the third chip body on the third microchannel, and several third cavities are provided that are connected to the third microchannel.

[0036] A third circular plate is fixedly installed in a third cavity;

[0037] The third spray hole is provided in the third circular plate.

[0038] Compared with existing technologies:

[0039] 1. High-efficiency purification: The synergistic operation of numerous microchannels and spray tower components greatly increases the reaction area and reaction sites, enabling the purification process to be completed in a short time; compared with traditional production methods, efficiency has achieved a qualitative leap, like turning a trickle into a raging torrent, greatly improving production capacity;

[0040] 2. Low cost: It abandons complex and expensive genetic engineering operations, reducing reliance on high-end technical personnel and precision equipment; at the same time, it uses common animal bones as raw materials and combines innovative production processes to reduce the cost of raw materials and production processes, providing an economically feasible solution for the large-scale production of collagen. Attached Figure Description

[0041] Figure 1 This is a front view schematic diagram of the structure of this utility model;

[0042] Figure 2 This utility model Figure 1 Enlarged schematic diagram of the structure at point A in the middle;

[0043] Figure 3 This utility model Figure 1 Enlarged schematic diagram of the structure at point B;

[0044] Figure 4 This is a top sectional view of the main body of the first chip of this utility model;

[0045] Figure 5 This is a top sectional view of the main body of the second chip of this utility model;

[0046] Figure 6 This is a top-view cross-sectional view of the main body of the third chip of this utility model.

[0047] In the figure: First chip body 10, first microchannel 11, first connecting channel 12, first flow groove 13, first pipeline 14, first vertical channel 15, first cavity 16, first circular plate 17, first nozzle 18, second chip body 20, second microchannel 21, second connecting channel 22, second vertical channel 23, third vertical channel 24, second cavity 25, second circular plate 26, second nozzle 27, third chip body 30, third microchannel 31, third connecting channel 32, second flow groove 33, second pipeline 34, fourth vertical channel 35, third cavity 36, third circular plate 37, third nozzle 38. Detailed Implementation

[0048] To make the objectives, technical solutions, and advantages of this utility model clearer, the embodiments of this utility model will be described in further detail below with reference to the accompanying drawings.

[0049] This invention provides a production equipment for non-recombinant human collagen. Please refer to [link / reference]. Figures 1-6It includes a first chip body 10 and a third chip body 30, with a plurality of second chip bodies 20 disposed between the first chip body 10 and the third chip body 30. The first chip body 10, the second chip body 20, the two sets of second chip bodies 20, and the second chip body 20 and the third chip body 30 are all fixedly connected together by screws. By assembling the first chip body 10, the second chip body 20 and the third chip body 30 together, the flexibility of use is improved to a certain extent, and the number of second chip bodies 20 can be controlled according to the needs.

[0050] The first chip body 10 is provided with a first flow component for mixing supercritical fluid, peptides and enzyme preparations;

[0051] The first flow component includes: a first microchannel 11, a first connecting channel 12, a first flow groove 13, a first pipeline 14, and a first vertical channel 15;

[0052] The first chip body 10 has several parallel first microchannels 11. The first chip body 10 located between two sets of first microchannels 11 has several first connecting channels 12. The left side of the first chip body 10 has a first flow groove 13 connected to the first microchannels 11. The left end of the first chip body 10 has three sets of first pipes 14 connected to the first flow grooves 13. The right side of the first chip body 10 has a first vertical channel 15 connected to the first microchannels 11. The three sets of first pipes 14 respectively transport supercritical fluid, peptides and enzyme preparations.

[0053] Several first spray tower components are equidistantly arranged on the first microchannel 11;

[0054] The first spray tower assembly includes: a first cavity 16, a first circular plate 17, and a first spray hole 18;

[0055] The first chip body 10 located on the first microchannel 11 has a plurality of first cavities 16 connected to the first microchannel 11. The first circular plate 17 is fixedly installed in the first cavity 16, and the first circular plate 17 has a plurality of first nozzles 18.

[0056] The second chip body 20 is provided with a second flow assembly for mixing supercritical fluid, peptides and enzyme preparations;

[0057] The second flow component includes: a second microchannel 21, a second connecting channel 22, a second vertical channel 23, and a third vertical channel 24;

[0058] The second chip body 20 has several parallel second microchannels 21. The second chip body 20 located between two sets of second microchannels 21 has several second connecting channels 22. The second chip body 20 located on one side of the second microchannel 21 has a second vertical channel 23 connected to the second microchannel 21. The uppermost second vertical channel 23 is connected to the first vertical channel 15. The second chip body 20 located on the other side of the second microchannel 21 has a third vertical channel 24 connected to the second microchannel 21, and the third vertical channel 24 is connected to the second vertical channel 23. A sealing ring can be provided between the first chip body 10 and the second chip body 20 located at the second vertical channel 23 and the first vertical channel 15 as needed. A sealing ring can also be provided between the two sets of second chip bodies 20 located at the second vertical channel 23 and the third vertical channel 24 as needed.

[0059] Several second spray tower components are equidistantly arranged on the second microchannel 21;

[0060] The second spray tower assembly includes: a second cavity 25, a second circular plate 26, and a second spray hole 27;

[0061] The second chip body 20 located on the second microchannel 21 has several second cavities 25 that are connected to the second microchannel 21. The second circular plate 26 is fixedly installed in the second cavity 25, and the second circular plate 26 has several second nozzles 27.

[0062] The third chip body 30 is provided with a third flow component for mixing supercritical fluid, peptides and enzyme preparations;

[0063] The third flow component includes: a third microchannel 31, a third connecting channel 32, a second flow groove 33, a second pipeline 34, and a fourth vertical channel 35;

[0064] The third chip body 30 has several parallel third microchannels 31. The third chip body 30 located between two sets of third microchannels 31 has several third connecting channels 32. The left side of the third chip body 30 has a second flow groove 33 that communicates with the third microchannels 31. The left end of the third chip body 30 has a second pipe 34 that communicates with the second flow groove 33. The third chip body 30 located on the right side of the third microchannels 31 has a fourth vertical channel 35 that communicates with the third microchannels 31, and the fourth vertical channel 35 communicates with the lowest third vertical channel 24. A sealing ring can be provided between the third chip body 30 and the second chip body 20 located at the third vertical channel 24 and the fourth vertical channel 35 as needed.

[0065] Several third spray tower components are equidistantly arranged on the third microchannel 31;

[0066] The third spray tower assembly includes: a third cavity 36, a third circular plate 37, and a third spray hole 38;

[0067] The third chip body 30 located on the third microchannel 31 has several third cavities 36 that are connected to the third microchannel 31. The third circular plate 37 is fixedly installed in the third cavity 36, and several third nozzles 38 are opened in the third circular plate 37.

[0068] The specific operating procedures for producing non-recombinant human collagen by those skilled in the art are as follows:

[0069] Supercritical fluid, peptides, and enzymes are introduced into the first flow channel 13 via the first conduit 14 for initial mixing. Afterward, the supercritical fluid, peptides, and enzymes flow through the first microchannel 11, the second microchannel 21, and the third microchannel 31 into the second flow channel 33. Because the flow area of ​​the supercritical fluid, peptides, and enzymes decreases after entering the microchannels (including the first microchannel 11, the second microchannel 21, and the third microchannel 31), this allows for sufficient contact between the supercritical fluid, peptides, and enzymes within the confined space, achieving [the desired effect]. In the second mixing, when the supercritical fluid, peptides, and enzymes flow through the first microchannel 11, the second microchannel 21, and the third microchannel 31, they pass through the nozzles (including the first nozzle 18, the second nozzle 27, and the third nozzle 38) in the cavities (including the first cavity 16, the second cavity 25, and the third cavity 36). As the flow area is further reduced when passing through the nozzles, the supercritical fluid, peptides, and enzymes can make sufficient contact in the narrow space, thus achieving a third mixing; at this point, the collagen can be purified.

[0070] Although the present invention has been described above with reference to embodiments, various modifications can be made and components can be replaced with equivalents without departing from the scope of the present invention. In particular, as long as there is no structural conflict, the features in the embodiments disclosed in this invention can be combined with each other in any way. The lack of an exhaustive description of these combinations in this specification is merely for the sake of brevity and resource conservation. Therefore, the present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A production equipment for non-recombinant human-derived collagen, characterized in that, The device includes a first chip body (10) and a third chip body (30), with a plurality of second chip bodies (20) disposed between the first chip body (10) and the third chip body (30). The first chip body (10) is provided with a first flow component for mixing supercritical fluid, peptides and enzyme preparations, the second chip bodies (20) are provided with a second flow component for mixing supercritical fluid, peptides and enzyme preparations, and the third chip body (30) is provided with a third flow component for mixing supercritical fluid, peptides and enzyme preparations.

2. The production equipment for non-recombinant human collagen according to claim 1, characterized in that, The first chip body (10) and the second chip body (20), the two sets of the second chip bodies (20), and the second chip body (20) and the third chip body (30) are all fixedly connected together by screws.

3. The production equipment for non-recombinant human collagen according to claim 1, characterized in that, The first flow component includes: First microchannel (11), a plurality of parallel first microchannels (11) are formed in the first chip body (10); The first connection channel (12) is located in the first chip body (10) between the two sets of first microchannels (11), and a plurality of first connection channels (12) are provided therein; The first flow channel (13) is provided on the left side of the first chip body (10) and is connected to the first microchannel (11); The first conduit (14) is provided at the left end of the first chip body (10) with three sets of first conduits (14) connected to the first flow groove (13); The first vertical channel (15) is provided in the first chip body (10) located to the right of the first microchannel (11) and is connected to the first microchannel (11).

4. The production equipment for non-recombinant human collagen according to claim 3, characterized in that, A plurality of first spray tower components are provided at equal intervals on the first microchannel (11); The first spray tower assembly includes: The first cavity (16) is located in the first chip body (10) on the first microchannel (11) and has a plurality of first cavities (16) connected to the first microchannel (11); The first circular plate (17) is fixedly installed in the first cavity (16); First spray hole (18): A plurality of first spray holes (18) are provided in the first circular plate (17).

5. The production equipment for non-recombinant human collagen according to claim 3, characterized in that, The second flow component includes: The second microchannel (21) is provided in the second chip body (20) with several parallel second microchannels (21); The second connection channel (22) is provided in the second chip body (20) located between the two sets of second microchannels (21); The second vertical channel (23) is provided in the second chip body (20) located on one side of the second microchannel (21) and is connected to the second microchannel (21). The uppermost second vertical channel (23) is connected to the first vertical channel (15). The third vertical channel (24) is provided in the second chip body (20) on the other side of the second microchannel (21), and is connected to the second microchannel (21). The third vertical channel (24) is connected to the second vertical channel (23).

6. The production equipment for non-recombinant human collagen according to claim 5, characterized in that, Several second spray tower components are equidistantly arranged on the second microchannel (21); The second spray tower assembly includes: The second cavity (25) is located in the second chip body (20) on the second microchannel (21) and has several second cavities (25) that are connected to the second microchannel (21); The second circular plate (26) is fixedly installed in the second cavity (25); The second nozzle (27) is provided in the second circular plate (26).

7. The production equipment for non-recombinant human collagen according to claim 5, characterized in that, The third flow component includes: The third microchannel (31) is provided in the third chip body (30) with several parallel third microchannels (31); The third connection channel (32) is located between the two sets of third microchannels (31) and a plurality of third connection channels (32) are provided in the third chip body (30); The second flow channel (33) is provided on the left side of the third chip body (30) and is connected to the third microchannel (31); The second conduit (34) is provided at the left end of the third chip body (30) and is connected to the second flow groove (33); The fourth vertical channel (35) is located in the third chip body (30) to the right of the third microchannel (31), and is connected to the third microchannel (31). The fourth vertical channel (35) is connected to the bottom third vertical channel (24).

8. The production equipment for non-recombinant human collagen according to claim 7, characterized in that, The third microchannel (31) is provided with several third spray tower components at equal intervals; The third spray tower assembly includes: The third cavity (36) is located in the third chip body (30) on the third microchannel (31), and a plurality of third cavities (36) are provided in the third chip body (30) that are connected to the third microchannel (31); The third circular plate (37) is fixedly installed in the third cavity (36); The third nozzle (38) is provided in the third circular plate (37).

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