A Chinese medicine external application pollution-proof patch for condyloma acuminatum

Abstract

The utility model provides a kind of sharp condyloma acuminatum traditional chinese medicine external application pollution-preventing patch, it is related to medical technology field, including protective layer, control release layer, drug-loading layer and adhesive layer, the control release layer is below protective layer, the drug-loading layer is below control release layer, the adhesive layer is below drug-loading layer;The drug-loading layer includes grid structure layer, brucea javanica bitter alcohol layer and porous starch microsphere layer, the brucea javanica bitter alcohol layer and porous starch microsphere layer are inside grid structure layer;The utility model adopts multilayer composite structure, treatment main body is drug-loading layer, treat by podophyllotoxin cooperation brucea javanica bitter alcohol layer, brucea javanica bitter alcohol can alleviate symptom and auxiliary remove wart body by the effect of heat-clearing and detoxifying, antiviral and erosion wart, podophyllotoxin is cell division inhibitor, can directly destroy wart body, treatment effect is good, medicine is fixed by grid structure layer, podophyllotoxin is loaded by porous starch microsphere layer, improves the stability of drug loading.

Description

Technical Field

[0001] This utility model relates to the field of medical technology, and in particular to a traditional Chinese medicine external application anti-pollution patch for condyloma acuminata. Background Technology

[0002] Genital warts are a common sexually transmitted disease caused by human papillomavirus (HPV) infection. They mainly manifest as growths on the genitals, perianal area, and other parts of the body. Current treatments include physical removal, chemical drugs, and immunotherapy.

[0003] In the treatment of this disease with traditional Chinese medicine external application, there are already applications of Chinese medicine plasters and patches, which mostly use Chinese herbal extracts as the core ingredients to exert antiviral, antibacterial, and local immune-regulating effects through transdermal delivery. However, existing Chinese medicine plasters and patches generally involve directly applying ointments or powders made from Chinese herbs such as Coptis chinensis, Phellodendron chinense, and Isatis indigotica, which have heat-clearing, detoxifying, and antiviral effects, to the affected area to improve local blood circulation, enhance immunity, and inhibit viral replication. However, the therapeutic effect is insufficient, and there are generally problems such as insufficient drug load stability, low drug utilization rate, and high clothing contamination rate. Therefore, this utility model proposes a Chinese medicine external application anti-contamination patch for condyloma acuminata to solve the problems existing in the prior art. Utility Model Content

[0004] To address the aforementioned problems, this invention proposes a topical anti-pollution patch made from traditional Chinese medicine for condyloma acuminata. This patch has good therapeutic effects, uses a mesh structure layer to fix the drug, and loads podophyllotoxin through a porous starch microsphere layer to improve the stability of the drug loading.

[0005] To achieve the purpose of this utility model, the utility model is implemented through the following technical solution: a topical anti-pollution patch for traditional Chinese medicine for condyloma acuminata, comprising a protective layer, a controlled-release layer, a drug-carrying layer and an adhesive layer, wherein the controlled-release layer is located below the protective layer, the drug-carrying layer is located below the controlled-release layer, and the adhesive layer is located below the drug-carrying layer;

[0006] The drug-loaded layer comprises a mesh structure layer, a podophyllin layer, and a porous starch microsphere layer. The podophyllin layer and the porous starch microsphere layer are located inside the mesh structure layer, and the porous starch microsphere layer is loaded with podophyllotoxin.

[0007] A further improvement is that the mesh structure layer includes a first mesh layer and a second mesh layer, and the crotonic acid layer and the porous starch microsphere layer are located between the first mesh layer and the second mesh layer.

[0008] A further improvement is that the porous starch microsphere layer is composed of porous starch microspheres, and the pore size of the porous starch microspheres is 10-50 μm.

[0009] A further improvement is that the adhesive layer is a pressure-sensitive adhesive, and the adhesive layer is provided with vent holes, and there are multiple sets of vent holes.

[0010] A further improvement is that the lower surface of the adhesive layer is covered with a release film.

[0011] A further improvement is that the protective layer includes a composite membrane and reinforcing fibers, wherein the composite membrane is composed of a polyurethane membrane and a nano-silver membrane, and the reinforcing fibers are located between the polyurethane membrane and the nano-silver membrane.

[0012] A further improvement is that the controlled-release layer includes a pH-sensitive chitosan layer and a sodium alginate hydrogel layer, with the sodium alginate hydrogel layer located below the pH-sensitive chitosan layer.

[0013] A further improvement is that an embedded groove is provided at the middle position of the bottom of the controlled-release layer, and the drug-loaded layer is located inside the embedded groove.

[0014] A further improvement is that the drug loading of the podophyllotoxin is 5-15 mg / cm².

[0015] A further improvement is that the croton icteryl layer is composed of multiple groups of croton icteryl tablets.

[0016] The beneficial effects of this utility model are as follows:

[0017] 1. This utility model adopts a multi-layer composite structure. The main treatment layer is the drug-carrying layer. The treatment is carried out by combining podophyllotoxin with crotonol layer. Crotonol can relieve symptoms and help remove warts by clearing heat and detoxifying, antiviral and corroding warts. Podophyllotoxin is a cell division inhibitor that can directly destroy warts and has a good therapeutic effect. The drug is fixed by the grid structure layer and the podophyllotoxin is loaded by the porous starch microsphere layer to improve the stability of the drug loading.

[0018] 2. This invention uses pH-sensitive chitosan and sodium alginate hydrogel to form a controlled-release layer, which is located on the path of drug diffusion to the outside. Thus, the sustained or controlled release of the drug is achieved through the swelling properties of the materials. The composite film composed of polyurethane and nano-silver helps to protect the outside and block pollution. In summary, it improves drug utilization and reduces clothing pollution. Attached Figure Description

[0019] Figure 1 This is the front view of the present invention;

[0020] Figure 2 This is a schematic diagram showing the disassembled parts of this utility model;

[0021] Figure 3 This is a schematic diagram of the drug-carrying layer of this utility model;

[0022] Figure 4 This is a schematic diagram of the adhesive layer of this utility model;

[0023] Figure 5 This is a schematic diagram of the protective layer of this utility model;

[0024] Figure 6 This is a schematic diagram of the controlled-release layer of this utility model.

[0025] The components are: 1. Protective layer; 2. Controlled release layer; 3. Drug-carrying layer; 4. Adhesive layer; 5. Brucea javanica bitter alcohol layer; 6. Porous starch microsphere layer; 7. First grid layer; 8. Second grid layer; 9. Ventilation pores; 10. Release membrane; 11. Composite membrane; 12. Reinforcing fiber; 13. Embedded groove. Detailed Implementation

[0026] To deepen the understanding of this utility model, the following detailed description will be provided in conjunction with embodiments. These embodiments are only used to explain this utility model and do not constitute a limitation on the scope of protection of this utility model.

[0027] Example 1

[0028] according to Figure 1 , 2 As shown in Figures 3, 4, 5, and 6, this embodiment proposes a topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata, comprising a protective layer 1, a controlled-release layer 2, a drug-loaded layer 3, and an adhesive layer 4. The controlled-release layer 2 is located below the protective layer 1, the drug-loaded layer 3 is located below the controlled-release layer 2, and the adhesive layer 4 is located below the drug-loaded layer 3.

[0029] The drug-loaded layer 3 comprises a mesh structure layer, a podophyllin layer 5, and a porous starch microsphere layer 6. The podophyllin layer 5 and the porous starch microsphere layer 6 are located inside the mesh structure layer, and the porous starch microsphere layer 6 is loaded with podophyllotoxin. This multi-layered composite structure uses the drug-loaded layer 3 as the main treatment component. Treatment is achieved through the combination of podophyllotoxin and the podophyllin layer 5. Podophyllin, through its heat-clearing, detoxifying, antiviral, and wart-corroding effects, can alleviate symptoms and assist in the removal of warts. Podophyllotoxin, being a cell division inhibitor, can directly destroy warts, resulting in good therapeutic effects. The mesh structure layer fixes the drug, and the porous starch microsphere layer 6 loads the podophyllotoxin, improving the stability of the drug loading.

[0030] The mesh structure includes a first mesh layer 7 and a second mesh layer 8, with the crotonic acid layer 5 and the porous starch microsphere layer 6 located between the first mesh layer 7 and the second mesh layer 8. Drug fixation is achieved using a mesh-like structure, which is suitable for nanomaterials.

[0031] The porous starch microsphere layer 6 is composed of porous starch microspheres with a pore size of 10-50 μm. The podophyllotoxin loading capacity is 8 mg / cm². Loading podophyllotoxin (8 mg / cm²) onto porous starch microspheres (pore size 10-50 μm) improves the stability of the drug loading.

[0032] The adhesive layer 4 is a pressure-sensitive adhesive, and it has multiple sets of vent holes 9 for ventilation. A release film 10 covers the lower surface of the adhesive layer 4. Before use, the release film 10 is attached to the adhesive layer 4 for protection. During use, the release film 10 is peeled off, and the adhesive layer 4 is applied sideways to the skin. Adhesion performance: initial tack ≥ 1.2 N / cm, holding power ≥ 24h.

[0033] The protective layer 1 includes a composite membrane 11 and reinforcing fibers 12. The composite membrane 11 is composed of a polyurethane membrane and a nano-silver membrane, and the reinforcing fibers 12 are located between the polyurethane membrane and the nano-silver membrane. The composite membrane 11, composed of polyurethane and nano-silver, provides protection on the outside and blocks pollution. The polyurethane / nano-silver composite membrane has a breathability of 5000g / m² / 24h. The reinforcing fibers 12 enhance the overall strength of the patch, making it less prone to tearing.

[0034] The controlled-release layer 2 comprises a pH-sensitive chitosan layer and a sodium alginate hydrogel layer, with the sodium alginate hydrogel layer located below the pH-sensitive chitosan layer. The pH-sensitive chitosan / sodium alginate hydrogel (with a 300% increase in swelling at pH > 7.4) forms the controlled-release layer 2, positioned along the drug diffusion path, thereby achieving sustained or controlled drug release through the swelling properties of the materials.

[0035] Example 2

[0036] according to Figure 1 , 2 As shown in Figures 3, 4, 5, and 6, this embodiment proposes a topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata, comprising a protective layer 1, a controlled-release layer 2, a drug-loaded layer 3, and an adhesive layer 4. The controlled-release layer 2 is located below the protective layer 1, the drug-loaded layer 3 is located below the controlled-release layer 2, and the adhesive layer 4 is located below the drug-loaded layer 3.

[0037] The drug-loaded layer 3 comprises a mesh structure layer, a podophyllin layer 5, and a porous starch microsphere layer 6. The podophyllin layer 5 and the porous starch microsphere layer 6 are located inside the mesh structure layer, and the porous starch microsphere layer 6 is loaded with podophyllotoxin. This multi-layered composite structure uses the drug-loaded layer 3 as the main treatment component. Treatment is achieved through the combination of podophyllotoxin and the podophyllin layer 5. Podophyllin, through its heat-clearing, detoxifying, antiviral, and wart-corroding effects, can alleviate symptoms and assist in the removal of warts. Podophyllotoxin, being a cell division inhibitor, can directly destroy warts, resulting in good therapeutic effects. The mesh structure layer fixes the drug, and the porous starch microsphere layer 6 loads the podophyllotoxin, improving the stability of the drug loading.

[0038] An inset groove 13 is provided at the center of the bottom of the controlled-release layer 2, and the drug-loaded layer 3 is disposed inside the inset groove 13. The inset groove 13 fixes the position of the drug-loaded layer 3 to prevent drug displacement during use.

[0039] The 5th layer of croton bitterol consists of multiple groups of croton bitterol tablets. Croton bitterol can relieve symptoms and assist in the removal of warts through its effects of clearing heat and detoxifying, antiviral, and corroding warts.

[0040] This topical anti-pollution patch for condyloma acuminata employs a multi-layered composite structure. The main treatment layer is the drug-loaded layer 3, which combines podophyllotoxin with a layer of crotonol for treatment. Crotonol, through its heat-clearing, detoxifying, antiviral, and wart-corroding effects, can alleviate symptoms and assist in the removal of warts. Podophyllotoxin, a cell division inhibitor, can directly destroy warts, resulting in good therapeutic effects. The drug is fixed through a mesh structure layer, and podophyllotoxin is loaded into a porous starch microsphere layer 6 to improve the stability of the drug loading. Simultaneously, a controlled-release layer 2, composed of pH-sensitive chitosan and sodium alginate hydrogel, is located along the drug diffusion path, thus achieving sustained or controlled drug release through material swelling and other properties. A composite membrane 11, composed of polyurethane and nano-silver, provides protection on the outside, blocking contamination. In summary, this improves drug utilization and reduces clothing contamination.

[0041] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata, comprising a protective layer (1), a controlled-release layer (2), a drug-carrying layer (3), and an adhesive layer (4), characterized in that: The controlled-release layer (2) is located below the protective layer (1), the drug-loaded layer (3) is located below the controlled-release layer (2), and the adhesion layer (4) is located below the drug-loaded layer (3). The drug-loaded layer (3) includes a grid structure layer, a crotonol layer (5) and a porous starch microsphere layer (6), wherein the crotonol layer (5) and the porous starch microsphere layer (6) are located inside the grid structure layer, and the porous starch microsphere layer (6) is loaded with podophyllotoxin.

2. The topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata according to claim 1, characterized in that: The mesh structure layer includes a first mesh layer (7) and a second mesh layer (8), with the croton picrol layer (5) and the porous starch microsphere layer (6) located between the first mesh layer (7) and the second mesh layer (8).

3. The topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata according to claim 1, characterized in that: The porous starch microsphere layer (6) is composed of porous starch microspheres, and the pore size of the porous starch microspheres is 10-50 μm.

4. The topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata according to claim 1, characterized in that: The adhesive layer (4) is a pressure-sensitive adhesive, and the adhesive layer (4) is provided with vent holes (9), and the vent holes (9) are provided in multiple sets.

5. The topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata according to claim 4, characterized in that: The lower surface of the adhesive layer (4) is covered with a release film (10).

6. The topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata according to claim 1, characterized in that: The protective layer (1) includes a composite membrane (11) and reinforcing fibers (12). The composite membrane (11) is composed of a polyurethane membrane and a nano-silver membrane, and the reinforcing fibers (12) are located between the polyurethane membrane and the nano-silver membrane.

7. The topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata according to claim 1, characterized in that: The controlled-release layer (2) includes a pH-sensitive chitosan layer and a sodium alginate hydrogel layer, wherein the sodium alginate hydrogel layer is located below the pH-sensitive chitosan layer.

8. The topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata according to claim 7, characterized in that: The controlled-release layer (2) has an inset groove (13) at the middle position of its bottom, and the drug-carrying layer (3) is located inside the inset groove (13).

9. The topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata according to claim 1, characterized in that: The podophyllotoxin loading capacity is 5-15 mg / cm².

10. The topical anti-pollution patch for traditional Chinese medicine used to treat condyloma acuminata according to claim 1, characterized in that: The croton icteryl layer (5) is composed of multiple groups of croton icteryl tablets.

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