An apparatus for separating and preparing D-chiro-inositol

Abstract

The utility model discloses a kind of separation preparation devices of D-chiral inositol, it is related to D-chiral inositol production technical field, the outlet of conversion liquid tank is communicated with ceramic membrane device, the clear liquid outlet of ceramic membrane device is communicated with first concentrator, the outlet of first concentrator is communicated with first crystallizing tank, the outlet of first crystallizing tank is communicated with first filter, the liquid phase outlet of first filter is communicated with dealcoholization tank, the bottom outlet of dealcoholization tank is communicated with second concentrator, the outlet of second concentrator is communicated with second crystallizing tank, the outlet of second crystallizing tank is communicated with second filter, the solid phase outlet of second filter is communicated with D-chiral inositol tank. Through the series connection process of ceramic membrane filtration, twice concentration, twice crystallization and filtration, the step-by-step separation purification of D-chiral inositol is realized, using the selectivity of ethanol crystallization, effectively improve product purity.

Description

Technical Field

[0001] This utility model relates to the field of D-chiral inositol production technology, specifically to a device for the separation and preparation of D-chiral inositol. Background Technology

[0002] D-Chiral Inositol (DCI) is one of the nine isomers of inositol that exhibits optical activity. It is also the bioactive isomer of vitamin B8. It exists in relatively high levels in buckwheat seeds, soybeans, and some insects, primarily in the form of methylated or glycosylated derivatives, and is a biodegradation product of buckwheat glycosides. It possesses insulin-sensitizing properties and promotes hepatic fat metabolism, significantly lowering blood glucose levels and showing a marked therapeutic effect on diabetes. Furthermore, DCI also has effects such as improving polycystic ovary syndrome, anti-oxidation, anti-aging, and free radical scavenging, making it of considerable practical value.

[0003] In recent years, the preparation of D-chiral inositol has mostly adopted biotransformation synthesis, which mainly focuses on two aspects: modifying microorganisms to convert muscle inositol into chiral inositol and improving the conversion rate. However, the conversion rate is low, and the resulting D-chiral inositol and muscle inositol are difficult to separate, resulting in low purity of D-chiral inositol and making it difficult to achieve industrial production. Summary of the Invention

[0004] The technical problem to be solved by this utility model is to provide a separation and preparation device for D-chiral inositol, which provides a product with high purity and is suitable for industrial production, in order to address the shortcomings of the existing technology.

[0005] To solve the above-mentioned technical problems, the technical solution of this utility model is as follows:

[0006] An apparatus for the separation and preparation of D-chiral inositol includes a conversion tank, the outlet of which is connected to a ceramic membrane device via a pipeline; the clear liquid outlet of the ceramic membrane device is connected to a first concentrator via a pipeline; the outlet of the first concentrator is connected to a first crystallization tank via a pipeline; the inlet of the first crystallization tank is connected to a first ethanol tank via a pipeline; the outlet of the first crystallization tank is connected to a first filter via a pipeline; the liquid phase outlet of the first filter is connected to a dealcoholization tank via a pipeline; the bottom outlet of the dealcoholization tank is connected to a second concentrator via a pipeline; the outlet of the second concentrator is connected to a second crystallization tank via a pipeline; the inlet of the second crystallization tank is connected to a second ethanol tank via a pipeline; the outlet of the second crystallization tank is connected to a second filter via a pipeline; and the solid phase outlet of the second filter is connected to a D-chiral inositol tank via a pipeline.

[0007] As an improved technical solution, the outlet of the conversion liquid tank is connected to a pre-filter via a pipeline, and the outlet of the pre-filter is connected to the ceramic membrane device via a pipeline.

[0008] As an improved technical solution, the clear liquid outlet of the ceramic membrane device is connected to an ultrafiltration membrane device via a pipeline, and the clear liquid outlet of the ultrafiltration membrane device is connected to the first concentrator via a pipeline.

[0009] As an improved technical solution, the clarified liquid outlet of the ultrafiltration membrane device is connected to a cation exchange resin column via a pipeline, the outlet of the cation exchange resin column is connected to an anion exchange resin column via a pipeline, and the outlet of the anion exchange resin column is connected to the first concentrator via a pipeline.

[0010] As an improved technical solution, the inlet of the cation exchange resin column is connected to a hydrochloric acid solution tank via a pipeline, and the inlet of the anion exchange resin column is connected to a sodium hydroxide solution tank via a pipeline.

[0011] As an improved technical solution, the outlet of the anion exchange resin column is connected to a nanofiltration membrane device via a pipeline, and the outlet of the nanofiltration membrane device is connected to the first concentrator via a pipeline.

[0012] As a preferred technical solution, the solid phase outlet of the first filter is connected to a muscle inositol recovery tank.

[0013] As a preferred technical solution, the top gas phase outlet of the dealcoholization tank is connected to an ethanol recovery tank via a pipeline.

[0014] As a preferred technical solution, the outlet of the D-chiral inositol tank is connected to a dissolving tank via a pipeline, the inlet of the dissolving tank is connected to a purified water tank via a pipeline, the outlet of the dissolving tank is connected to a decolorizing tank via a pipeline, the inlet of the decolorizing tank is connected to an activated carbon tank and a diatomaceous earth tank via pipelines, the outlet of the decolorizing tank is connected to a third filter via a pipeline, the outlet of the third filter is connected to a third crystallization tank via a pipeline, the inlet of the third crystallization tank is connected to a third ethanol tank via a pipeline, the outlet of the third crystallization tank is connected to a fourth filter via a pipeline, the solid phase outlet of the fourth filter is connected to a dryer via a pipeline, and the outlet of the dryer is connected to a pure D-chiral inositol tank.

[0015] As a preferred technical solution, the liquid phase outlet of the second filter is connected to the first filtrate tank via a pipeline, the liquid phase outlet of the fourth filter is connected to the second filtrate tank via a pipeline, and the outlets of the first filtrate tank and the second filtrate tank are respectively connected to the first concentrator via pipelines.

[0016] Due to the adoption of the above technical solution, the beneficial effects of this utility model are:

[0017] This invention discloses a device for the separation and preparation of D-chiral inositol, comprising a conversion tank, the outlet of which is connected to a ceramic membrane device via a pipeline; the clear liquid outlet of the ceramic membrane device is connected to a first concentrator via a pipeline; the outlet of the first concentrator is connected to a first crystallization tank via a pipeline; the inlet of the first crystallization tank is connected to a first ethanol tank via a pipeline; the outlet of the first crystallization tank is connected to a first filter via a pipeline; the liquid phase outlet of the first filter is connected to a dealcoholization tank via a pipeline; the bottom outlet of the dealcoholization tank is connected to a second concentrator via a pipeline; the outlet of the second concentrator is connected to a second crystallization tank via a pipeline; the inlet of the second crystallization tank is connected to a second ethanol tank via a pipeline; the outlet of the second crystallization tank is connected to a second filter via a pipeline; and the solid phase outlet of the second filter is connected to a D-chiral inositol tank via a pipeline. Through a series of processes including ceramic membrane filtration, two concentrations, two crystallizations, and filtration, the stepwise separation and purification of D-chiral inositol is achieved. Utilizing the selectivity of ethanol crystallization, the product purity is effectively improved. Simultaneously, the secondary crystallization reprocesses the filtrate after the first crystallization, reducing product loss and improving yield and purity.

[0018] The outlet of the conversion liquid tank of this invention is connected to a pre-filter via a pipeline, and the outlet of the pre-filter is connected to the ceramic membrane device via a pipeline. The pre-filter filters out large particulate suspended impurities in the conversion liquid in advance, preventing them from entering the ceramic membrane device and causing membrane fouling or clogging, ensuring the filtration efficiency and service life of the ceramic membrane, ensuring the stable operation of subsequent separation and purification steps, and indirectly improving product purity and yield.

[0019] The clarified liquid outlet of the ceramic membrane device is connected to an ultrafiltration membrane device via a pipeline, and the clarified liquid outlet of the ultrafiltration membrane device is connected to the first concentrator via a pipeline. The ultrafiltration membrane can further remove small molecule organic matter, colloids and other impurities that the ceramic membrane cannot retain, improve the purity of the clarified liquid, provide a higher quality feed solution for subsequent concentration and crystallization, and help improve the purity of D-chiral inositol.

[0020] The superfiltration membrane device's clarified liquid outlet is connected via a pipeline to a cation exchange resin column, the outlet of which is connected via a pipeline to an anion exchange resin column, and the outlet of which is connected via a pipeline to the first concentrator. The cation exchange resin column removes cationic impurities from the solution, and the anion exchange resin column removes anionic impurities, thus deeply removing salts from the solution, reducing interference from impurities in the crystallization process, and significantly improving the purity of D-chiral inositol.

[0021] The inlet of the cation exchange resin column is connected to a hydrochloric acid solution tank via a pipe, and the inlet of the anion exchange resin column is connected to a sodium hydroxide solution tank via a pipe. This facilitates regeneration after the resin becomes saturated, restoring the resin's ion exchange capacity, ensuring the stability and continuity of impurity removal, and guaranteeing the long-term stable operation of the entire device. This also helps maintain the stability of product purity and yield.

[0022] The outlet of the anion exchange resin column is connected to a nanofiltration membrane device via a pipeline, and the outlet of the nanofiltration membrane device is connected to the first concentrator via a pipeline. The nanofiltration membrane can retain residual small molecule organic impurities and some salts in the solution, further improving the purity of the solution and making the material entering the first concentrator purer, thus creating favorable conditions for subsequent crystallization to prepare high-purity D-chiral inositol.

[0023] The solid phase outlet of the first filter is connected to a muscle inositol recovery tank. This recovers the muscle inositol separated in the first filtration step, avoiding waste of the active ingredient, improving the overall utilization rate of raw materials, and thus increasing the overall product yield.

[0024] The top vapor outlet of the dealcoholization tank is connected to an ethanol recovery tank via a pipeline. Recovering and reusing the ethanol volatilized during the dealcoholization process reduces ethanol consumption costs and minimizes losses caused by ethanol emissions. By improving solvent utilization, it indirectly ensures the economic efficiency and stability of the crystallization process, thus helping to maintain the yield.

[0025] The outlet of the D-chiral inositol container is connected to a dissolving tank via a pipeline. The inlet of the dissolving tank is connected to a purified water tank via a pipeline. The outlet of the dissolving tank is connected to a decolorizing tank via a pipeline. The inlet of the decolorizing tank is connected to an activated carbon tank and a diatomaceous earth tank via pipelines. The outlet of the decolorizing tank is connected to a third filter via a pipeline. The outlet of the third filter is connected to a third crystallization tank via a pipeline. The inlet of the third crystallization tank is connected to a third ethanol tank via a pipeline. The outlet of the third crystallization tank is connected to a fourth filter via a pipeline. The solid phase outlet of the fourth filter is connected to a dryer via a pipeline. The outlet of the dryer is connected to a pure D-chiral inositol container. Through steps such as dissolution, decolorization with activated carbon and diatomaceous earth, recrystallization, and drying, the initially obtained D-chiral inositol is deeply purified, effectively removing residual trace pigments, impurities, and solvents, significantly improving the purity of the product. In addition, high-purity pure D-chiral inositol is obtained through recrystallization.

[0026] The liquid phase outlet of the second filter is connected to the first filtrate tank via a pipeline, and the liquid phase outlet of the fourth filter is connected to the second filtrate tank via a pipeline. The outlets of the first and second filtrate tanks are respectively connected to the first concentrator via pipelines. Returning the filtrate after two filtrations to the first concentrator for reprocessing allows for the recovery of uncrystallized chiral inositol, minimizing product loss and significantly increasing the overall yield of D-chiral inositol. Attached Figure Description

[0027] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0028] Figure 1 This is a structural schematic diagram of an embodiment of the present utility model;

[0029] The components are as follows: 1. Conversion liquid tank; 2. Ceramic membrane device; 3. First concentrator; 4. First crystallization tank; 5. First ethanol tank; 6. First filter; 7. De-alcoholization tank; 8. Second concentrator; 9. Second crystallization tank; 10. Second ethanol tank; 11. Second filter; 12. D-chiral inositol tank; 13. Pre-filter; 14. Ultrafiltration membrane device; 15. Cation exchange resin column; 16. Anion exchange resin column; 17. Hydrochloric acid solution tank; 18. Sodium hydroxide solution tank; 19. Nanofiltration membrane device; 20. Muscle inositol recovery tank; 21. Ethanol recovery tank; 22. Dissolving tank; 23. Purified water tank; 24. Decolorization tank; 25. Activated carbon tank; 26. Diatomaceous earth tank; 27. Third filter; 28. Third crystallization tank; 29. ​​Third ethanol tank; 30. Fourth filter; 31. Dryer; 32. D-chiral inositol pure product tank; 33. First filtrate tank; 34. Second filtrate tank. Detailed Implementation

[0030] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0031] like Figure 1As shown, an apparatus for the separation and preparation of D-chiral inositol includes a conversion tank 1. The outlet of the conversion tank 1 is connected to a ceramic membrane device 2 via a pipeline. The clear liquid outlet of the ceramic membrane device 2 is connected to a first concentrator 3 via a pipeline. The outlet of the first concentrator 3 is connected to a first crystallizer 4 via a pipeline. The inlet of the first crystallizer 4 is connected to a first ethanol tank 5 via a pipeline. Because chiral inositol has a higher solubility in ethanol solution than muscle inositol, adding ethanol causes more muscle inositol to precipitate from the system, thereby increasing the proportion of chiral inositol in the liquid and achieving a preliminary separation effect. The outlet of the first crystallizer 4 is connected to a first ethanol tank 5 via a pipeline. The first filter 6 has a liquid phase outlet connected to a dealcoholization tank 7 via a pipeline. The bottom outlet of the dealcoholization tank 7 is connected to a second concentrator 8 via a pipeline. The outlet of the second concentrator 8 is connected to a second crystallization tank 9 via a pipeline. The inlet of the second crystallization tank 9 is connected to a second ethanol tank 10 via a pipeline. By adding ethanol again, chiral inositol is crystallized from the system, increasing the content of chiral inositol in the solid to more than 95%, thus achieving the purpose of purification. The outlet of the second crystallization tank 9 is connected to a second filter 11 via a pipeline. The solid phase outlet of the second filter 11 is connected to a D-chiral inositol tank 12 via a pipeline. D-chiral inositol conversion solution (derived from the substrate muscle inositol by adding inositol dehydrogenase and 2-ketoinositol isomerase) is processed through a series of steps including filtration, two concentrations, two crystallizations, and filtration using a ceramic membrane device 2. This process achieves the stepwise separation and purification of D-chiral inositol. The selectivity of ethanol crystallization effectively improves product purity. At the same time, the secondary crystallization further treats the filtrate after the first crystallization, reducing product loss and improving yield and purity.

[0032] The outlet of the conversion liquid tank 1 is connected to a pre-filter 13 via a pipeline, and the outlet of the pre-filter 13 is connected to the ceramic membrane device 2 via a pipeline. The pre-filter 13 filters out large particulate suspended impurities in the conversion liquid in advance, preventing them from entering the ceramic membrane device 2 and causing membrane fouling or clogging, ensuring the filtration efficiency and service life of the ceramic membrane, ensuring the stable operation of subsequent separation and purification steps, and indirectly improving product purity and yield.

[0033] The clarified liquid outlet of the ceramic membrane device 2 is connected to an ultrafiltration membrane device 14 via a pipeline, and the clarified liquid outlet of the ultrafiltration membrane device 14 is connected to the first concentrator 3 via a pipeline. The ultrafiltration membrane can further remove small molecule organic matter, colloids and other impurities that the ceramic membrane cannot retain, improve the purity of the clarified liquid, provide a higher quality feed liquid for subsequent concentration and crystallization, and help improve the purity of D-chiral inositol.

[0034] The clarified liquid outlet of the ultrafiltration membrane device 14 is connected via a pipeline to a cation exchange resin column 15. The outlet of the cation exchange resin column 15 is connected via a pipeline to an anion exchange resin column 16. The outlet of the anion exchange resin column 16 is connected via a pipeline to the first concentrator 3. The cation exchange resin column 15 removes cationic impurities from the solution, and the anion exchange resin column 16 removes anionic impurities, thus deeply removing salts from the solution, reducing the interference of impurities on the crystallization process, and significantly improving the purity of D-chiral inositol.

[0035] The inlet of the cation exchange resin column 15 is connected to a hydrochloric acid solution tank 17 via a pipe, and the inlet of the anion exchange resin column 16 is connected to a sodium hydroxide solution tank 18 via a pipe. This facilitates regeneration after the resin becomes saturated, restoring the resin's ion exchange capacity, ensuring the stability and continuity of impurity removal, and guaranteeing the long-term stable operation of the entire device. This also helps maintain the stability of product purity and yield.

[0036] The outlet of the anion exchange resin column 16 is connected to a nanofiltration membrane device 19 via a pipe, and the outlet of the nanofiltration membrane device 19 is connected to the first concentrator 3 via a pipe. The nanofiltration membrane can retain residual small molecule organic impurities and some salts in the solution, further improving the purity of the solution and making the material entering the first concentrator 3 purer, thus creating favorable conditions for subsequent crystallization to prepare high-purity D-chiral inositol.

[0037] The solid phase outlet of the first filter 6 is connected to a muscle inositol recovery tank 20. This recovers the muscle inositol separated in the first filtration step, avoiding waste of the active ingredient, improving the overall utilization rate of raw materials, and thus increasing the overall product yield.

[0038] The top gas phase outlet of the dealcoholization tank 7 is connected to an ethanol recovery tank 21 via a pipeline. This process recovers and reuses the ethanol volatilized during dealcoholization, reducing ethanol consumption costs and minimizing losses from ethanol emissions. It also indirectly ensures the economic efficiency and stability of the crystallization process by improving solvent utilization, thus helping to maintain the yield.

[0039] The outlet of the D-chiral inositol tank 12 is connected to a dissolving tank 22 via a pipe. The inlet of the dissolving tank 22 is connected to a purified water tank 23 via a pipe. The outlet of the dissolving tank 22 is connected to a decolorizing tank 24 via a pipe. The inlets of the decolorizing tank 24 are connected to an activated carbon tank 25 and a diatomaceous earth tank 26 via pipes. The outlet of the decolorizing tank 24 is connected to a third filter 27 via a pipe. The outlet of the third filter 27 is connected to a third crystallization tank 28 via a pipe. The inlet of the third crystallization tank 28 is connected to a third ethanol tank 29 via a pipe. The outlet of the third crystallization tank 28 is connected to a fourth filter 30 via a pipe. The solid phase outlet of the fourth filter 30 is connected to a dryer 31 via a pipe. The outlet of the dryer 31 is connected to a pure D-chiral inositol tank 32. Adding diatomaceous earth can adsorb impurities and aid filtration, resulting in better filtration. After steps such as recrystallization and drying, the initially obtained D-chiral inositol is deeply purified, effectively removing residual trace pigments, impurities, and solvents. Ethanol is an inert solvent, and its addition allows more chiral inositol to crystallize out of the solution, increasing the yield. The addition of ethanol also reduces the viscosity of the crystallization system, improving its fluidity. During crystallization, the crystals can grow more uniformly, resulting in more homogeneous crystals and significantly improving the purity of the product. Furthermore, high-purity D-chiral inositol is obtained through recrystallization.

[0040] The liquid phase outlet of the second filter 11 is connected to the first filtrate tank 33 via a pipeline, and the liquid phase outlet of the fourth filter 30 is connected to the second filtrate tank 34 via a pipeline. The outlets of the first filtrate tank 33 and the second filtrate tank 34 are respectively connected to the first concentrator 3 via pipelines. Returning the filtrate after two filtrations to the first concentrator 3 for reprocessing allows for the recovery of uncrystallized chiral inositol, minimizing product loss and significantly increasing the overall yield of D-chiral inositol.

[0041] It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that after reading the teachings of this invention, those skilled in the art can make various alterations or modifications to the invention, and these equivalent forms also fall within the scope defined by the appended claims.

Claims

1. An apparatus for the separation and preparation of D-chiral inositol, comprising a conversion tank, characterized in that: The outlet of the conversion liquid tank is connected to a ceramic membrane device via a pipeline. The clear liquid outlet of the ceramic membrane device is connected to a first concentrator via a pipeline. The outlet of the first concentrator is connected to a first crystallizer via a pipeline. The inlet of the first crystallizer is connected to a first ethanol tank via a pipeline. The outlet of the first crystallizer is connected to a first filter via a pipeline. The liquid phase outlet of the first filter is connected to a dealcoholizer via a pipeline. The bottom outlet of the dealcoholizer is connected to a second concentrator via a pipeline. The outlet of the second concentrator is connected to a second crystallizer via a pipeline. The inlet of the second crystallizer is connected to a second ethanol tank via a pipeline. The outlet of the second crystallizer is connected to a second filter via a pipeline. The solid phase outlet of the second filter is connected to a D-chiral inositol tank via a pipeline.

2. The apparatus for separating and preparing D-chiral inositol as described in claim 1, characterized in that: The outlet of the conversion liquid tank is connected to a pre-filter via a pipeline, and the outlet of the pre-filter is connected to the ceramic membrane device via a pipeline.

3. The apparatus for separating and preparing D-chiral inositol as described in claim 1, characterized in that: The clear liquid outlet of the ceramic membrane device is connected to an ultrafiltration membrane device via a pipeline, and the clear liquid outlet of the ultrafiltration membrane device is connected to the first concentrator via a pipeline.

4. The apparatus for separating and preparing D-chiral inositol as described in claim 3, characterized in that: The superfiltration membrane device's clarified liquid outlet is connected via a pipeline to a cation exchange resin column, the outlet of the cation exchange resin column is connected via a pipeline to an anion exchange resin column, and the outlet of the anion exchange resin column is connected via a pipeline to the first concentrator.

5. The apparatus for separating and preparing D-chiral inositol as described in claim 4, characterized in that: The inlet of the cation exchange resin column is connected to a hydrochloric acid solution tank via a pipe, and the inlet of the anion exchange resin column is connected to a sodium hydroxide solution tank via a pipe.

6. The apparatus for separating and preparing D-chiral inositol as described in claim 4, characterized in that: The outlet of the anion exchange resin column is connected to a nanofiltration membrane device via a pipeline, and the outlet of the nanofiltration membrane device is connected to the first concentrator via a pipeline.

7. The apparatus for separating and preparing D-chiral inositol as described in claim 1, characterized in that: The solid phase outlet of the first filter is connected to a muscle inositol recovery tank.

8. The apparatus for separating and preparing D-chiral inositol as described in claim 1, characterized in that: The top gas phase outlet of the dealcoholization tank is connected to an ethanol recovery tank via a pipeline.

9. The apparatus for separating and preparing D-chiral inositol as described in claim 1, characterized in that: The outlet of the D-chiral inositol container is connected to a dissolving tank via a pipeline. The inlet of the dissolving tank is connected to a purified water tank via a pipeline. The outlet of the dissolving tank is connected to a decolorizing tank via a pipeline. The inlets of the decolorizing tank are connected to an activated carbon tank and a diatomaceous earth tank via pipelines. The outlet of the decolorizing tank is connected to a third filter via a pipeline. The outlet of the third filter is connected to a third crystallization tank via a pipeline. The inlet of the third crystallization tank is connected to a third ethanol tank via a pipeline. The outlet of the third crystallization tank is connected to a fourth filter via a pipeline. The solid phase outlet of the fourth filter is connected to a dryer via a pipeline. The outlet of the dryer is connected to a pure D-chiral inositol container.

10. The apparatus for separating and preparing D-chiral inositol as described in claim 9, characterized in that: The liquid phase outlet of the second filter is connected to the first filtrate tank via a pipeline, and the liquid phase outlet of the fourth filter is connected to the second filtrate tank via a pipeline. The outlets of the first filtrate tank and the second filtrate tank are respectively connected to the first concentrator via pipelines.

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