An apparatus for the synthesis of 2-methoxyethylamine

Abstract

The utility model belongs to chemical organic synthesis equipment technical field discloses a kind of synthesis device of 2-methoxyethylamine, and realizes continuous production by dehydration kettle, methylation kettle, acidification kettle, alkalization kettle, crude distillation kettle and rectifying column in series.The core reaction unit is all made of enamel material and is equipped with stirrer, significantly improves corrosion resistance and reaction uniformity;Methylation kettle and acidification kettle bottom are provided with double valve structure with glass sight glass, to realize liquid layer accurate separation;Vacuum system is connected multiple stage vacuum pump by buffer tank water seal design, effectively prevent reverse suction;Rectification unit uses stainless steel tower body in cooperation with multiple stage condenser, guarantee high purity product output.The device is based on benzaldehyde and ethanolamine azeotropic dehydration process, and reaction temperature is reduced to 28-100 ℃, product yield is improved to more than 50%, and final product purity reaches more than 98.5%.

Description

Technical Field

[0001] This utility model belongs to the technical field of chemical organic synthesis equipment, and specifically relates to a synthesis apparatus for 2-methoxyethylamine. Background Technology

[0002] 2-Methoxyethylamine, as an important organic synthesis intermediate, is widely used in the synthesis of pharmaceuticals, pesticides, dyes, and other fine chemicals. Its strong nucleophilicity makes it readily react with various compounds through nucleophilic substitution reactions, introducing alkyl, acyl, and other functional groups to construct complex molecular structures. In drug development, 2-methoxyethylamine is often used as a key structural unit in the synthesis of target drug molecules. Its applications are particularly extensive in the pharmaceutical field. It is not only an important raw material for the synthesis of many drugs but also, due to its unique biological activity, is directly used in the treatment of certain diseases. For example, some compounds containing the 2-methoxyethylamine structure have been reported to act as potassium ion regulators and can be used to treat diseases related to potassium ion channels; other compounds, as end-anchored polymerase inhibitors, have shown promising applications in the treatment of cancer and other diseases.

[0003] Currently, there are two main synthetic methods for 2-methoxyethylamine: 1) High-temperature dehydration of ethylene glycol monomethyl ether with ammonia: This is one of the more mature industrial synthetic routes. Under the catalysis of nickel or alumina, ethylene glycol monomethyl ether reacts with ammonia at high temperatures (usually above 200-250℃) to produce 2-methoxyethylamine. However, this method has high requirements for equipment and operation, and the yield is relatively low (6%-17%), thus limiting its practical application. 2) Azeotropic dehydration of ethanolamine with benzaldehyde: In recent years, our researchers have proposed a new synthetic method using inexpensive ethanolamine as a raw material. This involves a dehydration reaction with benzaldehyde under azeotropic conditions to produce an aldimine. Subsequently, a methylation reaction is carried out under alkaline conditions to remove the protecting group. After alkalization, high-purity 2-methoxyethylamine is obtained by distillation. This method not only uses readily available raw materials but also has high yield and low cost, showing broad application prospects. Utility Model Content

[0004] The purpose of this invention is to overcome the shortcomings of existing technologies and provide a synthesis apparatus for 2-methoxyethylamine. This apparatus seamlessly integrates six core processes—dehydration, methylation, acidification, alkalization, crude distillation, and distillation—within a dehydration reactor, methylation reactor, acidification reactor, alkalization reactor, crude distillation reactor, and distillation column, forming a continuous production process. This integrated design shortens the production cycle, reduces losses and potential pollution caused by intermediate product transfer, and significantly improves production efficiency.

[0005] The technical solution adopted by this utility model to solve its technical problem is as follows: A synthesis apparatus for 2-methoxyethylamine is provided, comprising: a dehydration reactor, a methylation reactor, an acidification reactor, an alkalization reactor, a crude distillation reactor, and a distillation column; the inlet of the dehydration reactor is connected to a first high-level tank, another outlet at the top of the dehydration reactor is connected to the inlet of a first condenser, and another outlet at the top of the dehydration reactor is connected to a water separator; a control valve at the bottom of the dehydration reactor is connected to the top inlet of the methylation reactor, another inlet at the top of the methylation reactor is connected to a second high-level tank, and a control valve at the bottom of the methylation reactor is connected to the top inlet of the acidification reactor; another inlet at the top of the acidification reactor is connected to a third high-level tank, and a control valve at the bottom of the acidification reactor is connected to the top inlet of the alkalization reactor; another inlet at the top of the alkalization reactor is connected to a fourth high-level tank, and another inlet at the bottom of the alkalization reactor is connected to the fourth high-level tank. The feed inlet is connected to the second condenser; the second condenser is connected to the first buffer tank, and the first buffer tank is connected to the first vacuum pump; the bottom control valve of the alkalization kettle is connected to the top feed inlet of the crude distillation kettle; another feed inlet at the top of the crude distillation kettle is connected to the feed inlet of the third condenser, the outlet of the third condenser is connected to the top feed inlet of the crude product receiving tank, another feed inlet at the top of the crude product receiving tank is connected to the top feed inlet of the buffer tank, another feed inlet at the top of the buffer tank is connected to the second vacuum pump; the bottom control valve of the crude product receiving tank is connected to the top feed inlet of the heating kettle, another outlet at the top of the heating kettle is connected to the bottom of the distillation column, the top outlet of the distillation column is connected to the feed inlet of the fourth condenser, the outlet of the fourth condenser is connected to the product receiving tank, the product receiving tank is connected to the vacuum buffer tank, and the vacuum buffer tank is connected to the third vacuum pump.

[0006] Furthermore, the dehydration kettle, methylation kettle, acidification kettle, alkalization kettle, crude steaming kettle, and heating kettle are all made of enamel and are equipped with a stirrer inside.

[0007] Furthermore, the first high-level tank, the second high-level tank, the third high-level tank, the fourth high-level tank, the first condenser, the second condenser, the third condenser, the fourth condenser, the crude product receiving tank, the buffer tank, the product receiving tank, and the vacuum buffer tank are all made of PP material.

[0008] Furthermore, the water distributor is made of glass, with one end connected to the outlet of the first condenser and the other end connected to the third outlet at the top of the dehydration vessel.

[0009] Furthermore, both the discharge control valves at the bottom of the methylation reactor and the acidification reactor are equipped with glass sight glasses.

[0010] Furthermore, the crude product receiving tank and the product receiving tank are connected to the vacuum pump through the second buffer tank and the vacuum buffer tank, respectively, and the first buffer tank, the second buffer tank and the vacuum buffer tank are all made of PP.

[0011] Furthermore, the distillation column is made of stainless steel.

[0012] Furthermore, heating jackets are fitted around the heating vessel, product receiving tank, and product buffer tank.

[0013] Furthermore, the second outlet at the top of the dehydration vessel is connected in sequence to the fourth condenser and the water distributor, and the return port of the water distributor is connected to the dehydration vessel.

[0014] Furthermore, the discharge control valve at the bottom of the methylation reactor adopts a dual-valve design, and the glass sight glass is located between the two valves.

[0015] This utility model has the following beneficial effects:

[0016] 1. The 2-methoxyethylamine synthesis apparatus provided by this utility model seamlessly integrates six core processes—dehydration, methylation, acidification, alkalization, crude distillation, and distillation—into a dehydration reactor, methylation reactor, acidification reactor, alkalization reactor, crude distillation reactor, and distillation column, forming a continuous production process. This integrated design shortens the production cycle, reduces losses and potential pollution caused by intermediate product transfer, and improves production efficiency.

[0017] 2. The dehydration kettle, methylation kettle, acidification kettle, alkalization kettle, crude steaming kettle, and heating kettle of this application are all made of enamel material and have built-in agitators, which ensures excellent resistance to strong acid and strong alkali corrosion and the uniformity of the reaction system, thus extending the service life of the equipment.

[0018] 3. The vacuum system of this application adopts a multi-layered buffer protection design, and water is added to the buffer tank to form a liquid seal, effectively preventing backflow of the vacuum pump and ensuring the stability and safety of system operation. For material conveying, gravity feeding is achieved through multiple PP material high-level tanks, reducing the frequency of use and energy consumption of the power pump. Furthermore, heating jackets are installed on the exterior of the heating vessel, product receiving tank, and vacuum buffer tank, achieving more precise temperature control and reducing overall energy consumption by more than 30% compared to traditional devices. Attached Figure Description

[0019] Figure 1 This is a partial structural schematic diagram of a 2-methoxyethylamine synthesis apparatus according to the present invention;

[0020] Figure 2 This is a schematic diagram of another part of the apparatus for synthesizing 2-methoxyethylamine according to the present invention;

[0021] The components in the attached diagram are labeled as follows: 2. Dehydration vessel; 3. First high-level tank; 4. First condenser; 5. Water separator; 6. Methylation vessel; 9. Second high-level tank; 10. Acidification vessel; 13. Third high-level tank; 14. Fourth high-level tank; 15. Alkalization vessel; 17. Second condenser; 18. First buffer tank; 19. First vacuum pump; 21. Crude distillation vessel; 22. Third condenser; 23. Crude product receiving tank; 24. Buffer tank; 25. Second vacuum pump; 27. Heating vessel; 29. ​​Distillation column; 30. Fourth condenser; 32. Product receiving tank; 35. Vacuum buffer tank; 37. Third vacuum pump. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present utility model.

[0023] Example:

[0024] This embodiment provides an apparatus for synthesizing 2-methoxyethylamine, such as... Figure 1 and Figure 2As shown, the system includes: a dehydration kettle 2, a methylation kettle 6, an acidification kettle 10, an alkalization kettle 15, a crude distillation kettle 21, and a distillation column 29; the inlet of the dehydration kettle 2 is connected to the first high-level tank 3, another outlet at the top of the dehydration kettle 2 is connected to the inlet of the first condenser 4, and another outlet at the top of the dehydration kettle 2 is connected to the water separator 5; the control valve at the bottom of the dehydration kettle 2 is connected to the top inlet of the methylation kettle 6, another inlet at the top of the methylation kettle 6 is connected to the second high-level tank 9, and the control valve at the bottom of the methylation kettle 6 is connected to the top inlet of the acidification kettle 10; another inlet at the top of the acidification kettle 10 is connected to the third high-level tank 13, and the control valve at the bottom of the acidification kettle 10 is connected to the top inlet of the alkalization kettle 15; another inlet at the top of the alkalization kettle 15 is connected to the fourth high-level tank 14, and another inlet at the bottom top of the alkalization kettle 15 is connected to the second condenser 17; the second condenser 17 is connected to the first buffer tank. Connection 18: The first buffer tank 18 is connected to the first vacuum pump 19; the bottom control valve of the alkalization kettle 15 is connected to the top feed port of the crude steaming kettle 21; another feed port at the top of the crude steaming kettle 21 is connected to the feed port of the third condenser 22; the outlet of the third condenser 22 is connected to the top feed port of the crude product receiving tank 23; another feed port at the top of the crude product receiving tank 23 is connected to the top feed port of the buffer tank 24; another feed port at the top of the buffer tank 24 is connected to the second vacuum pump 25; the bottom control valve of the crude product receiving tank 23 is connected to the top feed port of the heating kettle 27; another outlet at the top of the heating kettle 27 is connected to the bottom of the distillation column 29; the top outlet of the distillation column 29 is connected to the feed port of the fourth condenser 30; the outlet of the fourth condenser 30 is connected to the product receiving tank 32; the product receiving tank 32 is connected to the vacuum buffer tank 35; and the vacuum buffer tank 35 is connected to the third vacuum pump 37.

[0025] Specifically, the dehydration kettle 2, methylation kettle 6, acidification kettle 10, alkalization kettle 15, crude steaming kettle 21, and heating kettle 27 are all made of enamel and are equipped with a stirrer inside.

[0026] Specifically, the materials of the first high-level tank 3, the second high-level tank 9, the third high-level tank 13, the fourth high-level tank 14, the first condenser 4, the second condenser 17, the third condenser 22, the fourth condenser 30, the crude product receiving tank 23, the buffer tank 24, the product receiving tank 32, and the vacuum buffer tank 35 are all PP material.

[0027] Specifically, the water distributor 5 is made of glass. One end of the water distributor 5 is connected to the outlet of the first condenser 4, and the other end is connected to the third outlet at the top of the dehydration vessel 2.

[0028] Specifically, both the discharge control valves at the bottom of the methylation reactor 6 and the acidification reactor 10 are equipped with glass sight glasses.

[0029] Specifically, the crude product receiving tank 23 and the product receiving tank 32 are connected to the vacuum pump 37 through the second buffer tank 24 and the vacuum buffer tank 35, respectively, and the first buffer tank 18, the second buffer tank 24 and the vacuum buffer tank 35 are all made of PP.

[0030] Specifically, distillation column 29 is made of stainless steel.

[0031] Specifically, heating jackets are fitted around the heating vessel 27, the product receiving tank 32, and the product buffer tank 35.

[0032] Specifically, the second outlet at the top of the dehydration vessel 2 is connected in sequence to the fourth condenser 30 and the water distributor 5, and the return port of the water distributor 5 is connected to the dehydration vessel 2.

[0033] Specifically, the discharge control valve at the bottom of the methylation reactor 6 adopts a dual-valve design, and the glass sight glass is located between the two valves.

[0034] In the diagram, 1, 7, 16, 20, 26, 33, and 36 are stirrers.

[0035] Working principle:

[0036] The synthesis apparatus for 2-methoxyethylamine of this invention includes the following process: using benzaldehyde and ethanolamine as main raw materials, benzaldehyde and toluene are pumped into a dehydration reactor 2, and then ethanolamine is pumped into a first high-level tank 3. Stirring is started, and ethanolamine is slowly added dropwise. After the addition is complete, the mixture is refluxed for dehydration for 12 hours. A water separator 5 is then turned on to separate a certain amount of water, which is considered qualified. The qualified product after water separation is pumped into a methylation reactor 6. A 30% sodium hydroxide solution is then pumped into the methylation reactor 6. Stirring 7 is turned on, and the internal temperature of the methylation reactor 6 is controlled between 28-32°C. Dimethyl sulfate is pumped into a second high-level tank 9 connected to the methylation reactor 6, and the dropwise addition of dimethyl sulfate begins. The reaction is exothermic during the dropwise addition process. After the dropwise addition is complete, the reaction is kept at a constant temperature for 1 hour. The reaction proceeds in stages: an upper material layer and a lower water layer. The water layer is separated and discarded via the control valve (glass sight glass 8 at the bottom of methylation reactor 6), leaving the material layer in methylation reactor 6. The material layer in methylation reactor 6 is then pumped into acidification reactor 10. The stirrer 11 is activated to cool the internal temperature of acidification reactor 10 to 15°C. During cooling, 31% hydrochloric acid is pumped into the third high-level tank 13 connected to acidification reactor 10. When the internal temperature of acidification reactor 10 reaches 15°C, 31% hydrochloric acid is added dropwise. After the addition is complete, the reaction is maintained at 15°C, resulting in stratification: a lower layer of 2-methoxyethylamine hydrochloride aqueous solution and a lower layer of a mixture of toluene and benzaldehyde. This is observed through the control valve (glass sight glass 12 at the bottom of acidification reactor 10). The lower layer is then pumped into the alkalization reactor. Inside reactor 15, the remaining upper layer is recycled. The 2-methoxyethylamine hydrochloride aqueous layer pumped into alkalization reactor 15 is heated to 80℃-100℃. Stirrer 16, second condenser 17, and first vacuum pump 19 are turned on. At this time, the entire system is under positive air, and pressure distillation begins until the moisture content of the material in alkalization reactor 15 reaches below 1%, which is considered qualified. After dehydration, the material in alkalization reactor 15 begins to cool down. When the temperature drops to 50℃, methanol is pumped into alkalization reactor 15, and the temperature is lowered again. During the cooling process, sodium hydroxide solution is pumped into the fourth high-level tank 14 connected to alkalization reactor 15. After the pumping is completed, drip addition begins. After the drip addition is completed, the mixture is stirred and clarified. The clear liquid enters the next step of coarse distillation. The clear liquid in alkalization reactor 15 is pumped into In the crude distillation vessel 21, stirrer 20 and vacuum pump 25 are turned on. Methanol is first distilled at atmospheric pressure. When the methanol reaches 75°C, crude product is distilled under reduced pressure. When the purity of the crude product reaches 95%, the crude product in the crude product receiving vessel 23 is pumped into the heating vessel 27. Water circulation vacuum pump 37 is turned on to slowly heat the entire distillation system to a certain vacuum level, causing the material in the heating vessel 27 to boil and form steam. The steam is condensed into liquid in the fourth condenser 30 at the top of the distillation column 29. A certain reflux ratio is controlled by a rotor flow meter. After distillation for a period of time, a sample is taken at the outlet valve for testing. After the gas phase test shows that the purity is above 98.5%, the sample is gradually separated into the product receiving tank 32 until all the crude product in the heating vessel 27 is distilled.

[0037] The 2-methoxyethylamine synthesis apparatus of this invention uses benzaldehyde and ethanolamine as main raw materials. Benzaldehyde and toluene are pumped into a dehydration reactor, and then ethanolamine is pumped into a high-level tank. Stirring is started, and ethanolamine is slowly added dropwise. After the addition is complete, the mixture is refluxed for dehydration for 12 hours. A water separator is then activated, and a certain amount of water is separated as qualified. The qualified product after water separation is pumped into a methylation reactor. A 30% sodium hydroxide solution is then pumped into the methylation reactor, and stirring is started. The internal temperature of the methylation reactor is controlled between 28-32°C. Dimethyl sulfate is pumped into a high-level tank connected to the methylation reactor, and the dropwise addition of dimethyl sulfate begins. The dropwise addition process is exothermic. After the dropwise addition is complete... The reaction was maintained at a constant temperature for 1 hour, resulting in stratification: an upper layer of material and a lower layer of water. The water layer was separated and discarded via the sight glass control valve at the bottom of the methylation reactor, leaving the material layer in the methylation reactor. The material layer from the methylation reactor was then pumped into the acidification reactor, and stirring was started to cool the internal temperature of the acidification reactor to 15°C. During the cooling process, 31% hydrochloric acid was pumped into a high-level tank connected to the acidification reactor. When the internal temperature of the acidification reactor reached 15°C, 31% hydrochloric acid was added dropwise. After the addition was complete, the reaction was maintained at 15°C, resulting in stratification: a lower layer of 2-methoxyethylamine hydrochloride aqueous solution and a lower layer of a mixture of toluene and benzaldehyde. This was observed through the sight glass control valve at the bottom of the acidification reactor. The lower layer is pumped into the alkalization reactor, while the remaining upper layer is recycled. The 2-methoxyethylamine hydrochloride aqueous layer, pumped into the alkalization reactor, is heated to 80℃-100℃. Stirring, condensing, and vacuum pumping are then activated. At this point, the entire system is under positive air pressure, and vacuum distillation begins until the moisture content of the material in the alkalization reactor reaches below 1%, indicating it is qualified. After dehydration, the material in the alkalization reactor is cooled. When the temperature reaches 50℃, methanol is pumped into the alkalization reactor, and further cooling is performed. During the cooling process, sodium hydroxide solution is pumped into a high-level tank connected to the alkalization reactor. After the initial pumping is complete, drip addition begins. After drip addition, stirring and clarification are performed, and the clear liquid proceeds to the next step of coarse distillation. The clear liquid in the alkalization reactor is then pumped... The crude product is placed in the crude distillation vessel, and the stirring and vacuum pump are turned on. Methanol is first distilled at atmospheric pressure. When the methanol reaches 75°C, the crude product is distilled under reduced pressure. When the purity of the crude product reaches 95%, the crude product in the receiving vessel is pumped into the heating vessel. The water circulation vacuum pump is turned on to slowly heat the entire distillation system to a certain vacuum level, causing the material in the heating vessel to boil and form vapor. The vapor is then condensed into liquid in the condenser at the top of the distillation column. A certain reflux ratio is controlled by a rotor flow meter. After a period of distillation, a sample is taken at the outlet valve for testing. Once the vapor phase purity reaches 98.5% or higher, the sample is gradually separated into the product receiving vessel until all the crude product in the heating vessel has been distilled.

[0038] The above description is merely a preferred embodiment of this utility model. The protection scope of this utility model is not limited to the above embodiments. All technical solutions falling within the scope of this utility model's concept are protected. It should be noted that for those skilled in the art, continuous updates and advancements made without departing from the principle of this utility model should also be considered within the protection scope of this utility model.

Claims

1. An apparatus for the synthesis of 2-methoxyethylamine, characterized in that, include: The distillation vessel consists of a dehydration vessel (2), a methylation vessel (6), an acidification vessel (10), an alkalization vessel (15), a crude distillation vessel (21), and a distillation column (29). The inlet of the dehydration vessel (2) is connected to the first high-level tank (3), the other outlet at the top of the dehydration vessel (2) is connected to the inlet of the first condenser (4), and the other outlet at the top of the dehydration vessel (2) is connected to the water separator (5). The control valve at the bottom of the dehydration vessel (2) is connected to the top inlet of the methylation vessel (6), and the other inlet at the top of the methylation vessel (6) is connected to the second high-level tank (29). The bottom control valve of the methylation reactor (6) is connected to the feed inlet at the top of the acidification reactor (10); another feed inlet at the top of the acidification reactor (10) is connected to the third high-level tank (13); the bottom control valve of the acidification reactor (10) is connected to the feed inlet at the top of the alkalization reactor (15); another feed inlet at the top of the alkalization reactor (15) is connected to the fourth high-level tank (14); another feed inlet at the bottom top of the alkalization reactor (15) is connected to the second condenser (17); the second condenser (17) is connected to the first buffer tank ( 18) Connection: The first buffer tank (18) is connected to the first vacuum pump (19); the bottom control valve of the alkalization kettle (15) is connected to the top feed port of the crude steaming kettle (21); another feed port at the top of the crude steaming kettle (21) is connected to the feed port of the third condenser (22); the outlet of the third condenser (22) is connected to the top feed port of the crude product receiving tank (23); another feed port at the top of the crude product receiving tank (23) is connected to the feed port at the top of the buffer tank (24); another feed port at the top of the buffer tank (24) The inlet is connected to the second vacuum pump (25); the bottom control valve of the crude product receiving tank (23) is connected to the feed inlet at the top of the heating vessel (27); the other outlet at the top of the heating vessel (27) is connected to the bottom of the distillation column (29); the top outlet of the distillation column (29) is connected to the feed inlet of the fourth condenser (30); the outlet of the fourth condenser (30) is connected to the product receiving tank (32); the product receiving tank (32) is connected to the vacuum buffer tank (35); and the vacuum buffer tank (35) is connected to the third vacuum pump (37).

2. A device for the synthesis of 2-methoxyethylamine according to claim 1, characterized in that: The dehydration kettle (2), methylation kettle (6), acidification kettle (10), alkalization kettle (15), crude steaming kettle (21) and heating kettle (27) are all made of enamel and are equipped with a stirrer inside.

3. The apparatus for synthesizing 2-methoxyethylamine according to claim 1, characterized in that: The materials of the first high-level tank (3), the second high-level tank (9), the third high-level tank (13), the fourth high-level tank (14), the first condenser (4), the second condenser (17), the third condenser (22), the fourth condenser (30), the crude product receiving tank (23), the buffer tank (24), the product receiving tank (32), and the vacuum buffer tank (35) are all PP.

4. The apparatus for synthesizing 2-methoxyethylamine according to claim 1, characterized in that: The water separator (5) is made of glass. One end of the water separator (5) is connected to the outlet of the first condenser (4), and the other end is connected to the third outlet at the top of the dehydration vessel (2).

5. The apparatus for synthesizing 2-methoxyethylamine according to claim 1, characterized in that: Both the discharge control valves at the bottom of the methylation reactor (6) and the acidification reactor (10) are equipped with glass sight glasses.

6. The apparatus for synthesizing 2-methoxyethylamine according to claim 1, characterized in that: The crude product receiving tank (23) and the product receiving tank (32) are connected to the vacuum pump (37) through the second buffer tank (24) and the vacuum buffer tank (35), respectively, and the first buffer tank (18), the second buffer tank (24) and the vacuum buffer tank (35) are all made of PP.

7. The apparatus for synthesizing 2-methoxyethylamine according to claim 1, characterized in that: The distillation column (29) is made of stainless steel.

8. The apparatus for synthesizing 2-methoxyethylamine according to claim 1, characterized in that: Heating jackets are fitted around the heating vessel (27), product receiving tank (32), and vacuum buffer tank (35).

9. The apparatus for synthesizing 2-methoxyethylamine according to claim 1, characterized in that: The second outlet at the top of the dehydration vessel (2) is connected in sequence to the fourth condenser (30) and the water distributor (5), and the return port of the water distributor (5) is connected to the dehydration vessel (2).

10. The apparatus for synthesizing 2-methoxyethylamine according to claim 1, characterized in that: The discharge control valve at the bottom of the methylation reactor (6) adopts a dual-valve design, and the glass sight glass is located between the two valves.

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