A PCR tube cryopreservation box

Abstract

This utility model belongs to the technical field of cell culture equipment, specifically relating to a PCR tube cryopreservation box. The utility model includes: a box body with a plurality of arrayed grooves on its top surface and a plurality of annular grooves on its side walls; a thermosensitive color-changing silicone ring correspondingly fitted into each of the annular grooves; and a box lid positioned above the box body, with protrusions on the bottom surface of the lid corresponding to the grooves. This utility model addresses the technical problem of insufficient durability in existing ice boxes.

Description

Technical Field

[0001] This utility model belongs to the field of cell culture equipment technology, specifically relating to a PCR tube cryopreservation box. Background Technology

[0002] During cell culture, samples stored in PCR tubes often need to be placed in a low-temperature refrigerator. To facilitate storage and short-term warming after retrieval, the PCR tubes need to be placed in an ice box. In the prior art, a Chinese utility model patent application with application number 2022233957377 discloses a low-temperature indicator ice box. Its main structure is a cavity set in a well plate, into which a thermochromic liquid containing thermochromic particles is injected. By observing the color of the liquid, the current temperature range of the ice box is reflected. However, this type of ice box has many problems in use. For example, in this patent, the thermochromic liquid is used not only as a temperature indicator but also as a cold storage agent. In order to achieve a good cold storage effect, the thermochromic liquid must fill the cavity. If there is also gas in the cavity, the gas will be above the liquid when the ice box is placed upright. The liquid cannot completely cover the storage hole. The heat transfer effect of gas is inferior to that of liquid, so it cannot achieve a continuous heat preservation effect on the storage hole. However, the patent also records that the solvent of the thermochromic liquid is water. In a low-temperature environment, water freezes into ice and its volume will increase and expand, which will expand the cavity. If the ice box is used for a long time, the cavity in the perforated plate will be cracked, causing the thermochromic liquid to flow out, which will pollute the environment and render it useless. Utility Model Content

[0003] This invention provides a PCR tube cryopreservation box to solve the technical problem of insufficient durability of existing ice boxes.

[0004] This utility model includes: a box body, the top surface of which has a plurality of arrayed grooves, and the side wall of which has a plurality of annular grooves;

[0005] A thermochromic silicone ring is fitted into each of the annular grooves.

[0006] A lid is located on top of the box body, and the bottom surface of the lid has a protrusion corresponding to the groove.

[0007] This invention uses a thermochromic silicone ring to indicate temperature changes. The thermochromic silicone ring is fitted onto a groove on the outer wall of the box. Even if the thermochromic silicone ring is damaged, it will not pollute the environment or affect the normal use of the box itself. Furthermore, the thermochromic silicone ring is replaceable.

[0008] Furthermore, an annular anti-slip groove is also provided below the annular groove. The beneficial effect of this step is that the annular anti-slip groove mainly serves to prevent slipping.

[0009] Furthermore: the box body is made of aluminum alloy, and the surface of the box body is provided with an anodized layer. The beneficial effect of this step is that the box body itself has cold storage capacity, which can maintain a low temperature for a short time and play the role of temporarily storing PCR tubes.

[0010] Furthermore: the inner side wall of the box lid is provided with a number of protrusions, and the box body is provided with a limiting groove corresponding to the position of the protrusions;

[0011] The lid is made of transparent plastic. The benefits of this step are: it ensures that the lid and the box body can be tightly connected, and that the protrusion inside the lid presses down on the PCR tube cap.

[0012] Furthermore, the grooves are arranged in an array of 8*12 or 16*24. The advantage of this step is that it can be selected according to the number of samples.

[0013] Furthermore, the bottom surface of the box is provided with a support ring, which has the beneficial effect of reducing the contact area between the box and the table surface.

[0014] The beneficial effects of this utility model are:

[0015] 1. This application can reflect the current temperature of the box body through a temperature-sensitive color-changing silicone ring;

[0016] 2. This application can distinguish whether a sample is stored for a short period or for a long period by the number of annular grooves;

[0017] 3. The protrusion on the lid can press down on the top of the PCR tube to secure the cap, preventing the cap from coming off.

[0018] 4. The annular anti-slip groove serves to prevent slipping and sticking. Attached Figure Description

[0019] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0020] Figure 1 A perspective view of a PCR tube cryopreservation box provided by this utility model;

[0021] Figure 2 A schematic diagram of the structure of a PCR tube cryopreservation box provided by this utility model;

[0022] Figure 3 for Figure 2 The left view;

[0023] Figure 4 for Figure 3 Sectional view along the AA direction.

[0024] Figure label:

[0025] 1-Box body; 2-Box lid; 3-Temperature-sensitive color-changing silicone ring;

[0026] 11-Annular groove; 12-Annular anti-slip groove; 13-Groove; 14-Support ring; 21-Protrusion. Detailed Implementation

[0027] The embodiments of the present invention will now be described in detail with reference to the accompanying drawings. These embodiments are merely illustrative of the present invention and should not be construed as limiting the scope of protection of the present invention.

[0028] It should be noted that, unless otherwise stated, the technical or scientific terms used in this application shall have the ordinary meaning as understood by one of ordinary skill in the art to which this utility model pertains.

[0029] Implementation of this application, for example Figures 1-4 As shown, this utility model provides a PCR tube cryopreservation box.

[0030] This application includes: a box body 1, the top surface of which has a plurality of arrayed grooves 13, and the side wall of which has a plurality of annular grooves 11; PCR tubes are placed in the grooves 13 and are generally stored in a low temperature environment of -20°C.

[0031] Thermochromic silicone rings 3 are fitted into each of the annular grooves 11. Thermochromic silicone rings 3 are made by dispersing thermochromic powder in hot-melt silicone, and then injection molding or extruding the hot-melt silicone into a ring shape. Generally, they are adapted to fit the annular grooves 11, and their circumference can be slightly smaller than the circumference of the annular grooves 11. The silicone has a certain degree of elasticity and can be elastically stretched. Thermochromic powder is made by placing thermosensitive material in microcapsules. The thermosensitive material has the ability to change color with temperature gradient, which is a mature existing technology.

[0032] The lid 2 is located above the box body 1. The bottom surface of the lid 2 has a protrusion 21 corresponding to the groove 13. When the lid 2 is fastened to the box body 1, the position of the protrusion 21 corresponds to the PCR tube. Generally, a PCR tube includes a tube body and a cap connected to the tube body. However, sometimes the cap and the tube body are not fastened tightly, which can cause the contents to deteriorate. Therefore, when the lid 2 is fastened to the box body 1, the protrusion 21 can squeeze the cap to ensure that the cap and the tube body of the PCR tube are tightly fastened to prevent leakage.

[0033] This invention uses a thermochromic silicone ring 3 to indicate temperature changes. The thermochromic silicone ring 3 is fitted onto a groove on the outer wall of the box 1. Even if the thermochromic silicone ring 3 is damaged, it will not pollute the environment or affect the normal use of the box 1 itself. Furthermore, the thermochromic silicone ring 3 is replaceable.

[0034] In addition, the number of annular grooves 11 can be set to different numbers. For example, one annular groove 11 indicates that the cryopreservation box is used for short-term sample preservation, two annular grooves 11 indicate that the cryopreservation box is used for medium-term sample preservation, and three annular grooves 11 indicate that the cryopreservation box is used for long-term sample preservation. Operators can intuitively determine the duration of sample preservation in the cryopreservation box based on the number of annular grooves 11, which can improve storage and retrieval efficiency.

[0035] Based on the above technical solution, an annular anti-slip groove 12 is also provided below the annular groove 11. The cross-section of the annular anti-slip groove 12 is serrated. The annular anti-slip groove 12 serves to prevent slipping and sticking. These two effects seem contradictory, but they are actually due to the difference caused by the cryopreservation box being at different temperatures. Under normal operating conditions, operators need to wear gloves. The surface of the gloves is smooth. In a normal temperature environment, the friction between the gloves and the smooth surface of the box 1 is small. The serration can increase the friction and achieve anti-slip. However, when taking out the cryopreservation box stored at low temperature, after the operator takes the cryopreservation box away from the low temperature environment, the low temperature of the cryopreservation box will cause the moisture in the air to condense into ice, sticking the operator's gloves to the cryopreservation box and making it difficult to separate. The serrated annular anti-slip groove 12 reduces the contact area between the two, making them easier to separate.

[0036] Based on the above technical solution, the box body 1 is made of aluminum alloy, and the surface of the box body 1 is provided with an anodized layer. Aluminum alloy has a larger specific heat capacity than plastic, and its ability to maintain low temperature after leaving the low temperature environment is stronger than that of plastic. It has a certain cold storage capacity and can maintain low temperature for a short time, thus playing the role of temporarily storing PCR tubes. The anodized layer can act as a protective film, and the anodized layer can also be set to different colors, which can also distinguish the cryopreservation boxes.

[0037] Based on the above technical solution, the inner side wall of the box cover 2 is provided with a number of protrusions, and the box body 1 is provided with a limiting groove corresponding to the position of the protrusions;

[0038] The lid 2 is made of transparent plastic, allowing observation of the storage status of the PCR tubes inside. The lid 2 also has a certain degree of elasticity. When the protrusion is pressed against the side wall of the box body 1, the side wall of the lid 2 can open slightly until the protrusion is inserted into the limiting groove and squeezed. The lid 2 then returns to its shape, ensuring that the lid 2 and the box body 1 can be tightly connected and that the protrusion 21 inside the lid 2 presses down on the PCR tube cap.

[0039] Based on the above technical solution, the groove 13 is set with an array number of 8*12 or 16*24, which can be selected according to the number of samples.

[0040] Based on the above technical solution, the bottom surface of the box 1 is provided with a support ring 14. Generally, clean benches are mirrored. When the low-temperature box 1 is placed on the clean bench, the moisture in the air will condense between the bottom of the box 1 and the clean bench, sticking the two together. Therefore, the support ring 14 is used to reduce the contact area between the box 1 and the clean bench, reduce the adhesive force, and separate the box 1 and the clean bench.

[0041] In the above content, this application can not only determine the current temperature of the cryopreservation box by color, but also determine the storage period of the cryopreservation box by the number of annular grooves 11.

[0042] Numerous specific details are set forth in this specification. However, it will be understood that embodiments of this invention may be practiced without these specific details. In some instances, well-known methods, structures, and techniques have not been shown in detail so as not to obscure the understanding of this specification. In the description of this specification, references to the terms "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Furthermore, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of the different embodiments or examples.

[0043] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and not to limit it. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this utility model, and they should all be covered within the scope of the claims and specification of this utility model.

Claims

1. A PCR tube cryo box, characterized in that, include: The box has several arrayed grooves on its top surface and several annular grooves on its side walls. A thermochromic silicone ring is fitted into each of the annular grooves. A lid is located on top of the box body, and the bottom surface of the lid has a protrusion corresponding to the groove.

2. The PCR tube freezer box according to claim 1, characterized in that, Below the annular groove, there is also an annular anti-slip groove.

3. The PCR tube freezer box of claim 1, wherein, The box is made of aluminum alloy, and the surface of the box is covered with an anodized layer.

4. The PCR tube freezer box of claim 1, wherein, The inner side wall of the box lid is provided with several protrusions, and the box body is provided with a limiting groove corresponding to the position of the protrusions; The lid is made of transparent plastic.

5. The PCR tube cryopreservation box according to claim 1, characterized in that, The grooves are arranged in an array of 8*12 or 16*24.

6. The PCR tube freezer box of claim 1, wherein, The bottom surface of the box is provided with a support ring.

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