Extrusion device for producing and processing clindamycin palmitate hydrochloride granules

Abstract

This utility model relates to the field of granulated pharmaceutical production technology, and in particular to an extrusion device for the production and processing of clindamycin palmitate hydrochloride granules. It includes: a granulation tank with multiple granulation holes at its top; and an extrusion tube fixedly connected to the top of the granulation tank, with a conveying pipe fixedly connected to its surface. A perforated forming plate is fixedly installed inside the extrusion tube. This utility model uses a dual-axis motor to control the simultaneous rotation of a lead screw and a rotating shaft. The lead screw drives a moving plate, causing a piston to move downwards, extruding the raw material in the extrusion tube through the perforated forming plate and extruding it into strips. When the piston contacts the perforated forming plate, it stops moving, while the granulating blades continuously and thoroughly granulate the strip-shaped raw material. Thus, with a single dual-axis motor drive, the extrusion and granulation operations of clindamycin palmitate hydrochloride can be completed simultaneously, eliminating the need for an additional drive unit, reducing costs, and improving the practicality of the device.

Description

Technical Field

[0001] This utility model relates to the field of granular pharmaceutical production technology, and in particular to an extrusion device for the production and processing of clindamycin palmitate hydrochloride granules. Background Technology

[0002] Clindamycin palmitate hydrochloride granules are a derivative of clindamycin. They have no antibacterial activity in vitro, but exert their antibacterial activity in vivo through esterase hydrolysis to form clindamycin. Clindamycin's mechanism of action is to inhibit bacterial protein synthesis, primarily targeting Gram-positive cocci and anaerobic bacterial infections. This product has good antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Streptococcus pyogenes. It is moderately sensitive to Haemophilus influenzae and Neisseria gonorrhoeae. Some erythromycin-resistant Staphylococcus aureus and Staphylococcus epidermidis remain sensitive to this product.

[0003] Traditional extrusion devices for the production and processing of clindamycin palmitate hydrochloride granules typically involve first extruding the granules into blocks or strips using an extruder, and then using a granulation device to prepare the granules. This process involves numerous independent drive components, resulting in high costs and cumbersome operation. Therefore, this invention provides an extrusion device for the production and processing of clindamycin palmitate hydrochloride granules to solve the above problems. Utility Model Content

[0004] The purpose of this invention is to solve the problems in the background art by proposing an extrusion device for the production and processing of clindamycin palmitate hydrochloride granules.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] An extrusion apparatus for the production and processing of clindamycin palmitate hydrochloride granules, comprising:

[0007] A pelletizing tank, wherein the top of the pelletizing tank is provided with multiple pellet outlet holes;

[0008] An extrusion tube is fixedly connected to the top of the pelletizing tank, and a conveying tube is fixedly connected to the surface of the extrusion tube. A perforated forming plate is fixedly installed inside the extrusion tube.

[0009] The extrusion pelletizing assembly includes a rotating shaft rotatably mounted on the top of a pelletizing tank. Multiple pelletizing blades are fixedly mounted on the surface of the rotating shaft. A dual-axis motor for driving the rotating shaft to rotate is fixedly mounted on the top of the pelletizing tank. A lead screw is fixedly mounted on the other drive end of the dual-axis motor. A movable plate is threadedly connected to the surface of the lead screw and slides against the surface of the extrusion tube. A spring is located below the movable plate, and the lower end of the spring is fixedly mounted on the top of the pelletizing tank. A portal-shaped rod is fixedly mounted on the top of the movable plate, and a piston is fixedly mounted on the other end of the portal-shaped rod, and the piston is airtightly fitted against the inner surface of the extrusion tube.

[0010] Preferably, a plurality of cooling tubes are fixedly installed inside the extrusion tube, and the cooling tubes are positioned below the perforated forming plate.

[0011] Preferably, the top of the pelletizing tank is fixedly connected to a feed hopper.

[0012] Preferably, a support plate is rotatably mounted on the top of the lead screw, and the support plate is slidably sleeved on the portal rod and fixedly mounted on the surface of the extrusion tube.

[0013] Preferably, the end of the movable plate is provided with an arc surface, and the arc surface matches the extrusion tube.

[0014] Compared with existing technologies, the extrusion device for producing and processing clindamycin palmitate hydrochloride granules provided by this utility model has the following advantages:

[0015] This invention utilizes a dual-axis motor to control the simultaneous rotation of a lead screw and a rotating shaft. The lead screw drives a moving plate, causing the piston to move downwards. This forces the raw material in the extrusion tube through a perforated forming plate and extrudes it into strips. When the piston contacts the perforated forming plate, the moving plate disengages from the threaded connection with the lead screw, at which point the piston stops moving. Meanwhile, the rotating shaft continues to drive the pelletizing blades to rotate, thoroughly pelletizing the strip-shaped raw material. Thus, with a single dual-axis motor drive, the extrusion and pelletizing operations of clindamycin palmitate hydrochloride can be completed simultaneously, eliminating the need for additional drive components, reducing costs, and improving the practicality of the device. Attached Figure Description

[0016] Fig. 1 This is a cross-sectional structural schematic diagram of the extrusion device for the production and processing of clindamycin palmitate hydrochloride granules proposed in this utility model.

[0017] Fig. 2 This is a schematic diagram of the extrusion device for the production and processing of clindamycin palmitate hydrochloride granules proposed in this utility model.

[0018] Fig. 3 This is a schematic diagram of the structure of the extrusion device for the production and processing of clindamycin palmitate hydrochloride granules proposed in this utility model after the piston moves.

[0019] In the diagram: 1 pelletizing tank, 2 extrusion tube, 3 conveying tube, 4 perforated forming plate, 5 rotating shaft, 6 pelletizing blade, 7 dual-axis motor, 8 lead screw, 9 moving plate, 10 spring, 11 gantry rod, 12 piston, 13 refrigeration pipe, 14 hopper, 15 support plate. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0021] Reference Figs. 1 to 3 An extrusion apparatus for the production and processing of clindamycin palmitate hydrochloride granules, comprising:

[0022] The pelletizing tank 1 has multiple pellet discharge holes on its top, and a feeding hopper 14 is fixedly connected to the top of the pelletizing tank 1 to facilitate centralized discharge.

[0023] The extrusion tube 2 is fixedly connected to the top of the pelletizing tank 1, and the surface of the extrusion tube 2 is fixedly connected to the conveying tube 3. A perforated forming plate 4 is fixedly installed inside the extrusion tube 2, and multiple cooling tubes 13 are fixedly installed inside the extrusion tube 2. The cooling tubes 13 are placed below the perforated forming plate 4, which can cool the extruded strip material, which is conducive to rapid shaping and convenient subsequent pelletizing.

[0024] The extrusion pelletizing assembly includes a rotating shaft 5 rotatably mounted on the top of the pelletizing tank 1. Multiple pelletizing blades 6 are fixedly mounted on the surface of the rotating shaft 5. A dual-axis motor 7 for driving the rotating shaft 5 to rotate is fixedly mounted on the top of the pelletizing tank 1. A lead screw 8 is fixedly mounted on the other drive end of the dual-axis motor 7. A support plate 15 is rotatably mounted on the top of the lead screw 8. The support plate 15 is slidably sleeved on the portal rod 11 and fixedly mounted on the surface of the extrusion tube 2 to ensure the stability of the rotation of the lead screw 8.

[0025] The screw 8 is threadedly connected to a movable plate 9, which slides against the surface of the extrusion tube 2. The end of the movable plate 9 is provided with an arc surface that matches the extrusion tube 2. The threads on the surface of the screw 8 are only partially present and do not cover the entire screw body. This allows the dual-axis motor 7 to continue to start and control the pelletizing blade 6 to rotate continuously when the movable plate 9 moves down and disengages from the threads on the screw 8, thus performing full pelletizing.

[0026] A spring 10 is provided below the moving plate 9, and the lower end of the spring 10 is fixedly installed on the top of the pelletizing tank 1. A gate-shaped rod 11 is fixedly installed on the top of the moving plate 9, and a piston 12 is fixedly installed on the other end of the gate-shaped rod 11. The piston 12 is airtightly fitted to the inner surface of the extrusion tube 2.

[0027] The working principle of this utility model is as follows:

[0028] In use, the raw materials for preparing clindamycin palmitate hydrochloride granules are conveyed to the extrusion tube 2 through the conveying pipe 3. Then, the dual-shaft motor 7 is started to control the rotation shaft 5 and the lead screw 8 to rotate. The lead screw 8 drives the piston 12 to move down through the moving plate 9 and the gate rod 11, and squeezes the spring 10 to extrude the raw materials in the extrusion tube 2 into strip-shaped materials through the perforated forming plate.

[0029] At this time, the rotating shaft 5 drives multiple pelletizing blades 6 to rotate, which can pelletize the strip material. At the same time, the lead screw 8 drives the moving plate 9 to move down and disengage from the threaded connection with the lead screw 8, so that the piston 12 no longer moves down. However, the dual-shaft motor 7 will continue to drive each pelletizing blade 6 to perform a full pelletizing operation. Finally, clindamycin palmitate hydrochloride granules are produced and discharged through the pellet outlet through the hopper 14.

[0030] After granulation is completed, the dual-shaft motor 7 controls the lead screw 8 to reverse. At this time, the spring 10 pushes the moving plate 9 upward to re-engage with the lead screw 8, so that the moving plate 9 moves upward again and drives the piston 12 to move upward and reset.

[0031] To further clarify, the aforementioned fixed connection should be interpreted broadly unless otherwise explicitly specified and limited. For example, it may be welding, gluing, or integral molding, or other conventional methods well known to those skilled in the art.

[0032] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. An extrusion apparatus for producing clindamycin palmitate hydrochloride granules, characterized in that, include: A pelletizing tank (1) is provided with multiple pellet outlet holes at the top; An extrusion tube (2) is fixedly connected to the top of the pelletizing tank (1), and a conveying tube (3) is fixedly connected to the surface of the extrusion tube (2). A perforated forming plate (4) is fixedly installed inside the extrusion tube (2). The extrusion pelletizing assembly includes a rotating shaft (5) rotatably mounted on the top of the pelletizing tank (1). Multiple pelletizing blades (6) are fixedly mounted on the surface of the rotating shaft (5). A dual-axis motor (7) for driving the rotating shaft (5) to rotate is fixedly mounted on the top of the pelletizing tank (1). A lead screw (8) is fixedly mounted on the other drive end of the dual-axis motor (7). A movable plate (9) is threadedly connected to the surface of the lead screw (8). The movable plate (9) slides against the surface of the extrusion tube (2). A spring (10) is provided below the movable plate (9). The lower end of the spring (10) is fixedly mounted on the top of the pelletizing tank (1). A gate-shaped rod (11) is fixedly mounted on the top of the movable plate (9). A piston (12) is fixedly mounted on the other end of the gate-shaped rod (11). The piston (12) is airtightly attached to the inner surface of the extrusion tube (2).

2. The extrusion apparatus for producing clindamycin palmitate hydrochloride granules according to claim 1, characterized in that, Multiple cooling tubes (13) are fixedly installed inside the extrusion tube (2), and the cooling tubes (13) are placed below the perforated forming plate (4).

3. The extrusion apparatus for producing clindamycin palmitate hydrochloride granules according to claim 1, characterized in that, The top of the pelletizing tank (1) is fixedly connected to the feed hopper (14).

4. The extrusion apparatus for producing clindamycin palmitate hydrochloride granules according to claim 1, characterized in that, The top of the lead screw (8) is rotatably mounted with a bracket plate (15), and the bracket plate (15) is slidably sleeved on the portal rod (11) and fixedly installed on the surface of the extrusion tube (2).

5. The extrusion apparatus for producing clindamycin palmitate hydrochloride granules according to claim 1, characterized in that, The end of the movable plate (9) is provided with an arc surface, and the arc surface matches the extrusion tube (2).

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