A polypeptide synthesis reactor set combination docking mechanism

Abstract

The utility model relates to polypeptide processing technical field discloses a kind of polypeptide synthesis reactor combined docking mechanism, including shell, the inner wall of shell is fixedly connected with connecting plate, the inside of shell is equipped with flow subassembly, the upper end surface of shell is penetrated and is equipped with control component, and the circumferential side of shell is penetrated and is equipped with the connecting component for connecting reactor;Flow subassembly includes the flow channel of being opened in the inner wall of connecting plate, the inner wall of connecting plate is equipped with cavity, the inner wall of cavity is equipped with several through holes, several through holes are slidably connected with slide bar, the outer surface of slide bar is fixedly connected with spring, the outer surface of each spring is equipped with electromagnetic ring;The cooperation of contact switch in control component and electromagnetic ring, the intelligent management of flow control is realized, greatly improve the material management ability in polypeptide synthesis process, reduce artificial intervention, improve production efficiency and the stability of reactor docking.

Description

Technical Field

[0001] This utility model relates to the field of peptide processing technology, and more specifically, to a peptide synthesis reactor assembly docking mechanism. Background Technology

[0002] Peptides are linear molecules composed of amino acids linked by peptide bonds. They widely participate in biological processes such as signal transduction, immune regulation, and enzyme catalysis, exhibiting significant biological activity and application value. With the rapid development of industries such as biomedicine, food processing, and cosmetics, peptide synthesis and processing technologies have received widespread attention. Common peptide synthesis methods include solid-phase synthesis, liquid-phase synthesis, and enzyme-catalyzed synthesis. These methods typically require continuous amino acid condensation and subsequent processing steps within a specific reaction environment. Therefore, peptide synthesis reactors, as reaction carrier equipment, are one of the key devices in the peptide production process. To achieve process continuity and modularity of the reaction process, multiple reactors are often combined in actual production to complete multi-stage synthesis tasks.

[0003] In existing technologies, multiple reactors are usually connected by mechanical links or fluid joints. However, existing connection structures generally suffer from problems such as low connection accuracy, unstable sealing performance, and low fluid control efficiency. In particular, when multiple reactors are used in parallel or series connection, the flow of materials between reactors is difficult to control precisely, and errors in material flow direction are prone to occur. This not only affects the reaction effect and product purity, but also restricts the synthesis efficiency and the level of production automation.

[0004] Therefore, there is a need to provide a docking mechanism for peptide synthesis reactors to solve the problem of material flow errors that easily occur between existing reactors. Utility Model Content

[0005] The main objective of this invention is to provide a docking mechanism for a polypeptide synthesis reactor, which aims to solve the technical problems mentioned in the background section.

[0006] The present invention adopts the following technical solution:

[0007] A docking mechanism for a polypeptide synthesis reactor includes: a shell, a connecting plate fixedly connected to the inner wall of the shell, a flow component disposed inside the shell, a control component penetrating the upper end face of the shell, and a connecting component for connecting the reactor penetrating the periphery of the shell.

[0008] The flow component includes a flow channel formed in the inner wall of a connecting plate. The inner wall of the connecting plate has a cavity, and the inner wall of the cavity has several through holes. Each of the several through holes is slidably connected to a slide rod. The outer surface of each slide rod is fixedly connected to a spring, and each spring has an electromagnetic ring sleeved on its outer surface.

[0009] Furthermore, push blocks are fixedly connected to the ends of the two sets of sliding rods that are close to each other, and sealing plates are fixedly connected to the ends of the two sets of sliding rods that are far apart from each other.

[0010] Furthermore, the connecting assembly includes a set of connectors mounted on the outer surface of the connecting plate, with the ends of the two sets of connectors located away from each other penetrating the housing and extending to the outside of the housing.

[0011] Furthermore, the control component includes a connecting ring mounted on the upper surface of the housing, and a set of contact switches are fixedly connected to the upper surface of the connecting ring.

[0012] Furthermore, sealing plugs are fixedly connected to the opposite sides of the two sets of sealing plates, and the two sets of sealing plugs respectively contact the inner walls of the two sets of connectors.

[0013] Furthermore, each of the connectors has a fixing ring fixedly connected to its outer surface, and the two sets of fixing rings are fixedly connected to the outer surface of the housing on their adjacent sides.

[0014] Furthermore, a pull rod is fixedly connected to the upper surface of the housing, and a pull block is fixedly connected to the upper surface of the pull rod.

[0015] Furthermore, two sets of mounting brackets are provided at the bottom of the housing, and the upper surface of each mounting bracket is fixedly connected to the bottom surface of the housing.

[0016] Beneficial effects:

[0017] This invention provides a docking mechanism for a peptide synthesis reactor assembly. Through the connection of the connector to the reactor, a tight connection between reactors is ensured, preventing material loss or cross-contamination. The flow channel, slide bar, and electromagnetic ring structure of the flow assembly control the material flow, preventing misalignment of materials between different reactors. When material flow is initiated, pressing the contact switch releases the electromagnetic ring from the push block, the spring moves the slide bar, and the sealing plate opens, allowing material to flow into the reactor through the flow channel, effectively preventing incorrect material flow. Furthermore, the cooperation between the contact switch and the electromagnetic ring in the control assembly enables intelligent management of flow control, greatly improving material management capabilities during peptide synthesis, reducing manual intervention, and increasing production efficiency and reactor docking stability. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of a combined docking mechanism for a polypeptide synthesis reactor according to this utility model;

[0019] Figure 2 This is a top view cross-sectional structural diagram of the present invention;

[0020] Figure 3 yes Figure 2 Enlarged structural diagram at point A;

[0021] Figure 4 This is an exploded structural diagram of the flow component of this utility model;

[0022] The components are: 1. Housing; 101. Connecting plate; 2. Connecting assembly; 201. Connector; 202. Fixing ring; 3. Control assembly; 301. Connecting ring; 302. Contact switch; 4. Pull rod; 401. Pull block; 5. Mounting bracket; 6. Flow assembly; 601. Flow channel; 602. Sealing plate; 603. Cavity; 604. Slide rod; 605. Through hole; 606. Push block; 607. Electromagnetic ring; 608. Spring; 609. Sealing plug.

[0023] The realization of the purpose, functional features and advantages of this utility model will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0024] It should be understood that the specific embodiments described herein are merely illustrative of the present invention and are not intended to limit the present invention.

[0025] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined with "first" or "second" may explicitly or implicitly include one or more of the stated features. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0026] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection, a direct connection, or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0027] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0028] Reference Figures 1 to 4 This utility model proposes a docking mechanism for a polypeptide synthesis reactor, comprising: a shell 1, a connecting plate 101 fixedly connected to the inner wall of the shell 1, a flow component 6 provided inside the shell 1, a control component 3 penetrating the upper end face of the shell 1, and a connecting component 2 for connecting the reactor penetrating the periphery of the shell 1.

[0029] The flow component 6 includes a flow channel 601 formed in the inner wall of the connecting plate 101. The inner wall of the connecting plate 101 has a cavity 603. The inner wall of the cavity 603 has a plurality of through holes 605. Each of the plurality of through holes 605 is slidably connected to a slide rod 604. The outer surface of each slide rod 604 is fixedly connected to a spring 608. Each spring has an electromagnetic ring 607 sleeved on its outer surface.

[0030] In the above embodiment, a connecting plate 101 is fixedly connected to the inner wall of the shell 1. A flow assembly 6 is disposed inside the shell 1, a control assembly 3 is disposed through the upper end face, and a connecting assembly 2 for connecting to the reactor is disposed through the periphery. The flow assembly 6 includes a flow channel 601 formed in the inner wall of the connecting plate 101. A cavity 603 is also formed in the inner wall of the connecting plate 101. A plurality of through holes 605 are provided in the inner wall of the cavity 603. A slide rod 604 is slidably connected in each through hole 605. A spring 608 is fixedly connected to the outer surface of the slide rod 604, and an electromagnetic ring 607 is sleeved on the outer surface of the spring 608. The shell 1 serves as the main supporting structure, with the connecting plate 101 fixed to its inner wall to support the flow assembly 6 and the connecting assembly 2. The flow channel 601 serves as a material transfer channel to ensure precise flow of materials between reactors. The cavity 603 and through-hole 605 allow the slide bar 604 to slide within them. The spring 608 provides the elastic force for the slide bar 604 to move. The electromagnetic ring 607 controls the position of the slide bar 604 by energizing or de-energizing it, thereby adjusting the opening and closing state of the flow channel 601. When the electromagnetic ring 607 is energized, it holds the slide bar 604 in place, keeping the flow channel 601 closed. When de-energized, the spring 608 pushes the slide bar 604 to open the flow channel 601, allowing material to flow. The cooperation of the electromagnetic ring 607 and the spring 608 achieves precise control of material flow, preventing cross-flow or leakage and improving the stability of peptide synthesis. The connecting component 2 docks with the external reactor to ensure a sealed connection, while the control component 3 facilitates operator adjustment of the flow state. The entire mechanism is compact, easy to operate, and suitable for material management between multiple reactors in peptide synthesis.

[0031] refer to Figure 3 In one embodiment, push blocks 606 are fixedly connected to the ends of the two sets of sliding rods 604 that are close to each other, and sealing plates 602 are fixedly connected to the ends of the two sets of sliding rods 604 that are far apart from each other.

[0032] In the above embodiment, two sets of opposing slide rods 604 are fixedly connected to a push block 606 at one end and a sealing plate 602 at the other end. The push block 606 and the sealing plate 602 are respectively installed at both ends of the slide rod 604. The push block 606 is located inside the cavity 603, near the center of the flow channel 601, and the sealing plate 602 is located near the side of the connecting assembly 2. The push block 606 interacts with the electromagnetic ring 607. When the electromagnetic ring 607 is energized, it attracts the push block 606, keeping the slide rod 604 fixed, and the sealing plate 602 tightly closes the flow channel 601, preventing material flow. After the power is turned off, the spring 608 pushes the slide rod 604, causing the push block 606 and the sealing plate 602 to move synchronously. The sealing plate 602 leaves the port of the flow channel 601, and the material enters the connecting assembly 2 through the flow channel 601. Through the coordinated work of the push block 606 and the sealing plate 602, the reliability of the opening and closing of the flow channel 601 is enhanced. The sealing plate 602 is made of a high-sealing material and fits tightly with the port of the flow channel 601 to ensure no material leakage when closed.

[0033] refer to Figure 1 In one example, the connecting assembly 2 includes a set of connectors 201 mounted on the outer surface of the connecting plate 101, with the ends of the two sets of connectors 201 that are far apart from each other penetrating the housing 1 and extending to the outside of the housing 1.

[0034] In the above embodiment, connector 201, serving as the connection between the reactor and the shell 1, is made of a corrosion-resistant and high-strength material. One end is fixed to the connecting plate 101 to ensure accurate alignment with the flow channel 601, while the other end extends to the outside of the shell 1, connecting to an external reactor via a standard interface. The inner diameter of connector 201 matches the flow channel 601 to ensure smooth material flow, and the external interface is designed with a sealing ring to prevent material leakage or the entry of external impurities. The portion of connector 201 penetrating the shell 1 is fixed by welding or threading to ensure stability during long-term use. In practical applications, operators mate the reactor interface with connector 201, relying on the extension structure of connector 201 to achieve quick installation and disassembly.

[0035] refer to Figure 1 In one embodiment, the control component 3 includes a connecting ring 301 mounted on the upper surface of the housing 1, and a set of contact switches 302 are fixedly connected to the upper surface of the connecting ring 301.

[0036] In the above embodiment, the connecting ring 301 is fixed to the upper surface of the housing 1, serving to support the contact switch 302. The contact switch 302 is connected to the electromagnetic ring 607 via a wire. By pressing the contact switch 302, the operator can control the energization or de-energization of the electromagnetic ring 607, thereby indirectly adjusting the movement of the slide rod 604 and the sealing plate 602. The annular structure of the connecting ring 301 facilitates installation on the top of the housing 1 without occupying additional space, while ensuring the stability of the contact switch 302 and preventing accidental activation. In actual operation, pressing the contact switch 302 de-energizes the electromagnetic ring 607, and the spring 608 pushes the slide rod 604 to move, opening the flow channel 601; pressing it again energizes the electromagnetic ring 607, attracting the slide rod 604 and closing the flow channel 601.

[0037] refer to Figure 4 In one embodiment, sealing plugs 609 are fixedly connected to the opposite sides of the two sets of sealing plates 602, and the two sets of sealing plugs 609 are in contact with the inner walls of the two sets of connectors 201 respectively.

[0038] In the above embodiments, the sealing plug 609 is made of highly elastic, corrosion-resistant rubber or silicone material and is fixed to the outside of the sealing plate 602. Its outer diameter precisely matches the inner wall of the connector 201, forming a tight sealing contact. When the sealing plate 602 closes the flow channel 601 under the action of the slide rod 604, the sealing plug 609 is embedded in the inner wall of the connector 201, further enhancing the sealing effect and preventing material leakage through the connector 201.

[0039] In one embodiment, each connector 201 has a fixing ring 202 fixedly connected to its outer surface, and the two sets of fixing rings 202 are fixedly connected to the outer surface of the housing 1 on their sides that are close to each other.

[0040] In the above embodiment, the retaining ring 202 surrounds the outer surface of the connector 201 and is fixed to the connector 201 by welding or bolts. Its inner side is tightly connected to the outer surface of the shell 1, enhancing the installation stability of the connector 201. The retaining ring 202 effectively distributes the force on the connector 201 when docking with the reactor, preventing the connector 201 from loosening or deforming due to long-term use. The outer diameter of the retaining ring 202 is larger than that of the connector 201, making it easier for operators to position it during installation. At the same time, its fixed connection with the shell 1 ensures the long-term alignment accuracy of the connector 201 and the flow channel 601. In practical applications, the stabilizing effect of the retaining ring 202 enables the connector 201 to withstand frequent reactor docking operations, making it particularly suitable for high-intensity production environments.

[0041] In one embodiment, a pull rod 4 is fixedly connected to the upper surface of the housing 1, and a pull rod 4 is fixedly connected to the upper surface of the pull rod 4.

[0042] In the above embodiment, the pull rod 4 is fixed to the upper surface of the housing 1 by welding or bolting, extending vertically upwards. The pull block 401 is fixed to the top of the pull rod 4, forming a block structure that is easy to grip, and its surface can be coated with an anti-slip texture. The pull rod 4 and pull block 401 facilitate the operator's movement or adjustment of the position of the housing 1, especially in multi-reactor groups.

[0043] In one embodiment, two sets of mounting brackets 5 are provided below the housing 1, and the upper surface of each mounting bracket 5 is fixedly connected to the bottom surface of the housing 1.

[0044] In the above embodiments, the upper surface of the mounting bracket 5 is fixed to the bottom surface of the housing 1 by bolts or welding, ensuring the stability of the housing 1 during operation. Two sets of mounting brackets 5 are symmetrically distributed at the bottom of the housing 1, increasing the overall load-bearing capacity and anti-overturning ability of the structure. Anti-slip pads or fixing holes can be added to the bottom surface of the mounting bracket 5 for easy fixing to the ground or equipment platform on the production site. In practical applications, the mounting brackets 5 allow the housing 1 to adapt to different installation environments. In peptide synthesis equipment requiring long-term operation, the stabilizing effect of the mounting brackets 5 effectively reduces the impact of vibration or displacement on the reactor docking accuracy.

[0045] The above description is only a preferred embodiment of the present utility model and does not limit the patent scope of the present utility model. Any equivalent structural or procedural transformations made based on the content of the present utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of the present utility model.

Claims

1. A docking mechanism for a polypeptide synthesis reactor, characterized in that, Includes a shell (1), the inner wall of the shell (1) is fixedly connected to a connecting plate (101), the interior of the shell (1) is provided with a flow component (6), the upper end face of the shell (1) is provided with a control component (3), and the periphery of the shell (1) is provided with a connecting component (2) for connecting to the reactor. The flow component (6) includes a flow channel (601) formed on the inner wall of the connecting plate (101). The inner wall of the connecting plate (101) is provided with a cavity (603). The inner wall of the cavity (603) is provided with a plurality of through holes (605). Each of the plurality of through holes (605) is slidably connected to a slide rod (604). The outer surface of each slide rod (604) is fixedly connected to a spring (608). Each spring (608) is fitted with an electromagnetic ring (607) on its outer surface.

2. The polypeptide synthesis reactor combined docking mechanism according to claim 1, characterized in that, Push blocks (606) are fixedly connected to the ends of the two sets of sliding rods (604) that are close to each other, and sealing plates (602) are fixedly connected to the ends of the two sets of sliding rods (604) that are far apart from each other.

3. The polypeptide synthesis reactor combined docking mechanism according to claim 1, characterized in that, The connecting assembly (2) includes a set of connectors (201) mounted on the outer surface of the connecting plate (101), with the ends of the two sets of connectors (201) being far apart from each other, both penetrating the housing (1) and extending to the outside of the housing (1).

4. The polypeptide synthesis reactor combined docking mechanism according to claim 1, characterized in that, The control component (3) includes a connecting ring (301) mounted on the upper surface of the housing (1), and a set of contact switches (302) are fixedly connected to the upper surface of the connecting ring (301).

5. The polypeptide synthesis reactor combined docking mechanism according to claim 2, characterized in that, Both sets of sealing plates (602) have sealing plugs (609) fixedly connected to their opposite sides, and the two sets of sealing plugs (609) are in contact with the inner walls of the two sets of connectors (201).

6. The polypeptide synthesis reactor combined docking mechanism according to claim 5, characterized in that, Each of the connectors (201) has a fixing ring (202) fixedly connected to its outer surface, and the two sets of fixing rings (202) are fixedly connected to the outer surface of the housing (1) on their sides that are close to each other.

7. The polypeptide synthesis reactor combined docking mechanism according to claim 1, characterized in that, A pull rod (4) is fixedly connected to the upper surface of the housing (1), and a pull block (401) is fixedly connected to the upper surface of the pull rod (4).

8. The polypeptide synthesis reactor combined docking mechanism according to claim 1, characterized in that, Two sets of mounting brackets (5) are provided below the housing (1), and the upper surface of each mounting bracket (5) is fixedly connected to the bottom surface of the housing (1).

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